Nkhaniyi idapangidwanso kuchokera ku magazini ya 97 ya "Ganoderma" mu 2023, yofalitsidwa ndi chilolezo cha wolemba.Ufulu wonse pankhaniyi ndi wa wolemba.

Kusiyana kwakukulu kumatha kuwonedwa muubongo pakati pa munthu wathanzi (kumanzere) ndi wodwala matenda a Alzheimer's (kumanja).

(Chithunzi: Wikimedia Commons)

Matenda a Alzheimer's (AD), omwe amadziwika kuti senile dementia, ndi matenda omwe amayamba chifukwa cha ukalamba komanso kuwonongeka kwa kukumbukira.Chifukwa cha kuchuluka kwa moyo wa anthu komanso kukalamba kwa anthu, kuchuluka kwa matenda a Alzheimer's kukukulirakulira, zomwe zikubweretsa vuto lalikulu kwa mabanja ndi anthu.Chifukwa chake, kufufuza njira zingapo zopewera ndi kuchiza matenda a Alzheimer's wakhala mutu wofunikira kwambiri pakufufuza.

M'nkhani yanga yotchedwa "Kufufuza Kafukufuku waGanodermaKupewa ndi Kuchiza Matenda a Alzheimer's, "yofalitsidwa mu 83 ya magazini ya "Ganoderma" mu 2019, ndidayambitsa matenda a Alzheimer's and pharmacological zotsatira.Ganodermalucidumpopewa ndi kuchiza matenda a Alzheimer.Makamaka,Ganodermalucidumzowonjezera,Ganodermalucidumma polysaccharides,Ganodermalucidumtriterpenes, ndiGanodermalucidumufa wa spore unapezeka kuti umathandizira kuphunzira komanso kuwonongeka kwa kukumbukira mumitundu ya makoswe a matenda a Alzheimer's.Zigawozi zikuwonetsanso zoteteza motsutsana ndi kusintha kwaubongo wa hippocampal mumtundu wa makoswe a matenda a Alzheimer's, kuchepetsedwa kwa neuroinflammation mu minyewa yaubongo, kukulitsa ntchito ya superoxide dismutase (SOD) mu minyewa yaubongo ya hippocampal, kumachepetsa milingo ya malondialdehyde (MDA). ) monga mankhwala obwera chifukwa cha okosijeni, ndipo adawonetsa zodzitetezera ndi zochizira pazoyeserera za nyama za matenda a Alzheimer's.

Maphunziro awiri oyambirira azachipatala paGanoderma lucidumpopewa ndi kuchiza matenda a Alzheimer's, omwe adafotokozedwa m'nkhaniyi, sanatsimikizire mwatsatanetsatane kugwira ntchito kwaGanoderma lucidummu matenda a Alzheimer's.Komabe, kuphatikizidwa ndi zopeza zambiri zodalirika zofufuza zamankhwala, zimapereka chiyembekezo chamaphunziro opitilira azachipatala.

Zotsatira zakugwiritsa ntchitoGanoderma lucidumspore ufa yekha kuchiza matenda a Alzheimer si zoonekeratu.

Kuwunikanso pepala lofufuzira lotchedwa "Spore powder ofGanoderma lucidumZochizira matenda a Alzheimer's: Kafukufuku woyendetsa ndege" wofalitsidwa m'magazini ya "Medicine"^[1], olembawo adagawanitsa odwala 42 omwe adakumana ndi matenda a Alzheimer's mu gulu loyesera ndi gulu lolamulira, ndi odwala 21 mu gulu lirilonse.Gulu loyesera linalandira kayendetsedwe ka pakamwa kaGanodermalucidummakapisozi a ufa wa spore (gulu la SPGL) pa mlingo wa makapisozi a 4 (250 mg kapsule iliyonse) katatu patsiku pamene gulu lolamulira linangolandira makapisozi a placebo.Magulu onsewa adalandira chithandizo cha milungu 6.

Pamapeto pa chithandizo, poyerekeza ndi gulu lolamulira, gulu la SPGL linasonyeza kuchepa kwa chiwerengero cha Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) ndi Neuropsychiatric Inventory (NPI), kusonyeza kusintha kwa chidziwitso ndi khalidwe. kuwonongeka, koma kusiyana sikunali kofunikira kwambiri (Table 1).Funso la World Health Organization Quality of Life-BREF (WHOQOL-BREF) linasonyeza kuwonjezeka kwa chiwerengero cha moyo, kusonyeza kusintha kwa moyo, koma kachiwiri, kusiyana sikunali kofunika kwambiri (Table 2).Magulu onse awiriwa adakumana ndi zovuta zochepa, popanda kusiyana kwakukulu.

