June 15, 2018 / Gyeongsang National University, South Korea / Journal of Clinical Medicine

Zolemba / Wu Tingyao

Gyeongsang National University School of Medicine ku South Korea idasindikiza pepala mu Journal of Clinical Medicine mu June 2018 kutiGanoderma lucidumZitha kuchepetsa kuchuluka kwa mafuta m'chiwindi chifukwa cha zakudya zamafuta ambiri, koma zoyeserera zokhudzana ndi nyama zinapezanso kuti mbewa zomwe zimanenepa ndi zakudya zamafuta ambiri zimakhalanso ndi vuto lochepa kwambiri la shuga m'magazi ndi lipids m'magazi chifukwa cholowererapo.Ganoderma lucidum.

Mbewa zoyesera zidagawidwa m'magulu anayi: zakudya zabwinobwino (ND), zakudya zanthawi zonse (ND) +Ganoderma lucidum(GL), zakudya zamafuta ambiri (HFD), zakudya zamafuta ambiri (HFD) +Ganoderma lucidum(GL).M'zakudya zamagulu amtundu wamba, mafuta amawerengera 6% ya zopatsa mphamvu zonse;mu chakudya cha zakudya zamafuta ambiri, mafuta amawerengera 45% ya zopatsa mphamvu zonse, zomwe zinali nthawi 7.5 zakale.TheGanoderma lucidumkudyetsedwa kwa mbewa kwenikweni Mowa Tingafinye wa fruiting thupi laGanoderma lucidum.Ofufuzawo adadyetsa mbewa pa mlingo wa 50 mg / kgGanoderma lucidumEthanol Tingafinye patsiku kwa masiku asanu pa sabata.

Pambuyo pa masabata khumi ndi asanu ndi limodzi (miyezi inayi) yoyesera, zinapezeka kuti zakudya zamafuta ambiri zimatha kuwirikiza kawiri kulemera kwa mbewa.Ngakhale amadyaGanoderma lucidum, n'zovuta kuletsa chizolowezi cholemera (Chithunzi 1).

Komabe, pansi pamaziko a zakudya zamafuta ambiri, ngakhale mbewa zomwe zimadyaGanoderma lucidumndi mbewa zosadyaGanoderma lucidumamaoneka kuti ali ndi milingo yofanana ya kunenepa kwambiri, thanzi lawo lidzakhala losiyana kwambiri chifukwa cha kudya kapena kusadyaGanoderma lucidum.

Chithunzi 1　Zotsatira zaGanoderma lucidumpa thupi la mbewa zodyetsedwa ndi HFD

Ganoderma lucidumamachepetsa kuchuluka kwa mafuta a visceral mu mbewa za HFD-Fed.

Chithunzi 2 ndi chiwerengero cha chiwerengero cha maonekedwe ndi kulemera kwa chiwindi, mafuta a perirenal ndi mafuta a epididymal a gulu lililonse la mbewa kumapeto kwa kuyesera.

Chiwindi ndi malo opangira zakudya m'thupi.Zakudya zonse zomwe zimatengedwa m'matumbo zimawonongeka, kupangidwa ndikusinthidwa ndi chiwindi kukhala mawonekedwe ogwiritsidwa ntchito ndi maselo, kenako ndikugawidwa kulikonse kudzera m'magazi.Zikachulukirachulukira, chiwindi chimatembenuza ma calories owonjezera kukhala mafuta (triglycerides) ndikusunga pakagwa mwadzidzidzi.

Mafuta ochulukirapo akasungidwa, chiwindi chimakhala chachikulu komanso cholemera.Kumene, mafuta owonjezera adzaunjikana kuzungulira ziwalo zina zamkati, ndi perirenal mafuta ndi epididymal mafuta ndi oimira visceral mafuta kudzikundikira anawona mu zoyesera nyama.

Zitha kuwoneka pa Chithunzi 2 kutiGanoderma lucidumimatha kuchepetsa kwambiri kuchuluka kwa mafuta m'chiwindi ndi ziwalo zina zamkati zomwe zimayambitsidwa ndi zakudya zamafuta ambiri.

