Le ndatshana ikhiqizwe kabusha isuka kumagazini we-“Ganoderma” wama-97 ngo-2023, eshicilelwe ngemvume yombhali.Wonke amalungelo alesi sihloko angawombhali.

Umehluko omkhulu ungabonwa ebuchosheni phakathi komuntu ophile kahle (kwesokunxele) kanye nesiguli se-Alzheimer's disease (kwesokudla).

(Umthombo wesithombe: Wikimedia Commons)

Isifo i-Alzheimer's (AD), esivame ukwaziwa ngokuthi ukuwohloka komqondo kokudangala, ukuwohloka komqondo okuthuthukayo okubonakala ngokukhubazeka kwengqondo okuhlobene nobudala nokulahlekelwa inkumbulo.Ngokukhula kwesikhathi sokuphila kwabantu kanye nokuguga kwabantu, ukwanda kwesifo i-Alzheimer's kukhula kancane kancane, kubangela umthwalo omkhulu emindenini nasemphakathini.Ngakho-ke, ukuhlola izindlela eziningi zokuvimbela nokwelapha isifo i-Alzheimer's sekuyisihloko esithakaselwa kakhulu ocwaningweni.

Esihlokweni sami esinesihloko esithi “Ukuhlola Ucwaningo kuI-GanodermaUkuvimbela Nokwelapha Isifo i-Alzheimer's," eyanyatheliswa kumagazini wama-83 we-"Ganoderma" ngo-2019, ngethula i-pathogenesis yesifo i-Alzheimer's kanye nemiphumela ye-pharmacological ofI-Ganodermalucidumekuvimbeleni nasekwelapheni isifo i-Alzheimer's.Ngokuqondile,I-Ganodermalucidumokukhishwe,I-Ganodermalucidumama-polysaccharides,I-Ganodermalucidumtriterpenes, futhiI-Ganodermalucidumi-spore powder yatholwa yenza ngcono ukukhubazeka kokufunda kanye nenkumbulo kumamodeli wamagundane esifo i-Alzheimer's.Lezi zingxenye ziphinde zibonise imiphumela yokuzivikela ngokumelene nezinguquko ze-neuropathological eziwohlokayo ezicutshini zobuchopho ze-hippocampal ze-Alzheimer's rat rat, ukunciphisa i-neuroinflammation ezicutshini zobuchopho, zandisa umsebenzi we-superoxide dismutase (SOD) kuzicubu zobuchopho ze-hippocampal, zehlisa amazinga e-malondialdehyde (MDA). ) njengomkhiqizo we-oxidative, futhi yabonisa imiphumela yokuvimbela kanye nokwelapha kumamodeli ezilwane okuhlola zesifo i-Alzheimer's.

Izifundo ezimbili zokuqala zomtholampilo kuI-Ganoderma lucidumukuvimbela nokwelapha isifo i-Alzheimer's, okwethulwe esihlokweni, akukuqinisekisanga ngokuphelele ukusebenza kwe-Alzheimer's.I-Ganoderma lucidumkwisifo i-Alzheimer's.Kodwa-ke, kuhlanganiswe nemiphumela eminingi ethembisayo yocwaningo lwesayensi yezemithi, kunikeza ithemba ngezifundo zomtholampilo ezengeziwe.

Umphumela wokusebenzisaI-Ganoderma lucidumI-spore powder iyodwa yokwelapha isifo i-Alzheimer's ayibonakali.

