Iyi ngingo yakuwe mu nomero ya 97 yikinyamakuru "Ganoderma" mu 2023, cyasohowe uruhushya rwumwanditsi.Uburenganzira bwose kuriyi ngingo ni ubwanditsi.

Itandukaniro rikomeye rirashobora kugaragara mubwonko hagati yumuntu muzima (ibumoso) numurwayi wa Alzheimer (iburyo).

(Inkomoko y'amashusho: Wikimedia Commons)

Indwara ya Alzheimer (AD), izwi cyane ku izina rya senile dementia, ni indwara igenda itera indwara ya neurodegenerative igenda irangwa no guta ubwenge no guta ubwenge.Ubwiyongere bw'ubuzima bw'abantu no gusaza kw'abaturage, ubwiyongere bw'indwara ya Alzheimer buragenda bwiyongera, bikaba bitera umutwaro ukomeye imiryango ndetse na sosiyete.Kubwibyo, gushakisha uburyo bwinshi bwo gukumira no kuvura indwara ya Alzheimer byabaye ingingo ishimishije mubushakashatsi.

Mu kiganiro cyanjye nise “Gucukumbura Ubushakashatsi kuriGanodermayo gukumira no kuvura indwara ya Alzheimer, ”yasohotse mu nomero ya 83 y’ikinyamakuru“ Ganoderma ”mu 2019, natangije indwara y’indwara ya Alzheimer n'ingaruka za farumasiGanodermalucidummu gukumira no kuvura indwara ya Alzheimer.By'umwihariko,Ganodermalucidumibice,Ganodermalucidumpolysaccharide,Ganodermalucidumtriterpene, naGanodermalucidumifu ya spore yabonetse kugirango itezimbere imyigire nubumuga bwo kutibuka mubyitegererezo byimbeba ya Alzheimer.Ibi bice kandi byagaragaje ingaruka zo gukingira indwara ziterwa na neuropathologique ihinduka mu bwonko bwa hippocampal ubwonko bw’imbeba z’indwara ya Alzheimer, kugabanya neuroinflammation mu ngingo z’ubwonko, byongera ibikorwa bya superoxide dismutase (SOD) mu ngingo z’ubwonko bwa hippocampal, bigabanya urugero rwa malondialdehyde (MDA) ) nk'igicuruzwa cya okiside, kandi kigaragaza ingaruka zo gukumira no kuvura muburyo bw'inyamaswa zigerageza indwara ya Alzheimer.

Ubushakashatsi bubiri bwibanze bwubuvuzi kuriGanoderma lucidumyo gukumira no kuvura indwara ya Alzheimer, yatangijwe mu ngingo, ntabwo yemeje neza imikorere yaGanoderma lucidumindwara ya Alzheimer.Nyamara, hamwe nubushakashatsi bwinshi butanga ubushakashatsi bwa farumasi, butanga ibyiringiro byubushakashatsi bwubuvuzi.

Ingaruka zo gukoreshaGanoderma lucidumifu ya spore yonyine yo kuvura indwara ya Alzheimer ntabwo igaragara.

Gusubiramo impapuro zubushakashatsi zitwa "Spore powder yaGanoderma lucidumyo kuvura indwara ya Alzheimer: Ubushakashatsi bw'icyitegererezo ”bwasohotse mu kinyamakuru“ Ubuvuzi ”^[1], abanditsi batagabanije kugabanya abarwayi 42 bujuje ibisabwa kugira ngo basuzume indwara ya Alzheimer mu itsinda ry’ubushakashatsi hamwe nitsinda rishinzwe kugenzura, hamwe n’abarwayi 21 muri buri tsinda.Itsinda ryubushakashatsi ryakiriye ubuyobozi bwo munwa bwaGanodermalucidumspore ifu ya capsules (itsinda rya SPGL) kuri dosiye ya capsules 4 (250 mg buri capsule) inshuro eshatu kumunsi mugihe itsinda rishinzwe kugenzura ryakiriye gusa capsules.Amatsinda yombi yabazwe ibyumweru 6.

Nyuma yo kuvura, ugereranije nitsinda rishinzwe kugenzura, itsinda rya SPGL ryerekanye ko igabanuka ryamanota ya Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) hamwe n’ibarura rya Neuropsychiatricique (NPI), byerekana ko hari iterambere ry’imyumvire n’imyitwarire; ubumuga, ariko itandukaniro ntabwo ryari rifite imibare (Imbonerahamwe 1).Ishami ry'Umuryango w'Abibumbye ryita ku Buzima Bwiza-BREF (WHOQOL-BREF) ikibazo cyerekanye ko hiyongereyeho amanota y’ubuzima, byerekana ko ubuzima bwazamutse, ariko na none, itandukaniro ntabwo ryari rifite imibare (Imbonerahamwe 2).Amatsinda yombi yahuye ningaruka zoroheje, nta tandukaniro rigaragara.

