Hoʻopuka hou ʻia kēia ʻatikala mai ka pukana 97th o ka puke "Ganoderma" ma 2023, i paʻi ʻia me ka ʻae o ka mea kākau.No ka mea kākau nā kuleana a pau o kēia ʻatikala.

Hiki ke ʻike ʻia kahi ʻokoʻa nui ma ka lolo ma waena o ke kanaka olakino (hema) a me kahi maʻi maʻi Alzheimer (ʻākau).

(Kumu kiʻi: Wikimedia Commons)

ʻO ka maʻi o Alzheimer (AD), i kapa ʻia ʻo senile dementia, kahi maʻi neurodegenerative holomua i hōʻike ʻia e ka makahiki pili i ka cognitive impairment a me ka nalowale hoʻomanaʻo.Me ka piʻi ʻana o ke ola kanaka a me ka ʻelemakule o ka lehulehu, ke piʻi mau nei ka maʻi o Alzheimer, e kau ana i kahi kaumaha nui i nā ʻohana a me ke kaiāulu.No laila, ʻo ka ʻimi ʻana i nā ala he nui e pale a mālama i ka maʻi Alzheimer ua lilo i kumuhana o ka hoihoi noiʻi nui.

Ma kaʻu ʻatikala i kapa ʻia ʻo "Exploring the Research onGanodermano ka pale ʻana a me ka mālama ʻana i ka maʻi o Alzheimer," i paʻi ʻia ma ka pukana 83rd o "Ganoderma" magazine ma 2019, ua hoʻolauna wau i ka pathogenesis o ka maʻi o Alzheimer a me nā hopena pharmacological oGanodermalucidumi ka pale ʻana a me ka mālama ʻana i ka maʻi o Alzheimer.ʻOiaʻiʻo,Ganodermalucidumnā unuhi,Ganodermalucidumnā polysaccharides,Ganodermalucidumtriterpenes, a meGanodermalucidumUa ʻike ʻia ka pauka spore e hoʻomaikaʻi i ke aʻo ʻana a me ka hoʻomanaʻo ʻana i nā ʻano ʻiole maʻi Alzheimer.Ua hōʻike pū kēia mau ʻāpana i nā hopena pale e kū'ē i nā hoʻololi neuropathological degenerative i ka ʻiʻo o ka lolo hippocampal o nā ʻano ʻiole maʻi Alzheimer, hoʻemi ʻia ka neuroinflammation i loko o nā ʻiʻo lolo, hoʻonui i ka hana o ka superoxide dismutase (SOD) i loko o ka ʻiʻo lolo hippocampal, hoʻemi i nā pae o malondialdehyde (MDA). ) ma ke ʻano he huahana oxidative, a hōʻike i nā hopena pale a me nā hopena lapaʻau i nā ʻano holoholona hoʻokolohua o ka maʻi Alzheimer.

ʻO nā haʻawina lapaʻau mua ʻelua maʻO Ganoderma lucidumno ka pale ʻana a me ka mālama ʻana i ka maʻi o Alzheimer, i hoʻopuka ʻia ma ka ʻatikala, ʻaʻole i hōʻoia i ka pono o kaʻO Ganoderma lucidumi ka maʻi o Alzheimer.Eia nō naʻe, i hui pū ʻia me nā ʻike noiʻi pharmacological he nui, hāʻawi lākou i ka manaolana no nā noiʻi lapaʻau hou.

Ka hopena o ka hoʻohana ʻanaʻO Ganoderma lucidumʻO ka pauka spore wale nō e mālama i ka maʻi o Alzheimer ʻaʻole maopopo.

