La 25 Hlakubele 2018/Univesithi ea Hokkaido & Univesithi ea Hokkaido Pharmaceutical/Journal of Ethnopharmacology

Mongolo/ Hong Yurou, Wu Tingyao

IgA antibody le defensin ke moeli oa pele oa tšireletso ea 'mele khahlanong le tšoaetso ea likokoana-hloko tse ka ntle ka maleng.Ho ea ka phuputso e phatlalalitsoeng ke Univesithi ea Hokkaido le Univesithi ea Hokkaido Pharmaceutical ho Journal of Ethnopharmacology ka December 2017,Ganoderma lucidume ka khothaletsa secretion ea li-antibodies tsa IgA le ho eketsa li-defensins ntle le ho baka ho ruruha.Ho hlakile hore ke mothusi ea molemo bakeng sa ho ntlafatsa tšireletso ea mala le ho fokotsa tšoaetso ea mala.

Ha libaktheria tsa pathogenic li hlasela,Ganoderma lucidume tla eketsa tlhahiso ea li-antibodies tsa IgA.

Mala a manyenyane ha se feela setho sa ho sila lijo empa hape ke setho sa 'mele sa ho itšireletsa mafung.Ntle le ho cheka le ho monya limatlafatsi lijong, e boetse e sireletsa khahlanong le likokoana-hloko tse sa tšoaneng tsa pathogenic tse kenang molomong.

Ka hona, ntle le li-villi tse ngata (ho monya limatlafatsi) leboteng la ka hare la lerako la mala, ho boetse ho na le lisele tsa lymphatic tse bitsoang "Peyer's patches (PP)" ka maleng a manyane, a sebetsang e le bahlokomeli ba 'mele oa ho itšireletsa mafung.Hang ha libaktheria tsa pathogenic li sibolloa ke macrophages kapa lisele tsa dendritic lipacheng tsa Peyer, ho ke ke ha nka nako e telele hore lisele tsa B li hlahise li-antibodies tsa IgA ho hapa libaktheria tsa pathogenic le ho haha ​​​​firewall ea pele bakeng sa pampitšana ea mala.

Liphuputso li tiisitse hore ho ba le secretion e kholo ea li-antibodies tsa IgA, ho thata le ho feta hore libaktheria tsa pathogenic li khone ho ikatisa, ho fokola ho tsamaea ha libaktheria tsa pathogenic, ho thata le ho feta hore libaktheria tsa pathogenic li fete ka maleng ebe li kena maling.Bohlokoa ba li-antibodies tsa IgA bo ka bonoa ho sena.

E le ho utloisisa phello eaGanoderma lucidumka li-antibodies tsa IgA tse patiloeng ke li-patches tsa Peyer leboteng la mala a manyane, bafuputsi ba Univesithi ea Hokkaido Japane ba ile ba ntša maqeba a Peyer leboteng la mala a manyenyane a likhoto, 'me ba arola lisele tse ka har'a likotoana le ho li hlahisa ka lipopolysaccharide (LPS). ) ho tloha Escherichia coli ka lihora tse 72.Ho ile ha fumanoa hore haeba palo e kholo eaGanoderma lucidumHo fanoe ka nako ena, secretion ea li-antibodies tsa IgA e ne e tla ba e phahameng haholo ho feta e se nang Ganoderma lucidum - empa tekanyo e tlaase.Ganoderma lucidume ne e se na phello e joalo.

Leha ho le joalo, tlas'a maemo a tšoanang a nako, haeba feela Peyer ea likoatipa lisele tse ba cultured leGanoderma lucidumntle le ts'usumetso ea LPS, secretion ea li-antibodies tsa IgA e ke ke ea eketseha ka ho khetheha (joalokaha ho bontšitsoe setšoantšong se ka tlase).Ho hlakile hore ha mala a tobane le tšokelo ea tšoaetso ea ka ntle,Ganoderma lucidume ka eketsa boemo ba ts'ireletso ea mala ka ho khothaletsa secretion ea IgA, 'me phello ena e lekana le lethal dose.Ganoderma lucidum.

Phello eaGanoderma lucidumka ho ntšoa ha li-antibodies ka li-lymph nodes tsa mala a manyane (Peyer's patches)

[Tlhokomeliso] “-” e botlaaseng ba chate e bolela “ha ea kenyelletsoa”, ’me “+” e bolela “kenyellelitsoe”.LPS e tsoa ho Escherichia coli, 'me mahloriso a sebelisitsoeng tekong ke 100μg/mL;Ganoderma lucidume sebelisitsoeng tekong ke ho emisoa ho entsoeng ka phofo ea 'mele e omeletseng ea Reishi mushroom le saline ea' mele, 'me litekanyetso tsa liteko ke 0.5, 1, le 5 mg / kg, ka ho latellana.(Mohloli/J Ethnopharmacol. 2017 Dec 14;214:240-243.)

Ganoderma lucidumhangata e boetse e ntlafatsa maemo a polelo a defensins

Karolo e 'ngoe ea bohlokoa karolong e ka pele ea ho itšireletsa ha mala ke "defensin", e leng molek'hule ea protheine e patiloeng ke lisele tsa Paneth ka epithelium ea mala a manyenyane.Defensin e nyane feela e ka thibela kapa ea bolaea libaktheria, li-fungus le mefuta e itseng ea livaerase.