Abanditsi b'uru rupapuro bemeza ko kuvura indwara ya Alzheimer hamweGanoderma lucidumspore powder capsules kumyumweru 6 ntabwo yerekanye ingaruka zikomeye zo kuvura, bishoboka bitewe nigihe gito cyo kuvura.Ibizamini bya kliniki bizaza hamwe nubunini bwikitegererezo hamwe nigihe kirekire cyo kuvura birakenewe kugirango dusobanukirwe neza imikorere yubuvuzi bwaGanoderma lucidumspore powder capsules mukuvura indwara ya Alzheimer.

Gukoresha hamweGanoderma lucidumifu ya spore hamwe nimiti isanzwe ivura itezimbere cyane uburyo bwo kuvura indwara ya Alzheimer.

Vuba aha, ubushakashatsi bwasuzumye ingaruka ziterwa naGanoderma lucidumifu ya spore hamwe n’imiti y’indwara ya Alzheimer yibuka ku bumenyi n’ubuzima bwiza ku barwayi bafite indwara ya Alzheimer yoroheje cyangwa yoroheje [2].Abarwayi 48 basuzumwe indwara ya Alzheimer, bafite hagati y’imyaka 50 na 86, bagabanijwe ku buryo butunguranye mu itsinda rishinzwe kugenzura no mu itsinda ry’ubushakashatsi, hamwe n’abarwayi 24 muri buri tsinda (n = 24).

Mbere yo kuvurwa, nta tandukanyirizo rishingiye ku mibare ryagaragaye hagati yaya matsinda yombi mu bijyanye n’uburinganire, impamyabumenyi yo guta umutwe, ADAS-cog, NPI, na WHOQOL-BREF amanota (P> 0.5).Itsinda rishinzwe kugenzura ryakiriye capsules ya memantine ku gipimo cya mg 10, kabiri ku munsi, mu gihe itsinda ry’ubushakashatsi ryakiriye urugero rumwe rwa memantine hamweGanoderma lucidumspore powder capsules (SPGL) kumupanga wa mg 1000, inshuro eshatu kumunsi.Amatsinda yombi yavuwe ibyumweru 6, kandi amakuru y’ibanze y’abarwayi yaranditswe.Imikorere yubwenge nubuzima bw abarwayi yasuzumwe hifashishijwe umunzani wa ADAS-cog, NPI, na WHOQOL-BREF.

Nyuma yo kuvurwa, amatsinda yombi y’abarwayi yerekanye ko yagabanutse cyane amanota ya ADAS-cog na NPI ugereranije na mbere yo kuvurwa.Byongeye kandi, itsinda ryubushakashatsi ryaragabanutse cyane amanota ya ADAS-cog na NPI kuruta itsinda rishinzwe kugenzura, hamwe n’imibare itandukanye igaragara (P <0.05) (Imbonerahamwe 3, Imbonerahamwe 4).Nyuma yo kuvurwa, amatsinda yombi y’abarwayi yerekanye ko yiyongereye cyane mu manota ya physiologiya, psychologiya, imibanire myiza, ibidukikije, ndetse n’ubuzima rusange muri rusange mubibazo bya WHOQOL-BREF ugereranije na mbere yo kuvurwa.Byongeye kandi, itsinda ryubushakashatsi ryagize amanota menshi ya WHOQOL-BREF kurusha itsinda rishinzwe kugenzura, hamwe n’imibare itandukanye (P <0.05) (Imbonerahamwe 5).

Memantine, izwi nka roman N-methyl-D-aspartate (NMDA) reseptor antagonist, irashobora guhagarika amarushanwa ya reseptor ya NMDA, bityo bikagabanya aside glutamic iterwa na reseptor ya NMDA ikabije kandi ikarinda apoptose.Itezimbere imikorere yubwenge, ihungabana ryimyitwarire, ibikorwa byubuzima bwa buri munsi, nuburemere bukabije bwo guta umutwe kubarwayi barwaye Alzheimer.Ikoreshwa mukuvura indwara yoroheje, iringaniye, kandi ikomeye ya Alzheimer.Nyamara, gukoresha iyi miti byonyine biracyafite inyungu nke kubarwayi barwaye Alzheimer.

Ibisubizo by'ubu bushakashatsi byerekana ko gushyira hamwe kwaGanoderma lucidumifu ya spore na memantine birashobora kongera ubushobozi bwimyitwarire yabarwayi no kumenya ubwenge no kuzamura imibereho yabo.

Guhitamo uburyo bwiza bwo gufata imiti ningirakamaro mu kuvura indwara ya Alzheimer.

