Yuni 15, 2018 / Jami'ar Kasa ta Gyeongsang, Koriya ta Kudu / Journal of Clinical Medicine

Rubutu/ Wu Tingyao

Makarantar Magunguna ta Jami'ar Gyeongsang a Koriya ta Kudu ta buga wata takarda a cikin Journal of Clinical Medicine a watan Yuni 2018 yana mai cewaGanoderma lucidumna iya rage yawan kitsen hanta da cin abinci mai yawan kitse ke haifarwa, amma gwaje-gwajen dabbobi masu alaka da su kuma sun gano cewa berayen da suke kitso da abinci mai kitse suma za su sami karancin glucose na jini da matsalolin lipid na jini saboda sa baki.Ganoderma lucidum.

An raba berayen gwaji zuwa ƙungiyoyi huɗu: abinci na yau da kullun (ND), abinci na yau da kullun (ND) +Ganoderma lucidum(GL), abinci mai yawan mai (HFD), abinci mai yawan mai (HFD) +Ganoderma lucidum(GL).A cikin abinci na ƙungiyar abinci na al'ada, mai ya ƙunshi 6% na adadin adadin kuzari;a cikin abincin abinci mai yawan kitse, mai ya kai 45% na adadin adadin kuzari, wanda shine sau 7.5 na tsohon.TheGanoderma lucidumciyar da beraye shine ainihin tsantsa ethanol na jikin 'ya'yan itaceGanoderma lucidum.Masu binciken sun ciyar da berayen a kashi 50 mg/kgGanoderma lucidumAna cire ethanol kowace rana don kwana biyar a mako.

Bayan makonni goma sha shida (watanni hudu) na gwaje-gwaje, an gano cewa cin abinci mai yawan kitse na dogon lokaci zai iya ninka nauyin beraye.Ko da sun ci abinciGanoderma lucidum, yana da wuya a toshe hali don samun nauyi (Figure 1).

Koyaya, a ƙarƙashin tsarin abinci mai ƙima, kodayake berayen da ke ciGanoderma lucidumda berayen da ba sa ciGanoderma lucidumsun bayyana suna da matakan kiba iri ɗaya, yanayin lafiyarsu zai bambanta sosai saboda cin abinci ko rashin ciGanoderma lucidum.

Hoto 1　TasirinGanoderma lucidumakan nauyin jikin mice masu ciyar da HFD

Ganoderma lucidumyana rage tarin kitse na visceral a cikin berayen HFD-Fed.

Hoto 2 shine zane-zane na kididdiga na bayyanar da nauyin hanta, kitse mai kauri da kitsen epididymal na kowane rukuni na mice a ƙarshen gwajin.

Hanta ita ce shukar sarrafa sinadarai a cikin jiki.Dukkan sinadirai da aka sha daga hanji za su lalace, hanta su hada su sarrafa su zuwa wani nau'i mai amfani da kwayoyin halitta, sannan a rarraba su a ko'ina ta hanyar yaduwar jini.Da zarar an sami abin da ya wuce kima, hanta za ta canza yawan adadin kuzari zuwa mai (triglycerides) kuma ta adana shi don gaggawa.

Da yawan kitsen da aka adana, hanta ya fi girma da nauyi.Tabbas, kitse mai yawa kuma zai taru a kusa da sauran gabobin ciki, kuma kitse mai kitse da kitse na epididymal wakilai ne na tarin kitse na visceral da aka lura a gwaje-gwajen dabbobi.

Ana iya gani daga Hoto na 2 cewaGanoderma lucidumna iya rage yawan kitse a cikin hanta da sauran gabobin ciki da abinci mai kitse ke haifarwa.

Hoto 2　TasirinGanoderma lucidumakan mai visceral a cikin HFD-Fed mice

Ganoderma lucidumyana rage hanta mai kitse a cikin berayen HFD-Fed.

Masu binciken sun kara yin nazari kan kitsen da ke cikin hantar berayen: sassan hanta na berayen da ke cikin kowace kungiya an yi musu tabo da rini na musamman, kuma ɗigon mai da ke cikin hanta zai haɗu da rini ya zama ja.Kamar yadda aka nuna a hoto na 3, kitsen da ke cikin hanta ya bambanta sosai a cikin abinci mai kitse iri ɗaya tare da ko ba tare da ƙari ba.Ganoderma lucidum.

