Emegharịrị akụkọ a site na mbipụta nke 97 nke akwụkwọ akụkọ "Ganoderma" na 2023, nke e bipụtara site na ikike onye edemede.Ikike niile nke edemede a bụ nke onye odee.
Enwere ike ịhụ nnukwu ọdịiche na ụbụrụ n'etiti onye ahụike (aka ekpe) na onye ọrịa Alzheimer (n'aka nri).
(Isi foto: Wikimedia Commons)
Ọrịa Alzheimer (AD), nke a na-akpọkarị dementia senile, bụ ọrịa neurodegenerative na-aga n'ihu nke nwere nhụsianya ọgụgụ isi metụtara afọ na ọnwụ ebe nchekwa.Site na mmụba nke ndụ mmadụ na ịka nká, ọnụ ọgụgụ nke ọrịa Alzheimer na-arị elu nke ukwuu, na-etinye nnukwu ibu n'ahụ ezinụlọ na ọha mmadụ.Ya mere, ịgagharị ọtụtụ ụzọ iji gbochie na ịgwọ ọrịa Alzheimer abụrụla isiokwu nke mmasị nyocha dị ukwuu.
N'ime edemede m akpọrọ "Ịnyocha nyocha naGanodermamaka Mgbochi na Ọgwụgwọ Ọrịa Alzheimer,” nke e bipụtara na mbipụta 83 nke akwụkwọ akụkọ “Ganoderma” na 2019, ewebata m pathogenesis nke ọrịa Alzheimer na mmetụta ọgwụ ọgwụ.Ganodermalucidumn'igbochi na ịgwọ ọrịa Alzheimer.Kpọmkwem,Ganodermalucidumextracts,Ganodermalucidumpolysaccharides,Ganodermalucidumtriterpenes, naGanodermalucidumAchọpụtara ntụ ntụ spore iji melite mmụta mmụta na nsogbu ebe nchekwa na ụdị oke ọrịa Alzheimer.Akụkụ ndị a gosipụtara mmetụta nchebe megide mgbanwe neuropathological degenerative na anụ ahụ hippocampal nke ụdị oke oke ọrịa Alzheimer, belata neuroinflammation na anụ ahụ ụbụrụ, mụbaa ọrụ superoxide dismutase (SOD) na anụ ahụ ụbụrụ hippocampal, belata ọkwa nke malondialdehyde (MDA). ) dị ka ngwaahịa oxidative, ma gosipụta mmetụta mgbochi na ọgwụgwọ na ụdị anụmanụ nnwale nke ọrịa Alzheimer.
The abụọ mbụ clinical ọmụmụ onGanoderma lucidumn'ihi na igbochi na ịgwọ ọrịa Alzheimer, ẹkenam ke ibuotikọ, na-adịghị definitively kwadoro irè nkeGanoderma lucidumna ọrịa Alzheimer.Otú ọ dị, jikọtara ya na ọtụtụ nchọpụta nyocha ọgwụ na-ekwe nkwa, ha na-enye olileanya maka ọmụmụ ihe ọmụmụ ụlọ ọgwụ ọzọ.
Mmetụta nke ijiGanoderma lucidumspore ntụ ntụ naanị iji gwọọ ọrịa Alzheimer abụghị ihe doro anya.
Na-enyocha akwụkwọ nyocha nke akpọrọ "Spore powder ofGanoderma lucidummaka ọgwụgwọ ọrịa Alzheimer: Nnyocha ụgbọelu" nke e bipụtara na magazin "Medicine"[1], ndị na-ede akwụkwọ na-ekewa ndị ọrịa 42 na-enweghị ihe ọ bụla bụ ndị zutere usoro nyocha nke ọrịa Alzheimer n'ime otu nnwale na otu njikwa, yana ndị ọrịa 21 na otu ọ bụla.Ndị nnwale ahụ nwetara nchịkwa ọnụ nkeGanodermalucidumspore powder capsules (SPGL otu) na onunu ogwu nke 4 capsules (250 mg nke ọ bụla capsule) ugboro atọ n'ụbọchị ebe ndị na-achịkwa na-enweta naanị placebo capsules.Otu abụọ ahụ nwetara ọgwụgwọ izu isii.
Na njedebe nke ọgwụgwọ ahụ, ma e jiri ya tụnyere ndị na-ahụ maka njikwa, ndị SPGL gosipụtara mbelata ọnụ ọgụgụ maka nyocha nyocha nke ọrịa Alzheimer Scale-Cognitive Subscale (ADAS-cog) na Neuropsychiatric Inventory (NPI), na-egosi mmụba nke ọgụgụ isi na omume. emezighị emezi, ma ndịiche adịghị mkpa na ọnụ ọgụgụ (Table 1).Akwụkwọ ajụjụ Health Organisation Quality of Life-BREF (WHOQOL-BREF) gosipụtara mmụba nke ogo ndụ ndụ, na-egosi mmụba nke ịdị mma ndụ, mana ọzọ, ọdịiche ndị ahụ adịchaghị mkpa (Ntọala 2).Otu abụọ ahụ nwetara mmeghachi omume dị nro, na-enweghị nnukwu ọdịiche.
