Iune 15, 2018 / Gyeongsang National University, South Korea / Journal of Clinical Medicine

Text/ Wu Tingyao

Ua paʻi ʻo Gyeongsang National University School of Medicine ma South Korea i kahi pepa ma ka Journal of Clinical Medicine i Iune 2018 e ʻōlelo ana.ʻO Ganoderma lucidumhiki ke hōʻemi i ka hōʻiliʻili o ka momona ma muli o ka ʻai momona nui, akā ua ʻike pū ʻia nā hoʻokolohua holoholona e pili ana i nā ʻiole i momona ʻia e ka ʻai momona nui e loaʻa pū kekahi pilikia koʻikoʻi o ka glucose koko a me ka lipid koko ma muli o ke komo ʻana oʻO Ganoderma lucidum.

Ua māhele ʻia nā ʻiole hoʻokolohua i ʻehā mau pūʻulu: ʻai maʻamau (ND), meaʻai maʻamau (ND) +ʻO Ganoderma lucidum(GL), ʻai momona momona (HFD), ʻai momona momona (HFD) +ʻO Ganoderma lucidum(GL).I ka hānaiʻana o ka hui meaʻai maʻamau,ʻo ka momona ka 6% o ka nui o nā calories;i ka hānaiʻana i ka meaʻai momona momona, ua heluʻia ka momona no 45% o ka nui o nā calories,ʻo ia ka 7.5 manawa o ka mua.ʻO kaʻO Ganoderma lucidumhānai ʻia i nā ʻiole, he ethanol extract o ke kino hua oʻO Ganoderma lucidum.Ua hānai nā mea noiʻi i nāʻiole ma kahi o 50 mg / kgʻO Ganoderma lucidumethanol extract i ka lā no ʻelima mau lā o ka pule.

Ma hope o nā pule he ʻumikumamāono (ʻehā mahina) o nā hoʻokolohua, ua ʻike ʻia e hiki i ka ʻai momona momona lōʻihi ke pālua i ke kaumaha o nā ʻiole.ʻOiai lākou e ʻaiʻO Ganoderma lucidum, he paʻakikī ke ālai i ka manaʻo e loaʻa ke kaumaha (Figure 1).

Eia naʻe, ma lalo o ka manaʻo o ka momona momona, ʻoiai nā ʻiole e ʻaiʻO Ganoderma luciduma me na iole ai oleʻO Ganoderma lucidumʻike ʻia he mau pae like o ka momona, ʻokoʻa loa ko lākou kūlana olakino ma muli o ka ʻai ʻana a i ʻole ka ʻai ʻoleʻO Ganoderma lucidum.

Helu 1　Ka hopena oʻO Ganoderma lucidumma ke kaumaha o ke kino o na iole hānai HFD

ʻO Ganoderma lucidumhōʻemi i ka hōʻiliʻili momona visceral i nā ʻiole HFD-Fed.

He kiʻi helu helu 2 o ke ʻano a me ke kaumaha o ke ake, ka momona perirenal a me ka momona epididymal o kēlā me kēia hui ʻiole ma ka hopena o ka hoʻokolohua.

ʻO ka ate ka mea kanu meaʻai i loko o ke kino.ʻO nā meaʻai a pau i lawe ʻia mai ka ʻōpū e hoʻoheheʻe ʻia, synthesized a hana ʻia e ke ake i kahi ʻano hiki ke hoʻohana ʻia e nā cell, a laila puʻunaue ʻia ma nā wahi āpau ma o ke kahe koko.Ke loaʻa ka hoʻolako nui ʻana, e hoʻohuli ke ake i nā calorie keu i ka momona (triglycerides) a mālama iā ia no nā pilikia pilikia.

ʻOi aku ka nui o ka momona i mālama ʻia, ʻoi aku ka nui a me ke kaumaha o ke ake.ʻOiaʻiʻo, e hōʻiliʻili ʻia ka momona nui a puni nā ʻōpū o loko, a ʻo ka momona perirenal a me ka momona epididymal nā ʻelele o ka hōʻiliʻili momona visceral i ʻike ʻia i nā hoʻokolohua holoholona.

Hiki ke ʻike ʻia mai ka Figure 2 kēlāʻO Ganoderma lucidumhiki ke hoʻemi nui i ka hōʻiliʻili momona i loko o ke ake a me nā ʻāpana ʻē aʻe i hana ʻia e ka ʻai momona momona.

Kiʻi 2　Ka hopena oʻO Ganoderma lucidumma ka momona visceral i nā ʻiole HFD-Fed

ʻO Ganoderma lucidumhōʻemi i ka momona momona i nā ʻiole HFD-Fed.

