Ku ya 15 Kamena 2018 / Kaminuza nkuru ya Gyeongsang, Koreya y'Epfo / Ikinyamakuru cy’ubuvuzi bwa Clinical

Inyandiko / Wu Tingyao

Ishuri ry’ubuvuzi rya kaminuza ya Gyeongsang muri Koreya yepfo ryasohoye urupapuro mu kinyamakuru cy’ubuvuzi bwa Clinical muri Kamena 2018 ruvuga koGanoderma lucidumirashobora kugabanya ibinure byumwijima biterwa nimirire yuzuye amavuta, ariko ubushakashatsi bwibikoko bifitanye isano nabwo bwagaragaje ko imbeba zabyibushye nimirire yuzuye amavuta nayo izagira glucose nke yamaraso hamwe nibibazo bya lipide yamaraso bitewe no gutabaraGanoderma lucidum.

Imbeba zigeragezwa zagabanyijwemo amatsinda ane: indyo isanzwe (ND), indyo isanzwe (ND) +Ganoderma lucidum(GL), indyo yuzuye amavuta (HFD), indyo yuzuye amavuta (HFD) +Ganoderma lucidum(GL).Mu biryo by'itsinda risanzwe ryimirire, ibinure bingana na 6% bya karori zose;mu biryo by'amafunguro yuzuye amavuta, ibinure bingana na 45% bya karori zose, zikubye inshuro 7.5 za mbere.UwitekaGanoderma lucidumkugaburirwa imbeba mubyukuri ni Ethanol ikuramo umubiri weraGanoderma lucidum.Abashakashatsi bagaburiye imbeba ku kigero cya 50 mg / kgGanoderma lucidumgukuramo Ethanol kumunsi iminsi itanu mucyumweru.

Nyuma yibyumweru cumi na bitandatu (amezi ane) yubushakashatsi, byagaragaye ko indyo yigihe kirekire ibinure byinshi ishobora kwikuba kabiri uburemere bwimbeba.Nubwo baryaGanoderma lucidum, biragoye guhagarika impengamiro yo kongera ibiro (Ishusho 1).

Ariko, hashingiwe ku ndyo yuzuye ibinure, nubwo imbeba ziryaGanoderma lucidumn'imbeba zitaryaGanoderma lucidumbigaragara ko bafite urwego rumwe rwumubyibuho ukabije, ubuzima bwabo buzaba butandukanye cyane kubera kurya cyangwa kutaryaGanoderma lucidum.

Igishushanyo 1　Ingaruka yaGanoderma lucidumku buremere bw'imbeba zagaburiwe na HFD

Ganoderma lucidumigabanya ibinure bya visceral mu mbeba za HFD-Fed.

Igishushanyo cya 2 nigishushanyo mbonera cyerekana isura nuburemere bwumwijima, ibinure bya perirenal hamwe n amavuta ya epididymal ya buri tsinda ryimbeba nurangiza ubushakashatsi.

Umwijima ni igihingwa gitunganya intungamubiri mu mubiri.Intungamubiri zose zinjizwa mu mara zizabora, zunganwe kandi zitunganyirizwe n'umwijima muburyo bukoreshwa na selile, hanyuma bigakwirakwizwa hose binyuze mumaraso.Iyo habaye gukabya, umwijima uzahindura karori zirenze ibinure (triglyceride) hanyuma ubibike byihutirwa.

Ibinure byinshi bibitswe, nini kandi iremereye umwijima uba.Birumvikana ko ibinure byinshi bizarundanya no mu zindi ngingo zimbere, kandi ibinure bya perirenal hamwe n amavuta ya epididymal ni uguhagararira ibinure byumubiri bigaragara mubushakashatsi bwinyamaswa.

Birashobora kugaragara kuva ku gishushanyo cya 2 koGanoderma lucidumirashobora kugabanya cyane kwegeranya ibinure mu mwijima no mu zindi ngingo zimbere ziterwa nimirire yuzuye amavuta.

Igishushanyo 2　Ingaruka yaGanoderma lucidumku binure bya visceral mu mbeba za HFD-Fed

Ganoderma lucidumigabanya umwijima w'amavuta mu mbeba za HFD-Fed.

Abashakashatsi bakomeje gusesengura ibinure biri mu mwijima w’imbeba: ibice bigize umwijima w’imbeba muri buri tsinda wasize irangi ryihariye, kandi ibitonyanga byamavuta mu ngingo yumwijima byahuza irangi bigahinduka umutuku.Nkuko bigaragara ku gishushanyo cya 3, ibinure biri mu mwijima byari bitandukanye cyane mu ndyo yuzuye ibinure byinshi cyangwa utongeyehoGanoderma lucidum.

