Sengoliloeng sena se hlahisitsoe khatisong ea bo97 ea makasine ea "Ganoderma" ka 2023, e hatisitsoeng ka tumello ea mongoli.Litokelo tsohle tsa sengoloa sena ke tsa mongoli.
Phapang e kholo e ka bonoa bokong lipakeng tsa motho ea phetseng hantle (ka ho le letšehali) le mokuli oa lefu la Alzheimer (ka ho le letona).
(Mohloli oa setšoantšo: Wikimedia Commons)
Lefu la Alzheimer's (AD), leo hangata le tsejoang ka hore ke senile dementia, ke lefu le tsoelang pele la neurodegenerative le tšoauoang ke ho holofala ho amanang le lilemo le tahlehelo ea mohopolo.Ka keketseho ea nako ea bophelo ba batho le botsofali ba baahi, ho ata ha lefu la Alzheimer ho ntse ho eketseha, ho beha moroalo o moholo malapeng le sechabeng.Ka hona, ho hlahloba mekhoa e mengata ea ho thibela le ho alafa lefu la Alzheimer e fetohile sehlooho sa thahasello e kholo ea lipatlisiso.
Sengoliloeng sa ka se nang le sehlooho se reng "Ho Fuputsa Lipatlisiso kaKhanodermaBakeng sa Thibelo le Phekolo ea Lefu la Alzheimer," e phatlalalitsoeng tokollong ea bo83 ea makasine ea "Ganoderma" ka 2019, ke ile ka hlahisa pathogenesis ea lefu la Alzheimer's le litlamorao tsa pharmacological.Khanodermalucidumho thibela le ho alafa lefu la Alzheimer.Ka ho khetheha,Khanodermalucidumlihlahisoa,Khanodermalucidumli-polysaccharides,Khanodermalucidumtriterpenes, leKhanodermalucidumspore powder e ile ea fumanoa e ntlafatsa ho ithuta le ho holofala ha mohopolo mefuteng ea likhoto tsa lefu la Alzheimer.Likarolo tsena li boetse li bonts'a litlamorao tse sirelletsang khahlano le liphetoho tse senyehang tsa neuropathological liseleng tsa boko ba hippocampal tsa mefuta ea lefu la Alzheimer's rat, ho fokotsa neuroinfigueation liseleng tsa boko, ho eketsa ts'ebetso ea superoxide dismutase (SOD) liseleng tsa boko ba hippocampal, ho fokotsa maemo a malondialdehyde (MDA). ) e le sehlahisoa sa oxidative, mme e bontšitse litlamorao tsa thibelo le kalafo mefuteng ea liteko ea liphoofolo tsa lefu la Alzheimer's.
Lithuto tse peli tsa pele tsa kliniki kaGanoderma lucidumbakeng sa ho thibela le ho alafa lefu la Alzheimer, le hlahisitsoeng sehloohong sena, ha le so ka le tiisa ka ho hlaka katleho eaGanoderma lucidumlefung la Alzheimer.Leha ho le joalo, hammoho le liphuputso tse ngata tse tšepisang tsa pharmacological, li fana ka tšepo bakeng sa lithuto tse ling tsa bongaka.
Phello ea ho sebelisaGanoderma lucidumspore powder feela ho phekola lefu la Alzheimer ha ho totobetse.
Ho hlahloba pampiri ea lipatlisiso e bitsoang "Spore powder ofGanoderma lucidumbakeng sa phekolo ea lefu la Alzheimer: Thuto ea lifofane "e hatisitsoeng koranteng ea "Medicine"[1], bangoli ba ile ba arola bakuli ba 42 ka tšohanyetso ba ileng ba finyella litekanyetso tsa ho hlahloba lefu la Alzheimer ho sehlopha sa liteko le sehlopha sa taolo, le bakuli ba 21 sehlopheng ka seng.Sehlopha sa liteko se amohetse tsamaiso ea molomo eaKhanodermalucidumli-capsules tsa phofo ea spore (SPGL sehlopha) ka tekanyo ea li-capsules tsa 4 (250 mg capsule ka 'ngoe) ka makhetlo a mararo ka letsatsi ha sehlopha sa taolo se fumana li-capsules tsa placebo feela.Lihlopha tsena ka bobeli li ile tsa fumana phekolo ea libeke tse 6.
Qetellong ea phekolo, ha e bapisoa le sehlopha sa taolo, sehlopha sa SPGL se bontšitse ho fokotseha ha lintlha bakeng sa Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) le Neuropsychiatric Inventory (NPI), e bontšang ntlafatso ea kelello le boitšoaro. ho senyeha, empa phapang e ne e se ea bohlokoa ka lipalo (Letlapa la 1).Lethathamo la lipotso tsa Mokhatlo oa Lefatše oa Bophelo bo Boleng ba Bophelo-BREF (WHOQOL-BREF) li bontšitse keketseho ea lintlha tsa boleng ba bophelo, tse bontšang ntlafatso ea boleng ba bophelo, empa hape, phapang e ne e se ea bohlokoa ka lipalo (Letlapa la 2).Lihlopha tsena ka bobeli li bile le maikutlo a bobebe, ho se na liphapang tse kholo.
