Kab lus no yog luam tawm los ntawm 97th qhov teeb meem ntawm "Ganoderma" magazine hauv 2023, luam tawm nrog tus sau ntawv tso cai.Txhua txoj cai rau kab lus no yog tus sau.

Qhov sib txawv tseem ceeb tuaj yeem pom hauv lub hlwb ntawm tus neeg noj qab haus huv (sab laug) thiab tus neeg mob Alzheimer's disease (txoj cai).

(Duab qhov chaw: Wikimedia Commons)

Alzheimer's disease (AD), feem ntau hu ua senile dementia, yog ib qho kev mob neurodegenerative uas tshwm sim los ntawm hnub nyoog txog kev paub tsis meej thiab nco tsis tau.Nrog rau kev nce hauv tib neeg lub neej thiab kev laus ntawm cov neeg laus, qhov tshwm sim ntawm Alzheimer's tus kab mob tau nce tsis tu ncua, ua rau lub nra hnyav rau tsev neeg thiab zej zog.Yog li, kev tshawb nrhiav ntau txoj hauv kev los tiv thaiv thiab kho Alzheimer's tus kab mob tau dhau los ua lub ntsiab lus ntawm kev tshawb fawb zoo.

Hauv kuv tsab xov xwm hu ua "Kev Tshawb Nrhiav Kev Tshawb Fawb ntawmGanodermaKev Tiv Thaiv thiab Kho Mob Alzheimer's Disease," luam tawm nyob rau hauv 83rd qhov teeb meem ntawm "Ganoderma" magazine nyob rau hauv 2019, Kuv tau qhia txog cov kab mob ntawm Alzheimer's disease thiab cov tshuaj pharmacological ntawmGanodermalucidumhauv kev tiv thaiv thiab kho Alzheimer's disease.Tshwj xeeb,Ganodermalucidumextracts,Ganodermalucidumpolysaccharides,Ganodermalucidumtriterpenes, thiabGanodermalucidumspore hmoov tau pom los txhim kho kev kawm thiab kev nco tsis zoo hauv Alzheimer tus kab mob nas qauv.Cov Cheebtsam no kuj tau nthuav tawm cov teebmeem tiv thaiv kev hloov pauv ntawm cov kabmob neuropathological hauv hippocampal hlwb cov ntaub so ntswg ntawm Alzheimer's kab mob nas qauv, txo cov neuroinflammation hauv cov ntaub so ntswg hauv hlwb, nce kev ua haujlwm ntawm superoxide dismutase (SOD) hauv hippocampal hlwb cov ntaub so ntswg, txo cov qib malondialdehyde (MDA). ) raws li cov khoom siv oxidative, thiab ua kom pom kev tiv thaiv thiab kho cov teebmeem hauv kev sim tsiaj cov qauv ntawm Alzheimer's disease.

Ob qhov kev tshawb fawb soj ntsuam ua ntej ntawmGanoderma lucidumrau kev tiv thaiv thiab kho tus kab mob Alzheimer's, qhia nyob rau hauv tsab xov xwm, tsis tau paub meej tias qhov ua tau zoo ntawmGanoderma lucidumhauv Alzheimer's disease.Txawm li cas los xij, ua ke nrog ntau qhov kev tshawb fawb tshuaj muaj txiaj ntsig zoo, lawv muab kev cia siab rau kev tshawb fawb soj ntsuam ntxiv.

Cov nyhuv ntawm kev sivGanoderma lucidumspore hmoov ib leeg los kho Alzheimer's kab mob tsis pom tseeb.