Kitsen da ke cikin kyallen hanta na beraye a kowace rukuni an ƙididdige shi zuwa Hoto na 4, kuma ana iya ganin cewa hanta mai kitse a cikin rukunin abinci mai kitse ya kai mataki na 3 (abin da ke cikin mai ya fi 66% na nauyin hanta gabaɗaya. , yana nuna hanta mai kitse mai tsanani).A lokaci guda, kitsen da ke cikin hanta na berayen da ke ciyar da HFD wanda ya ciGanoderma luciduman rage da rabi.

Hoto 3　Sakamakon tabon kitse na sassan hanta na linzamin kwamfuta

Hoto 4　TasirinGanoderma lucidumakan tarin kitsen hanta a cikin beraye masu ciyar da HFD

[Bayyana] An rarraba tsananin hanta mai kitse zuwa maki 0, 1, 2, da 3 bisa ga girman kitsen mai a cikin nauyin hanta: ƙasa da 5%, 5-33%, fiye da 33% -66% da fiye da 66%, bi da bi.Mahimmancin asibiti yana wakiltar al'ada, mai laushi, matsakaici kuma mai tsanani hanta.

Ganoderma lucidumyana hana ciwon hanta a cikin beraye masu ciyar da HFD.

Yawan kitse mai yawa zai kara yawan radicals a cikin hanta, yana sa ƙwayoyin hanta su zama masu kumburi saboda lalacewar oxidative, ta haka yana rinjayar aikin hanta.Duk da haka, ba duk hanta mai kitse za su ci gaba zuwa matakin cutar hanta ba.Muddin ƙwayoyin hanta ba su da yawa sosai, ana iya kiyaye su a cikin “tarin kitse mai sauƙi” mara lahani.

Ana iya gani daga Hoto na 5 cewa cin abinci mai kitse na iya ninka maganin ALT (GPT), mafi mahimmancin alamar cutar hanta, daga matakin al'ada na kusan 40 U / L;duk da haka, idanGanoderma luciduman dauki lokaci guda, yiwuwar ciwon hanta yana raguwa sosai.Babu shakka,Ganoderma lucidumyana da tasiri mai kariya akan ƙwayoyin hanta da ke shiga cikin mai.

Hoto 5 TasirinGanoderma lucidumakan alamomin hanta a cikin mice masu ciyar da HFD

Ganoderma lucidumyana kawar da matsalolin lipid na jini a cikin mice masu ciyar da HFD.

Lokacin da hanta ta haɗu da kitse da yawa, lipids na jini kuma yana da haɗari ga rashin daidaituwa.Wannan gwajin dabbar da aka yi a Koriya ta Kudu ya gano cewa cin abinci mai yawan kitse na wata hudu na iya tayar da cholesterol, ammaGanoderma lucidumzai iya rage tsananin matsalar (Hoto na 6).

Hoto 6　TasirinGanoderma lucidumakan jimlar ƙwayar cholesterol a cikin berayen da ke ciyar da HFD

Ganoderma lucidumyana hana hawan glucose na jini a cikin mice masu ciyar da HFD.

Gwaje-gwaje kuma sun gano cewa cin abinci mai yawan gaske na iya haifar da hawan jini.Duk da haka, idanGanoderma lucidumAna ɗauka a lokaci guda, matakin glucose na jini a fili za a iya sarrafa shi a ƙaramin karuwa (Hoto na 7).

Hoto 7　TasirinGanoderma lucidumakan glucose na jini a cikin mice masu ciyar da HFD

Ganoderma lucidumyana inganta ƙarfin jikin berayen da ke ciyar da HFD don daidaita sukarin jini.

Masu binciken sun kuma yi gwajin maganin glucose a kan berayen a sati na goma sha hudu na gwajin, wato a lokacin azumi bayan awanni 16 da suka yi azumi, an yi wa berayen allura mai yawa na glucose, sannan glucose na jini ya canza cikin biyu. an kiyaye sa'o'i.Karamin canjin matakin glucose na jini, mafi kyawun ikon jikin linzamin kwamfuta don daidaita glucose na jini.

An gano cewa canjin matakan glucose na jini na ƙungiyar HFD + GL ya yi ƙasa da na ƙungiyar HFD (Hoto 8).Wannan yana nufin hakaGanoderma lucidumyana da tasirin inganta tsarin glucose na jini wanda ya haifar da abinci mai yawan gaske.

Hoto 8　TasirinGanoderma lucidumakan jurewar glucose a cikin mice masu ciyar da HFD

Ganoderma lucidumyana inganta juriya na insulin a cikin beraye masu ciyar da HFD.