E nānā ana i ka pepa noiʻi i kapa ʻia ʻo “Spore powder ofʻO Ganoderma lucidumno ka mālama ʻana i ka maʻi o Alzheimer: He noiʻi hoʻokele" i paʻi ʻia ma ka puke pai "Lapaʻau"^[1], ua hoʻokaʻawale nā ​​mea kākau i nā maʻi 42 i hālāwai i nā pae hoʻohālikelike no ka maʻi o Alzheimer i kahi hui hoʻokolohua a me kahi pūʻulu mana, me nā maʻi 21 i kēlā me kēia hui.Ua loaʻa i ka hui hoʻokolohua ka hoʻoponopono waha oGanodermalucidumspore pauda capsules (SPGL group) ma ke ano o 4 capsules (250 mg kela a me keia capsule) ekolu manawa i ka lā aʻo ka pūʻulu mana i loaʻa i ka placebo capsules.Ua mālama ʻia nā hui ʻelua i kahi mālama 6-wiki.

I ka pau ʻana o ka mālama ʻana, i hoʻohālikelike ʻia me ka pūʻulu mana, ua hōʻike ka hui SPGL i ka hōʻemi ʻana i nā helu no ka Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) a me ka Neuropsychiatric Inventory (NPI), e hōʻike ana i ka hoʻomaikaʻi ʻana i ka cognitive a me ka hana. impairments, akā, ʻaʻole i koʻikoʻi nā ʻokoʻa (Papa 1).Ua hōʻike ka World Health Organization Quality of Life-BREF (WHOQOL-BREF) i ka piʻi ʻana o nā helu maikaʻi o ke ola, e hōʻike ana i ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola, akā eia hou, ʻaʻole nui nā ʻokoʻa (Table 2).Ua ʻike nā hui ʻelua i nā hopena ʻino, me ka ʻole o nā ʻokoʻa nui.

Manaʻo nā mea kākau o ka pepa i ka mālama ʻana i ka maʻi o Alzheimer meʻO Ganoderma lucidumʻAʻole i hōʻike ʻia nā hopena therapeutic koʻikoʻi i nā capsules spore powder no nā wiki 6, ma muli paha o ka lōʻihi o ka mālama ʻana.Pono nā hoʻokolohua lapaʻau i ka wā e hiki mai ana me ka nui o ka laʻana a me ka lōʻihi o ka mālama ʻana i mea e ʻike maopopo ai i ka maikaʻi o ka lāʻau lapaʻau.ʻO Ganoderma lucidumspore pauda capsules i ka mālama 'ana i ka ma'i o Alzheimer.

ʻO ka hoʻohana hui ʻana oʻO Ganoderma lucidumʻO ka pauka spore me nā lāʻau lapaʻau maʻamau e hoʻomaikaʻi nui i ka therapeutic efficacy i ka mālama ʻana i ka maʻi o Alzheimer.

I kēia mau lā, ua loiloi kahi haʻawina i nā hopena hui oʻO Ganoderma lucidumʻO ka pauka spore a me ka lāʻau lapaʻau maʻi Alzheimer memantine ma ka cognition a me ka maikaʻi o ke ola i nā poʻe maʻi me ka maʻi Alzheimer haʻahaʻa a haʻahaʻa [2].He kanahākūmāwalu mau maʻi i loaʻa i ka maʻi o Alzheimer, nā makahiki he 50 a hiki i ka 86 makahiki, ua māhele like ʻia i loko o kahi pūʻulu mana a me kahi hui hoʻokolohua, me nā maʻi 24 i kēlā me kēia hui (n=24).

Ma mua o ka mālama ʻana, ʻaʻohe ʻokoʻa koʻikoʻi ma waena o nā hui ʻelua e pili ana i ke kāne, dementia dementia, ADAS-cog, NPI, a me nā helu WHOQOL-BREF (P>0.5).Ua loaʻa i ka pūʻulu mana nā capsules memantine ma kahi ʻano o 10 mg, ʻelua i ka lā, aʻo ka hui hoʻokolohua i loaʻa i ka nui like o memantine me kaʻO Ganoderma lucidumspore pauka capsules (SPGL) ma kahi o 1000 mg, ekolu manawa i ka la.Ua mālamaʻia nā huiʻelua no nā wiki 6, a ua hoʻopaʻaʻia nāʻikepili kumu o nā maʻi.Ua loiloi ʻia ka hana cognitive a me ka maikaʻi o ke ola o ka poʻe maʻi me ka hoʻohana ʻana i ka helu helu helu ADAS-cog, NPI, a me WHOQOL-BREF.