Ndị na-ede akwụkwọ ahụ kwenyere na ọgwụgwọ ọrịa Alzheimer naGanoderma lucidumspore powder capsules maka izu 6 egosighi mmetụta ọgwụgwọ dị ịrịba ama, ikekwe n'ihi obere oge ọgwụgwọ.Ọnwụnwa ụlọ ọgwụ n'ọdịnihu nwere nnukwu nlele na ogologo oge ọgwụgwọ dị mkpa iji nweta nghọta doro anya maka ịdị irè ụlọ ọgwụ nke.Ganoderma lucidumspore powder capsules na ọgwụgwọ ọrịa Alzheimer.
The jikọtara ojiji nkeGanoderma lucidumspore ntụ ntụ na ọgwụ ọgwụgwọ omenala na-eme ka ọgwụgwọ ọgwụgwọ dị mma n'ịgwọ ọrịa Alzheimer.
N'oge na-adịbeghị anya, otu nnyocha nyochara mmetụta jikọtara ọnụ nkeGanoderma lucidumspore powder and the Alzheimer's disease medicine memantine on cognition and quality of life na ndị ọrịa nwere ọrịa Alzheimer dị nwayọọ ma na-agafeghị oke [2].Ndị ọrịa iri anọ na asatọ a chọpụtara na ọrịa Alzheimer, ndị dị afọ 50 ruo 86, kewara n'enweghị usoro n'ime otu njikwa na otu nnwale, yana ndị ọrịa 24 na otu ọ bụla (n=24).
Tupu ọgwụgwọ, enweghi ọdịiche dị ịrịba ama dị n'etiti otu abụọ ahụ n'ihe gbasara okike, ogo dementia, ADAS-cog, NPI, na WHOQOL-BREF (P> 0.5).Ndị na-ahụ maka njikwa ahụ nwetara capsules memantine na dose nke 10 mg, ugboro abụọ n'ụbọchị, ebe ndị nyocha ahụ nwetara otu dose nke memantine yanaGanoderma lucidumspore powder capsules (SPGL) na dose nke 1000 mg, ugboro atọ n'ụbọchị.A na-agwọ ndị otu abụọ ahụ maka izu 6, ma dekọọ data ndị bụ isi nke ndị ọrịa.A na-enyocha ọrụ ọgụgụ isi na ndụ ndụ nke ndị ọrịa site na iji akara akara ADAS-cog, NPI, na WHOQOL-BREF.
Mgbe ọgwụgwọ gasịrị, ìgwè abụọ nke ndị ọrịa gosipụtara mbelata dị ukwuu na ADAS-cog na akara NPI ma e jiri ya tụnyere tupu ọgwụgwọ.Na mgbakwunye, otu nnwale ahụ nwere akara ADAS-cog na NPI nke ukwuu karịa otu njikwa, nwere ọdịiche dị ịrịba ama (P<0.05) (Table 3, Tebụl 4).N'ịgbaso ọgwụgwọ, ìgwè abụọ nke ndị ọrịa gosipụtara mmụba dị ukwuu na ọnụ ọgụgụ maka physiology, nkà mmụta uche, mmekọrịta ọha na eze, gburugburu ebe obibi, na ndụ ndụ zuru oke na ajụjụ WHOQOL-BREF ma e jiri ya tụnyere tupu ọgwụgwọ.Ọzọkwa, otu nnwale ahụ nwere akara WHOQOL-BREF dị elu karịa ndị na-ahụ maka njikwa, na-enwe ọdịiche dị ịrịba ama (P<0.05) (Table 5).
Memantine, nke a maara dị ka akwụkwọ akụkọ N-methyl-D-aspartate (NMDA) onye na-anabata ndị na-anabata ya, nwere ike igbochi ndị na-anabata NMDA na-enweghị asọmpi, si otú a na-ebelata glutamic acid na-ebute NMDA nnabata nke ukwuu na igbochi apoptosis cell.Ọ na-eme ka ọrụ ọgụgụ isi dịkwuo mma, nsogbu omume, ihe omume nke ndụ kwa ụbọchị, na oke mgbaka n'ime ndị ọrịa nwere ọrịa Alzheimer.A na-eji ya maka ọgwụgwọ ọrịa Alzheimer dị nro, nke na-agafeghị oke na nke siri ike.Agbanyeghị, iji ọgwụ a naanị ka nwere oke uru maka ndị ọrịa nwere ọrịa Alzheimer.
Nsonaazụ nke ọmụmụ a na-egosi na ngwakọta ngwa nkeGanoderma lucidumspore ntụ ntụ na memantine nwere ike ime ka ndị ọrịa na-akpa àgwà na ikike nghọta ma mee ka ndụ ha dịkwuo mma.
Ịhọrọ usoro ọgwụgwọ ziri ezi dị oke mkpa maka ịgwọ ọrịa Alzheimer.