Masu binciken sun kuma yi gwajin jurewar insulin akan beraye: A cikin mako na goma sha hudu na gwajin, an yi wa berayen masu azumi allura da insulin, kuma an yi amfani da sauye-sauyen matakan glucose na jini don sanin yadda kwayoyin beraye suke da insulin.

Insulin wani hormone ne, wanda ke taka rawar maɓalli, yana barin glucose a cikin abincinmu ya shiga cikin kwayoyin jikinmu daga jini don samar da makamashi.A cikin yanayi na al'ada, bayan allurar insulin, ainihin matakin glucose na jini zai ragu zuwa wani yanki.Saboda yawan glucose na jini zai shiga cikin sel tare da taimakon insulin, matakin sukarin jini zai ragu a zahiri.

Duk da haka, sakamakon gwajin ya gano cewa cin abinci mai yawan kitse na dogon lokaci zai sa sel su zama marasa ji da insulin don haka matakin glucose na jini ya kasance mai girma bayan allurar insulin, amma a lokaci guda, canjin glucose na jini a cikin beraye masu ciyar da HFD. wanda ya ciGanoderma lucidumyayi kama da na berayen masu ciyar da ND (Hoto na 9).A bayyane yake cewaGanoderma lucidumyana da tasirin inganta juriya na insulin.

Hoto 9　TasirinGanoderma lucidumakan juriya na insulin a cikin beraye masu ciyar da HFD

Hanyar naGanoderma luciduma rage kiba hanta

Kiba na iya haifar da juriya na insulin, kuma juriya na insulin ba kawai yana haifar da hyperglycemia ba amma kuma shine mafi mahimmancin abin da ke haifar da hanta mai ƙiba mara giya.Don haka, lokacin da aka rage juriya na insulin taGanoderma lucidum, hanta a dabi'a ba ta da wuyar tara mai.

Bugu da kari, masu binciken sun kuma tabbatar da cewa sinadarin ethanol naGanoderma lucidumfruiting jiki amfani da dabba gwaje-gwaje ba zai iya ba kawai kai tsaye tsara ayyuka na wasu enzymes hannu a lipid metabolism a cikin hanta amma kuma kai tsaye hana kira na mai da hanta Kwayoyin, da kuma sakamako ne daidai da sashi na.Ganoderma lucidum.Mafi mahimmanci, bayan waɗannan ingantattun allurai naGanoderma lucidumsun kasance masu al'ada tare da ƙwayoyin hanta na ɗan adam na tsawon sa'o'i 24, ƙwayoyin suna da rai kuma suna da kyau.

Ganoderma lucidumyana da tasirin rage glucose na jini, rage mai da kuma kare hanta.

Sakamakon binciken da aka ambata a sama ba kawai ya gaya mana cewa an cire barasa naGanoderma lucidumJikin 'ya'yan itace na iya rage alamun hyperglycemia, hyperlipidemia, da hanta mai kitse da ke haifar da abinci mai yawa amma kuma yana tunatar da mu cewa yana yiwuwa a sami hanta mai kitse ba tare da shan barasa ba.

A cikin magani, hanta mai kitse da ke haifar da abubuwan da ba na giya ba ana kiranta gaba ɗaya a matsayin “Hanta mai kitse mara-giya.”Ko da yake akwai wasu abubuwa masu yuwuwa (kamar kwayoyi), halayen cin abinci da salon rayuwa har yanzu sune abubuwan da suka fi yawa.Ka yi tunani game da yadda ake yin foie gras, wanda masu cin abinci ke so sosai?Haka yake da mutane!

Bisa kididdigar da aka yi, kusan kashi daya bisa uku na manya suna da sauki (wato, babu alamun cutar hanta) ba tare da shan barasa ba, kuma kusan kashi daya bisa hudu na su za su kara kamuwa da ciwon hanta a cikin shekaru goma sha biyar.Har ma akwai rahotannin cewa hanta mai kitse ba ta barasa ba ta zama babban abin da ke haifar da rashin daidaituwar ALT index a Taiwan (33.6%), wanda ya zarce ƙwayar cutar hanta ta B (28.5%) da cutar hanta C (13.2%).(Duba shafi na 2 don cikakkun bayanai)

Wani abin ban mamaki shi ne, yayin da hukumomin lafiya na duniya ke ci gaba da yaki da cutar hanta ta hanyar alluran rigakafi da magunguna, ana samun yawaitar cutar hanta mai kitse da ake samu ta hanyar cin abinci da yawa ko kuma yawan shan barasa.