Ma hope o ka hoʻomaʻamaʻa ʻana, ua hōʻike nā hui ʻelua o nā maʻi i kahi hōʻemi nui o nā helu ADAS-cog a me NPI i hoʻohālikelike ʻia ma mua o ka mālama ʻana.Eia hou, ua emi loa ka hui hoʻokolohua i nā helu ADAS-cog a me NPI ma mua o ka pūʻulu mana, me nā ʻokoʻa koʻikoʻi (P <0.05) (Table 3, Table 4).Ma hope o ka mālama ʻana, ua hōʻike nā hui ʻelua o nā maʻi i ka piʻi nui ʻana o nā helu no ka physiology, psychology, social relations, environment, and overall quality of life in the WHOQOL-BREF questionnaire i hoʻohālikelike ʻia ma mua o ka mālama ʻana.Eia kekahi, ʻoi aku ka nui o nā helu WHOQOL-BREF o ka hui hoʻokolohua ma mua o ka pūʻulu mana, me nā ʻokoʻa koʻikoʻi (P<0.05) (Papa 5).

ʻO Memantine, i kapa ʻia ʻo N-methyl-D-aspartate (NMDA) receptor antagonist, hiki ke hoʻopaʻapaʻa ʻole i nā mea hoʻokipa NMDA, a laila e hōʻemi i ka glutamic acid-induced NMDA receptor overexcitation a me ka pale ʻana i ka apoptosis cell.Hoʻomaikaʻi ia i ka hana cognitive, ka maʻi maʻi, nā hana o ke ola i kēlā me kēia lā, a me ka paʻakikī dementia i nā maʻi me ka maʻi Alzheimer.Hoʻohana ʻia ia no ka mālama ʻana i ka maʻi Alzheimer maʻi, haʻahaʻa, a koʻikoʻi.Eia nō naʻe, ʻo ka hoʻohana ʻana i kēia lāʻau lapaʻau wale nō he mau pono liʻiliʻi no nā poʻe maʻi me ka maʻi Alzheimer.

Hōʻike nā hopena o kēia haʻawina i ka hoʻohana ʻana i ka hui ʻana oʻO Ganoderma lucidumHiki i ka pauka spore a me ka memantine ke hoʻoikaika i ka hana a me ka noʻonoʻo o ka poʻe maʻi a hoʻomaikaʻi nui i ko lākou ola.

He mea koʻikoʻi ke koho ʻana i ke ala lāʻau kūpono no ka mālama ʻana i ka maʻi o Alzheimer.

Ma luna o elua randomized hoʻokoloʻia hoʻokolohua oʻO Ganoderma lucidumʻO ka pauka spore no ka mālama ʻana i ka maʻi o Alzheimer, ke koho ʻana i nā hihia, ka maʻi maʻi, ke kumu o Ganoderma lucidum spore pauka, ka dosage, ke ʻano o ka mālama ʻana, a me nā hōʻailona loiloi efficacy ua like ia, akā ʻokoʻa ka hopena o ka maʻi.Ma hope o ka ʻikepili helu, hoʻohana ʻia kaʻO Ganoderma lucidumʻO ka pauka spore wale nō e mālama i ka maʻi o Alzheimer ʻaʻole i hōʻike i ka hoʻomaikaʻi nui ʻana i nā helu AS-cog, NPI, a me WHOQOL-BREF i hoʻohālikelike ʻia me kahi placebo;nae, ka hoohana hui ana oʻO Ganoderma lucidumʻO ka pauka spore a me ka memantine i hōʻike i ka hoʻomaikaʻi nui ʻana i nā helu ʻekolu i hoʻohālikelike ʻia me ka memantine wale nō, ʻo ia hoʻi, ka hoʻohana ʻana oʻO Ganoderma lucidumʻO ka pauka spore a me ka memantine hiki ke hoʻomaikaʻi maikaʻi i ka hiki ke hana, ka mana cognitive a me ka maikaʻi o ke ola o nā maʻi me ka maʻi Alzheimer.

