June 15, 2018 / Gyeongsang National University, South Korea / Journal of Clinical Medicine

Chinyorwa/ Wu Tingyao

Gyeongsang National University Chikoro cheMishonga muSouth Korea yakaburitsa bepa mu Journal of Clinical Medicine muna Chikumi 2018 ichiti.Ganoderma luciduminogona kuderedza kuunganidzwa kwemafuta echiropa kunokonzerwa nekudya kwemafuta akawandisa, asi zviedzo zvemhuka zvine hukama zvakaonawo kuti mbeva dzakakodzwa nekudya kwemafuta akawanda dzichavawo neshuga yeropa uye matambudziko eropa lipid nekuda kwekupindiraGanoderma lucidum.

Mbeva dzekuyedza dzakakamurwa kuita mapoka mana: zvakajairika kudya (ND), zvakajairika kudya (ND) +Ganoderma lucidum(GL), kudya kwemafuta akawanda (HFD), kudya kwemafuta akawanda (HFD) +Ganoderma lucidum(GL).Muchikafu cheboka rekudya rakajairwa, mafuta akaverengera 6% yehuwandu hwemacalorie;mukudya kwekudya kwemafuta akawanda, mafuta akaverengera 45% yehuwandu hwemakoriori, ayo aive 7.5 nguva dzekare.TheGanoderma lucidumkudyiswa kumakonzo chaizvoizvo ethanol inotorwa yemuviri wemuchero weGanoderma lucidum.Vatsvakurudzi vakadyisa mbeva pamwero we50 mg/kgGanoderma lucidumethanol inobvisa pazuva kwemazuva mashanu pavhiki.

Mushure memavhiki gumi nematanhatu (mwedzi mina) yekuedza, zvakaonekwa kuti kudya kwenguva refu kwemafuta akawanda kunogona kuwedzera kurema kwemakonzo.Kunyange vakadyaGanoderma lucidum, zvakaoma kuvhara tsika yekuwedzera uremu (Mufananidzo 1).

Zvisinei, pasi pechirevo chekudya kwemafuta akawanda, kunyange zvazvo mbeva dzinodyaGanoderma lucidumnembeva dzisingadyiGanoderma lucidumvanoita kunge vane mazinga akafanana ekufutisa, hutano hwavo huchasiyana zvakanyanya nekuda kwekudya kana kusadyaGanoderma lucidum.

Mufananidzo 1　Mhedzisiro yeGanoderma lucidumpahuremu hwemuviri wemakonzo akadyiswa neHFD

Ganoderma luciduminoderedza visceral mafuta kuunganidzwa muHFD-Fed mbeva.

Mufananidzo 2 mufananidzo wehuwandu hwekuonekwa uye uremu hwechiropa, perirenal mafuta uye epididymal mafuta eboka rimwe nerimwe remakonzo pakupera kwekuedza.

Chiropa ndicho chirimwa chekugadzirisa zvinovaka muviri mumuviri.Zvese zvinovaka muviri zvinotorwa kubva muura zvichaparara, zvinogadzirwa uye zvinogadziriswa nechiropa kuita fomu rinoshandiswa nemasero, uye zvino kugoverwa kwese kwese kuburikidza nekutenderera kweropa.Kana paine kuwandisa, chiropa chinoshandura macalorie akawandisa kuita mafuta (triglycerides) uye woichengeta kuitira emergency.

Iyo yakawanda mafuta inochengetwa, iyo yakakura uye inorema chiropa chinova.Ehe, mafuta akawandisa anozounganawo akapoteredza dzimwe nhengo dzomukati, uye perirenal mafuta uye epididymal mafuta vamiririri visceral mafuta accumulation inocherechedzwa mukuedza mhuka.

Inogona kuonekwa kubva mumufananidzo 2 kutiGanoderma luciduminogona kuderedza zvakanyanya kuunganidza mafuta muchiropa uye dzimwe nhengo dzomukati dzinokonzerwa nekudya kwemafuta akawanda.

Mufananidzo 2　Mhedzisiro yeGanoderma lucidumpane visceral mafuta muHFD-Fed mbeva

Ganoderma luciduminoderedza mafuta echiropa muHFD-Fed mice.

Vatsvakurudzi vakaongorora zvakare mafuta ari muchiropa chemakonzo: zvikamu zvechiropa zvemakonzo muboka rimwe nerimwe zvakasvibiswa nedhayi yakakosha, uye madonhwe emafuta ari mumucheka wechiropa aizosanganiswa nedhayi uye anoshanduka akatsvuka.Sezvinoratidzwa muMufananidzo 3, mafuta ari muchiropa akanga akasiyana zvakanyanya mukudya kwakafanana kwemafuta ane mafuta akawanda kana pasina kuwedzera.Ganoderma lucidum.