Bangoli ba pampiri ba lumela hore phekolo ea lefu la Alzheimer leGanoderma lucidumLi-capsules tsa phofo bakeng sa libeke tsa 6 ha lia ka tsa bontša liphello tse kholo tsa phekolo, mohlomong ka lebaka la nako e khutšoanyane ea phekolo.Liteko tsa nakong e tlang tsa kliniki tse nang le mehlala e meholo le nako e telele ea kalafo lia hlokahala ho fumana kutloisiso e hlakileng ea katleho ea bongaka.Ganoderma lucidumli-capsules tsa phofo ea spore kalafo ea lefu la Alzheimer's.
Tšebeliso e kopaneng eaGanoderma lucidumphofo ea spore e nang le lithethefatsi tse tloaelehileng tsa kalafo e ntlafatsa haholo ts'ebetso ea kalafo ea ho phekola lefu la Alzheimer's.
Haufinyane tjena, phuputso e ile ea hlahloba liphello tse kopantsoeng tsaGanoderma lucidumspore powder le meriana ea lefu la Alzheimer's memantine mabapi le tsebo le boleng ba bophelo ho bakuli ba nang le lefu la Alzheimer's le bobebe ho isa boemong bo itekanetseng [2].Bakuli ba mashome a mane a metso e robeli ba fumanoeng ba e-na le lefu la Alzheimer, ba lilemo li 50 ho isa ho tse 86, ba arotsoe ka mokhoa o sa reroang ka sehlopha sa taolo le sehlopha sa liteko, le bakuli ba 24 sehlopheng ka seng (n = 24).
Pele ho kalafo, ho ne ho se na phapang e kholo lipakeng tsa lihlopha tsena tse peli ho latela tekano, tekano ea 'dementia', ADAS-cog, NPI, le lintlha tsa WHOQOL-BREF (P> 0.5).Sehlopha sa taolo se ile sa fumana li-capsules tsa memantine ka tekanyo ea 10 mg, habeli ka letsatsi, ha sehlopha sa liteko se fumana tekanyo e tšoanang ea memantine hammoho leGanoderma lucidumli-capsules tsa phofo ea spore (SPGL) ka tekanyo ea 1000 mg, ka makhetlo a mararo ka letsatsi.Lihlopha tsena ka bobeli li ile tsa phekoloa libeke tsa 6, 'me lintlha tsa motheo tsa bakuli li ngotsoe.Ts'ebetso ea ts'ebetso ea kelello le boleng ba bophelo ba bakuli li ile tsa hlahlojoa ho sebelisoa sekala sa lintlha tsa ADAS-cog, NPI, le WHOQOL-BREF.
Ka mor'a phekolo, lihlopha ka bobeli tsa bakuli li bontšitse ho fokotseha ho hoholo ha lintlha tsa ADAS-cog le NPI ha li bapisoa le pele ho phekolo.Ho phaella moo, sehlopha sa liteko se ne se e-na le lintlha tse fokolang haholo tsa ADAS-cog le NPI ho feta sehlopha sa taolo, se nang le phapang e kholo ea lipalo (P <0.05) (Letlapa la 3, Letlapa la 4).Ka mor'a phekolo, lihlopha tsena ka bobeli tsa bakuli li bontšitse keketseho e kholo ea lintlha tsa physiology, psychology, likamano tsa sechaba, tikoloho, le boleng ba bophelo ka kakaretso lethathamong la lipotso tsa WHOQOL-BREF ha li bapisoa le pele ho phekolo.Ho feta moo, sehlopha sa liteko se ne se e-na le lintlha tse phahameng haholo tsa WHOQOL-BREF ho feta sehlopha sa taolo, se nang le phapang e kholo ea lipalo (P <0.05) (Letlapa la 5).
Memantine, e tsejoang e le mohanyetsi oa li-receptor tsa N-methyl-D-aspartate (NMDA), e ka thibela li-receptor tsa NMDA ntle le tlholisano, kahoo ea fokotsa ho fetella ha li-receptor tsa NMDA le ho thibela apoptosis ea lisele.E ntlafatsa ts'ebetso ea kelello, bothata ba boitšoaro, mesebetsi ea bophelo ba letsatsi le letsatsi, le ho teba ha 'dementia' ho bakuli ba nang le lefu la Alzheimer's.E sebelisetsoa ho phekola lefu la Alzheimer le bobebe, le itekanetseng, le le matla.Leha ho le joalo, tšebeliso ea meriana ena feela e ntse e na le melemo e fokolang ho bakuli ba nang le lefu la Alzheimer.
Liphetho tsa phuputso ena li bontša hore ts'ebeliso e kopaneng eaGanoderma lucidumspore powder le memantine li ka ntlafatsa boitšoaro ba bakuli le bokhoni ba kelello ba kelello le ho ntlafatsa bophelo ba bona haholo.
Ho bohlokoa ho khetha mokhoa o nepahetseng oa ho phekola lefu la Alzheimer's.