Ibuyekeza iphepha locwaningo elinesihloko esithi “Spore powder ofI-Ganoderma lucidumekwelapheni isifo i-Alzheimer's: Ucwaningo lokulinga" olwanyatheliswa kumagazini othi "Medicine"^[1], abalobi bahlukanise ngokungahleliwe iziguli ze-42 ezihlangabezane nenqubo yokuxilonga yesifo se-Alzheimer eqenjini lokuhlola kanye neqembu lokulawula, neziguli ze-21 eqenjini ngalinye.Iqembu lokuhlola lithole ukuphathwa ngomlomo kweI-Ganodermalucidumama-capsules we-spore powder (iqembu le-SPGL) esikalini sama-capsules angu-4 (250 mg capsule ngayinye) kathathu ngosuku ngenkathi iqembu lokulawula lithola kuphela amaphilisi e-placebo.Womabili amaqembu athole ukwelashwa kwamaviki angu-6.

Ekupheleni kokwelashwa, uma kuqhathaniswa neqembu elilawulayo, iqembu le-SPGL libonise ukuncipha kwezikolo ze-Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) kanye ne-Neuropsychiatric Inventory (NPI), ebonisa ukuthuthukiswa kwengqondo nokuziphatha. ukonakala, kodwa umehluko wawungabalulekile ngokwezibalo (Ithebula 1).Uhlu lwemibuzo lwe-World Health Organization Quality of Life-BREF (WHOQOL-BREF) lubonise ukukhuphuka kwamaphuzu ekhwalithi yempilo, okubonisa ukuthuthuka kwekhwalithi yokuphila, kodwa futhi, umehluko wawungabalulekile ngokwezibalo (Ithebula 2).Womabili amaqembu ahlangabezane nokusabela okubi okuncane, kungekho mehluko omkhulu.

Ababhali bephepha bakholelwa ukuthi ukwelashwa kwesifo i-Alzheimer'sI-Ganoderma lucidumama-capsules we-spore powder amasonto e-6 awazange abonise imiphumela ebalulekile yokwelapha, mhlawumbe ngenxa yesikhathi esifushane sokwelashwa.Izivivinyo zemitholampilo zesikhathi esizayo ezinosayizi abakhulu besampula kanye nobude besikhathi bokwelashwa kuyadingeka ukuze uthole ukuqonda okucacile kokusebenza komtholampiloI-Ganoderma lucidumi-spore powder capsules ekwelapheni isifo i-Alzheimer's.

Ukusetshenziswa okuhlanganisiwe kweI-Ganoderma lucidumI-spore powder enemithi yokwelapha evamile ithuthukisa kakhulu ukusebenza kahle kokwelapha ekwelapheni isifo i-Alzheimer's.

Muva nje, ucwaningo luhlole imiphumela ehlanganisiwe yeI-Ganoderma lucidumi-spore powder kanye nemithi ye-Alzheimer's disease i-memantine ekuqondeni kanye nezinga lempilo ezigulini ezinesifo i-Alzheimer's esithambile kuya kokulinganisela [2].Iziguli ezingamashumi amane nesishiyagalombili ezitholwe zinesifo i-Alzheimer, ezineminyaka engama-50 kuya kwengama-86, zahlukaniswa ngokungahleliwe zaba yiqembu elilawulayo kanye neqembu lokuhlola, neziguli ezingama-24 eqenjini ngalinye (n=24).

Ngaphambi kokwelashwa, ubungekho umehluko obalulekile ngokwezibalo phakathi kwamaqembu amabili ngokobulili, idigri yokuwohloka komqondo, i-ADAS-cog, NPI, kanye nezikolo ze-WHOQOL-BREF (P>0.5).Iqembu elilawulayo lathola amaphilisi e-memantine ngethamo lika-10 mg, kabili ngosuku, kuyilapho iqembu lokuhlola lathola umthamo ofanayo we-memantine kanyeI-Ganoderma lucidumi-spore powder capsules (SPGL) ngethamo lika-1000 mg, kathathu ngosuku.Womabili amaqembu alashwa amasonto e-6, futhi idatha eyisisekelo yeziguli yabhalwa.Umsebenzi wokuqonda kanye nekhwalithi yempilo yeziguli kwahlolwa kusetshenziswa izikali zamagoli ze-ADAS-cog, NPI, kanye ne-WHOQOL-BREF.