Olemba pepala amakhulupirira kuti chithandizo cha matenda a Alzheimer ndiGanoderma lucidummakapisozi a spore powder kwa masabata a 6 sanawonetse zotsatira zochiritsira, mwina chifukwa cha nthawi yochepa ya chithandizo.Mayesero azachipatala am'tsogolo okhala ndi zitsanzo zazikulu komanso nthawi yayitali yamankhwala amafunikira kuti mumvetsetse bwino momwe ntchito yachipatala imagwirira ntchito.Ganoderma lucidumspore powder makapisozi pochiza matenda a Alzheimer's.

Kugwiritsa ntchito pamodziGanoderma lucidumspore ufa ndi ochiritsira mankhwala mankhwala kwambiri bwino achire lapamwamba pochiza matenda Alzheimer.

Posachedwapa, kafukufuku adawunikira zotsatira zophatikizana zaGanoderma lucidumspore powder ndi mankhwala a Alzheimer's disease memantine pa kuzindikira komanso moyo wabwino mwa odwala omwe ali ndi matenda a Alzheimer's ofatsa mpaka olimba [2].Odwala makumi anayi ndi asanu ndi atatu omwe adapezeka ndi matenda a Alzheimer's, azaka za 50 mpaka zaka 86, adagawidwa mwachisawawa kukhala gulu lolamulira ndi gulu loyesera, ndi odwala 24 mu gulu lirilonse (n = 24).

Asanayambe kulandira chithandizo, panalibe kusiyana kwakukulu pakati pa magulu awiriwa ponena za jenda, digiri ya dementia, ADAS-cog, NPI, ndi WHOQOL-BREF scores (P> 0.5).Gulu lolamulira linalandira makapisozi a memantine pa mlingo wa 10 mg, kawiri pa tsiku, pamene gulu loyesera linalandira mlingo womwewo wa memantine pamodzi ndiGanoderma lucidummakapisozi a ufa wa spore (SPGL) pa mlingo wa 1000 mg, katatu patsiku.Magulu onsewa adathandizidwa kwa masabata a 6, ndipo zofunikira za odwala zidalembedwa.Ntchito yachidziwitso ndi umoyo wa odwala adayesedwa pogwiritsa ntchito miyeso ya ADAS-cog, NPI, ndi WHOQOL-BREF.

Pambuyo pa chithandizo, magulu onse awiri a odwala adawonetsa kuchepa kwakukulu kwa ADAS-cog ndi NPI zambiri poyerekeza ndi chithandizo chisanachitike.Kuonjezera apo, gulu loyesera linali ndi zochepa kwambiri za ADAS-cog ndi NPI kuposa gulu lolamulira, ndi zosiyana kwambiri (P <0.05) (Table 3, Table 4).Pambuyo pa chithandizo, magulu onse awiri a odwala adawonetsa kuwonjezeka kwakukulu kwa physiology, psychology, maubwenzi a anthu, chilengedwe, ndi moyo wonse mu mafunso a WHOQOL-BREF poyerekeza ndi mankhwala asanakhalepo.Komanso, gulu loyesera linali ndi ziwerengero zapamwamba kwambiri za WHOQOL-BREF kuposa gulu lolamulira, ndi kusiyana kwakukulu (P <0.05) (Table 5).

Memantine, yemwe amadziwika kuti buku la N-methyl-D-aspartate (NMDA) receptor antagonist, amatha kuletsa mopanda mpikisano zolandilira NMDA, potero amachepetsa kutengeka kwa glutamic acid-induced NMDA receptor ndikuletsa ma cell apoptosis.Zimathandizira kuzindikira, kusokonezeka kwamakhalidwe, zochita za tsiku ndi tsiku, komanso kuopsa kwa dementia kwa odwala omwe ali ndi matenda a Alzheimer's.Amagwiritsidwa ntchito pochiza matenda a Alzheimer's ofatsa, odziletsa komanso ovuta.Komabe, kugwiritsa ntchito mankhwalawa kokha kumakhalabe ndi phindu lochepa kwa odwala omwe ali ndi matenda a Alzheimer's.

Zotsatira za kafukufukuyu zikuwonetsa kuti kugwiritsa ntchito pamodzi kwaGanoderma lucidumspore powder ndi memantine amatha kukulitsa luso la odwala komanso kuzindikira komanso kuwongolera moyo wawo.

Kusankha njira yoyenera yamankhwala ndikofunikira pochiza matenda a Alzheimer's.

