Lub Rau Hli 15, 2018 / Gyeongsang National University, South Kauslim / Phau ntawv Journal of Clinical Medicine

Text/Wu Tingyao

Gyeongsang National University Lub Tsev Kawm Ntawv Tshuaj Kho Mob hauv Kaus Lim Qab Teb tau luam tawm ib daim ntawv hauv Phau Tsom Faj Tshuaj Kho Mob thaum Lub Rau Hli 2018 hais tiasGanoderma lucidumtuaj yeem txo cov rog hauv siab los ntawm kev noj zaub mov muaj rog, tab sis lwm yam kev sim tsiaj kuj pom tau tias cov nas fattened los ntawm kev noj zaub mov muaj roj kuj tseem muaj cov ntshav qabzib tsawg thiab cov ntshav lipid vim muaj kev cuam tshuam ntawmGanoderma lucidum.

Cov nas sim tau muab faib ua plaub pawg: noj zaub mov zoo (ND), noj zaub mov zoo (ND) +Ganoderma lucidum(GL), kev noj zaub mov muaj roj ntau (HFD), kev noj zaub mov muaj roj ntau (HFD) +Ganoderma lucidum(GL).Nyob rau hauv cov zaub mov ntawm ib txwm noj pab pawg neeg, rog accounted rau 6% ntawm tag nrho cov calories;Hauv kev noj zaub mov uas muaj roj ntau, rog suav txog 45% ntawm tag nrho cov calories, uas yog 7.5 npaug ntawm qhov qub.CovGanoderma lucidumpub rau nas yog ua tau ib qho ethanol extract ntawm fruiting lub cev ntawmGanoderma lucidum.Cov kws tshawb fawb tau noj cov nas ntawm qhov koob tshuaj ntawm 50 mg / kgGanoderma lucidumethanol extract ib hnub rau tsib hnub hauv ib lub lis piam.

Tom qab kaum rau lub lis piam (plaub lub hlis) ntawm kev sim, nws tau pom tias kev noj zaub mov muaj roj ntev ntev tuaj yeem ua ob npaug ntawm qhov hnyav ntawm nas.Txawm tias lawv nojGanoderma lucidum, nws yog ib qho nyuaj rau thaiv txoj kev nyiam kom nce qhov hnyav (Daim duab 1).

Txawm li cas los xij, nyob rau hauv qhov chaw ntawm kev noj zaub mov muaj rog, txawm tias cov nas uas nojGanoderma lucidumthiab cov nas uas tsis nojGanoderma lucidumzoo nkaus li muaj qhov sib xws ntawm kev rog, lawv cov kev noj qab haus huv yuav txawv heev vim noj los yog tsis nojGanoderma lucidum.

Daim duab 1　Cov nyhuv ntawmGanoderma lucidumntawm lub cev hnyav ntawm HFD-fed nas

Ganoderma lucidumtxo visceral rog tsub zuj zuj hauv HFD-Fed nas.

Daim duab 2 yog daim duab statistical ntawm cov tsos thiab qhov hnyav ntawm daim siab, perirenal rog thiab epididymal rog ntawm txhua pawg nas thaum kawg ntawm qhov kev sim.

Lub siab yog cov khoom noj khoom haus hauv lub cev.Tag nrho cov as-ham absorbed los ntawm txoj hnyuv yuav decomposed, synthesized thiab ua tiav los ntawm lub siab mus rau hauv ib daim ntawv uas siv tau los ntawm cov hlwb, thiab ces muab faib rau txhua qhov chaw los ntawm cov ntshav ncig.Thaum muaj cov khoom siv ntau dhau, lub siab yuav hloov cov calorie ntau ntau rau hauv cov rog (triglycerides) thiab khaws cia rau thaum muaj xwm txheej ceev.

Cov roj ntau yog khaws cia, lub siab loj thiab hnyav dua.Yog lawm, cov roj ntau dhau kuj tseem tuaj yeem sib sau nyob ib puag ncig lwm yam kabmob hauv nruab nrog cev, thiab cov roj perirenal thiab cov roj ntsha epididymal yog cov neeg sawv cev ntawm cov roj visceral tsub zuj zuj hauv cov tsiaj sim.

Nws tuaj yeem pom los ntawm daim duab 2 ntawdGanoderma lucidumtuaj yeem txo cov rog hauv daim siab thiab lwm yam hauv nruab nrog cev los ntawm kev noj zaub mov muaj roj ntau.