Ua nānā hou ka poʻe noiʻi i ka momona momona i loko o ke akepaʻa o nā ʻiole: ʻo nā ʻāpana o ke akepaʻa o nā ʻiole i kēlā me kēia hui i hoʻopaʻa ʻia me kahi kala kūikawā, a ʻo nā kulu ʻaila i loko o ka ʻiʻo o ke ake e hui pū me ka wai a lilo i ʻulaʻula.E like me ka mea i hōʻike ʻia ma ke Kiʻi 3, ʻokoʻa loa ka momona o ke akepaʻa i ka meaʻai momona kiʻekiʻe like me ka hoʻohui ʻana a i ʻole.ʻO Ganoderma lucidum.

Ua helu ʻia ka momona i loko o nā ʻiʻo ate o nā ʻiole i kēlā me kēia hui i ka Figure 4, a hiki ke ʻike ʻia ua hiki i ke akepaʻa momona i ka pūʻulu meaʻai momona i ka papa 3 (ʻoi aku ka momona ma mua o 66% o ke kaumaha o ke akepaʻa holoʻokoʻa. , e hōʻike ana i ka momona momona koʻikoʻi).I ka manawa like, ʻo ka momona momona i loko o ke ake o nā ʻiole hānai HFD i ʻaiʻO Ganoderma lucidumua hoemi i ka hapalua.

Helu 3　Nā hopena hoʻopaʻa momona o nā ʻāpana ʻiʻo o ka ʻiole

Helu 4　Ka hopena oʻO Ganoderma lucidumma ka hoʻoulu ʻana o ka momona o ke ake i nā ʻiole hānai HFD

[Description] Ua hoʻokaʻawale ʻia ke koʻikoʻi o ke akepaʻa momona i nā papa 0, 1, 2, a me 3 e like me ka nui o ka momona momona i ke kaumaha o ke ake: emi iho ma mua o 5%, 5-33%, ʻoi aku ma mua o 33% -66% a ʻoi aku ma mua o 66%, kēlā me kēia.ʻO ke koʻikoʻi koʻikoʻi i hōʻike ʻia i ke akepaʻa momona maʻamau, ʻoluʻolu, haʻahaʻa a koʻikoʻi.

ʻO Ganoderma lucidumpale i ka maʻi hepatitis i nā ʻiole hānai HFD.

ʻO ka hōʻiliʻili momona nui e hoʻonui i nā radical manuahi i loko o ke akepaʻa, e hoʻoneʻe ana i nā pūnaʻi ate i ka mumū ma muli o ka pōʻino oxidative, a laila e pili ana i ka hana ate.Eia naʻe, ʻaʻole e holomua nā ate momona a pau i ka pae o ka maʻi hepatitis.ʻOiai ʻaʻole i hōʻino nui ʻia nā pūnaʻi ate, hiki ke mālama ʻia i loko o kahi "hui momona maʻalahi."

Hiki ke ʻike ʻia mai ka Figure 5 e hiki i ka ʻai momona momona ke pālua i ka serum ALT (GPT), ka hōʻailona koʻikoʻi o ka maʻi hepatitis, mai ka pae maʻamau ma kahi o 40 U/L;akā, ināʻO Ganoderma lucidumlawe ʻia i ka manawa like, hoʻemi nui ʻia ka hiki o ka hepatitis.ʻIke loa,ʻO Ganoderma lucidumloaʻa i ka hopena pale i nā pūnaewele ate infiltrated i loko o ka momona.

Helu 5 Ka hopena oʻO Ganoderma lucidumma nā helu helu hepatitis i nā ʻiole hānai HFD

ʻO Ganoderma lucidumhoʻokuʻu i nā pilikia lipid koko i nā ʻiole hānai HFD.

Ke hoʻohui ka ate i ka momona nui loa, hiki i nā lipids koko ke maʻalahi i nā mea ʻino.Ua ʻike ʻia kēia hoʻokolohua holoholona ma South Korea e hiki i ka ʻai momona momona ʻehā ke hoʻonui i ka cholesterol, akāʻO Ganoderma lucidumhiki ke hōʻemi i ka paʻakikī o ka pilikia (Figure 6).

Helu 6　Ka hopena oʻO Ganoderma lucidume pili ana i ka nui o ka cholesterol ma nā ʻiole hānai HFD

ʻO Ganoderma lucidumpale i ka piʻi ʻana o ka glucose koko i nā ʻiole hānai HFD.