I kēia manawa, ʻo nā lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i ka maʻi o Alzheimer, e like me donepezil, rivastigmine, memantine, a me galantamine (Reminyl), he liʻiliʻi nā hopena therapeutic a hiki ke hōʻoluʻolu wale i nā hōʻailona a hoʻopaneʻe i ke ala o ka maʻi.Eia kekahi, aneane ʻaʻohe lāʻau lapaʻau hou no ka mālama ʻana i ka maʻi o Alzheimer i hoʻomohala maikaʻi ʻia i nā makahiki he 20 i hala.No laila, ka hoʻohana ʻana iʻO Ganoderma lucidumʻO ka pauka spore e hoʻonui i ka maikaʻi o nā lāʻau lapaʻau no ka mālama ʻana i ka maʻi o Alzheimer pono e hāʻawi ʻia i ka nānā.

No nā hoʻokolohua lapaʻau hou aku o ka hoʻohana ʻanaʻO Ganoderma lucidumʻO ka pauka spore wale nō, hiki paha ke noʻonoʻo e hoʻonui i ka dosage, no ka laʻana, 2000 mg i kēlā me kēia manawa, ʻelua i ka lā, no kahi papa o 12 mau pule.Inā hiki kēia, ke kakali nei mākou i nā hopena noiʻi ma kēia wahi e haʻi iā mākou i ka pane.

[Nā Haʻawina]

1. Guo-hui Wang, et al.Spora pauda oʻO Ganoderma lucidumno ka mālama ʻana i ka maʻi Alzheimer: He haʻawina hoʻokele.Lapaʻau (Baltimore).2018；97(19): e0636.

2. Wang Lichao, et al.ʻO ka hopena o ka memantine i hui pū meʻO Ganoderma lucidumʻO ka pauka spore ma ka cognition a me ka maikaʻi o ke ola i nā maʻi me ka maʻi o Alzheimer.Nūpepa o ke Kulanui Lapaʻau Makai Pūʻali (Medical Edition).2019, 28(12): 18-21.

Hoʻolauna iā Professor Lin Zhibin

Mr. Lin Zhibin, he paionia maGanodermanoiʻi ma Kina, ua hoʻolaʻa kokoke i ka hapalua kenekulia i ke kula.Ua paʻa ʻo ia i kekahi mau kūlana ma ke Kulanui Lapaʻau ʻo Beijing, ʻo ia hoʻi ka Hope Peresidena, Hope Dean o ke Kula o nā Kauka Lapaʻau kumu, Luna Hoʻokele o ka Institute of Basic Medical Sciences, a me ka Luna Hoʻokele o ka Department of Pharmacology.He polopeka 'o ia i ka 'Oihana o Pharmacology ma Peking University School of Basic Medical Sciences.Mai 1983 a i 1984, he haumana kipa ʻo ia ma ka WHO Traditional Medicine Research Center ma ke Kulanui o Illinois ma Chicago.Mai ka makahiki 2000 a i ka makahiki 2002, he polopeka kipa ʻo ia ma ke Kulanui o Hong Kong.Mai ka makahiki 2006, he loea hanohano ʻo ia ma ka Perm State Pharmaceutical Academy ma Rusia.

Mai ka makahiki 1970, ua hoʻohana ʻo ia i nā ʻano ʻepekema hou e aʻo i nā hopena pharmacological a me nā hana o ka lāʻau lapaʻau Kina.Ganodermaa me kāna mau mea hana.Ua paʻi ʻo ia ma luna o hoʻokahi haneli mau pepa noiʻi ma Ganoderma.Mai 2014 a 2019, ua koho ʻia ʻo ia no ka Elsevier's China Highly Cited Researchers List no ʻeono mau makahiki.

Ua kākau ʻo ia i nā puke he nui ma Ganoderma, me ka "Modern Research on Ganoderma" (1st-4th editions), "Lingzhi from Mystery to Science" (1st-3rd editions), "Ganoderma supports the health energy and dispels pathogenic factors, assisting in the ka mālama ʻana i nā maʻi ʻōpū", "Nā kūkākūkā ma Ganoderma", a me "Ganoderma a me ke Ola".