Ngemuva kokwelashwa, amaqembu womabili eziguli abonise ukwehla okuphawulekayo kwezikolo ze-ADAS-cog ne-NPI uma kuqhathaniswa nangaphambi kokwelashwa.Ukwengeza, iqembu lokuhlola lalinamaphuzu e-ADAS-cog ne-NPI aphansi kakhulu kuneqembu lokulawula, elinomehluko ophawulekayo wezibalo (P <0.05) (Ithebula 3, Ithebula 4).Ngemva kokwelashwa, womabili amaqembu eziguli abonise ukukhuphuka okuphawulekayo kwamaphuzu e-physiology, psychology, ubudlelwano bomphakathi, indawo ezungezile, kanye nezinga lempilo lilonke kuhlu lwemibuzo lwe-WHOQOL-BREF uma kuqhathaniswa nangaphambi kokwelashwa.Ngaphezu kwalokho, iqembu lokuhlola lalinamaphuzu aphezulu kakhulu we-WHOQOL-BREF kuneqembu lokulawula, elinomehluko ophawulekayo wezibalo (P <0.05) (Ithebula 5).

I-Memantine, eyaziwa ngokuthi inoveli i-N-methyl-D-aspartate (NMDA) receptor antagonist, ayikwazi ukuvimba ngokungekona ukuncintisana ama-NMDA receptors, ngaleyo ndlela yehlise i-glutamic acid-induced NMDA receptor overexcitation futhi ivimbele i-apoptosis yeseli.Ithuthukisa ukusebenza kwengqondo, ukuphazamiseka kokuziphatha, imisebenzi yokuphila kwansuku zonke, nokuqina kokuwohloka komqondo ezigulini ezinesifo i-Alzheimer's.Isetshenziselwa ukwelapha isifo i-Alzheimer's esithambile, esimaphakathi, nesinzima kakhulu.Nokho, ukusetshenziswa kwalo muthi kukodwa kusenezinzuzo ezilinganiselwe ezigulini ezinesifo i-Alzheimer's.

Imiphumela yalolu cwaningo ikhombisa ukuthi ukusetshenziswa okuhlangene kweI-Ganoderma lucidumI-spore powder kanye ne-memantine kungathuthukisa amakhono eziguli okuziphatha nengqondo futhi kuthuthukise kakhulu izinga lempilo yazo.

Ukukhetha indlela efanele yokwelapha kubalulekile ekwelapheni isifo i-Alzheimer's.

Ezivivinyweni ezimbili zomtholampilo ezilawulwa ngokungahleliwe ezingenhla zeI-Ganoderma lucidumi-spore powder yokwelapha isifo se-Alzheimer, ukukhethwa kwamacala, ukuxilongwa, umthombo we-Ganoderma lucidum spore powder, umthamo, inkambo yokwelashwa, kanye nezinkomba zokuhlola ukusebenza kahle kwakufana, kodwa ukusebenza kahle komtholampilo kwakuhlukile.Ngemuva kokuhlaziywa kwezibalo, ukusetshenziswa kweI-Ganoderma lucidumi-spore powder yodwa yokwelapha isifo se-Alzheimer ayizange ibonise ukuthuthukiswa okuphawulekayo kumaphuzu we-AS-cog, NPI, kanye ne-WHOQOL-BREF uma kuqhathaniswa ne-placebo;Nokho, ukusetshenziswa okuhlangeneI-Ganoderma lucidumi-spore powder kanye ne-memantine kubonise ukuthuthuka okuphawulekayo kumaphuzu amathathu uma kuqhathaniswa ne-memantine iyodwa, okungukuthi, ukusetshenziswa okuhlangene kwe-memantine.I-Ganoderma lucidumI-spore powder kanye ne-memantine kungathuthukisa kakhulu ikhono lokuziphatha, ikhono lokucabanga kanye nezinga lempilo yeziguli ezinesifo i-Alzheimer's.