Daim duab 2　Cov nyhuv ntawmGanoderma lucidumntawm visceral rog hauv HFD-Fed nas

Ganoderma lucidumtxo cov rog rog hauv HFD-Fed nas.

Cov kws tshawb fawb tau soj ntsuam ntxiv cov roj cov ntsiab lus nyob rau hauv daim siab ntawm nas: daim siab cov ntaub so ntswg ntawm cov nas nyob rau hauv txhua pab pawg tau stained nrog ib tug tshwj xeeb zas xim, thiab cov roj droplets nyob rau hauv daim siab cov ntaub so ntswg yuav ua ke nrog cov zas xim thiab tig liab.Raws li pom nyob rau hauv daim duab 3, cov roj cov ntsiab lus nyob rau hauv lub siab yog sib txawv heev nyob rau hauv tib cov khoom noj uas muaj roj ntau nrog los yog tsis muaj ntxiv ntawmGanoderma lucidum.

Cov rog hauv daim siab ntawm cov nas nyob rau hauv txhua pab pawg tau muab xam rau hauv daim duab 4, thiab nws tuaj yeem pom tias cov rog rog nyob rau hauv pawg neeg noj zaub mov muaj rog tau mus txog qib 3 (cov ntsiab lus rog ntau dua 66% ntawm qhov hnyav ntawm tag nrho lub siab. , qhia tias mob siab rau daim siab).Nyob rau tib lub sijhawm, cov roj cov ntsiab lus hauv daim siab ntawm HFD-fed nas uas tau nojGanoderma lucidumraug txo los ntawm ib nrab.

Daim duab 3　Fat staining tshwm sim ntawm nas daim siab cov ntaub so ntswg

Daim duab 4　Cov nyhuv ntawmGanoderma lucidumntawm daim siab rog tsub zuj zuj hauv HFD-fed nas

[Kev piav qhia] Qhov hnyav ntawm lub siab rog tau muab faib ua qib 0, 1, 2, thiab 3 raws li kev faib ua feem ntawm cov rog hauv daim siab hnyav: tsawg dua 5%, 5-33%, ntau dua 33% -66% thiab ntau dua 66%, feem.Qhov tseem ceeb ntawm kev kho mob yog sawv cev ib txwm, me, nruab nrab thiab hnyav fatty siab.

Ganoderma lucidumtiv thaiv kab mob siab hauv HFD-fed nas.

Cov rog ntau dhau yuav ua rau cov dawb radicals nyob rau hauv daim siab, ua rau cov hlwb ua rau mob o vim oxidative puas tsuaj, yog li cuam tshuam rau daim siab ua haujlwm.Txawm li cas los xij, tsis yog txhua lub siab rog yuav nce mus rau qib ntawm kab mob siab.Ntev npaum li lub siab lub hlwb tsis muaj kev puas tsuaj ntau dhau, lawv tuaj yeem khaws cia rau hauv qhov tsis muaj teeb meem "cov rog yooj yim."

Nws tuaj yeem pom los ntawm daim duab 5 tias kev noj zaub mov muaj rog tuaj yeem ua rau ob leeg ntshav ALT (GPT), qhov taw qhia tseem ceeb tshaj plaws ntawm kab mob siab, los ntawm qib ib txwm muaj txog 40 U / L;txawm li cas los xij, yog tiasGanoderma lucidumyog noj nyob rau tib lub sij hawm, muaj peev xwm ntawm kab mob siab yog heev txo.Pom tseeb,Ganoderma lucidummuaj kev tiv thaiv ntawm daim siab hlwb infiltrated hauv rog.

Daim duab 5 Cov nyhuv ntawmGanoderma lucidumntawm kab mob siab indexes hauv HFD-fed nas

Ganoderma lucidumrelieves ntshav lipid teeb meem hauv HFD-fed nas.

Thaum lub siab ua kom muaj roj ntau dhau, cov ntshav lipids kuj ua rau muaj qhov txawv txav.Qhov kev sim tsiaj no hauv Kaus Lim Qab Teb tau pom tias plaub lub hlis noj zaub mov muaj roj tuaj yeem nce cov roj cholesterol, tab sisGanoderma lucidumtuaj yeem txo qhov hnyav ntawm qhov teeb meem (Daim duab 6).