Ua ʻike pū ʻia nā hoʻokolohua e hiki i ka meaʻai momona ke hoʻonui i ka glucose koko.Eia naʻe, ināʻO Ganoderma lucidumlawe ʻia i ka manawa like, hiki ke hoʻomalu ʻia ke kiʻekiʻe o ka glucose i ke koko ma kahi piʻi liʻiliʻi (Figure 7).

Helu 7　Ka hopena oʻO Ganoderma lucidumma ke koko koko i nā ʻiole hānai HFD

ʻO Ganoderma lucidumhoʻomaikaʻi i ka hiki o ke kino o nā ʻiole hānai HFD e hoʻoponopono i ke kō koko.

Ua hana pū nā mea noiʻi i kahi hoʻāʻo hoʻomanawanui glucose i nā ʻiole i ka hebedoma ʻumikumamāhā o ka hoʻokolohua, ʻo ia hoʻi, i ka mokuʻāina hoʻokēʻai ma hope o 16 mau hola o ka hoʻokē ʻai ʻana, ua hoʻokomo ʻia nā ʻiole me ka nui o ka glucose, a hoʻololi ke koko glucose i loko o ʻelua. ua malamaia na hora.ʻOi aku ka liʻiliʻi o ka piʻi ʻana o ka pae glucose koko, ʻoi aku ka maikaʻi o ke kino o ka ʻiole e hoʻoponopono i ka glucose koko.

Ua ʻike ʻia he haʻahaʻa haʻahaʻa ka loli o nā pae glucose koko o ka hui HFD + GL ma mua o ka hui HFD (Figure 8).ʻO ia hoʻiʻO Ganoderma lucidumLoaʻa ka hopena o ka hoʻomaikaʻi ʻana i ka hoʻoponopono ʻana i ka glucose koko ma muli o ka ʻai momona momona.

Helu 8　Ka hopena oʻO Ganoderma lucidume pili ana i ka hoʻomanawanui glucose i nā ʻiole hānai HFD

ʻO Ganoderma lucidumhoʻomaikaʻi i ka pale ʻana o ka insulin i nā ʻiole hānai HFD.

Ua hana pū ka poʻe noiʻi i ka hoʻāʻo ʻana i ka insulin tolerance i nā ʻiole: I ka ʻumikūmāhā pule o ka hoʻokolohua, ua hoʻopiʻi ʻia nā ʻiole hoʻokēʻai me ka insulin, a ua hoʻohana ʻia nā loli o ke kiʻekiʻe o ka glucose koko e hoʻoholo ai i ka naʻau o nā ʻiole o nā ʻiole i ka insulin.

He hormone ka insulin, e hana ana i ke kī, e ʻae ana i ka glucose i loko o kā mākou meaʻai e komo i loko o ke kino mai ke kahe koko e hana i ka ikehu.Ma lalo o nā kūlana maʻamau, ma hope o ka hoʻokomo ʻana i ka insulin, e hāʻule ke kiʻekiʻe o ka glucose koko kumu i kekahi ʻano.Ma muli o ka nui o ka glucose koko e komo i loko o nā keena me ke kōkua o ka insulin, e emi maoli ke kiʻekiʻe o ke kō koko.

Eia naʻe, ua ʻike ʻia nā hopena o ka hoʻokolohua ʻo ka ʻai ʻana i ka momona momona lōʻihi e lilo nā cell i mea ʻole i ka insulin no laila e mau ke kiʻekiʻe o ke kiʻekiʻe o ka glucose koko ma hope o ka hoʻokomo ʻana i ka insulin, akā i ka manawa like, ʻo ka fluctuation koko koko i nā ʻiole hānai HFD. i aiʻO Ganoderma lucidumua like ia me ka ND-fed mice (Figure 9).Ua maopopo iaʻO Ganoderma lucidumLoaʻa ka hopena o ka hoʻomaikaʻi ʻana i ka insulin resistance.

Helu 9　Ka hopena oʻO Ganoderma lucidume pili ana i ka pale ʻana o ka insulin i nā ʻiole hānai HFD

ʻO ka mīkini oʻO Ganoderma lucidumi ka hōʻemi ʻana i ka momona momona

Hiki i ka momona ke hoʻoulu i ka pale ʻana o ka insulin, a ʻaʻole wale ka hoʻoulu ʻana o ka insulin i ka hyperglycemia akā ʻo ia ke kumu nui e alakaʻi ai i ka momona momona ʻole.No laila, i ka wā e hoʻemi ʻia ai ke kūpaʻa o ka insulin eʻO Ganoderma lucidum, ʻo ke akepaʻa maoli ka emi ʻana o ka momona.