Njengamanje, imithi esetshenziselwa ukwelapha isifo se-Alzheimer, njenge-donepezil, i-rivastigmine, i-memantine, ne-galantamine (i-Reminyl), inemiphumela elinganiselwe yokwelapha futhi ingadambisa kuphela izimpawu futhi ibambezele ukuqhubeka kwesifo.Ngaphezu kwalokho, cishe ayikho imithi emisha yokwelapha isifo i-Alzheimer eyenziwe ngempumelelo eminyakeni engu-20 edlule.Ngakho-ke, ukusetshenziswa kweI-Ganoderma lucidumI-spore powder yokuthuthukisa ukusebenza kwezidakamizwa ekwelapheni isifo i-Alzheimer's kufanele kunakwe.

Ngokuqondene nezinye izivivinyo zomtholampilo zokusebenzisaI-Ganoderma lucidumI-powder spore iyodwa, kungase kwenzeke ukucabangela ukwandisa umthamo, isibonelo, i-2000 mg isikhathi ngasinye, kabili ngosuku, isikhathi esingamaviki angu-12.Ukuthi kungenzeka yini lokhu, sibheke ngabomvu imiphumela yocwaningo kule ndawo ukuze isitshele impendulo.

[Izithenjwa]

1. UGuo-hui Wang, et al.I-spore powder yeI-Ganoderma lucidumyokwelashwa kwesifo i-Alzheimer: Ucwaningo lokulinga.Umuthi (i-Baltimore).2018; 97(19): e0636.

2. Wang Lichao, et al.Umphumela we-memantine uhlanganiswe neI-Ganoderma lucidumI-spore powder ekuqondeni kanye nezinga lempilo ezigulini ezinesifo i-Alzheimer's.Ijenali ye-Armed Police Medical College (I-Medical Edition).2019, 28(12): 18-21.

Isingeniso kuSolwazi uLin Zhibin

UMnu. Lin Zhibin, iphayona kuI-Ganodermaucwaningo eChina, selinikele cishe ingxenye yekhulu leminyaka kulo mkhakha.Ubambe izikhundla eziningana e-Beijing Medical University, okuhlanganisa iPhini Likamongameli, iPhini LikaDean weSikole Semithi Eyisisekelo, uMqondisi we-Institute of Basic Medical Sciences, kanye noMqondisi woMnyango Wezemithi.Manje usenguprofesa eMnyangweni Wezemithi ePeking University School of Basic Medical Sciences.Kusukela ngo-1983 kuya ku-1984, ubeyisifundiswa esivakashile e-WHO Traditional Medicine Research Center eNyuvesi yase-Illinois eChicago.Kusukela ngo-2000 kuya ku-2002, wayenguprofesa ovakashile eNyuvesi yaseHong Kong.Kusukela ngo-2006, ube nguprofesa ohlonishwayo ePerm State Pharmaceutical Academy eRussia.

Kusukela ngo-1970, usebenzise izindlela zesayensi zesimanje ukutadisha imiphumela yemithi kanye nezindlela zokwelapha zendabuko zaseShayinaI-Ganodermakanye nezithako zayo ezisebenzayo.Ushicilele amaphepha ocwaningo angaphezu kwekhulu nge-Ganoderma.Kusukela ngo-2014 kuya ku-2019, wakhethwa ohlwini lwabacwaningi base-Elsevier's China Highly Cited Researchers iminyaka eyisithupha ilandelana.

Ubhale izincwadi eziningi nge-Ganoderma, kuhlanganise nethi “Modern Research on Ganoderma” (1st-4th editions), “Lingzhi from Mystery to Science” (1st-3rd editions), “Ganoderma isekela amandla anempilo futhi ixosha izici ze-pathogenic, esiza ukwelashwa kwezimila”, “Izingxoxo nge-Ganoderma”, kanye ne-“Ganoderma and Health”.