Daim duab 6　Cov nyhuv ntawmGanoderma lucidumntawm cov cholesterol tag nrho hauv cov nas HFD noj

Ganoderma luciduminhibits ntshav qabzib nce hauv HFD-fed nas.

Kev sim kuj pom tau tias kev noj zaub mov muaj roj ntau tuaj yeem ua rau cov ntshav qabzib nce siab.Txawm li cas los xij, yog tiasGanoderma lucidumnoj tib lub sijhawm, cov ntshav qabzib tuaj yeem tswj tau ntawm qhov nce me me (Daim duab 7).

Daim duab 7　Cov nyhuv ntawmGanoderma lucidumntawm cov ntshav qabzib hauv HFD-fed nas

Ganoderma lucidumtxhim kho lub peev xwm ntawm lub cev ntawm HFD-fed nas los tswj cov ntshav qab zib.

Cov kws tshawb fawb kuj tau ua qhov kev kuaj ntshav qabzib rau cov nas thaum lub sijhawm kaum plaub lub limtiam ntawm qhov kev sim, uas yog, hauv lub xeev yoo mov tom qab 16 teev ntawm kev yoo mov, cov nas tau txhaj tshuaj nrog cov piam thaj ntau, thiab cov ntshav qabzib hloov hauv ob. teev tau pom.Qhov me dua qhov hloov pauv ntawm cov ntshav qabzib, qhov muaj peev xwm ntawm tus nas lub cev kom tswj tau cov ntshav qabzib zoo.

Nws tau pom tias qhov hloov pauv ntawm cov ntshav qabzib ntawm pawg HFD + GL qis dua li ntawm pawg HFD (Daim duab 8).Qhov no txhais tau tiasGanoderma lucidummuaj cov nyhuv ntawm kev txhim kho cov ntshav qabzib kev tswj hwm los ntawm kev noj zaub mov muaj roj ntau.

Daim duab 8　Cov nyhuv ntawmGanoderma lucidumntawm Glucose kam rau ua hauv HFD-fed nas

Ganoderma lucidumtxhim kho insulin tsis kam hauv HFD-fed nas.

Cov kws tshawb fawb kuj tau ua qhov kev sim tshuaj insulin rau cov nas: Hauv lub lis piam thib kaum plaub ntawm qhov kev sim, cov nas yoo mov tau txhaj tshuaj insulin, thiab cov kev hloov pauv hauv cov ntshav qabzib tau siv los txiav txim siab qhov rhiab ntawm nas cov hlwb rau insulin.

Insulin yog ib yam tshuaj hormones, uas ua lub luag haujlwm tseem ceeb, tso cai rau cov piam thaj hauv peb cov zaub mov nkag mus rau hauv lub cev cov hlwb los ntawm cov hlab ntsha los tsim lub zog.Raws li ib txwm muaj, tom qab txhaj tshuaj insulin, cov ntshav qabzib qub yuav poob qis rau qee qhov.Vim tias cov ntshav qabzib ntau yuav nkag mus rau hauv cov hlwb nrog kev pab ntawm insulin, cov ntshav qab zib yuav poob qis.

Txawm li cas los xij, cov txiaj ntsig ntawm qhov kev sim pom tau tias kev noj zaub mov muaj roj ntev ntev yuav ua rau cov hlwb tsis nkag siab rau insulin yog li cov ntshav qabzib tseem siab tom qab txhaj tshuaj insulin, tab sis tib lub sijhawm, cov ntshav qabzib hloov pauv hauv HFD-fed nas. uas tau nojGanoderma lucidumtau zoo ib yam li hauv ND-fed nas (Daim duab 9).Nws yog pom tseeb tiasGanoderma lucidummuaj cov nyhuv ntawm kev txhim kho cov tshuaj insulin.

Daim duab 9　Cov nyhuv ntawmGanoderma lucidumntawm insulin tsis kam hauv HFD-fed nas

Lub mechanism ntawmGanoderma lucidumhauv kev txo cov rog rog

Kev rog rog tuaj yeem ua rau cov tshuaj insulin tsis kam, thiab insulin tsis kam tsis tsuas yog ua rau hyperglycemia tab sis kuj yog qhov tseem ceeb tshaj plaws uas ua rau lub siab tsis muaj dej cawv.Yog li ntawd, thaum cov tshuaj insulin txo qisGanoderma lucidum, daim siab yog ib txwm tsis tshua muaj rog tsub zuj zuj.