Eia hou, ua hōʻoia ka poʻe noiʻi i ka ethanol extract oʻO Ganoderma lucidumʻAʻole hiki i ke kino hua i hoʻohana ʻia i nā hoʻokolohua holoholona ke hoʻoponopono pololei i ka hana o kekahi mau enzyme e pili ana i ka metabolism lipid i loko o ke ake, akā ke kaohi pono pū nō hoʻi i ka synthesis o ka momona e nā pūpū ate, a ua like ka hopena i ka dosage oʻO Ganoderma lucidum.ʻO ka mea nui, ma hope o kēia mau hopena kūpono oʻO Ganoderma lucidumua hoʻomaʻamaʻa ʻia me nā puʻupaʻa o ke ake kanaka no 24 mau hola, e ola mau ana nā pūnaewele.

ʻO Ganoderma lucidumloaʻa nā hopena o ka hoʻohaʻahaʻa ʻana i ka glucose koko, hoʻohaʻahaʻa i ka momona a pale i ke ake.

ʻAʻole i haʻi wale ʻia nā hopena noiʻi i ʻōlelo ʻia iā mākou i ka extract o ka waiʻonaʻO Ganoderma lucidumHiki i ke kino hua ke hoʻemi i nā hōʻailona o ka hyperglycemia, hyperlipidemia, a me ke ake momona i hoʻokumu ʻia e ka ʻai momona nui akā e hoʻomanaʻo mai iā mākou he hiki ke loaʻa i ka momona momona me ka inu ʻole i ka waiʻona.

I loko o ka lāʻau lapaʻau, kapa ʻia ka ate momona i hoʻokumu ʻia e nā kumu waiʻona ʻole ʻo "non-alcoholic fatty liver."ʻOiai aia kekahi mau kumu ʻē aʻe (e like me nā lāʻau lapaʻau), ʻo ka ʻai ʻana a me nā ʻano nohona ke kumu maʻamau.E noʻonoʻo e pili ana i ka hana ʻana i ka foie gras, ka mea i aloha nui ʻia e ka poʻe ʻai?Ua like nō me nā kānaka!

Wahi a nā helu, kokoke i ka hapakolu o ka poʻe mākua i maʻalahi (ʻo ia hoʻi, ʻaʻohe hōʻailona o ka maʻi hepa) ʻaʻohe waiʻona momona momona, a ma kahi o hoʻokahi hapahā o lākou e ulu hou i ka maʻi hepatitis i loko o ʻumikumamālima makahiki.Aia kekahi mau hōʻike ua lilo ke akepaʻa momona ʻole i ke kumu nui o ka ALT index ma Taiwan (33.6%), ʻoi aku ka nui o ka maʻi hepatitis B (28.5%) a me ka maʻi hepatitis C (13.2%).(E nānā i ka helu 2 no nā kikoʻī)

ʻO ka mea hoʻohenehene, ʻoiai ke hoʻomau nei nā keʻena olakino o ka honua i ka hakakā ʻana i ka maʻi hepatitis viral me nā lāʻau lapaʻau a me nā lāʻau lapaʻau, ke piʻi nei ka nui o ka maʻi ate momona ma muli o ka ʻai ʻana a i ʻole ka inu nui ʻana.

Hiki mai ka ma'i ate momona (steatosis) ke pi'i ka momona o ke ake a oi aku paha i ka 5% o ke kaumaha o ke ake.ʻO ka hōʻailona mua o ka maʻi ate momona pono e hilinaʻi i ka ultrasound abdominal a i ʻole computed tomography (CT).Inā ʻaʻole ʻoe i hoʻomohala i ka hana maʻamau o ka nānā ʻana i ke olakino, hiki iā ʻoe ke noʻonoʻo inā loaʻa iā ʻoe ka maʻi momona o ka ate mai ka loaʻa ʻana o nā maʻi metabolic e like me ka momona haʻahaʻa, hyperglycemia (type 2 diabetes) a me hyperlipidemia no ka mea e ulu pinepine kēia mau hōʻailona a me nā maʻi. maʻi ʻaʻai momona ʻole (NAFLD).