Mafuta ari mumakumbo echiropa emakonzo muboka rimwe nerimwe akaverengerwa muMufananidzo 4, uye zvaigona kuonekwa kuti chiropa chine mafuta muboka rekudya kwemafuta akawanda chakasvika giredhi 3 (mafuta emukati aipfuura 66% ehuremu hwechiropa chose. , zvichiratidza chiropa chakakora chakanyanya).Panguva imwecheteyo, mafuta ari muchiropa cheHFD-akadyiswa mbeva dzaidyaGanoderma lucidumyakaderedzwa nehafu.

Mufananidzo 3　Mafuta anosvibisa mhedzisiro yembeva chiropa tishu zvikamu

Mufananidzo 4　Mhedzisiro yeGanoderma lucidumpachiropa kuunganidzwa kwemafuta muHFD-yakadyiswa mbeva

[Tsanangudzo] Kuomarara kwechiropa chemafuta kwakaiswa mugiredhi 0, 1, 2, uye 3 zvichienderana nehuwandu hwehuremu hwemafuta muhuremu hwechiropa: isingasviki 5%, 5-33%, kupfuura 33% -66% uye zvinodarika 66%, zvichiteerana.Kukosha kwekiriniki kwaimiririra zvakajairika, zvinyoro, zvine mwero uye zvakanyanya mafuta chiropa.

Ganoderma luciduminodzivirira hepatitis mumakonzo anodyiswa neHFD.

Kuwanda kwemafuta kuunganidza kunowedzera mahara radicals muchiropa, zvichiita kuti masero echiropa awedzere kuzvimba nekuda kwekukuvara kweiyo oxidative, zvichikanganisa kushanda kwechiropa.Zvisinei, hazvisi zvose zviropa zvine mafuta zvichafambira mberi kusvika pamwero wehepatitis.Chero bedzi masero echiropa asina kukuvadzwa zvakanyanya, anogona kuchengetedzwa mune zvisingakuvadzi "kuunganidza mafuta kuri nyore".

Inogona kuonekwa kubva kuMufananidzo 5 kuti kudya kwemafuta akawanda kunogona kaviri serum ALT (GPT), iyo inonyanya kukosha chiratidzo chehepatitis, kubva pachiyero chepamusoro che40 U / L;zvisinei, kanaGanoderma luciduminotorwa panguva imwe chete, mukana wehepatitis unoderedzwa zvikuru.Zviri pachena,Ganoderma lucidumine simba rekudzivirira pamasero echiropa akapinzwa mumafuta.

Mufananidzo 5 Mhedzisiro yeGanoderma lucidumpane hepatitis indexes mumakonzo anodyiswa neHFD

Ganoderma luciduminobvisa matambudziko eropa lipid mumakonzo anodyiswa neHFD.

Kana chiropa chikagadzira mafuta akawandisa, lipids yeropa zvakare inokonzeresa kusagadzikana.Ichi chiyedzo chemhuka muSouth Korea chakawana kuti chikafu chemwedzi mina chakanyanya-mafuta chinogona kusimudza cholesterol, asiGanoderma luciduminogona kuderedza kuoma kwedambudziko (Mufananidzo 6).

Mufananidzo 6　Mhedzisiro yeGanoderma lucidumpane serum yakazara cholesterol muHFD-yakadyiswa mice

Ganoderma luciduminodzivisa kukwira kweglucose yeropa mumakonzo anodyiswa neHFD.

Ongororo dzakawanawo kuti kudya kwakawanda-mafuta kunogona kuita kuti glucose yeropa ikwire.Zvisinei, kanaGanoderma luciduminotorwa panguva imwe chete, muzinga weglucose weropa unogona pachena kudzorwa pakuwedzera kuduku (Mufananidzo 7).

Mufananidzo 7　Mhedzisiro yeGanoderma lucidumpaglucose yeropa mumakonzo anodyiswa neHFD

Ganoderma luciduminovandudza kugona kwemuviri wemakonzo akadyiswa neHFD kugadzirisa shuga yeropa.

Vatsvakurudzi vakaitawo kuongorora kweglucose kushivirira pamakonzo mukati mevhiki yegumi nemana yekuedza, kureva, mumamiriro ekutsanya mushure memaawa 16 ekutsanya, mbeva dzakaiswa jekiseni nehuwandu hweglucose, uye kuchinja kweglucose yeropa mukati memaviri. maawa akaonekwa.Iko kudiki kuchinja kweglucose yeropa, ndiko kugona kwemuviri wembeva kugadzirisa shuga yeropa.

Zvakaonekwa kuti kuchinja kwemazinga eglucose eropa eboka reHFD + GL kwaive kwakaderera pane kweboka reHFD (Mufananidzo 8).Izvi zvinoreva kutiGanoderma lucidumine mhedzisiro yekuvandudza kurongeka kweglucose yeropa kunokonzerwa nekudya kwemafuta akawanda.