Kev tshuaj xyuas cov ntawv tshawb fawb hu ua "Spore hmoov ntawmGanoderma lucidumrau kev kho mob ntawm Alzheimer's disease: Ib txoj kev tshawb nrhiav" luam tawm nyob rau hauv phau ntawv journal "Medicine"^[1], cov kws sau ntawv tau muab faib ua 42 tus neeg mob uas tau ntsib cov txheej txheem kuaj mob Alzheimer's tus kab mob rau hauv ib pawg sim thiab pawg tswj hwm, nrog rau 21 tus neeg mob hauv txhua pab pawg.Cov pab pawg sim tau txais kev tswj hwm qhov ncauj ntawmGanodermalucidumspore hmoov capsules (SPGL pawg) ntawm qhov ntau npaum ntawm 4 tsiav tshuaj (250 mg txhua lub tshuaj ntsiav) peb zaug hauv ib hnub thaum pawg tswj tsuas tau txais cov placebo capsules.Ob pawg tau txais kev kho mob 6 lub lis piam.

Thaum kawg ntawm kev kho mob, piv rau pawg tswj hwm, pawg SPGL tau pom qhov txo qis hauv cov qhab nia rau Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) thiab Neuropsychiatric Inventory (NPI), qhia txog kev txhim kho kev txawj ntse thiab kev coj cwj pwm. kev puas tsuaj, tab sis qhov sib txawv tsis tseem ceeb (Table 1).Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv Zoo ntawm Lub Neej-BREF (WHOQOL-BREF) cov lus nug tau qhia txog kev nce qib hauv lub neej zoo, qhia txog kev txhim kho lub neej zoo, tab sis dua, qhov sib txawv tsis tseem ceeb (Table 2).Ob pab pawg tau ntsib kev cuam tshuam me me, tsis muaj qhov sib txawv loj.

Cov neeg sau ntawv ntawm daim ntawv ntseeg hais tias kev kho mob ntawm Alzheimer's kab mob nrogGanoderma lucidumspore hmoov capsules rau 6 lub lis piam tsis tau qhia txog kev kho mob tseem ceeb, tej zaum vim yog lub sijhawm luv luv ntawm kev kho mob.Kev sim tshuaj ntsuam xyuas yav tom ntej nrog cov qauv loj thiab ntev kev kho mob yuav tsum tau ua kom tau txais kev nkag siab zoo dua ntawm kev siv tshuaj kho mob.Ganoderma lucidumspore hmoov capsules hauv kev kho mob Alzheimer's kab mob.

Kev siv ua ke ntawmGanoderma lucidumspore hmoov nrog cov tshuaj kho cov pa ua haujlwm tau zoo txhim kho cov txiaj ntsig ntawm kev kho mob Alzheimer's.

Tsis ntev los no, ib txoj kev tshawb fawb tau soj ntsuam cov txiaj ntsig ua ke ntawmGanoderma lucidumspore hmoov thiab Alzheimer's kab mob tshuaj memantine ntawm kev paub thiab kev ua neej zoo nyob rau hauv cov neeg mob uas mob me mus rau nruab nrab Alzheimer's disease [2].Plaub caug yim tus neeg mob tau kuaj pom tus kab mob Alzheimer, hnub nyoog 50 txog 86 xyoo, tau muab faib ua pawg tswj hwm thiab pab pawg sim, nrog 24 tus neeg mob hauv txhua pab pawg (n = 24).

Ua ntej kev kho mob, tsis muaj qhov sib txawv tseem ceeb ntawm ob pawg ntawm poj niam txiv neej, dementia degree, ADAS-cog, NPI, thiab WHOQOL-BREF cov qhab nia (P> 0.5).Pab pawg tswj hwm tau txais memantine capsules ntawm koob tshuaj 10 mg, ob zaug ib hnub, thaum pab pawg sim tau txais tib koob tshuaj memantin nrog rauGanoderma lucidumspore hmoov capsules (SPGL) ntawm ib koob ntawm 1000 mg, peb zaug ib hnub twg.Ob pawg tau kho rau 6 lub lis piam, thiab cov ntaub ntawv tseem ceeb ntawm cov neeg mob tau raug kaw.Kev paub txog kev ua haujlwm thiab lub neej zoo ntawm cov neeg mob tau raug ntsuas los ntawm ADAS-cog, NPI, thiab WHOQOL-BREF cov qhab nia ntsuas.