Ciwon hanta mai kitse (steatosis) yana faruwa ne lokacin da mai a cikin hanta ya kai ko ya wuce kashi 5 na nauyin hanta.Binciken farko na cutar hanta mai kitse dole ne ya dogara da duban dan tayi na ciki ko na'urar daukar hoto (CT).Idan baku haɓaka dabi'ar yin gwajin lafiyar ku ba, zaku iya yanke hukunci ko kuna da ciwon hanta mai kitse daga ko kuna da cututtukan rayuwa kamar matsakaicin kiba, hyperglycemia (nau'in ciwon sukari na 2) da hyperlipidemia saboda waɗannan alamun ko cututtuka galibi suna faruwa tare da. Ciwon hanta mai kitse mara giya (NAFLD).

Kawai dai babu takamaiman magungunan cutar hanta mai kitse.Wannan shine dalilin da ya sa, bayan ganewar asali na hanta mai kitse, likita zai iya rubuta maka abinci mai sauƙi, motsa jiki da asarar nauyi maimakon jiyya masu aiki.Duk da haka, ba shi da sauƙi a canza dabi'un cin abinci da halaye na rayuwa.Yawancin mutane sun makale ko dai a cikin ɓacin rai na "rashin sarrafa abinci da ƙara yawan motsa jiki" ko kuma a cikin gwagwarmayar "kasawar kawar da hanta mai kitse ko da ta hanyar sarrafa abinci da haɓaka aikin jiki".

Me ya kamata mu yi a duniya?Bayan karanta sakamakon bincike na jami'ar Gyeongsang a Koriya ta Kudu, mun san cewa akwai wani makamin sihiri, wato, cin sinadarin ethanol.Ganoderma lucidumfruiting jiki.

Ganoderma lucidum, wanda ke da ayyuka na kare hanta, rage yawan sukarin jini, da rage kitsen mai, yana da tasiri sosai;ko da yake har yanzu ba zai iya sa ka rasa nauyi ba, yana iya ƙara samun lafiya koda kuwa kana da kiba.

[Madogararsa]

Jung S, et al. Ganoderma lucidumyana inganta steatosis mara-giya ta hanyar haɓaka kuzarin haɓakar enzymes a cikin hanta.J Clin Med.2018 Juni 15;7(6).ku: E152.doi: 10.3390/jcm7060152.

[Ƙari Karatu]

Ba zato ba tsammani, a farkon 2017, rahoton "Ayyukan Antidiabetic naGanoderma lucidumpolysaccharides F31 rage-kayyade tsarin sarrafa glucose na hanta enzymes a cikin berayen masu ciwon sukari" tare da Cibiyar Kula da Cututtuka ta Guangdong da Cibiyar Kula da Cututtuka ta lardin Guangdong suka buga tare.Dangane da samfurin dabba na nau'in ciwon sukari na 2, yana bincika tsarin tsari naGanoderma lucidumfruiting jiki aiki polysaccharides a kan jini glucose da kuma rigakafi da kuma lura da hepatitis lalacewa ta hanyar ciwon sukari.Tsarin aikinsa kuma yana da alaƙa da ka'idodin enzymes da ke cikin kuzarin makamashi a cikin hanta da haɓaka juriya na insulin.Shi da wannan rahoto na Koriya ta Kudu sun zo karshe ta hanyoyi daban-daban.Abokai masu sha'awar suna iya duba wannan rahoton.

Abubuwan magana game da hanta mai kitse mara-giya

1. Teng-cing Huang et al.Hanta mai kitse mara giya.Magungunan Iyali da Kulawa na Farko, 2015;30 (11): 314-319.

2. Ching-feng Su da al.Ganewa da kuma maganin cututtukan hanta mai kitse mara giya.2015;30 (11): 255-260.

3. Ying-tao Wu et al.Gabatarwa game da maganin cututtukan hanta mai kitse mara-giya.Jaridar Pharmaceutical, 2018;34 (2): 27-32.

4. Huei-wun Liang: Cutar hanta mai kitse za a iya juyawa kuma a ce bankwana da hanta mai kitse!Gidan yanar gizo na Gidauniyar Bincike Kan Cutar Hanta & Jiyya.

KARSHE

Game da marubucin / Ms. Wu Tingyao
Wu Tingyao ta kasance tana ba da rahoto game da bayanan Ganoderma na farko tun 1999. Ita ce marubucin labarun Ganoderma.Waraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).
 
★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin.★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin marubuci ba.★ Don keta bayanin da ke sama, marubucin zai bi alhakin da ya dace na shari'a.★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.