Chithunzi 2　Zotsatira zaGanoderma lucidumpa mafuta a visceral mu mbewa za HFD-Fed

Ganoderma lucidumamachepetsa chiwindi chamafuta mu mbewa za HFD-Fed.

Ofufuzawo adasanthulanso mafuta omwe ali m'chiwindi cha mbewa: zigawo za chiwindi cha mbewa mu gulu lirilonse zinali zodetsedwa ndi utoto wapadera, ndipo madontho a mafuta mu minofu ya chiwindi amaphatikizana ndi utoto ndikukhala wofiira.Monga momwe tawonetsera pa Chithunzi 3, mafuta omwe ali m'chiwindi anali osiyana kwambiri ndi zakudya zomwe zimakhala ndi mafuta ambiri kapena popanda kuwonjezeraGanoderma lucidum.

Mafuta omwe ali m'chiwindi cha mbewa pagulu lililonse adawerengedwa mu Chithunzi 4, ndipo zitha kuwoneka kuti chiwindi chamafuta m'gulu lazakudya zamafuta ambiri chimafika giredi 3 (mafuta ochulukirapo anali oposa 66% ya kulemera kwa chiwindi chonse. , kusonyeza chiwindi chamafuta kwambiri).Nthawi yomweyo, mafuta omwe ali m'chiwindi cha mbewa zodyetsedwa ndi HFD zomwe zimadyaGanoderma lucidumidachepetsedwa ndi theka.

Chithunzi 3　Zotsatira zodetsa mafuta za zigawo za chiwindi cha mbewa

Chithunzi 4　Zotsatira zaGanoderma lucidumpa kuchuluka kwa mafuta a chiwindi mu mbewa zodyetsedwa ndi HFD

[Kufotokozera] Kuopsa kwa chiwindi chamafuta kunagawidwa m'makalasi 0, 1, 2, ndi 3 malinga ndi kuchuluka kwa kulemera kwamafuta m'chiwindi: zosakwana 5%, 5-33%, kuposa 33% -66% ndi kuposa 66%, motero.Kufunika kwachipatala kumayimira bwino, pang'ono, pang'onopang'ono komanso chiwindi chamafuta kwambiri.

Ganoderma lucidumamateteza chiwindi ku mbewa zodyetsedwa ndi HFD.

Kuchuluka kwa mafuta ochulukirapo kumawonjezera ma radicals aulere m'chiwindi, zomwe zimapangitsa kuti maselo a chiwindi azikhala ndi kutupa chifukwa cha kuwonongeka kwa okosijeni, zomwe zimakhudza ntchito ya chiwindi.Komabe, si ziŵindi zonse zamafuta zomwe zidzakula mpaka kufika pamlingo wa hepatitis.Malingana ngati maselo a chiwindi sanawonongeke mopitirira muyeso, amatha kusungidwa mu "mafuta ochuluka" osavulaza.

Zitha kuwoneka kuchokera ku Chithunzi 5 kuti zakudya zamafuta kwambiri zimatha kuwirikiza kawiri seramu ALT (GPT), chizindikiro chofunikira kwambiri cha chiwindi cha hepatitis, kuchokera pamlingo wabwinobwino wa 40 U / L;komabe, ngatiGanoderma lucidumamatengedwa nthawi yomweyo, kuthekera kwa chiwindi chafupika kwambiri.Mwachiwonekere,Ganoderma lucidumimakhala ndi chitetezo pama cell a chiwindi omwe amalowetsedwa mumafuta.

Chithunzi 5 Zotsatira zaGanoderma lucidumpa ma index a hepatitis mu mbewa zodyetsedwa ndi HFD

Ganoderma lucidumimachepetsa mavuto a lipid m'magazi mu mbewa zodyetsedwa ndi HFD.

Chiwindi chikapanga mafuta ochulukirapo, ma lipids am'magazi amathanso kukhala ndi zolakwika.Kuyesera kwa nyama ku South Korea kunapeza kuti kudya kwa miyezi inayi yamafuta ambiri kumatha kukweza cholesterol, komaGanoderma lucidumakhoza kuchepetsa kuopsa kwa vutoli (Chithunzi 6).