Litekong tse ka holimo tse peli tse laoloang ka mokhoa o sa reroang tsaGanoderma lucidumphofo ea spore bakeng sa phekolo ea lefu la Alzheimer, khetho ea linyeoe, ho hlahlojoa, mohloli oa phofo ea Ganoderma lucidum spore, tekanyo, mokhoa oa phekolo, le lipontšo tsa tlhahlobo ea katleho li ne li tšoana, empa katleho ea kliniki e ne e fapane.Ka mor'a tlhahlobo ea lipalo-palo, tšebeliso eaGanoderma lucidumspore powder feela ho phekola lefu la Alzheimer ha e bontše ntlafatso e kholo ho AS-cog, NPI, le WHOQOL-BREF scores bapisoa le placebo;leha ho le joalo, ts'ebeliso e kopaneng eaGanoderma lucidumspore powder le memantine li bontšitse ntlafatso e kholo ho lintlha tse tharo ha li bapisoa le memantine feela, ke hore, tšebeliso e kopantsoeng eaGanoderma lucidumspore powder le memantine li ka ntlafatsa haholo bokhoni ba boitšoaro, bokhoni ba kelello le boleng ba bophelo ba bakuli ba nang le lefu la Alzheimer.
Hona joale, lithethefatsi tse sebelisoang ho phekola lefu la Alzheimer, tse kang donepezil, rivastigmine, memantine, le galantamine (Reminyl), li na le liphello tse fokolang tsa phekolo 'me li ka fokotsa matšoao feela le ho liehisa nako ea lefu lena.Ho phaella moo, hoo e ka bang ha ho meriana e mecha bakeng sa phekolo ea lefu la Alzheimer e entsoeng ka katleho lilemong tse 20 tse fetileng.Ka hona, tšebeliso eaGanoderma lucidumphofo ea spore ho matlafatsa ts'ebetso ea lithethefatsi bakeng sa kalafo ea lefu la Alzheimer's e lokela ho ela hloko.
Ha e le liteko tse ling tsa kliniki tsa tšebelisoGanoderma lucidumphofo ea spore feela, ho ka khoneha ho nahana ka ho eketsa litekanyetso, mohlala, 2000 mg nako le nako, habeli ka letsatsi, bakeng sa nako ea bonyane libeke tsa 12.Hore na sena se ka etsahala, re lebelletse liphetho tsa lipatlisiso sebakeng sena ho re bolella karabo.
[Litšupiso]
1. Guo-hui Wang, le ba bang.Spore phofo eaGanoderma lucidumbakeng sa phekolo ea lefu la Alzheimer: Thuto ea lifofane.Meriana (Baltimore).2018;97(19): e0636.
2. Wang Lichao, et al.Phello ea memantine e kopantsoe leGanoderma lucidumspore powder ka temoho le boleng ba bophelo ho bakuli ba nang le lefu la Alzheimer.Journal of Armed Police Medical College (Khatiso ea Bongaka).2019, 28(12): 18-21.
Kenyelletso ho Moprofesa Lin Zhibin
Monghali Lin Zhibin, pula-maliboho hoKhanodermalipatlisiso China, e se e nehetse hoo e ka bang halofo ea lekholo la lilemo tšimong.O ne a e-na le maemo a 'maloa Univesithing ea Bongaka ea Beijing, ho kopanyelletsa le Motlatsi oa Motlatsi, Motlatsi oa Motlatsi oa Sekolo sa Meriana ea Motheo, Mookameli oa Setsi sa Mahlale a Mahlale a Bongaka, le Motsamaisi oa Lefapha la Pharmacology.Hona joale ke moprofesa Lefapheng la Pharmacology Sekolong sa Peking University of Basic Medical Sciences.Ho tloha 1983 ho isa 1984, e ne e le setsebi sa ketelo Setsing sa Lipatlisiso sa Meriana ea Tloaelo ea WHO Univesithing ea Illinois e Chicago.Ho tloha ka 2000 ho isa 2002, e ne e le moprofesa oa ketelo Univesithing ea Hong Kong.Ho tloha ka 2006, e bile moprofesa ea hlomphehang Setsing sa Pharmaceutical sa Perm State Russia.
Ho tloha ka 1970, o sebelisitse mekhoa ea morao-rao ea saense ho ithuta liphello tsa meriana le mekhoa ea meriana ea setso ea ChaenaKhanodermale metsoako ea eona e sebetsang.O phatlalalitse lipampiri tsa lipatlisiso tse fetang lekholo ka Ganoderma.Ho tloha 2014 ho isa 2019, o ile a khetheloa Lethathamo la Bafuputsi ba Haholo ba China ba Elsevier bakeng sa lilemo tse tšeletseng tse latellanang.
O ngotse libuka tse ngata ka Ganoderma, ho kenyelletsa "Lipatlisiso tsa Kajeno ka Ganoderma" (likhatiso tsa 1st-4th), "Lingzhi ho tloha Mystery ho ea ho Saense" (likhatiso tsa 1st-3rd), "Ganoderma e tšehetsa matla a bophelo bo botle 'me e leleka lintho tsa pathogenic, tse thusang phekolo ea lihlahala", "Lipuisano ka Ganoderma", le "Ganoderma le Bophelo bo Botle".
Nako ea poso: Jun-30-2023