Lisele tsa Paneth li tsepamisitsoe haholo ho ileum (halofo ea bobeli ea mala a manyenyane).Ho latela liteko tsa liphoofolo tsa thuto, ha ho se na ts'usumetso ea LPS, likhoto li ne li tsamaisoa ka intragastric.Ganoderma lucidum(ka tekanyo ea 0.5, 1, 5 mg ka kilo ea boima ba 'mele) bakeng sa lihora tse 24, litekanyetso tsa liphatsa tsa lefutso tsa defensin-5 le defensin-6 ka leleum li tla eketseha ka keketseho eaGanoderma lucidumtekanyo, 'me e phahame ho feta maemo a polelo ha a susumetsoa ke LPS (joalokaha ho bontšitsoe setšoantšong se ka tlase).

Ho hlakile hore le linakong tsa khotso ha ho se na ts'okelo ea libaktheria tsa pathogenic,Ganoderma lucidume tla boloka li-defensins ka maleng boemong ba ho itokisetsa ntoa ho arabela maemong a tšohanyetso ka nako leha e le efe.

Maemo a liphatsa tsa lefutso a defensins a lekantsoeng ho rat ileum (karolo ea ho qetela le e telele ka ho fetisisa ea mala a manyane)

Ganoderma lucidumha e bake ho ruruha ho feteletseng

E le ho hlakisa mokhoa oo kaGanoderma lucidume kenya tšebetsong boits'ireletso, bafuputsi ba tsepamisitse maikutlo ts'ebetsong ea TLR4.TLR4 ke mokelikeli liseleng tsa 'mele tsa ho itšireletsa mafung tse ka khethollang bahlaseli ba tsoang linaheng tse ling (joaloka LPS), ho kenya tšebetsong limolek'hule tse fetisang molaetsa liseleng tsa' mele tsa 'mele, le ho etsa hore lisele tsa 'mele tsa 'mele li arabele.

Teko e ile ea fumana hore naGanoderma lucidume khothalletsa tlhahiso ea li-antibodies tsa IgA kapa e eketsa maemo a liphatsa tsa lefutso tsa defensins e amana haufi-ufi le ts'ebetso ea li-receptor tsa TLR4 - li-receptor tsa TLR4 ke senotlolo saGanoderma lucidumho matlafatsa sesole sa mala.

Le hoja ho kenya ts'ebetsong TLR4 ho ka ntlafatsa ho itšireletsa mafung, ts'ebetso e feteletseng ea TLR4 e tla etsa hore lisele tsa 'mele tsa ho itšireletsa mafung li tsoele pele ho boloka TNF-α (tumor necrosis factor), e bakang ho ruruha ho feteletseng le ho beha kotsi ea bophelo bo botle.Ka hona, bafuputsi ba ile ba boela ba leka litekanyetso tsa TNF-α ka maleng a manyenyane a likhoto.

Ho ile ha fumanoa hore polelo ea TNF-α le maemo a secretion likarolong tse ka pele le tse ka morao tsa mala a manyenyane (jejunum le ileum) le liphatleng tsa Peyer leboteng la mala a likhoto ha lia ka tsa eketseha ka ho khetheha haGanoderma lucidume ile ea tsamaisoa (joalokaha ho bontšitsoe setšoantšong se ka tlase), le litekanyetso tse phahameng tsaGanoderma lucidume ka ba ea thibela TNF-α.

TheGanoderma lucidumlisebelisoa tse sebelisoang litekong tse ka holimo kaofela li lokiselitsoe ka ho sila li omisitsoeGanoderma lucidum'mele e behang litholoana hore e be phofo e ntle le ho eketsa letsoai la 'mele.Bafuputsi ba boletse joalo hobaneGanoderma lucidume sebelisitsoeng tekong e na le ganoderic acid A, 'me liphuputso tse fetileng li bontšitse hore ganoderic acid A e ka thibela ho ruruha, ba hakanya hore ts'ebetsong ea ho matlafatsa tšireletso ea mala kaGanoderma lucidumpolysaccharides, ganoderic acid A e kanna ea ba le karolo ea ho leka-lekanya ka nako e nepahetseng.

TNF-α ea liphatsa tsa lefutso tse lekantsoeng likarolong tse sa tšoaneng tsa mala a manyenyane a likhoto

[Mohloli] Kubota A, et al.Reishi mushroom Ganoderma lucidum e fetola tlhahiso ea IgA le polelo ea alpha-defensin ka maleng a manyane a rat..J Ethnopharmacol.2018 Mar 25;214:240-243.

QETA

Mabapi le mongoli/ Mme Wu Tingyao

Wu Tingyao esale a tlaleha ka litaba tsa Ganoderma tsa pele ho tloha 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).

★ Sengoliloeng sena se hatisitsoe tlas'a tumello e khethehileng ea mongoli.
★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli.
★ Bakeng sa tlōlo ea polelo e ka holimo, mongoli o tla phehella boikarabelo bo nepahetseng ba molao.
★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Wu Tingyao mme se fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.