Tsis tas li ntawd, cov kws tshawb fawb kuj tau lees paub tias ethanol extract ntawmGanoderma lucidumTxiv hmab txiv ntoo lub cev siv nyob rau hauv cov tsiaj thwmsim tsis tau tsuas yog ncaj qha tswj cov kev ua ntawm ib co enzymes koom nyob rau hauv lipid metabolism hauv daim siab, tab sis kuj ncaj qha inhibit lub synthesis ntawm cov rog los ntawm daim siab hlwb, thiab cov nyhuv yog proportional rau cov tshuaj.Ganoderma lucidum.Qhov tseem ceeb tshaj, tom qab cov koob tshuaj zoo ntawm noGanoderma lucidumtau kab lis kev cai nrog tib neeg lub siab hlwb rau 24 teev, cov hlwb tseem muaj sia nyob thiab zoo.

Ganoderma lucidummuaj cov teebmeem ntawm kev txo cov ntshav qabzib, txo cov rog thiab tiv thaiv daim siab.

Cov kev tshawb fawb saum toj no tsis tau tsuas yog qhia peb tias cov cawv extract ntawmGanoderma lucidumCov txiv hmab txiv ntoo lub cev tuaj yeem txo cov tsos mob ntawm hyperglycemia, hyperlipidemia, thiab lub siab rog uas tshwm sim los ntawm kev noj zaub mov muaj roj, tab sis kuj tseem ceeb rau peb tias nws muaj peev xwm ua rau lub siab rog yam tsis tau haus cawv.

Nyob rau hauv cov tshuaj, fatty daim siab tshwm sim los ntawm cov yam uas tsis yog-alcoholic yam yog collectively hu ua "tsis-alcoholic fatty siab."Txawm hais tias muaj lwm yam ua tau (xws li tshuaj), kev noj zaub mov thiab kev ua neej nyob yog qhov tseem ceeb tshaj plaws.Xav txog yuav ua li cas foie gras, uas yog hlub los ntawm gluttons, yog ua li cas?Nws yog tib yam nrog tib neeg!

Raws li kev txheeb cais, ze li ntawm ib feem peb ntawm cov neeg laus muaj qhov yooj yim (uas yog, tsis muaj cov tsos mob ntawm tus kab mob siab) uas tsis yog haus dej cawv fatty siab, thiab kwv yees li ib feem peb ntawm lawv yuav txuas ntxiv mus ua rog rog hauv kaum tsib xyoos.Tseem muaj cov ntaub ntawv tshaj tawm tias daim siab tsis muaj dej cawv tau dhau los ua qhov tseem ceeb ntawm qhov txawv txav ALT qhov ntsuas hauv Taiwan (33.6%), tshaj li tus kab mob siab B (28.5%) thiab tus kab mob siab C (13.2%).(Saib cov ntaub ntawv 2 kom paub meej)

Ironically, raws li cov koom haum saib xyuas kev noj qab haus huv thoob ntiaj teb txuas ntxiv tawm tsam tus kab mob siab kab mob siab nrog tshuaj tiv thaiv thiab tshuaj, qhov tshwm sim ntawm cov kab mob rog rog tshwm sim los ntawm kev noj zaub mov zoo lossis haus dej ntau ntxiv.

Cov kab mob rog rog (steatosis) tshwm sim thaum cov rog hauv siab nce mus txog lossis ntau dua 5% ntawm lub siab lub cev hnyav.Kev kuaj pom thawj zaug ntawm cov kab mob siab rog yuav tsum vam khom lub plab ultrasound lossis suav tomography (CT).Yog tias koj tsis tau tsim tus cwj pwm ntawm kev kuaj xyuas kev noj qab haus huv, koj tuaj yeem txiav txim siab seb koj puas muaj kab mob hauv siab los ntawm seb koj puas muaj cov kab mob metabolic xws li kev rog rog, hyperglycemia (hom 2 mob ntshav qab zib) thiab hyperlipidemia vim tias cov tsos mob lossis kab mob no feem ntau tshwm sim ua ke nrog. Nonalcoholic fatty siab kab mob (NAFLD).

