Tsib Hlis 2015 / Jinan University, thiab lwm yam. / International Journal of Oncology

Sau / Wu Tingyao

Kev tiv thaiv ntawm cov qog nqaij hlav cancer rau ntau yam tshuaj chemotherapeutic ua rau kev kho mob qog noj ntshav nyuaj.Ib qho ntawm cov laj thawj tseem ceeb uas ua rau cov qog nqaij hlav cancer tsim ntau cov tshuaj tiv thaiv yog cov protein ABCB1 (ATP-binding cassette sub-family B tus tswv cuab 1) ntawm lub xov tooj ntawm tes yuav tshem tawm cov tshuaj tawm ntawm lub xov tooj, ua rau cov tshuaj tsis txaus hauv cov hlwb los tua. mob qog noj ntshav.

Raws li kev tshawb fawb luam tawm los ntawm Jinan University thiab lwm tus, ib qho triterpenoid "ganoderenic acid B" cais los ntawmGanoderma lucidumtuaj yeem tswj cov noob ntawm cov tshuaj tiv thaiv kab mob protein ABCB1, txo nws txoj kev qhia theem, thiab tib lub sijhawm inhibit qhov kev ua ntawm ABCB1 ATPase, tiv thaiv ABCB1 los ntawm kev ua nws txoj haujlwm ntawm "tawm cov kws khomob tawm ntawm tes."

Los ntawm kev cog qoob loo ganoderenic acid B thiab cov tshuaj tiv thaiv daim siab mob qog noj ntshav kab mob HepG2 / ADM ua ke, cov tshuaj chemotherapeutic (rhodamine-123) uas yog thawj zaug thaiv tuaj yeem nkag mus rau cov qog nqaij hlav qog noj ntshav thiab suav nrog ntau npaum li ntawd.Ganoderenic acid B tiag tiag tuaj yeem pab ua kom cov nyhuv tshuaj lom ntawm doxorubicin, vincristine thiab paclitaxel tiv thaiv cov tshuaj tiv thaiv HepG2 / ADM thiab txawm tias txhim kho cov nyhuv kho ntawm doxorubicin tiv thaiv cov tshuaj tiv thaiv kab mob qog noj ntshav mis MCF-7 / ADR.

Yav dhau los, kev tshawb fawb hauv Taiwan tau lees paub los ntawm kev sim ntawm tes thiab tsiaj txhu uas cov ethanol extract ntawmGanoderma tsugae(triterpenoid tag nrho cov extract) tuaj yeem txhim kho cov txiaj ntsig kho mob ntawm cov tshuaj chemotherapeutic tiv thaiv cov tshuaj tiv thaiv kab mob ntsws (Evid. Based compiement alternat Med. 2012; 2012: 371286).Tam sim no qhov kev sim ntawm Jinan University tau qhia meej meej tias cov ganoderenic acid B hauv triterpenoids yog cov khoom xyaw ua kom rov qab tshuaj tiv thaiv kab mob qog noj ntshav.Kev sib txuas ntawm cov kev sim sib txawv no tau ua haujlwm ntawmGanodermalucidumtriterpenoids nyob rau hauv thim rov qab tshuaj tiv thaiv ntawm cov qog nqaij hlav cancernce ntxiv pom tseeb.

Kev txhim kho ntawm inhibitors tiv thaiv cov tshuaj tiv thaiv kab mob xws li ABCB1 tam sim no yog lub hom phiaj ntawm kev mob siab rau hauv zej zog kev kho mob, tab sis zoo li tsis muaj cov tshuaj zoo tshaj plaws (Taiwan Medical Community, 2014, 57: 15-20).Cov txiaj ntsig kev tshawb fawb ua ntej tau taw qhia txog lub peev xwm ntawm ganoderenic acid B nyob rau hauv cheeb tsam no, thiab peb tos ntsoov yuav muaj kev sim tsiaj ntxiv los muab cov pov thawj muaj zog rau yav tom ntej.

[Source] Liu DL, et al.Ganoderma lucidu muab tau los ntawm ganoderenic acid B thim rov qab ABCB1-mediated multidrug resistance hauv HepG2 / ADM hlwb.Int J Oncol.46(5):2029-38.doi: 10.3892/ib.2015.2925.

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Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm thawj zaugLingzhkuv cov ntaub ntawv txij thaum 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).
 
★ Kab lus no yog luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau ★ Cov hauj lwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau txais kev tso cai los ntawm tus sau ★ Kev ua txhaum ntawm cov lus saum toj no, tus sau yuav ua raws li nws cov luag haujlwm raws cai ★ Thawj Cov ntawv ntawm tsab xov xwm no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.