Mubice bibiri byavuzwe haruguru byateganijwe kugeragezwa kwa kliniki yaGanoderma lucidumifu ya spore yo kuvura indwara ya Alzheimer, guhitamo indwara, gusuzuma, inkomoko ya Ganoderma lucidum ifu ya spore, dosiye, inzira yo kuvura, hamwe nibipimo byerekana isuzuma ryakozwe byari bimwe, ariko imikorere yubuvuzi yari itandukanye.Nyuma yisesengura ryibarurishamibare, ikoreshwa ryaGanoderma lucidumifu ya spore yonyine yo kuvura indwara ya Alzheimer yerekanye ko nta terambere ryagaragaye ryagaragaye mu manota AS-cog, NPI, na WHOQOL-BREF ugereranije na placebo;icyakora, hamwe hamweGanoderma lucidumifu ya spore na memantine byagaragaje iterambere ryinshi mumanota atatu ugereranije na memantine yonyine, ni ukuvuga gukoresha hamweGanoderma lucidumifu ya spore na memantine birashobora kuzamura cyane ubushobozi bwimyitwarire, ubushobozi bwubwenge nubuzima bwiza bwabarwayi barwaye Alzheimer.

Kugeza ubu, imiti ikoreshwa mu kuvura indwara ya Alzheimer, nka donepezil, rivastigmine, memantine, na galantamine (Reminyl), ifite ingaruka nke zo kuvura kandi ishobora kugabanya ibimenyetso gusa no gutinza inzira y’indwara.Byongeye kandi, nta miti mishya yo kuvura indwara ya Alzheimer yakozwe neza mu myaka 20 ishize.Kubwibyo, ikoreshwa ryaGanoderma lucidumifu ya spore kugirango yongere imbaraga zimiti yo kuvura indwara ya Alzheimer igomba kwitabwaho.

Kubijyanye nibindi bigeragezo byo kwa muganga byo gukoreshaGanoderma lucidumifu ya spore yonyine, birashoboka gutekereza gutekereza kongera dosiye, kurugero, 2000 mg buri gihe, kabiri kumunsi, mugihe cyibyumweru byibura 12.Niba ibi bishoboka, dutegereje ibisubizo byubushakashatsi muri kano karere kugirango utubwire igisubizo.

[Reba]

1. Guo-hui Wang, n'abandi.Ifu ya spore yaGanoderma lucidumkuvura indwara ya Alzheimer: Ubushakashatsi bwikigereranyo.Ubuvuzi （Baltimore）.2018 ； 97 (19): e0636.

2. Wang Lichao, n'abandi.Ingaruka ya memantine ihujwe naGanoderma lucidumifu ya spore kumyumvire nubuzima bwiza kubarwayi barwaye Alzheimer.Ikinyamakuru cya Polisi Yubuvuzi Yubuvuzi (Edition Edition).2019, 28 (12): 18-21.

Intangiriro kuri Porofeseri Lin Zhibin

Bwana Lin Zhibin, umupayiniya muriGanodermaubushakashatsi mu Bushinwa, bwatanze hafi igice cy'ikinyejana.Yakoze imyanya myinshi muri kaminuza y’ubuvuzi ya Beijing, harimo Visi Perezida, Umuyobozi wungirije w’ishuri ry’ubuvuzi bw’ibanze, umuyobozi w’ikigo cy’ubuvuzi bw’ibanze, n’umuyobozi w’ishami rya Farumasi.Ubu ni umwarimu mu ishami rya farumasi mu ishuri rya kaminuza rya Peking of Science Science Science.Kuva mu 1983 kugeza 1984, yari intiti yasuye mu kigo cy’ubushakashatsi cy’ubuvuzi gakondo cya OMS muri kaminuza ya Illinois i Chicago.Kuva mu 2000 kugeza 2002, yari umwarimu wasuye muri kaminuza ya Hong Kong.Kuva mu 2006, yabaye umwarimu w’icyubahiro mu ishuri ry’imiti rya Leta rya Perm mu Burusiya.

Kuva mu 1970, yakoresheje uburyo bwa siyansi bugezweho yiga ingaruka za farumasi nuburyo bwubuvuzi gakondo bwubushinwaGanoderman'ibiyigize.Yasohoye inyandiko zirenga ijana kuri Ganoderma.Kuva mu 2014 kugeza 2019, yatoranijwe ku rutonde rw'abashakashatsi ba Elsevier mu Bushinwa mu myaka itandatu ikurikiranye.

Yanditse ibitabo byinshi kuri Ganoderma, harimo "Ubushakashatsi bugezweho kuri Ganoderma" (inyandiko ya 1-4) kuvura ibibyimba "," Ibiganiro kuri Ganoderma ", na" Ganoderma n'Ubuzima ".