Tom qab kev kho mob, ob pawg neeg mob tau pom qhov txo qis hauv ADAS-cog thiab NPI cov qhab nia piv rau ua ntej kho.Tsis tas li ntawd, pawg kws sim tau qis dua ADAS-cog thiab NPI cov qhab nia ntau dua li pawg tswj hwm, nrog rau qhov sib txawv tseem ceeb (P<0.05) (Table 3, Table 4).Tom qab kev kho mob, ob pawg ntawm cov neeg mob tau pom qhov nce ntxiv hauv cov qhab nia ntawm lub cev, kev xav, kev sib raug zoo, ib puag ncig, thiab tag nrho lub neej zoo hauv daim ntawv nug WHOQOL-BREF piv rau ua ntej kho.Ntxiv mus, pawg neeg sim tau muaj cov qhab nia WHOQOL-BREF ntau dua li pawg tswj hwm, nrog rau qhov sib txawv tseem ceeb (P<0.05) (Table 5).

Memantine, paub tias yog ib qho tshiab N-methyl-D-aspartate (NMDA) receptor antagonist, tuaj yeem tsis sib tw los thaiv NMDA receptors, yog li txo qis glutamic acid-induced NMDA receptor overexcitation thiab tiv thaiv cell apoptosis.Nws txhim kho kev txawj ntse, kev coj cwj pwm tsis zoo, kev ua ub no ntawm kev ua neej nyob txhua hnub, thiab dementia hnyav rau cov neeg mob Alzheimer's.Nws yog siv rau kev kho mob me me, nruab nrab, thiab mob Alzheimer's mob hnyav.Txawm li cas los xij, kev siv cov tshuaj no ib leeg tseem muaj txiaj ntsig txwv rau cov neeg mob Alzheimer's disease.

Cov txiaj ntsig ntawm qhov kev tshawb fawb no qhia tau hais tias kev sib xyaw ua ke ntawmGanoderma lucidumspore hmoov thiab memantine tuaj yeem txhim kho cov neeg mob tus cwj pwm thiab kev txawj ntse thiab txhim kho lawv lub neej zoo.

Kev xaiv cov tshuaj kom raug yog qhov tseem ceeb rau kev kho mob Alzheimer's.

Nyob rau hauv cov saum toj no ob randomized tswj kev soj ntsuam sim ntawmGanoderma lucidumspore hmoov rau kev kho mob Alzheimer's tus kab mob, xaiv cov neeg mob, kuaj mob, qhov chaw ntawm Ganoderma lucidum spore hmoov, ntau npaum li cas, chav kawm ntawm kev kho mob, thiab cov kev ntsuam xyuas kev ua tau zoo yog tib yam, tab sis cov kev soj ntsuam kev ua tau zoo sib txawv.Tom qab kev txheeb xyuas kev txheeb xyuas, kev siv ntawmGanoderma lucidumspore hmoov ib leeg los kho Alzheimer's kab mob pom tsis muaj kev txhim kho tseem ceeb hauv AS-cog, NPI, thiab WHOQOL-BREF cov qhab nia piv rau cov placebo;txawm li cas los xij, kev siv ua ke ntawmGanoderma lucidumspore hmoov thiab memantine pom kev txhim kho tseem ceeb hauv peb cov qhab nia piv rau memantine ib leeg, uas yog, kev siv ua ke ntawmGanoderma lucidumspore hmoov thiab memantine tuaj yeem txhim kho tus cwj pwm muaj peev xwm, kev txawj ntse thiab lub neej zoo ntawm cov neeg mob Alzheimer's disease.

