Ku ya 25 Werurwe 2018 / Kaminuza ya Hokkaido & Kaminuza ya Farumasi ya Hokkaido / Ikinyamakuru cya Ethnopharmacology

Inyandiko / Hong Yurou, Wu Tingyao

Antibody ya IgA na defensin niwo murongo wambere wo kwirinda indwara zanduza mikorobe zo hanze mu mara.Nk’uko ubushakashatsi bwashyizwe ahagaragara na kaminuza ya Hokkaido na kaminuza y’imiti ya Hokkaido mu kinyamakuru cya Ethnopharmacology mu Kuboza 2017,Ganoderma lucidumIrashobora guteza imbere gusohora antibodies za IgA no kongera defensine idateye gucana.Biragaragara ko ari umufasha mwiza mugutezimbere ubudahangarwa bw'amara no kugabanya indwara zo munda.

Iyo bagiteri itera indwara,Ganoderma lucidumbizongera gusohora antibodies za IgA.

Amara mato ntabwo ari urugingo rwigifu gusa ahubwo ni urugingo rwumubiri.Usibye gusya no kunyunyuza intungamubiri mu biribwa, inirinda mikorobe zitandukanye zitera indwara ziva mu kanwa.

Kubwibyo, usibye villi itabarika (ikuramo intungamubiri) kumurongo wimbere wurukuta rw amara, hariho na tissue lymphatic bita "Peyer's patches (PP)" mumara mato, akora nk'abazamu b'ubudahangarwa.Iyo bagiteri zitera indwara zimaze kuvumburwa na macrophage cyangwa selile dendritic mu bice bya Peyer, ntibizatwara igihe kinini kugirango selile B zisohora antibodiyite za IgA kugirango zifate bagiteri zitera indwara kandi zubake firewall ya mbere yo mu mara.

Ubushakashatsi bwemeje ko uko ururenda rwa antibodiyide rwinshi rugenda rwiyongera, niko bigora cyane ko bagiteri zitera indwara zororoka, niko kugenda kwa bagiteri zitera indwara, niko bigoye ko bagiteri zitera indwara zanyura mu mara zikinjira mu maraso.Akamaro ka antibodies ya IgA irashobora kugaragara uhereye kuriyi.

Kugirango twumve ingaruka zaGanoderma lucidumkuri antibodies za IgA zasohowe nudusimba twa Peyer kurukuta rw amara mato, abashakashatsi bo muri kaminuza ya Hokkaido mu Buyapani bavanye ibishishwa bya Peyer murukuta rw amara mato yimbeba hanyuma batandukanya ingirabuzimafatizo ziri mubice hanyuma babihingamo lipopolysaccharide (LPS ) kuva Escherichia coli kumasaha 72.Byagaragaye ko niba umubare utari muto waGanoderma lucidumyatanzwe muri iki gihe, gusohora antibodies za IgA byaba hejuru cyane kurenza iyo Ganoderma lucidum - ariko ikabijeGanoderma lucidumnta ngaruka nk'izo.

Ariko, mubihe bimwe byigihe, niba gusa ingirabuzimafatizo za Peyer zifite umucoGanoderma lucidumhatabayeho gukangura LPS, gusohora antibodies za IgA ntiziyongera cyane (nkuko bigaragara ku gishushanyo gikurikira).Biragaragara, iyo amara ahuye niterabwoba ryo kwandura hanze,Ganoderma lucidumirashobora kongera urwego rwokwirinda amara mugutezimbere ururenda rwa IgA, kandi iyi ngaruka ihwanye nigipimo cyaGanoderma lucidum.

Ingaruka yaGanoderma lucidumku gusohora kwa antibodies na lymph node y'amara mato (Peyer's patch)

[Icyitonderwa] “-” hepfo yimbonerahamwe bisobanura “utarimo”, naho “+” bisobanura “harimo”.LPS iva muri Escherichia coli, kandi kwibanda gukoreshwa mubushakashatsi ni 100μg / mL;Ganoderma lucidumikoreshwa mubushakashatsi ni ihagarikwa ryakozwe mubutaka bwumye Reishi ibihumyo byera ifu yumubiri hamwe na saline physiologique, kandi dosiye yubushakashatsi ni 0.5, 1, na 5 mg / kg.(Inkomoko / J Ethnopharmacol. 2017 Ukuboza 14; 214: 240-243.)