Chithunzi 6　Zotsatira zaGanoderma lucidumpa seramu yonse ya cholesterol mu mbewa zodyetsedwa ndi HFD

Ganoderma lucidumimalepheretsa kuchuluka kwa shuga m'magazi mu mbewa zodyetsedwa ndi HFD.

Mayesero adapezanso kuti zakudya zokhala ndi mafuta ambiri zimatha kuyambitsa kuchuluka kwa shuga m'magazi.Komabe, ngatiGanoderma lucidumamatengedwa nthawi yomweyo, mulingo wa shuga m'magazi mwachiwonekere ukhoza kuwongoleredwa pakuwonjezeka pang'ono (Chithunzi 7).

Chithunzi 7　Zotsatira zaGanoderma lucidumpa glucose wamagazi mu mbewa zodyetsedwa ndi HFD

Ganoderma lucidumimapangitsa kuti thupi la mbewa zodyetsedwa ndi HFD lizitha kuyendetsa shuga wamagazi.

Ofufuzawo adayesanso kulekerera kwa glucose pa mbewa mkati mwa sabata lakhumi ndi chinayi la kuyesa, ndiko kuti, pakusala kudya pambuyo pa maola 16 akusala kudya, mbewa zidabayidwa ndi kuchuluka kwa glucose, ndipo kusintha kwa shuga m'magazi mkati mwa awiri. maola adawonedwa.Kusinthasintha kwa kuchuluka kwa shuga m'magazi kumapangitsa kuti thupi la mbewa lizitha kuwongolera shuga m'magazi.

Zinapezeka kuti kusinthasintha kwa kuchuluka kwa shuga m'magazi a gulu la HFD + GL kunali kotsika kuposa kwa gulu la HFD (Chithunzi 8).Izi zikutanthauza kutiGanoderma lucidumali ndi zotsatira zowongolera kuwongolera shuga m'magazi chifukwa cha zakudya zokhala ndi mafuta ambiri.

Chithunzi 8　Zotsatira zaGanoderma lucidumpa kulolera kwa glucose mu mbewa zodyetsedwa ndi HFD

Ganoderma lucidumimathandizira kukana insulini mu mbewa zodyetsedwa ndi HFD.

Ofufuzawa adayesanso kulekerera kwa insulini pa mbewa: Mu sabata lakhumi ndi chinayi lakuyesera, mbewa zosala kudya zinabayidwa ndi insulini, ndipo kusintha kwa shuga m'magazi kunagwiritsidwa ntchito kuti adziwe kukhudzidwa kwa maselo a mbewa ku insulini.

Insulin ndi timadzi tambiri timene timagwira ntchito yofunika kwambiri, motero glucose m’zakudya zathu kuloŵa m’maselo a thupi kuchokera m’magazi kuti apange mphamvu.Nthawi zonse, mutatha jakisoni wa insulin, kuchuluka kwa shuga m'magazi kumatsika pang'ono.Chifukwa chakuti shuga wambiri wam'magazi amalowa m'maselo mothandizidwa ndi insulin, shuga wamagazi amatsika mwachibadwa.

Komabe, zotsatira za kuyesako zidapeza kuti kudya kwanthawi yayitali kwamafuta ambiri kumapangitsa kuti maselo azikhala osakhudzidwa ndi insulin kotero kuti kuchuluka kwa shuga m'magazi kumakhalabe kokwera pambuyo pa jekeseni wa insulin, koma nthawi yomweyo, kusinthasintha kwa shuga m'magazi mu mbewa zodyetsedwa ndi HFD. amene anadyaGanoderma lucidumzinali zofanana ndi mbewa zodyetsedwa ndi ND (Chithunzi 9).Ndi zoonekeratu kutiGanoderma lucidumali ndi mphamvu yakuwongolera kukana kwa insulin.

