Ichi chinyorwa chakadhindwa kubva kumakumi mapfumbamwe nenomwe emagazini ye "Ganoderma" muna 2023, yakaburitswa nemvumo yemunyori.Kodzero dzese dzechinyorwa ichi ndedzemunyori.

Musiyano wakakosha unogona kucherechedzwa muuropi pakati pemunhu ane hutano (kuruboshwe) uye murwere weAlzheimer's disease (kurudyi).

(Mufananidzo: Wikimedia Commons)

Chirwere cheAlzheimer (AD), chinowanzozivikanwa sesenile dementia, chirwere chinofambira mberi neurodegenerative chinoratidzwa nekukanganisika kwekuziva kwakabatana nezera uye kurasikirwa kwendangariro.Nekuwedzera kwehupenyu hwevanhu uye kuchembera kwevanhu, kuwanda kwechirwere cheAlzheimer kuri kuramba kuchikwira, zvichiunza mutoro wakakura kumhuri nenzanga.Naizvozvo, kuongorora nzira dzakawanda dzekudzivirira nekurapa chirwere cheAlzheimer chave musoro wekutsvagisa kukuru.

Muchinyorwa changu chakanzi "Kuongorora Tsvagiridzo paGanodermaYekudzivirira uye Kurapa Chirwere cheAlzheimer, "yakabudiswa mumagazini yechi83 ye "Ganoderma" muna 2019, ndakaunza pathogenesis yechirwere cheAlzheimer uye mhedzisiro yemishonga.Ganodermalucidummukudzivirira nekurapa chirwere cheAlzheimer.Zvikurukuru,Ganodermalucidumzvinyorwa,Ganodermalucidumpolysaccharides,Ganodermalucidumtriterpenes, uyeGanodermalucidumspore poda yakawanikwa kuvandudza kudzidza uye kukanganisa kwendangariro muAlzheimer's disease rat modhi.Izvi zvikamu zvakaratidzawo kudzivirira kunopesana nekuderera kweuropathological shanduko muhuppocampal brain tissue yeAlzheimer's disease rat modhi, yakaderedza neuroinflammation muuropi tishu, yakawedzera basa re superoxide dismutase (SOD) muhuppocampal brain tissue, yakaderedza mazinga e malondialdehyde (MDA). ) seyakagadzirwa neoxidative, uye yakaratidza kudzivirira uye kurapa mhedzisiro mukuyedza mhando dzemhuka dzechirwere cheAlzheimer.

Iwo maviri ekutanga ekiriniki zvidzidzo paGanoderma lucidumyekudzivirira nekurapa chirwere cheAlzheimer, chakaunzwa muchinyorwa, hazvina kunyatso simbisa kushanda kweGanoderma lucidummuchirwere cheAlzheimer.Nekudaro, zvakasanganiswa nezvakawanda zvinovimbisa zvemishonga yekutsvagisa zvakawanikwa, zvinopa tariro yezvimwe zvidzidzo zvekiriniki.

Mhedzisiro yekushandisaGanoderma lucidumspore poda chete kurapa chirwere cheAlzheimer haisi pachena.

Kuongorora bepa rekutsvagisa rakanzi "Spore poda yeGanoderma lucidumkurapwa kwechirwere cheAlzheimer: Chidzidzo chemutyairi "yakabudiswa mumagazini "Medicine"^[1], vanyori vakaparadzanisa varwere ve42 avo vakawana nzira yekuongorora chirwere cheAlzheimer muboka rekuedza uye boka rekutonga, nevarwere ve21 muboka rimwe nerimwe.Boka rekuedza rakagamuchira hutungamiri hwemuromo weGanodermalucidumspore poda capsules (boka reSPGL) pachiyero che4 capsules (250 mg imwe neimwe capsule) katatu pazuva apo boka rekutonga raingogamuchira placebo capsules.Mapoka maviri aya akawana kurapwa kwemavhiki matanhatu.

Pakupera kwekurapa, zvichienzaniswa neboka rinodzora, boka reSPGL rakaratidza kuderedzwa kwezvibodzwa zveAlzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) uye Neuropsychiatric Inventory (NPI), zvichiratidza kuvandudzwa kwekuziva uye maitiro. kukanganisa, asi misiyano yakanga isingaverengeki yakakosha (Tafura 1).Bhuku reWorld Health Organisation Quality of Life-BREF (WHOQOL-BREF) remibvunzo yakaratidza kuwedzera kwehuwandu hwehuwandu hwehupenyu, zvichiratidza kuvandudzwa kwehupenyu hwehupenyu, asi zvakare, kusiyana kwakange kusingaverengeki (Tafura 2).Mapoka ose ari maviri akasangana nekusagadzikana kwakapfava, pasina misiyano yakakosha.