Ibinure biri mu mwijima w'ingirangingo z'imbeba muri buri tsinda byapimwe mu gishushanyo cya 4, kandi washoboraga kubona ko umwijima w'amavuta mu itsinda ry’amavuta menshi yageze mu cyiciro cya 3 (ibinure byari hejuru ya 66% by'uburemere bw'umwijima wose , byerekana umwijima mwinshi cyane).Muri icyo gihe, ibinure biri mu mwijima wimbeba zagaburiwe na HFD zariyeGanoderma lucidumyagabanutseho kimwe cya kabiri.

Igishushanyo 3　Ibinure byerekana ibisubizo byimbeba yumwijima

Igicapo 4　Ingaruka yaGanoderma lucidumku kwegeranya ibinure byumwijima mu mbeba zagaburiwe na HFD

[Ibisobanuro] Uburemere bwumwijima wamavuta bwashyizwe mubyiciro 0, 1, 2, na 3 ukurikije igipimo cyibiro byamavuta muburemere bwumwijima: munsi ya 5%, 5-33%, hejuru ya 33% -66% na barenga 66%.Ubusobanuro bwa clinique bwerekanaga umwijima usanzwe, woroshye, uringaniye kandi ukabije.

Ganoderma lucidumirinda hepatite mu mbeba zagaburiwe na HFD.

Kwiyegeranya ibinure byinshi bizongera radicals yubusa mu mwijima, bituma selile yumwijima ikunda gutwikwa kubera kwangirika kwa okiside, bityo bikagira ingaruka kumikorere yumwijima.Ariko, ibibyibushye byose ntabwo bizatera imbere kurwego rwa hepatite.Igihe cyose ingirangingo z'umwijima zangiritse cyane, zirashobora kubungabungwa muburyo bwo kutagira ingaruka "kwirundanya kw'amavuta."

Birashobora kugaragara ku gishushanyo cya 5 ko indyo yuzuye ibinure ishobora gukuba kabiri serumu ALT (GPT), ikimenyetso cyingenzi cya hepatite, uhereye kurwego rusanzwe rwa 40 U / L;ariko, nibaGanoderma lucidumifatwa icyarimwe, amahirwe ya hepatite aragabanuka cyane.Biragaragara,Ganoderma lucidumigira ingaruka zo kurinda ingirangingo z'umwijima zinjiye mu binure.

Igicapo 5 Ingaruka zaGanoderma lucidumkurutonde rwa hepatite mu mbeba zagaburiwe na HFD

Ganoderma lucidumikuraho ibibazo byamaraso ya lipide mumbeba zagaburiwe na HFD.

Iyo umwijima ushizemo ibinure byinshi, lipide yamaraso nayo ikunda guhura nibidasanzwe.Ubu bushakashatsi bw’inyamaswa muri Koreya yepfo bwagaragaje ko amezi ane indyo yuzuye ibinure ishobora kuzamura cholesterol, arikoGanoderma lucidumirashobora kugabanya ubukana bwikibazo (Ishusho 6).

Igicapo 6　Ingaruka yaGanoderma lucidumkuri serumu yuzuye cholesterol muri HFD yagaburiwe imbeba

Ganoderma lucidumibuza kwiyongera kw'amaraso glucose mu mbeba zagaburiwe na HFD.

Ubushakashatsi bwerekanye kandi ko indyo yuzuye ibinure ishobora gutera glucose yamaraso kwiyongera.Ariko, nibaGanoderma lucidumifatwa icyarimwe, urwego glucose yamaraso irashobora kugenzurwa no kwiyongera gake (Ishusho 7).

Igicapo 7　Ingaruka yaGanoderma lucidumku maraso glucose mu mbeba zagaburiwe na HFD

Ganoderma lucidumitezimbere ubushobozi bwumubiri wimbeba zagaburiwe na HFD kugenzura isukari yamaraso.

Abashakashatsi kandi bakoze ikizamini cyo kwihanganira glucose ku mbeba mu cyumweru cya cumi na kane cy’ubushakashatsi, ni ukuvuga mu gihe cyo kwiyiriza ubusa nyuma y’amasaha 16 yo kwiyiriza ubusa, imbeba zatewe na glucose nyinshi, kandi glucose yamaraso ihinduka muri bibiri amasaha yarubahirijwe.Iyo ihindagurika ryurwego rwamaraso glucose, niko ubushobozi bwumubiri wimbeba bugenga glucose yamaraso.

Byagaragaye ko ihindagurika ry’amaraso ya glucose yo mu itsinda rya HFD + GL ryari munsi y’iryo tsinda rya HFD (Ishusho 8).Ibi bivuze koGanoderma lucidumifite ingaruka zo kunoza amategeko ya glucose yamaraso aterwa nimirire yuzuye amavuta.