Chithunzi 9　Zotsatira zaGanoderma lucidumpa kukana insulini mu mbewa zodyetsedwa ndi HFD

Njira yaGanoderma lucidummu kuchepetsa mafuta chiwindi

Kunenepa kwambiri kungayambitse kukana kwa insulini, ndipo kukana insulini sikungoyambitsa hyperglycemia komanso ndi chinthu chofunikira kwambiri chomwe chimayambitsa chiwindi chamafuta osaledzera.Chifukwa chake, kukana insulini kumachepetsedwaGanoderma lucidum, chiwindi mwachibadwa sichimakonda kudziunjikira mafuta.

Komanso, ofufuza anatsimikiziranso kuti Mowa Tingafinye waGanoderma lucidumfruiting thupi ntchito zoyesera nyama sangathe mwachindunji zochita za ena michere nawo lipid metabolism m'chiwindi komanso mwachindunji ziletsa synthesis mafuta ndi maselo a chiwindi, ndipo zotsatira zake n'zofanana ndi mlingo waGanoderma lucidum.Chofunika kwambiri, pambuyo Mlingo wogwira mtima waGanoderma lucidumanali otukuka ndi maselo a chiwindi cha anthu kwa maola 24, maselo akadali amoyo komanso abwino.

Ganoderma lucidumali ndi zotsatira za kuchepetsa shuga m'magazi, kuchepetsa mafuta ndi kuteteza chiwindi.

The tatchulazi zotsatira kafukufuku osati amatiuza kuti mowa Tingafinye waGanoderma lucidumfruiting thupi akhoza kuchepetsa zizindikiro za hyperglycemia, hyperlipidemia, ndi mafuta chiwindi chifukwa cha zakudya mafuta ambiri komanso amatikumbutsa kuti n'zotheka kupeza mafuta chiwindi popanda kumwa mowa.

Muzamankhwala, chiwindi chamafuta chomwe chimayambitsidwa ndi zinthu zomwe si mowa chimatchedwa "chiwindi chopanda mowa".Ngakhale kuti pali zinthu zina zomwe zingatheke (monga mankhwala osokoneza bongo), zizoloŵezi zodyera ndi zizoloŵezi za moyo ndizo zomwe zimayambitsa kwambiri.Taganizirani momwe foie gras, yomwe imakondedwa kwambiri ndi osusuka, imapangidwira?Ndi momwemonso ndi anthu!

Malinga ndi ziwerengero, pafupifupi gawo limodzi mwa magawo atatu a anthu akuluakulu ali ndi chiwopsezo chosavuta (ndiko kuti, alibe zizindikiro za matenda a chiwindi) chiwindi chamafuta osaledzeretsa, ndipo pafupifupi gawo limodzi mwa magawo atatu aliwonse a iwo amakula kukhala chiwindi chamafuta mkati mwa zaka khumi ndi zisanu.Palinso malipoti akuti chiwindi chamafuta osaledzeretsa chakhala chomwe chimayambitsa kusokonekera kwa ALT ku Taiwan (33.6%), kuposa kachilombo ka hepatitis B (28.5%) ndi kachilombo ka hepatitis C (13.2%).(Onani tsamba 2 kuti mudziwe zambiri)

Chodabwitsa n’chakuti, pamene mabungwe a zaumoyo padziko lonse akupitiriza kulimbana ndi matenda otupa chiwindi a virus pogwiritsa ntchito katemera ndi mankhwala osokoneza bongo, kuchuluka kwa matenda a chiwindi chamafuta obwera chifukwa cha kudya kwambiri kapena kumwa kwambiri kukuwonjezereka.

Matenda a chiwindi amafuta (steatosis) amapezeka mafuta m'chiwindi akafika kapena kupitilira 5% ya kulemera kwa chiwindi.Kuzindikira koyamba kwa matenda a chiwindi chamafuta kuyenera kudalira pamimba yam'mimba kapena computed tomography (CT).Ngati simunayambe chizolowezi choyeza thanzi lanu, mutha kuweruza ngati muli ndi matenda a chiwindi chamafuta ngati muli ndi matenda a metabolic monga kunenepa kwambiri, hyperglycemia (mtundu wa 2 shuga) ndi hyperlipidemia chifukwa zizindikiro izi kapena matenda nthawi zambiri zimachitika limodzi ndi Nonalcoholic mafuta a chiwindi matenda (NAFLD).