Ganoderma lucidummubisanzwe kandi itezimbere imvugo ya defensins

Urundi ruhare rukomeye mumbere yubudahangarwa bwo munda ni "defensin", ni molekile ya poroteyine isohorwa na selile Paneth muri epitelium nto.Gusa defensine nkeya irashobora kubuza cyangwa kwica bagiteri, ibihumyo nubwoko bumwe na bumwe bwa virusi.

Utugingo ngengabuzima twibanda cyane muri ileum (igice cya kabiri cy'amara mato).Dukurikije ubushakashatsi bw’inyamaswa bwakozwe muri ubwo bushakashatsi, mu gihe hatabayeho gukurura LPS, imbeba zatanzwe mu buryo budasanzweGanoderma lucidum.Ganoderma lucidumikinini, kandi kiri hejuru yimvugo iyo igaragajwe na LPS (nkuko bigaragara ku gishushanyo gikurikira).

Biragaragara, no mubihe byamahoro mugihe nta terabwoba rya bagiteri zitera,Ganoderma lucidumizagumisha defensine mu mara muburyo bwintambara yiteguye guhangana nibyihutirwa umwanya uwariwo wose.

Urwego rwerekana imiterere ya defensine yapimwe muri imbeba ileum (igice cyanyuma kandi kirekire cyane cy amara mato)

Ganoderma lucidumntabwo itera uburibwe bukabije

Kugirango dusobanure uburyo bukoreshwaGanoderma lucidumikora ubudahangarwa, abashakashatsi bibanze ku mikorere ya TLR4.TLR4 niyakira ku ngirabuzimafatizo zishobora kumenya abanyamahanga bateye (nka LPS), igakora molekile zohereza ubutumwa mu ngirabuzimafatizo z'umubiri, kandi bigatuma selile z'umubiri zisubiza.

Ubushakashatsi bwerekanye ko nibaGanoderma lucidumiteza imbere gusohora antibodies ya IgA cyangwa ikongera urugero rwa gene imvugo ya defensine ifitanye isano rya bugufi nogukora kwa reseptor ya TLR4 - reseptor ya TLR4 nurufunguzo rwaGanoderma lucidumkongera ubudahangarwa bw'amara.

Nubwo gukora TLR4 bishobora guteza imbere ubudahangarwa, kurenza urugero kwa TLR4 bizatera selile immunite guhora zisohora TNF-α (tumor necrosis factor), bigatera umuriro mwinshi kandi bikangiza ubuzima.Kubwibyo, abashakashatsi banagerageje urwego rwa TNF-α mu mara mato yimbeba.

Byagaragaye ko imvugo ya TNF-α n'urwego rwo gusohora mu gice cy'imbere n'inyuma cy'amara mato mato (jejunum na ileum) no mu gishishwa cya Peyer ku rukuta rw'amara rw'imbeba zitigeze ziyongera cyane iyoGanoderma lucidumyatanzwe (nkuko bigaragara ku gishushanyo gikurikira), hamwe na dosiye ndende yaGanoderma lucidumirashobora no kubuza TNF-α.

UwitekaGanoderma lucidumibikoresho byakoreshejwe mubigeragezo byavuzwe haruguru byose byateguwe no gusya byumyeGanoderma lucidumkwera umubiri mubifu nziza no kongeramo saline physiologique.Abashakashatsi bavuze ko kubera koGanoderma lucidumikoreshwa mu bushakashatsi irimo aside ganoderic A, kandi ubushakashatsi bwashize bwerekanye ko aside ganoderic A ishobora kubuza gucana, bakeka ko mugihe cyo kongera ubudahangarwa bw'amara naGanoderma lucidumpolysaccharide, aside ganoderic A irashobora kuba yaragize uruhare runini mugihe gikwiye.

Imvugo ya TNF-α yapimwe mubice bitandukanye by amara mato yimbeba

[Inkomoko] Kubota A, n'abandi.Reishi mushroom Ganoderma lucidum ihindura umusaruro wa IgA hamwe na alpha-defensin imvugo mumara mato mato.J Ethnopharmacol.2018 Werurwe 25; 214: 240-243.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao

Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.
Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.
★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.
Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.