Igicapo 8　Ingaruka yaGanoderma lucidumkwihanganira glucose mu mbeba zagaburiwe na HFD

Ganoderma lucidumitezimbere insuline irwanya imbeba zagaburiwe na HFD.

Abashakashatsi kandi bakoze ikizamini cyo kwihanganira insuline ku mbeba: Mu cyumweru cya cumi na kane cy’ubushakashatsi, imbeba zo kwiyiriza ubusa zatewe insuline, kandi impinduka zo mu maraso glucose zarakoreshejwe kugira ngo hamenyekane ko ingirabuzimafatizo z’imbeba zifite insuline.

Insuline ni imisemburo, igira uruhare runini, ituma glucose mu biryo byacu yinjira mu ngirabuzimafatizo z'umubiri ziva mu maraso kugira ngo zitange ingufu.Mubihe bisanzwe, nyuma yo guterwa insuline, urwego rwambere glucose yamaraso ruzagabanuka kurwego runaka.Kuberako glucose yamaraso myinshi izinjira muri selile hifashishijwe insuline, urwego rwisukari rwamaraso ruzagabanuka.

Nyamara, ibyavuye mu bushakashatsi byagaragaje ko indyo y’amavuta maremare yatuma ingirabuzimafatizo ziba insuline bityo urugero rwa glucose mu maraso rukomeza kuba hejuru nyuma yo guterwa insuline, ariko icyarimwe, ihindagurika ry’amaraso mu mbeba zagaburiwe na HFD. yariyeGanoderma lucidumyari imeze nkiyo mu mbeba zagaburiwe ND (Ishusho 9).Biragaragara koGanoderma lucidumifite ingaruka zo kunoza insuline.

Igicapo 9　Ingaruka yaGanoderma lucidumkuri insuline irwanya imbeba zagaburiwe na HFD

Uburyo bwaGanoderma lucidummu kugabanya umwijima w'amavuta

Umubyibuho ukabije urashobora gutera insuline irwanya, kandi kurwanya insuline ntabwo bitera hyperglycemia gusa ahubwo ni nacyo kintu cyingenzi kiganisha ku mwijima utarimo inzoga.Kubwibyo, iyo insuline irwanya kugabanukaGanoderma lucidum, umwijima mubisanzwe usanga udakunda kwigwizaho amavuta.

Byongeye kandi, abashakashatsi bemeje kandi ko Ethanol ikuramoGanoderma lucidumimbuto zera zikoreshwa mubushakashatsi bwinyamanswa ntizishobora gusa kugenzura imikorere yimisemburo imwe n'imwe igira uruhare muri metabolisme ya lipide mu mwijima ariko kandi ikanabuza guhuza ibinure byama selile yumwijima, kandi ingaruka zingana na dosiye yaGanoderma lucidum.Icyingenzi cyane, nyuma yiyi dosiye yingirakamaro yaGanoderma lucidumbarezwe hamwe ningirabuzimafatizo zumwijima kumasaha 24, selile zari zikiri nzima kandi neza.

Ganoderma lucidumifite ingaruka zo kugabanya glucose yamaraso, kugabanya ibinure no kurinda umwijima.

Ibisubizo byubushakashatsi byavuzwe haruguru ntabwo bitubwira gusa ko ibisindisha bya alcool yaGanoderma lucidumumubiri wera urashobora kugabanya ibimenyetso bya hyperglycemia, hyperlipidemia, numwijima wamavuta uterwa nimirire yuzuye amavuta ariko bikatwibutsa kandi ko bishoboka kubona umwijima wamavuta utanyweye inzoga.

Mu buvuzi, umwijima w'amavuta uterwa n'impamvu zitari inzoga bakunze kwita “umwijima utari inzoga.”Nubwo hari izindi mpamvu zishoboka (nk'ibiyobyabwenge), ingeso yo kurya hamwe nubuzima bwo kubaho biracyari impamvu zikunze kugaragara.Tekereza uburyo foie gras, ikundwa cyane na gluttons, ikorwa?Ni kimwe n'abantu!

Dukurikije imibare, hafi kimwe cya gatatu cyabantu bakuru bafite umwijima woroshye (ni ukuvuga, nta bimenyetso bya hepatite) umwijima w’amavuta utarimo inzoga, kandi hafi kimwe cya kane cyabo uzarwara cyane mu mwijima w’umwijima mu myaka cumi n'itanu.Ndetse hari amakuru avuga ko umwijima w’amavuta utarimo inzoga wabaye intandaro y’igipimo cya ALT kidasanzwe muri Tayiwani (33,6%), urenze kure virusi ya hepatite B (28.5%) na virusi ya hepatite C (13.2%).(Reba ibisobanuro 2 kugirango ubone ibisobanuro)

Igitangaje, uko ibigo nderabuzima ku isi bikomeje kurwanya virusi ya hepatite ikingira inkingo n’ibiyobyabwenge, ubwiyongere bw’indwara z’umwijima zatewe no kurya neza cyangwa kunywa cyane biriyongera.