Tam sim no, cov tshuaj siv los kho Alzheimer's disease, xws li donepezil, rivastigmine, memantine, thiab galantamine (Reminyl), muaj kev txwv tsis pub siv tshuaj kho mob thiab tsuas tuaj yeem txo cov tsos mob thiab ncua sijhawm ntawm tus kab mob.Tsis tas li ntawd, yuav luag tsis muaj cov tshuaj tshiab rau kev kho mob Alzheimer's kab mob tau ua tiav hauv 20 xyoo dhau los.Yog li ntawd, kev siv ntawmGanoderma lucidumspore hmoov los txhim kho kev ua tau zoo ntawm cov tshuaj rau kev kho mob ntawm Alzheimer's tus kab mob yuav tsum tau saib xyuas.

Raws li kev soj ntsuam ntxiv ntawm kev sivGanoderma lucidumspore hmoov ib leeg, nws tuaj yeem txiav txim siab nce qhov ntau npaum li cas, piv txwv li, 2000 mg txhua lub sijhawm, ob zaug ib hnub, rau chav kawm tsawg kawg 12 lub lis piam.Txawm hais tias qhov no ua tau, peb tos ntsoov rau kev tshawb fawb hauv cheeb tsam no los qhia peb cov lus teb.

[References]

1. Guo-hui Wang, et al.Spore hmoov ntawmGanoderma lucidumrau kev kho mob ntawm Alzheimer: Ib txoj kev tshawb nrhiav.Tshuaj (Baltimore).2018; 97(19): e0636.

2. Wang Li, et al.Cov nyhuv ntawm memantine ua ke nrogGanoderma lucidumspore hmoov ntawm kev paub thiab kev ua neej zoo nyob rau hauv cov neeg mob Alzheimer's disease.Phau ntawv Journal of Armed Police Medical College (Medical Edition).2019, 28(12): 18-21.

Taw qhia rau xibfwb Lin Zhibin

Mr. Lin Zhibin, ib tug pioneer hauvGanodermakev tshawb fawb hauv Suav teb, tau mob siab rau ze li ib nrab xyoo pua rau thaj chaw.Nws tuav ntau txoj haujlwm ntawm Beijing Medical University, suav nrog Tus Lwm Thawj Coj, Tus Lwm Thawj Coj ntawm Lub Tsev Kawm Ntawv ntawm Cov Tshuaj Kho Mob, Tus Thawj Coj ntawm Lub Tsev Haujlwm Saib Xyuas Kev Kho Mob, thiab Tus Thawj Coj ntawm Lub Tsev Haujlwm Saib Xyuas Tshuaj.Tam sim no nws yog tus xibfwb hauv Department of Pharmacology ntawm Peking University School of Basic Medical Sciences.Los ntawm 1983 txog 1984, nws yog ib tug kws tshawb fawb ntawm WHO Traditional Medicine Research Center ntawm University of Illinois ntawm Chicago.Los ntawm 2000 mus rau 2002, nws yog ib tug mus ntsib xibfwb nyob rau hauv University of Hong Kong.Txij li thaum xyoo 2006, nws tau ua tus kws tshaj lij ntawm Perm State Pharmaceutical Academy hauv Russia.

Txij li thaum xyoo 1970, nws tau siv txoj kev tshawb fawb niaj hnub los kawm txog cov tshuaj pharmacological thiab cov txheej txheem ntawm cov tshuaj suav tshuaj.Ganodermathiab nws cov khoom xyaw nquag.Nws tau luam tawm ntau tshaj li ib puas daim ntawv tshawb fawb ntawm Ganoderma.Los ntawm 2014 txog 2019, nws tau raug xaiv rau Elsevier's China Highly Cited Researchers List rau rau xyoo sib law liag.

Nws tau sau ntau phau ntawv ntawm Ganoderma, suav nrog "Kev Tshawb Fawb Txog Niaj Hnub Nyoog ntawm Ganoderma" (1st-4th edition), "Lingzhi los ntawm Mystery to Science" (1st-3rd edition), "Ganoderma txhawb lub zog noj qab haus huv thiab dispels pathogenic yam, pab nyob rau hauv lub Kev kho mob ntawm cov qog", "Kev Sib Tham ntawm Ganoderma", thiab "Ganoderma thiab Kev Noj Qab Haus Huv".