Mufananidzo 8　Mhedzisiro yeGanoderma lucidumpane kushivirira kweglucose mumakonzo akadyiswa neHFD

Ganoderma luciduminovandudza insulin kuramba muHFD-inodyiswa mbeva.

Vatsvakurudzi vakaitawo muedzo we insulin kushivirira pamakonzo: Muvhiki yegumi nemana yekuedza, kutsanya mbeva dzakaiswa jekiseni ne insulini, uye kuchinja kwemazinga eglucose eropa kwakashandiswa kuona kunzwisiswa kwemasero emakonzo kune insulini.

Insulin ihomoni, inoita basa rekiyi, ichibvumira glucose iri muchikafu chedu kupinda mumasero emuviri kubva muropa kuti ibudise simba.Mumamiriro ezvinhu akajairwa, mushure mejekiseni re insulin, iyo yekutanga glucose yeropa inodonha kusvika pamwero wakati.Nekuti shuga yeropa yakawanda ichapinda mumaseru nerubatsiro rwe insulin, huwandu hweshuga hweropa huchadzikira.

Nekudaro, mhedzisiro yekuyedza yakawana kuti kudya kwenguva refu-yakawanda-mafuta kwaizoita kuti masero asave nehanya ne insulin kuitira kuti huwandu hweglucose hweropa hurambe hwakakwirira mushure mejekiseni re insulin, asi panguva imwecheteyo, kushanduka kweglucose yeropa mumakonzo akadyiswa neHFD. izvo zvakadyaGanoderma lucidumyakanga yakafanana neiyo muND-yakadyiswa mice (Mufananidzo 9).Zviripachena kutiGanoderma lucidumine mhedzisiro yekuvandudza insulin kuramba.

Mufananidzo 9　Mhedzisiro yeGanoderma lucidumpa insulin kuramba mumakonzo akadyiswa neHFD

The mechanism ofGanoderma lucidummukuderedza mafuta echiropa

Kufutisa kunogona kukonzera insulin kuramba, uye insulin kuramba haingokonzeri hyperglycemia asiwo ndiyo inonyanya kukosha inotungamira kune isiri-doro mafuta chiropa.Naizvozvo, kana insulin kuramba ichideredzwa neGanoderma lucidum, chiropa chinowanzoita zvishoma kuunganidza mafuta.

Mukuwedzera, vatsvakurudzi vakasimbisawo kuti iyo ethanol yakatorwa yeGanoderma lucidumfruiting muviri unoshandiswa mukuedza kwemhuka haugone chete kudzora zvakananga kuita kwemamwe ma enzymes anobatanidzwa mu lipid metabolism muchiropa asi zvakare inodzivirira zvakananga kuumbwa kwemafuta nemaseru echiropa, uye mhedzisiro yacho inoenderana nedosi.Ganoderma lucidum.Zvinotonyanya kukosha, mushure meaya madosi anoshanda eGanoderma lucidumdzakagadzirwa nemasero echiropa chemunhu kwemaawa makumi maviri nemana, masero acho akanga achiri mupenyu uye akanaka.

Ganoderma lucidumine migumisiro yekudzikisa glucose yeropa, kuderedza mafuta uye kudzivirira chiropa.

Mhedzisiro yataurwa pamusoro apa haingotiudzi chete kuti doro rakatorwa reGanoderma lucidumfruiting muviri unogona kuderedza zviratidzo zve hyperglycemia, hyperlipidemia, uye chiropa chemafuta chinokonzerwa nekudya kwemafuta akawanda asi zvinotiyeuchidza kuti zvinokwanisika kuwana chiropa chemafuta pasina kunwa doro.

Mumushonga, chiropa chine mafuta chinokonzerwa neasiri-doro zvinhu zvinonzi "zvisiri-doro mafuta chiropa."Kunyange zvazvo kune zvimwe zvinhu zvinobvira (zvakadai sezvinodhaka), madyiro nemararamiro ndiwo achiri zvikonzero zvakajairika.Funga nezvekuti foie gras, iyo inodiwa zvikuru nevanokara, inogadzirwa sei?Ndizvo zvakafanana nevanhu!

Maererano nenhamba, chinenge chikamu chimwe muzvitatu chevakuru vane nyore (kureva kuti, hapana zviratidzo zvehepatitis) chiropa chisiri-doro chine mafuta, uye chikamu chimwe muzvina chavo chichawedzera kukura kuva hepatitis ine mafuta mukati memakore gumi nemashanu.Kune mishumo yekuti chiropa chisiri-doro chine mafuta chave chikonzero chikuru chekusagadzikana kweALT index muTaiwan (33.6%), inodarika hutachiona hwehepatitis B (28.5%) uye hutachiona hwehepatitis C (13.2%).(Ona chinyorwa 2 kuti uwane ruzivo)

Zvinotoshamisa ndezvokuti sezvo masangano ezvehutano epasi rose ari kuramba achirwisa utachiona hwehepatitis nemishonga yekudzivirira zvirwere nemishonga, kuwanda kwechirwere chechiropa chine mafuta chinokonzerwa nekudya zvakanaka kana kunwa zvakanyanya kuri kuwedzera.