M'mayesero awiri omwe ali pamwambawa omwe amayendetsedwa mwachisawawa aGanoderma lucidumspore ufa wochizira matenda a Alzheimer's, kusankha milandu, matenda, gwero la Ganoderma lucidum spore powder, mlingo, njira ya chithandizo, ndi zizindikiro zowunika zowunikira zinali zofanana, koma mphamvu yachipatala inali yosiyana.Pambuyo pofufuza zowerengera, kugwiritsa ntchitoGanoderma lucidumspore powder yekha kuti athetse matenda a Alzheimer's sanawonetse kusintha kwakukulu mu AS-cog, NPI, ndi WHOQOL-BREF zambiri poyerekeza ndi placebo;komabe, kugwiritsidwa ntchito kophatikizana kwaGanoderma lucidumspore powder ndi memantine zinawonetsa kusintha kwakukulu m'magulu atatuwa poyerekeza ndi memantine okha, ndiko kuti, kugwiritsa ntchito pamodziGanoderma lucidumspore powder ndi memantine amatha kusintha kwambiri luso la khalidwe, luso lachidziwitso komanso moyo wa odwala omwe ali ndi matenda a Alzheimer's.

Pakalipano, mankhwala omwe amagwiritsidwa ntchito pochiza matenda a Alzheimer's, monga donepezil, rivastigmine, memantine, ndi galantamine (Reminyl), ali ndi zotsatira zochepa zochiritsira ndipo amatha kuchepetsa zizindikiro ndikuchedwetsa nthawi ya matendawa.Kuphatikiza apo, pafupifupi palibe mankhwala atsopano ochizira matenda a Alzheimer's omwe adapangidwa bwino m'zaka 20 zapitazi.Chifukwa chake, kugwiritsa ntchitoGanoderma lucidumspore ufa kumapangitsanso mphamvu ya mankhwala zochizira matenda a Alzheimer ayenera kupatsidwa chidwi.

Ponena za mayesero ena azachipatala ogwiritsira ntchitoGanoderma lucidumspore ufa yekha, n'zotheka kuganizira kuonjezera mlingo, mwachitsanzo, 2000 mg nthawi iliyonse, kawiri pa tsiku, kwa nthawi ya masabata osachepera 12.Kaya izi ndi zotheka, tikuyembekezera zotsatira za kafukufuku m'derali kuti atiuze yankho.

[Maumboni]

1. Guo-hui Wang, et al.Spore ufa waGanoderma lucidumpochiza matenda a Alzheimer: kafukufuku woyendetsa ndege.Mankhwala (Baltimore).2018; 97(19): e0636.

2. Wang Lichao, et al.Zotsatira za memantine kuphatikizaGanoderma lucidumspore powder pa kuzindikira ndi khalidwe la moyo kwa odwala omwe ali ndi matenda a Alzheimer's.Journal of Armed Police Medical College (Medical Edition).2019, 28 (12): 18-21.

Chiyambi cha Pulofesa Lin Zhibin

Bambo Lin Zhibin, mpainiya kuGanodermakafukufuku ku China, wapereka pafupifupi theka la zana kumunda.Anakhala ndi maudindo angapo ku Beijing Medical University, kuphatikizapo Wachiwiri kwa Purezidenti, Wachiwiri kwa Dean wa Sukulu ya Basic Medicine, Mtsogoleri wa Institute of Basic Medical Sciences, ndi Mtsogoleri wa Dipatimenti ya Pharmacology.Iye tsopano ndi pulofesa mu Dipatimenti ya Pharmacology ku Peking University School of Basic Medical Sciences.Kuchokera ku 1983 mpaka 1984, anali katswiri woyendera ku WHO Traditional Medicine Research Center ku yunivesite ya Illinois ku Chicago.Kuyambira 2000 mpaka 2002, anali pulofesa woyendera pa yunivesite ya Hong Kong.Kuyambira 2006, wakhala pulofesa wolemekezeka ku Perm State Pharmaceutical Academy ku Russia.

Kuyambira 1970, wakhala akugwiritsa ntchito njira zamakono zasayansi kuti aphunzire zotsatira za mankhwala ndi njira za mankhwala achi ChinaGanodermandi zinthu zake zogwira ntchito.Adasindikiza zolemba zopitilira zana pa Ganoderma.Kuyambira 2014 mpaka 2019, adasankhidwa kukhala mndandanda wa Elsevier's China Highly Cited Researchers kwa zaka zisanu ndi chimodzi zotsatizana.

Walemba mabuku ambiri okhudza Ganoderma, kuphatikizapo "Zofufuza Zamakono za Ganoderma" (zosindikiza za 1st-4th), "Lingzhi from Mystery to Science" (1st-3rd editions), "Ganoderma imathandizira mphamvu yathanzi ndikuchotsa zinthu zomwe zimayambitsa matenda, zomwe zimathandiza pa matenda. chithandizo cha zotupa", "Zokambirana pa Ganoderma", ndi "Ganoderma ndi Health".