Ganoderma lucidum imatha kukulitsa chitetezo chamthupi cha okalamba omwe ali ndi matenda amtima.

Kuchepa kwa chitetezo chokwanira ndi chinthu chosapeŵeka cha ukalamba, ndipo okalamba omwe ali ndi matenda a mtima amakhala ndi mavuto aakulu ndi matenda a chitetezo cha mthupi.Tiyeni tiwone momwe"Ganoderma lucidumzimakhudza chitetezo chamthupi cha okalamba" lofalitsidwa mu Chinese Journal of Geriatrics mu 1993.

Lipotilo linanena kuti okalamba omwe ali ndi zaka zapakati pa 65 ndipo akuvutika ndi hyperlipidemia kapena cardiocerebral atherosclerosis, atatenga masiku a 30 a Ganoderma ufa (4.5 magalamu patsiku), ntchito ya maselo akupha achilengedwe komanso kuchuluka kwa interferon.γndi interleukin 2 m'magazi anali bwino kwambiri, ndipo zotsatira zake zinapitirirabe ngakhale Ganoderma lucidum itathetsedwa kwa masiku a 10 (Chithunzi 1).

Maselo achilengedwe akupha amatha kupha ma cell omwe ali ndi kachilombo ndikutulutsa interferon γ;interferon γ sikuti amangolepheretsa kufalikira kwa ma virus komanso amathandizira kuti ma macrophages azitha kumeza kachilomboka;interleukin 2 ndi cytokine yopangidwa ndi maselo a T omwe atsegulidwa ndipo sangangolimbikitsa kuchuluka kwa T cell komanso kuchititsa maselo a B kupanga ma antibodies.Choncho, kusintha kwa zizindikiro zitatu zoteteza chitetezo cha mthupi ndizofunikira kwambiri kuti chitetezo cha mthupi chitetezeke.
Lingzhiimatha kupititsa patsogolo mphamvu ya antioxidant ya anthu azaka zapakati.

Mu 2017, gulu lofufuza motsogozedwa ndi Pulofesa Wang Jinkun wa ku Chung Shan Medical University linafalitsa kafukufuku wachipatala mu Pharmaceutical Biology.Kafukufukuyu adagwiritsa ntchito njira yosasinthika, yakhungu iwiri, yoyang'anira malo kuyerekezera anthu 39 azaka zapakati (40-54 zaka) pa kusiyana kwa antioxidant mphamvu pakati pa "Kudya Lingzhi" ndi "Osadya Lingzhi".

TheReishi bowagulu anatenga 225 mg wa Ganoderma lucidum fruiting Tingafinye thupi kukonzekera (muli 7% ganoderic asidi ndi 6% polysaccharide peptide) tsiku lililonse.Pambuyo pa miyezi 6, zizindikiro zosiyanasiyana za antioxidant za maphunzirowo zinawonjezeka (Table 1) pamene chiwindi chawo chimagwira ntchito bwino-chiwerengero cha AST ndi ALT chinatsika ndi 42% ndi 27% motsatira.M'malo mwake, gulu la placebo "palibe kusiyana kwakukulu" poyerekeza ndi kale.
Ganoderma lucidum imathandiza ana kulimbikitsa chitetezo cha mthupi.

Ngakhale kuti nthawi zambiri sikulimbikitsidwa kuti ana adye Ganoderma lucidum, ana asukulu ya pulayimale ndi gulu la anthu omwe amagwidwa mosavuta ndi chimfine ndi matenda, omwenso ndi mutu weniweni kwa makolo ambiri.Kafukufuku wofalitsidwa mu International Journal of Medicinal Mushrooms ndi University of Antioquia mu 2018 makamaka adawunikira momwe Ganoderma imakhudzira chitetezo chamthupi cha ana asukulu, kotero imayambitsidwanso pano kuti mufotokozere.

