Mee 2015 / Mahadum Jinan, wdg / International Journal of Oncology

Nchịkọta / Wu Tingyao

Nguzogide mkpụrụ ndụ kansa na ọtụtụ ọgwụ chemotherapeutic na-eme ka ọgwụgwọ ọrịa kansa sie ike.Otu n'ime isi ihe kpatara mkpụrụ ndụ kansa ji etolite nguzogide ọgwụ dị iche iche bụ na protein ABCB1 (ATP-binding cassette sub-family B member 1) n'elu cell ga-achụpụ ọgwụ n'ime cell, na-eme ka ọgwụ na-ezughị ezu na mkpụrụ ndụ gbuo. mkpụrụ ndụ cancer.

Dị ka nchọpụta nke Mahadum Jinan na ndị ọzọ bipụtara, otu triterpenoid "ganoderenic acid B" dịpụrụ adịpụ.Ganoderma lucidumnwere ike ịhazi mkpụrụ ndụ ihe nketa nke protein na-eguzogide ọgwụ ABCB1, belata ọkwa okwu ya, ma n'otu oge ahụ gbochie ọrụ ABCB1 ATPase, na-egbochi ABCB1 ịrụ ọrụ ya nke "ịchụpụ chemotherapeutics na cell."

Site n'ịzụlite ganoderenic acid B na ahịrị mkpụrụ ndụ cancer imeju na-eguzogide ọgwụ HepG2/ADM ọnụ, ọgwụ chemotherapeutic (rhodamine-123) nke e gbochiri na mbụ nwere ike ịbanye n'ime mkpụrụ ndụ kansa ma gbakọta nnukwu ego n'ebe ahụ.Ganoderenic acid B nwere ike inye aka n'ezie ịbawanye mmetụta na-egbu egbu nke doxorubicin, vincristine na paclitaxel megide HepG2/ADM na-eguzogide ọgwụ na ọbụna kwalite mmetụta ọgwụgwọ nke doxorubicin megide eriri mkpụrụ ndụ cancer ara na-eguzogide ọgwụ MCF-7/ADR.

N'oge gara aga, ọmụmụ na Taiwan kwadoro site na nyocha cell na anụmanụ nke ethanol wepụGanoderma ọrịa(triterpenoid total extract) nwere ike melite mmetụta ọgwụgwọ nke ọgwụ chemotherapeutic megide mkpụrụ ndụ cancer akpa ume na-eguzogide ọgwụ (Evid. Based compiement alternat Med. 2012; 2012: 371286).Ugbu a nnwale nke Mahadum Jinan gosipụtara n'ụzọ doro anya na ganoderenic acid B dị na triterpenoids bụ ihe na-arụ ọrụ iji mebie nguzogide ọgwụ nke mkpụrụ ndụ kansa.Njikọ nke nnwale ndị a dị iche iche emeela ọrụ nkeGanodermalucidumtriterpenoids na-agbanwe nguzogide ọgwụ nke mkpụrụ ndụ kansana-abawanye doro anya.

Mmepe nke inhibitors megide protein na-eguzogide ọgwụ dị ka ABCB1 bụ ugbu a ihe mgbaru ọsọ nke mgbalị na-arụsi ọrụ ike nke obodo ahụike, ma o yiri ka ọ dịghị ezigbo ọgwụ ma (Taiwan Medical Community, 2014, 57: 15-20).Nsonaazụ nyocha nke mbụ egosila ikike ganoderenic acid B na mpaghara a, anyị na-atụkwa anya nyocha ọzọ nke anụmanụ iji nye ihe akaebe siri ike n'ọdịnihu.

[Isi iyi] Liu DL, et al.Ganoderma lucidu nwetara ganoderenic acid B na-atụgharị ABCB1 nguzogide multidrug na sel HepG2/ADM.Int J Oncol.46 (5): 2029-38 .doi: 10.3892/ij.2015.2925.

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao
Wu Tingyao na-akọ akụkọ mbụLingzhi information since 1999. O bu odeeỌgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).
 
★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede ★ Ọrụ ndị a dị n'elu enweghị ike imepụtaghachi, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke onye edemede ★ imebi okwu a dị n'elu, onye edemede ga-agbaso ọrụ iwu metụtara ya ★ The mbụ Wu Tingyao dere ederede akụkọ a n'asụsụ Chinese ma Alfred Liu sụgharịrị ya na Bekee.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.