Kungoti palibe mankhwala enieni a matenda a chiwindi chamafuta.Ichi ndichifukwa chake, pambuyo pa matenda a chiwindi chamafuta, dokotala akhoza kukupatsani chakudya chochepa, masewera olimbitsa thupi komanso kuchepetsa thupi kusiyana ndi mankhwala ochiritsira.Komabe, sikophweka kusintha kadyedwe kake ndi zizoloŵezi za moyo.Anthu ambiri amakakamira m'matope a "kulephera kulamulira zakudya ndi kuonjezera zochitika zolimbitsa thupi" kapena kulimbana ndi "kulephera kuchotsa chiwindi chamafuta ngakhale poyendetsa zakudya komanso kuwonjezeka kwa masewera olimbitsa thupi".

Kodi tiyenera kuchita chiyani padziko lapansi?Titawerenga zotsatira za kafukufuku wa Gyeongsang National University ku South Korea, tikudziwa kuti pali chida china chamatsenga, ndiko kuti, kudya chotsitsa cha ethanol.Ganoderma lucidumfruiting thupi.

Ganoderma lucidum, yomwe ili ndi ntchito zoteteza chiwindi, kuchepetsa shuga wa magazi, ndi kuchepetsa mafuta, zimakhala zotsika mtengo;ngakhale sizingakupangitseni kuchepa thupi, zimatha kukupatsani thanzi ngakhale mutakhala onenepa kwambiri.

[Chitsime]

Jung S, ndi al. Ganoderma lucidumamathandizira steatosis yosakhala mowa mwa kuwongolera ma enzymes otulutsa mphamvu m'chiwindi.J Clin Med.2018 Jun 15; 7(6).ndi: E152.doi: 10.3390/jcm7060152.

[Kuwerenganso]

Mwachidziwitso, koyambirira kwa 2017, lipoti "Zochita za Antidiabetic zaGanoderma lucidumpolysaccharides F31 pansi-regulated glucose regulatory enzymes mu mbewa odwala matenda ashuga” linasindikizidwa limodzi ndi Guangdong Institute of Microbiology ndi Guangdong Provincial Center for Disease Control and Prevention.Kutengera mtundu wa nyama wamtundu wa 2 shuga, imayang'ana njira zoyendetseraGanoderma lucidumfruiting thupi yogwira polysaccharides pa shuga magazi ndi kupewa ndi kuchiza matenda a chiwindi chifukwa cha matenda a shuga.Kachitidwe kake kamagwiranso ntchito ndikuwongolera kwa michere yomwe imakhudzidwa ndi metabolism yamphamvu m'chiwindi komanso kusintha kwa insulin kukana.Ilo ndi lipoti ili laku South Korea likufika pamapeto omwewo mwanjira zosiyanasiyana.Anzanu achidwi atha kulozanso lipoti ili.

Zofotokozera za chiwindi chamafuta osamwa mowa

1. Teng-cing Huang et al.Chiwindi chamafuta osaledzeretsa.Mankhwala a Banja ndi Chithandizo Chachikulu Chachipatala, 2015;30 (11): 314-319.

2. Ching-feng Su ndi al.Kuzindikira ndi kuchiza matenda a chiwindi amafuta osaledzeretsa.2015;30 (11) : 255-260.

3. Ying-tao Wu et al.Mau oyamba pazamankhwala osagwiritsa ntchito mowa mafuta a chiwindi matenda.Pharmaceutical Journal, 2018;34 (2) : 27-32.

4. Huei-wun Liang: Matenda a chiwindi chamafuta amatha kusinthidwa ndikutsanzikana ndi chiwindi chamafuta!Liver Disease Prevention & Treatment Research Foundation webusaitiyi.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.