Motšeanong 2015/ Univesithi ea Jinan, joalo-joalo/ International Journal of Oncology

Ho bokella / Wu Tingyao

Ho hanyetsa ha lisele tsa mofets'e ho litlhare tse ngata tsa chemotherapeutic ho etsa hore kalafo ea mofetše e be thata.Le leng la mabaka a ka sehloohong a etsang hore lisele tsa mofetše li hanyetse lithethefatsi tse ngata ke hore protheine ABCB1 (ATP-binding cassette sub-family B member 1) e holim'a sele e tla leleka lithethefatsi ka ntle ho sele, e leng se bakang khatello e sa lekaneng ea lithethefatsi liseleng ho bolaea. lisele tsa kankere.

Ho ea ka lipatlisiso tse hatisitsoeng ke Jinan University le ba bang, triterpenoid e le 'ngoe "ganoderenic acid B" e arohaneng leGanoderma lucidume ka laola mofuta oa protheine ea ho hanyetsa lithethefatsi ABCB1, ea fokotsa boemo ba eona ba polelo, 'me ka nako e ts'oanang ea thibela ts'ebetso ea ABCB1 ATPase, ea thibela ABCB1 ho etsa mosebetsi oa eona oa "ho leleka chemotherapeutics ka ntle ho sele."

Ka ho lema ganoderenic acid B le mohala oa lisele tsa mofetše oa sebete oa HepG2/ADM hammoho, moriana oa chemotherapeutic (rhodamine-123) o neng o koetsoe qalong o ka kena liseleng tsa mofetše mme oa bokella chelete e ngata moo.Ganoderenic acid B e hlile e ka thusa ho eketsa phello e chefo ea doxorubicin, vincristine le paclitaxel khahlano le HepG2/ADM e hanyetsanang le lithethefatsi esita le ho ntlafatsa phello ea kalafo ea doxorubicin khahlano le mohala oa sele ea mofetše oa matsoele o hananang le lithethefatsi MCF-7/ADR.

Nakong e fetileng, lithuto tsa Taiwan li netefalitse ka liteko tsa lisele le liphoofolo hore ethanol ntsa eaGanoderma tsugae(triterpenoid total extract) e ka ntlafatsa phello ea phekolo ea meriana ea chemotherapeutic khahlanong le lisele tsa kankere ea matšoafo tse hanyetsanang le lithethefatsi (Evid. Based compiement alternat Med. 2012; 2012: 371286).Hona joale teko ea Univesithi ea Jinan e bontšitse ka ho hlaka hore ganoderenic acid B ho triterpenoids ke motsoako o sebetsang oa ho fetola khanyetso ea lithethefatsi ea lisele tsa mofetše.Khokahano ea liteko tsena tse fapaneng e entse mosebetsi oaKhanodermalucidumtriterpenoids ho khutlisa khanyetso ea lithethefatsi ea lisele tsa mofetšeka ho eketseha pepeneneng.

Tsoelo-pele ea li-inhibitors khahlanong le liprotheine tse hanyetsanang le lithethefatsi tse kang ABCB1 hajoale ke sepheo sa boiteko bo matla ba sechaba sa bongaka, empa ho bonahala eka ha ho na lithethefatsi tse loketseng (Taiwan Medical Community, 2014, 57: 15-20).Liphetho tsa pele tsa lipatlisiso li bontšitse bokhoni ba ganoderenic acid B sebakeng sena, 'me re lebeletse ho tsoela pele liteko tsa liphoofolo ho fana ka bopaki bo matla nakong e tlang.

[Mohloli] Liu DL, et al.Ganoderma lucidu derived ganoderenic acid B e fetola ABCB1-mediated multidrug resistance ka lisele tsa HepG2/ADM.Ke J Oncol.46(5):2029-38.doi: 10.3892/ijo.2015.2925.

QETA

Mabapi le mongoli/ Mme Wu Tingyao
Wu Tingyao o ntse a tlaleha ka letsoho la peleLingzhke litaba ho tloha ka 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).
 
★ Sengoliloeng sena se hatisitsoe ka tumello e khethehileng ea mongoli ★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli ★ Ho tlola polelo e ka holimo, mongoli o tla phethahatsa boikarabelo ba eona ba molao ★ Ea pele. mongolo oa sengoloa sena o ngotsoe ka Sechaena ke Wu Tingyao mme oa fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.