Chirwere chemafuta chiropa (steatosis) chinoitika kana mafuta ari muchiropa asvika kana kudarika 5% yeuremu hwechiropa.Kuongororwa kwekutanga kwechirwere chechiropa chemafuta kunofanirwa kuvimba neabdominal ultrasound kana computed tomography (CT).Kana iwe usati watanga tsika yekuongorora hutano, unogona zvakare kutonga kana uine mafuta echiropa chirwere kubva kana uine metabolic syndromes senge pakati nepakati kufutisa, hyperglycemia (Type 2 chirwere cheshuga) uye hyperlipidemia nekuti izvi zviratidzo kana zvirwere zvinowanzoitika pamwe chete. nonalcoholic fatty chiropa chirwere (NAFLD).

Kungoti hapana mishonga chaiyo yechirwere chechiropa chemafuta.Ichi ndicho chikonzero, mushure mekuongororwa kwechiropa chemafuta, chiremba anogona kungokupa iwe kudya kwakareruka, kurovedza muviri uye kuderedza uremu pane kurapa kunoshanda.Zvisinei, hazvisi nyore kuchinja madyiro nemararamiro.Vanhu vazhinji vakanamira mumatope e "kutadza kudzora kudya uye kuwedzera basa rekuita" kana muhondo ye "kutadza kubvisa chiropa chine mafuta kunyangwe nekudzora kudya uye kuwedzera basa remuviri".

Chii chatinofanira kuita panyika?Mushure mekuverenga mhedzisiro yekutsvagisa yeGyeongsang National University muSouth Korea, tinoziva kuti kune chimwe chombo chemashiripiti, ndiko kuti, kudya iyo ethanol inotorwaGanoderma lucidumfruiting muviri.

Ganoderma lucidum, iyo ine mabasa ekudzivirira chiropa, kuderedza shuga yeropa, uye kuderedza mafuta, inodhura chaizvo;kunyange zvazvo ichiri kusakwanisa kuita kuti uderedze uremu, inogona kukuita kuti uve neutano hwakanaka kunyangwe wakafuta.

[Kwakabva]

Jung S, nevamwe. Ganoderma luciduminonatsiridza isiri-doro steatosis nekusimudzira simba remebolizing enzymes muchiropa.J Clin Med.2018 Jun 15;7(6).pii: E152.doi: 10.3390/jcm7060152.

[Kuwedzera Kuverenga]

Sezvineiwo, mukutanga 2017, chirevo "Antidiabetic chiitiko cheGanoderma lucidumpolysaccharides F31 pasi-inodzorwa pasi-inodzorwa neshuga inodzora enzymes mumakonzo ane chirwere cheshuga" yakabudiswa pamwe chete neGuangdong Institute of Microbiology uye Guangdong Provincial Center for Disease Control and Prevention.Kubva pamuenzaniso wemhuka werudzi rwechirwere cheshuga 2, inotsvaga maitiro ekugadzirisaGanoderma lucidumfruiting body active polysaccharides paglucose yeropa uye kudzivirira uye kurapwa kwehepatitis inokonzerwa nechirwere cheshuga.Nzira yaro yekuita inobatanawo nekugadzirisa kwema enzymes anobatanidzwa musimba metabolism muchiropa uye kuvandudzwa kwe insulin kuramba.Iyo uye iyi chirevo cheSouth Korea inosvika pamagumo akafanana nenzira dzakasiyana.Shamwari dzinofarira dzinogonawo kutaura kune iyi rondedzero.

Reference zvinhu nezve asiri-doro mafuta chiropa

1. Teng-cing Huang et al.Nonalcoholic mafuta chiropa.Mushonga weMhuri uye Primary Medical Care, 2015;30 (11): 314-319.

2. Ching-feng Su et al.Kuongororwa uye kurapwa kwe-nonalcoholic fatty chiropa chirwere.2015;30 (11) : 255-260.

3. Ying-tao Wu et al.Nhanganyaya yekurapa kweasina-doro mafuta ane chiropa chirwere.Pharmaceutical Journal, 2018;34 (2) : 27-32.

4. Huei-wun Liang: Chirwere chemafuta chiropa chinogona kuchinjwa uye kutaura zvakanaka kune chiropa chakakora!Chiropa Kudzivirira & Kurapa Research Foundation webhusaiti.

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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.