Na n'elu abụọ randomized na-achịkwa ụlọ ọgwụ ọnwụnwa nkeGanoderma lucidumspore ntụ ntụ maka ọgwụgwọ ọrịa Alzheimer, nhọrọ nke ikpe, nchoputa, isi iyi nke Ganoderma lucidum spore powder, usoro onunu ogwu, usoro ọgwụgwọ, na nyocha nyocha nke ọma bụ otu, ma ọgwụgwọ ụlọ ọgwụ dị iche.Mgbe nchịkọta akụkọ nyocha, ojiji nkeGanoderma lucidumspore ntụ ntụ naanị iji gwọọ ọrịa Alzheimer egosighi ọganihu dị ịrịba ama na AS-cog, NPI, na WHOQOL-BREF scores tụnyere placebo;Otú ọ dị, jikọtara ojiji nkeGanoderma lucidumspore ntụ ntụ na memantine gosipụtara mmụba dị ịrịba ama na akara atọ ma e jiri ya tụnyere memantine naanị, ya bụ, ijikọta ọnụ.Ganoderma lucidumspore ntụ ntụ na memantine nwere ike imeziwanye ikike omume, ikike ọgụgụ isi na ndụ ndụ nke ndị ọrịa nwere ọrịa Alzheimer.
Ugbu a, ọgwụ ndị a na-eji agwọ ọrịa Alzheimer, dị ka donepezil, rivastigmine, memantine, na galantamine (Reminyl), nwere mmetụta ọgwụgwọ dị ntakịrị ma nwee ike ibelata mgbaàmà na igbu oge ọrịa ahụ.Tụkwasị na nke ahụ, ọ fọrọ nke nta ka ọ bụrụ na ọ dịghị ọgwụ ọhụrụ maka ọgwụgwọ ọrịa Alzheimer ka emepụtara nke ọma n'ime afọ 20 gara aga.Ya mere, ojiji nkeGanoderma lucidumspore ntụ ntụ iji welie irè ọgwụ maka ọgwụgwọ ọrịa Alzheimer kwesịrị inye nlebara anya.
Maka nnwale ụlọ ọgwụ ọzọ nke ijiGanoderma lucidumspore ntụ ntụ naanị, ọ ga-ekwe omume ịtụle ịbawanye usoro onunu ogwu, dịka ọmụmaatụ, 2000 mg oge ọ bụla, ugboro abụọ n'ụbọchị, maka usoro nke ọ dịkarịa ala izu 12.Ma nke a ọ ga-ekwe omume, anyị na-atụ anya nsonaazụ nyocha na mpaghara a iji gwa anyị azịza ya.
[Ntụaka]
1. Guo-hui Wang, et al.Spore ntụ ntụ nkeGanoderma lucidummaka ọgwụgwọ ọrịa Alzheimer: nchọpụta pilot.Ọgwụ (Baltimore).2018;97(19): e0636.
2. Wang Lichao, et al.Mmetụta nke memantine jikọtara ya naGanoderma lucidumspore ntụ ntụ na cognition na ndụ ndụ na ndị ọrịa nwere ọrịa Alzheimer.Akwụkwọ akụkọ ụlọ akwụkwọ ahụike ndị uwe ojii Armed (Mbipụta Ahụike).2019, 28 (12): 18-21.
Okwu mmalite nke Prọfesọ Lin Zhibin
Maazị Lin Zhibin, bụ́ onye ọsụ ụzọGanodermanyocha na China, etinyela ihe fọrọ nke nta ka ọ bụrụ ọkara narị afọ n'ọhịa.Ọ nwere ọtụtụ ọkwa na Mahadum Ahụike Beijing, gụnyere osote onye isi oche, Vice Dean of the School of Basic Medicine, Director nke Institute of Basic Medical Sciences, na Director nke Ngalaba Pharmacology.Ọ bụ ugbu a prọfesọ na Ngalaba Pharmacology na Mahadum Peking School of Basic Medical Sciences.Site na 1983 ruo 1984, ọ bụ ọkà mmụta nleta na WHO Traditional Medicine Research Center na Mahadum Illinois na Chicago.Site na 2000 ruo 2002, ọ bụ prọfesọ ọbịa na Mahadum Hong Kong.Kemgbe 2006, ọ bụ onye prọfesọ na-asọpụrụ na Perm State Pharmaceutical Academy na Russia.
Kemgbe 1970, o jirila usoro sayensị ọgbara ọhụrụ mụọ mmetụta ọgwụ na usoro ọgwụ ọdịnala ndị China.Ganodermana ihe ndị na-arụ ọrụ ya.O bipụtala akwụkwọ nyocha ihe karịrị otu narị na Ganoderma.Site na 2014 ruo 2019, ahọpụtara ya maka Ndepụta Elsevier's China Highly Ceted Researchers maka afọ isii sochiri.
O deela ọtụtụ akwụkwọ na Ganoderma, gụnyere "Nchọpụta ọgbara ọhụrụ na Ganoderma" (mbipụta 1st-4th), "Lingzhi si Mystery to Science" (1st-3rd mbipụta), "Ganoderma na-akwado ike ahụ ike ma na-achụpụ ihe ndị na-akpata ọrịa, na-enyere aka na ọgwụgwọ nke etuto ahụ "," Mkparịta ụka na Ganoderma ", na "Ganoderma na Health".
Oge nzipu: Jun-30-2023