Indwara yumwijima (steatose) ibaho mugihe ibinure byumwijima bigeze cyangwa birenze 5% byuburemere bwumwijima.Isuzuma ryambere ryindwara zumwijima zigomba gushingira kuri ultrasound yo munda cyangwa tomografiya yabazwe (CT).Niba utarigeze ugira akamenyero ko kwisuzumisha mubuzima, urashobora kandi kumenya niba ufite uburwayi bwumwijima buterwa no kuba ufite syndromes ya metabolike nkumubyibuho ukabije, hyperglycemia (diabete yo mu bwoko bwa 2) na hyperlipidemiya kuko ibi bimenyetso cyangwa indwara bikunze kugaragara hamwe hamwe indwara y'umwijima idafite inzoga (NAFLD).

Ni uko nta miti yihariye yindwara zumwijima.Niyo mpamvu, nyuma yo gusuzuma umwijima w'amavuta, umuganga arashobora kuguha gusa indyo yoroheje, imyitozo ngororamubiri no kugabanya ibiro aho kuvura neza.Ariko, ntibyoroshye guhindura ingeso yo kurya nubuzima.Abantu benshi bagumye mu gihirahiro cyo "kunanirwa kugenzura indyo no kongera imyitozo ngororamubiri" cyangwa mu rugamba rwo "kunanirwa kwikuramo umwijima w'amavuta ndetse no kugenzura indyo no kongera imyitozo ngororamubiri".

Tugomba gukora iki ku isi?Nyuma yo gusoma ibyavuye mu bushakashatsi bwakozwe na kaminuza nkuru ya Gyeongsang muri Koreya yepfo, tuzi ko hari indi ntwaro yubumaji, ni ukuvuga kurya ibinyobwa bya Ethanol yaGanoderma lucidumumubiri wera.

Ganoderma lucidum, ifite imirimo yo kurinda umwijima, kugabanya isukari mu maraso, no kugabanya ibinure, rwose birahenze;nubwo bitagishobora gutuma ugabanya ibiro, birashobora nibura gutuma ugira ubuzima bwiza nubwo waba ufite umubyibuho ukabije.

[Inkomoko]

Jung S, n'abandi. Ganoderma lucidumikosora steatose itari inzoga muguhuza ingufu metabolizing enzymes mumwijima.J Clin Med.2018 Jun 15; 7 (6).pii: E152.doi: 10.3390 / jcm7060152.

[Ibindi bisomwa]

Ku bw'amahirwe, mu ntangiriro za 2017, raporo “Igikorwa cya Antidiabete yaGanoderma lucidumpolysaccharide F31 imisemburo ya hepatike ya glucose igengwa n'imbeba za diyabete "yasohowe hamwe n'ikigo cya Guangdong Institute of Microbiology hamwe n'ikigo cy'intara cya Guangdong gishinzwe kurwanya no gukumira indwara.Ukurikije icyitegererezo cyinyamanswa ya diyabete yo mu bwoko bwa 2, irasesengura uburyo bwo kugenzuraGanoderma lucidumkwera umubiri ukora polysaccharide ikora kuri glucose yamaraso no kwirinda no kuvura hepatite iterwa na diyabete.Uburyo bwibikorwa byabwo bifitanye isano no kugenzura imisemburo igira uruhare mu guhinduranya ingufu mu mwijima no kunoza insuline.Niyi raporo ya koreya yepfo igera kumpera imwe muburyo butandukanye.Inshuti zishaka zishobora no kohereza kuri iyi raporo.

Ibikoresho byerekeranye n'umwijima utarimo inzoga

1. Teng-cing Huang n'abandi.Umwijima w'amavuta ya alcool.Ubuvuzi bwumuryango nubuvuzi bwibanze, 2015;30 (11): 314-319.

2. Ching-feng Su n'abandi.Gupima no kuvura indwara zumwijima zidafite inzoga.2015;30 (11): 255-260.

3. Ying-tao Wu n'abandi.Intangiriro yo kuvura indwara zumwijima zidafite inzoga.Ikinyamakuru cya farumasi, 2018;34 (2): 27-32.

4. Huei-wun Liang: Indwara y'umwijima irashobora guhinduka hanyuma ugasezera ku mwijima w'amavuta!Kurinda Indwara Zumwijima & Kuvura Ubushakashatsi Fondasiyo.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).
 
★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.