Nws tsuas yog tias tsis muaj cov tshuaj tshwj xeeb rau cov kab mob rog rog.Qhov no yog vim li cas, tom qab kuaj pom cov rog rog, tus kws kho mob tsuas tuaj yeem sau ntawv rau koj noj zaub mov, qoj ib ce thiab poob phaus ntau dua li kev kho mob.Txawm li cas los xij, nws tsis yooj yim los hloov kev noj zaub mov thiab kev ua neej nyob.Cov neeg feem coob tau daig nyob rau hauv quagmire ntawm "tsis tswj kev noj zaub mov thiab ua kom lub cev muaj zog" lossis hauv kev tawm tsam ntawm "ua tsis tau tshem ntawm lub siab rog txawm los ntawm kev tswj kev noj zaub mov thiab ua kom lub cev ua si".

Peb yuav tsum ua li cas hauv ntiaj teb no?Tom qab nyeem cov kev tshawb fawb ntawm Gyeongsang National University hauv South Kauslim, peb paub tias muaj lwm yam riam phom khawv koob, uas yog, noj cov ethanol extract ntawmGanoderma lucidumtxiv hmab txiv ntoo lub cev.

Ganoderma lucidum, uas muaj lub luag haujlwm ntawm kev tiv thaiv lub siab, txo cov ntshav qab zib, thiab txo cov rog, yog qhov zoo heev;Txawm hais tias nws tseem tsis tuaj yeem ua rau koj poob phaus, nws tuaj yeem ua rau koj noj qab haus huv txawm tias koj rog.

[Qhov chaw]

Jung S, et al. Ganoderma lucidumameliorates non-alcoholic steatosis los ntawm upregulating zog metabolizing enzymes nyob rau hauv daim siab.J Clin Med.2018 Lub Rau Hli 15; 7(6).ib: e152.doi: 10.3390/jcm7060152.

[Nyeem Nyeem ntxiv]

Coincidentally, nyob rau hauv thaum ntxov 2017, ib tsab ntawv ceeb toom "Antidiabetic kev ua ntawmGanoderma lucidumpolysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic nas" tau koom ua ke luam tawm los ntawm Guangdong Institute of Microbiology thiab Guangdong Provincial Center for Disease Control and Prevention.Raws li tus qauv tsiaj ntawm hom 2 mob ntshav qab zib mellitus, nws tshawb txog cov txheej txheem kev cai ntawmGanoderma lucidumfruiting lub cev active polysaccharides ntawm cov ntshav qabzib thiab kev tiv thaiv thiab kho kab mob siab los ntawm ntshav qab zib.Nws cov txheej txheem ntawm kev ua haujlwm tseem cuam tshuam nrog kev tswj hwm ntawm cov enzymes koom nrog hauv lub zog metabolism hauv lub siab thiab txhim kho cov tshuaj insulin.Nws thiab daim ntawv tshaj tawm Kaus Lim Qab Teb no tuaj txog tib qhov kawg los ntawm kev sib txawv.Cov phooj ywg txaus siab tuaj yeem xa mus rau daim ntawv qhia no.

Cov ntaub ntawv hais txog cov tsis-alcoholic fatty siab

1. Teng-Cing Huang et al.Nonalcoholic fatty siab.Tsev Neeg Tshuaj thiab Kev Kho Mob Hauv Paus Tsev Kawm Ntawv, 2015;30 (11): 314-319.

2. Ching-feng Su ua al.Kev kuaj mob thiab kev kho mob ntawm nonalcoholic fatty siab kab mob.2015;30 (11): 255-260 : kuv.

3. Ying-tao Wu et al.Taw qhia txog kev kho mob ntawm cov kab mob uas tsis yog-alcoholic fatty siab.Pharmaceutical Journal, 2018;34 (2): 27-32 : kuv.

4. Huei-wun Liang: Tus kab mob rog rog tuaj yeem thim rov qab thiab hais lus zoo rau lub siab rog!Kev Tiv Thaiv Kab Mob Siab & Kev Kho Mob Kev Tshawb Fawb Foundation lub vev xaib.

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Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma thawj zaug txij li xyoo 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).
 
★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau.★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai los ntawm tus sau.★ Rau kev ua txhaum ntawm cov lus hais saum toj no, tus sau yuav ua raws li cov luag haujlwm raug cai.★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.