NgoMeyi 2015/ IYunivesithi yaseJinan, njl./ Ijenali yeHlabathi ye-Oncology

Ukuhlanganiswa / Wu Tingyao

Ukumelana neeseli zomhlaza kumachiza amaninzi ekhemotherapeutic kwenza ukuba unyango lomhlaza lube nzima.Esinye sezizathu eziphambili zokuba kutheni iiseli zomhlaza zikhula ukumelana neziyobisi ezininzi kukuba iprotheyini i-ABCB1 (i-ATP-binding cassette sub-family member 1) kumphezulu weseli iya kukhupha amachiza ngaphandle kweseli, okubangela ukungonelanga kweziyobisi kwiiseli zokubulala. iiseli zomhlaza.

Ngokophando olupapashwe yiYunivesithi yaseJinan kunye nabanye, i-triterpenoid enye "i-ganoderenic acid B" eyodwaI-Ganoderma luciduminokulawula i-gene ye-protein yokumelana neziyobisi i-ABCB1, ukunciphisa inqanaba lokuthetha kwayo, kwaye kwangaxeshanye inqanda umsebenzi we-ABCB1 ATPase, ukuthintela i-ABCB1 ekubeni yenze umsebenzi wayo "wokugxotha i-chemotherapeutics ngaphandle kweseli."

Ngokuhlakulela i-ganoderenic acid B kunye nomgca weseli womhlaza wesibindi onganyangekiyo ngamachiza i-HepG2/ADM kunye, ichiza le-chemotherapeutic (i-rhodamine-123) elalivalwe ekuqaleni linokungena kwiiseli zomhlaza kwaye liqokelele isixa esikhulu apho.I-Ganoderenic acid B inokunceda ngenene ukunyusa isiphumo esiyityhefu se-doxorubicin, i-vincristine kunye ne-paclitaxel ngokuchasene ne-HepG2/ADM enganyangekiyo ngamachiza kwaye iphucule nesiphumo sonyango se-doxorubicin kumgca weseli yomhlaza webele onganyangekiyo ngamachiza we-MCF-7/ADR.

Kwixesha elidlulileyo, izifundo eTaiwan ziye zaqinisekisa ngovavanyo lweeseli kunye nezilwanyana ukuba isicatshulwa se-ethanolGanoderma tsugae(i-triterpenoid iyonke isicatshulwa) inokuphucula isiphumo sonyango lweziyobisi ze-chemotherapeutic ngokuchasene neeseli zomhlaza wemiphunga ezinganyangekiyo ngamachiza (Kucacile. Ngokusekelwe kwi-compiement alternat Med. 2012; 2012: 371286).Ngoku uvavanyo lweYunivesithi yaseJinan lubonise ngokucacileyo ukuba i-ganoderenic acid B kwi-triterpenoids sisithako esisebenzayo sokubuyisela umva ukunganyangeki kweziyobisi kwiiseli zomhlaza.Udibaniso lwale mifuniselo yahlukeneyo lwenze umsebenzi weI-Ganodermalucidumi-triterpenoids ekubuyiseleni umva ukunganyangeki kwechiza kwiiseli zomhlazangokwandayo ngokucacileyo.

Ukuphuhliswa kwee-inhibitors ngokuchasene neeprotheyini ezichasene neziyobisi ezifana ne-ABCB1 okwangoku yinjongo yemigudu esebenzayo yoluntu lwezonyango, kodwa kubonakala ngathi akukho mayeza afanelekileyo okwangoku (i-Taiwan Medical Community, i-2014, i-57: i-15-20).Iziphumo zophando lwangaphambili zibonise amandla e-ganoderenic acid B kule ndawo, kwaye sijonge phambili ekuqhubeleni phambili iimvavanyo zezilwanyana ukunika ubungqina obunamandla kwixesha elizayo.

[Umthombo] Liu DL, et al.I-Ganoderma lucidu evela kwi-ganoderenic acid B iguqula i-ABCB1-mediated multidrug resistance kwiiseli ze-HepG2 / ADM.Int J Oncol.46(5):2029-38.doi: 10.3892/ijo.2015.2925.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao unike ingxelo okokuqalaLingzhi ulwazi ukususela 1999. Ungumbhali weUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
 
★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali ★ Le misebenzi ingentla ayinakuphinda kuveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali ★ Ukwaphulwa kwale nkcazo ingasentla, umbhali uya kuqhuba uxanduva lwakhe lomthetho olunxulumeneyo ★ Eyokuqala umbhalo weli nqaku ubhalwe ngesiTshayina nguWu Tingyao kwaye waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.