Vanyori vepepa vanotenda kuti kurapwa kwechirwere cheAlzheimer neGanoderma lucidumspore powder capsules kwemavhiki e6 haana kuratidza maitiro makuru ekurapa, zvichida nekuda kwenguva pfupi yekurapa.Remangwana kiriniki miedzo ine hombe sampuli saizi uye yakareba nguva yekurapa inodiwa kuti uwane kunzwisisa kwakajeka kwekushanda kwekiriniki.Ganoderma lucidumspore poda capsules mukurapa kwechirwere cheAlzheimer.

Iko kushandiswa kwakasanganiswa kweGanoderma lucidumSpore powder nemishonga yakajairika yekurapa inovandudza zvakanyanya kurapa kwakanaka mukurapa chirwere cheAlzheimer.

Munguva pfupi yapfuura, chidzidzo chakaongorora zvakasanganiswa mhedzisiro yeGanoderma lucidumspore poda uye chirwere cheAlzheimer's chirwere memantine pakuziva uye mhando yehupenyu muvarwere vane hunyoro kusvika pakati nepakati chirwere cheAlzheimer [2].Varwere makumi mana nevasere vakaonekwa vaine chirwere cheAlzheimer, vane makore 50 kusvika kumakore makumi masere nematanhatu, vakapatsanurwa zvisina tsarukano kuita boka rinodzora uye boka rekuyedza, nevarwere ve24 muboka rega rega (n = 24).

Tisati tarapwa, pakanga pasina misiyano yakakosha pakati pemapoka maviri maererano nevakadzi, dementia degree, ADAS-cog, NPI, uye WHOQOL-BREF zvibodzwa (P> 0.5).Boka rekutonga rakawana memantine capsules pachiyero che10 mg, kaviri pazuva, nepo boka rekuyedza rakawana muyero mumwechete we memantine pamwe chete.Ganoderma lucidumspore poda capsules (SPGL) pamwero we1000 mg, katatu pazuva.Mapoka maviri aya akabatwa kwemavhiki e6, uye data yekutanga yevarwere yakanyorwa.Basa rekuziva uye hutano hwehupenyu hwevarwere vakaongororwa vachishandisa ADAS-cog, NPI, uye WHOQOL-BREF scoring scales.

Mushure mekurapa, mapoka maviri evarwere akaratidza kuderera kukuru kweADAS-cog uye NPI scores zvichienzaniswa nekutanga kurapwa.Uyezve, boka rekuedza rakanga rakanyanya kuderera ADAS-cog uye NPI zvibodzwa kupfuura boka rekutonga, rine nhamba yakasiyana yakasiyana (P <0.05) (Tafura 3, Tafura 4).Kutevera kurapwa, mapoka ese evarwere airatidza kuwedzera kukuru kwezvibodzwa zvefiziology, psychology, hukama hwemagariro, nharaunda, uye hupenyu hwese hwehupenyu mumibvunzo yeWHOQOL-BREF zvichienzaniswa nekutanga kurapwa.Uyezve, boka rekuedza raive nepamusoro zvakanyanya WHOQOL-BREF zvibodzwa kupfuura boka rekutonga, rine misiyano yakakosha (P <0.05) (Tafura 5).

Memantine, inozivikanwa serinovhero N-methyl-D-aspartate (NMDA) receptor antagonist, inogona kusakwanisa kuvharira NMDA receptors, nekudaro ichidzikisa glutamic acid-induced NMDA receptor overexcitation uye kudzivirira cell apoptosis.Inovandudza kugona kwekuziva, kusazvibata, zviitiko zvehupenyu hwezuva nezuva, uye kuomarara kwedementia muvarwere vane chirwere cheAlzheimer.Inoshandiswa kurapa zvinyoro, zvine mwero, uye zvakakomba chirwere cheAlzheimer.Nekudaro, kushandiswa kwemushonga uyu chete kuchiri kune mashoma mabhenefiti kune varwere vane chirwere cheAlzheimer.

Migumisiro yechidzidzo ichi inoratidza kuti kushandiswa kwakasanganiswa kweGanoderma lucidumspore poda uye memantine zvinogona kusimudzira hunhu hwevarwere uye kugona kwekuziva uye nekuvandudza zvakanyanya hupenyu hwavo.

Kusarudza nzira yekurapa kwayo kwakakosha pakurapa chirwere cheAlzheimer.