Kafukufukuyu adagwiritsa ntchito njira yowongolera, yakhungu iwiri, yoyang'anira malo kuti agawanitse ana athanzi azaka zapakati pa 3 mpaka 5 kukhala gulu la Ganoderma lucidum (ana 60) ndi gulu la placebo (ana 64).Yogurt yomweyi idaperekedwa kwa magulu awiri a maphunziro tsiku lililonse.Kusiyana kwake ndikuti yogurt mu gulu la Ganoderma ili ndi 350 mg ya Ganoderma lucidum polysaccharide yochokera ku Ganoderma lucidum mycelia pa kutumikira.

Pambuyo pa masabata a 12, chiwerengero cha maselo a T mu gulu la Ganoderma chinawonjezeka kwambiri, koma chiwerengero cha T cell subsets (CD4 + ndi CD8 +) sichinakhudzidwe (Table 3).

Ponena za ALT, AST, creatinine ndi ma cytokines okhudzana ndi kutupa kwachilendo (kuphatikizapo IL-12 p70, IL-1β, IL-6, IL-10, ndi TNF-α) komanso maselo akupha zachilengedwe ndi ma antibodies a IgA, panalibe kusiyana kwakukulu pakati pa magulu awiriwa asanayesedwe komanso atatha.
Chitetezo cha mthupi muubwana chimayenera kuthana ndi ma virus 10 mpaka 15 omwe amalumikizana koyamba chaka chilichonse.Chifukwa chake, ochita kafukufuku amakhulupirira kuti Ganoderma lucidum polysaccharide imatha kulimbikitsa kuchuluka kwa T cell, kuthandiza chitetezo cham'mimba cha ana asukulu kuti chifulumire kukhwima.

Kugona mokwanira, kudya zakudya zopatsa thanzi, kukhala ndi moyo wosangalala komanso kuchita masewera olimbitsa thupi moyenera kungathandize kuti chitetezo cha mthupi chitetezeke.Komabe, inertia yaumunthu, zaka, matenda ndi kupsinjika kwa moyo kungalepheretse kusunga chitetezo chabwino.

Ganoderma lucidum ndi yabwino kumenyana yekha, ndipo ikhoza kuphatikizidwa kukhala mankhwala.Ndi yotetezeka, yodalirika komanso yokwanira mu ntchito.Zonse ndi "zosagwirizana" (zotsutsana ndi mitundu yosiyanasiyana ya tizilombo toyambitsa matenda) ndi "zapadera" (zotsutsana ndi tizilombo toyambitsa matenda).Zitha kukhala zopindulitsa pazaumoyo wa anthu amisinkhu yosiyanasiyana powonjezera chitetezo chamthupi.

Ndikoyenera kulimbana ndi majeremusi osawoneka okhala ndi chitetezo chokwanira chosawoneka bwino.Ngati mphamvu yabwino ya antioxidant iwonjezeredwa, zidzakhala zovuta kuti mabakiteriya omwe akubwerawo apange mafunde.

[Maumboni]
1. Tao Sixiang etc. Zotsatira za Ganoderma lucidum pa maselo a chitetezo cha mthupi a okalamba.Chinese Journal of Geriatrics, 1993, 12 (5): 298-301.
2. Chiu HF, ndi al.Triterpenoids ndi polysaccharide peptides-olemeraGanoderma lucidum: kafukufuku wopangidwa mwachisawawa, wakhungu wapawiri-woyang'aniridwa ndi placebo wokhudzana ndi antioxidation ndi hepatoprotective efficacy mwa odzipereka athanzi.
Zotsatira Pharm Biol.2017, 55 (1): 1041-1046.
3. Henao SLD, et al.Mayesero Osasinthika Othandizira Kuwunika kwa Immune Modulation ndi Yogurt Yopangidwa ndi β-Glucans ochokera ku Lingzhi kapena Reishi Medicinal Mushroom,Ganoderma lucidum(Agaricomycetes), mu Ana ochokera ku Medellin.Colombia.Int J Med Bowa.2018;20(8):705-716.