ʻO ia wale nō ka loaʻa ʻole o nā lāʻau lapaʻau kūikawā no ka maʻi ate momona.ʻO kēia ke kumu, ma hope o ka hōʻoia ʻana o ka ate momona, hiki i ke kauka ke kuhikuhi wale iā ʻoe i kahi meaʻai māmā, hoʻomaʻamaʻa a me ka pohō kaumaha ma mua o nā lāʻau lapaʻau.Eia naʻe, ʻaʻole maʻalahi ka hoʻololi ʻana i ka ʻai a me nā ʻano ola.Paʻa ka hapa nui o ka poʻe i loko o ka quagmire o ka "ʻaʻole e hoʻomalu i ka meaʻai a hoʻonui i ka hoʻoikaika kino" a i ʻole i ka hakakā ʻana o ka "hoʻopau ʻole ʻana i ka momona momona ma o ka mālama ʻana i ka meaʻai a me ka hoʻonui ʻana i ka hana kino".

He aha kā mākou e hana ai ma ka honua?Ma hope o ka heluhelu ʻana i nā hopena noiʻi o Gyeongsang National University ma South Korea, ʻike mākou aia kekahi mea kaua kilokilo, ʻo ia hoʻi, ka ʻai ʻana i ka ethanol extract oʻO Ganoderma lucidumkino hua.

ʻO Ganoderma lucidum, nona nā hana o ka pale ʻana i ke akepaʻa, hoʻohaʻahaʻa i ke kō koko, a hoʻohaʻahaʻa i ka momona, ʻoi aku ka maikaʻi o ke kumukūʻai;ʻoiai ʻaʻole hiki iā ia ke hoʻolilo iā ʻoe i ke kaumaha, hiki iā ia ke hoʻomaikaʻi maikaʻi iā ʻoe inā ʻoe i ka momona.

[Kumu]

Jung S, et al. ʻO Ganoderma lucidumhoʻomaikaʻi i ka steatosis non-alcoholic ma ka hoʻoponopono ʻana i nā enzyme metabolizing ikehu i loko o ke ake.J Clin Med.2018 Iun 15;7(6).pii: E152.doi: 10.3390/jcm7060152.

[Heluhelu hou aku]

ʻO Coincidentally, i ka hoʻomaka ʻana o 2017, kahi hōʻike "Antidiabetic hana oʻO Ganoderma lucidumpolysaccharides F31 iho-regulated hepatic glucose regulatory enzymes in diabetic mice” i paʻi pū ʻia e Guangdong Institute of Microbiology and Guangdong Provincial Center for Disease Control and Prevention.Ma muli o ke ʻano holoholona o ka maʻi diabetes type 2, ʻimi ʻo ia i ke ʻano hoʻoponopono oʻO Ganoderma lucidumʻO nā polysaccharides ikaika i ke kino i ke koko koko a me ka pale ʻana a me ka mālama ʻana i ka maʻi hepaʻa i hoʻokumu ʻia e ka maʻi diabetes.ʻO kāna hana o ka hana e pili pū ana i ka hoʻoponopono ʻana i nā enzymes e pili ana i ka metabolism ikehu i loko o ke ake a me ka hoʻomaikaʻi ʻana i ka pale ʻana o ka insulin.ʻO ia a me kēia hōʻike South Korea e hōʻea i ka hopena like ma nā ʻano like ʻole.Hiki i nā hoa hoihoi ke nānā i kēia hōʻike.

Nā mea kuhikuhi e pili ana i ka momona momona ʻole

1. Teng-cing Huang et al.ʻO ke akepaʻa momona nonalcoholic.Lapaʻau ʻohana a me ka mālama Lapaʻau Primary, 2015;30 (11): 314-319.

2. ʻO Ching-feng Su et al.ʻO ka ʻike a me ka mālama ʻana i ka maʻi momona momona ʻole.2015;30 (11) : 255-260.

3. ʻO Ying-tao Wu et al.Hoʻolauna i ka mālama ʻana i ka maʻi ʻaʻai momona ʻole.Nūpepa Lapaʻau, 2018;34 (2) : 27-32.

4. Huei-wun Liang: Hiki ke hoʻohuli ʻia ka maʻi ate momona a ʻōlelo maikaʻi i ke ake momona!Paena pūnaewele ʻo Liver Disease Prevention & Treatment Research Foundation.

HOPE

No ka mea kākau/ Ms. Wu Tingyao
Ua hōʻike ʻo Wu Tingyao i ka ʻike Ganoderma lima mua mai 1999. ʻO ia ka mea kākau oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).
 
★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau.★ ʻAʻole hiki ke paʻi hou ʻia nā hana i luna, ʻokiʻoki a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻia e ka mea kākau.★ No ka uhaki ʻana i ka ʻōlelo ma luna, e ʻimi ka mea kākau i nā kuleana pili kānāwai.★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.