Mumakiriniki maviri ari pamusoro akarongeka anodzorwa makiriniki eGanoderma lucidumspore poda yekurapa chirwere cheAlzheimer, kusarudzwa kwezviitiko, kuongororwa, tsime reGanoderma lucidum spore powder, dosage, nzira yekurapa, uye efficacy evaluation zviratidzo zvakanga zvakafanana, asi kliniki inoshanda yakasiyana.Mushure mekuongorora kwenhamba, kushandiswa kweGanoderma lucidumspore poda chete kurapa chirwere cheAlzheimer chakaratidza kusakosha kwakakosha muAS-cog, NPI, uye WHOQOL-BREF zvibodzwa zvichienzaniswa ne placebo;zvisinei, kushandiswa kwakabatanidzwa kweGanoderma lucidumSpore powder uye memantine zvakaratidza kuvandudzwa kukuru muzvikamu zvitatu zvichienzaniswa nememantine chete, ndiko kuti, kushandiswa kwakabatanidzwaGanoderma lucidumspore poda uye memantine inogona kuvandudza zvakanyanya kugona kwemaitiro, kugona kwekuziva uye hupenyu hwevarwere vane chirwere cheAlzheimer.

Parizvino, mishonga inoshandiswa kurapa chirwere cheAlzheimer, senge donepezil, rivastigmine, memantine, uye galantamine (Reminyl), ine mhedzisiro yekurapa uye inogona chete kuderedza zviratidzo uye kunonoka kwechirwere.Mukuwedzera, inenge isina mishonga mitsva yekurapa chirwere cheAlzheimer yakabudirira kubudirira mumakore makumi maviri apfuura.Naizvozvo, kushandiswa kweGanoderma lucidumSpore poda yekuwedzera kushanda kwemishonga yekurapa chirwere cheAlzheimer inofanirwa kutariswa.

Nezve mamwe makiriniki miedzo yekushandisaGanoderma lucidumspore poda yoga, zvingave zvichibvira kufunga kuwedzera chipimo chemushonga, semuenzaniso, 2000 mg nguva imwe neimwe, kaviri pazuva, kwekanguva kanenge mavhiki gumi nemaviri.Kunyangwe izvi zvichigoneka, tinotarisira kutsvagisa mhinduro munzvimbo ino kutiudza mhinduro.

[Mazita]

1. Guo-hui Wang, nevamwe.Spore poda yeGanoderma lucidumyekurapa kwechirwere cheAlzheimer: Chidzidzo chemutyairi.Mushonga (Baltimore).2018; 97(19): e0636.

2. Wang Lichao, nevamwe.Mhedzisiro yememantine yakasanganiswa neGanoderma lucidumspore poda pakuziva uye hupenyu hwehupenyu muvarwere vane chirwere cheAlzheimer.Chinyorwa cheArmed Police Medical College (Medical Edition).2019, 28(12): 18-21.

Nhanganyaya kuna Purofesa Lin Zhibin

VaLin Zhibin, piyona muGanodermatsvakiridzo muChina, yakazvipira inoda kusvika hafu yezana kumunda.Akabata zvinzvimbo zvakati paBeijing Medical University, kusanganisira Mutevedzeri weMutungamiriri, Mutevedzeri weDhipatimendi reChikoro cheBasic Medicine, Director weInstitute of Basic Medical Sayenzi, uye Director weDhipatimendi rePharmacology.Iye zvino ari purofesa muDhipatimendi rePharmacology paPeking University Chikoro cheBasic Medical Sayenzi.Kubva 1983 kusvika 1984, aive nyanzvi yekushanya kuWHO Traditional Medicine Research Center paYunivhesiti yeIllinois kuChicago.Kubva 2000 kusvika 2002, aive purofesa anoshanya paYunivhesiti yeHong Kong.Kubva 2006, anga ari anokudzwa purofesa paPerm State Pharmaceutical Academy muRussia.

Kubva 1970, akashandisa nzira dzesainzi dzemazuva ano kudzidza mhedzisiro yemishonga uye maitirwo emushonga wechinyakare weChineseGanodermauye zvinhu zvayo zvinoshanda.Akaburitsa anopfuura zana mapepa ekutsvagisa paGanoderma.Kubva 2014 kusvika 2019, akasarudzwa kuElsevier's China Yakanyanya Cited Researchers Rondedzero kwemakore matanhatu akateedzana.

Akanyora mabhuku akawanda pamusoro peGanoderma, kusanganisira "Modern Research on Ganoderma" (1st-4th editions), "Lingzhi from Mystery to Science" (1st-3rd editions), "Ganoderma inotsigira simba rine hutano uye inodzinga pathogenic zvinhu, kubatsira mu kurapwa kwemamota", "Kukurukurirana paGanoderma", uye "Ganoderma uye Utano".