Kurume 25, 2018/Hokkaido University & Hokkaido Pharmaceutical University/Journal yeEthnopharmacology

Chinyorwa/ Hong Yurou, Wu Tingyao

IgA antibody uye defensin ndiyo yekutanga mutsara wekudzivirira kwekudzivirira kubva kunze kwehutachiona hwehutachiona mumatumbo.Zvinoenderana neongororo yakabudiswa neHokkaido University neHokkaido Pharmaceutical University muJournal yeEthnopharmacology muna Zvita 2017,Ganoderma luciduminogona kukurudzira secretion yeIgA antibodies uye kuwedzera defensins pasina kukonzera kuzvimba.Zviri pachena kuti mubatsiri akanaka wekuvandudza intestinal immune uye kuderedza zvirwere zvemukati.

Kana mabhakitiriya epathogenic anopinda,Ganoderma lucidumichawedzera secretion yeIgA antibodies.

Ura hudiki hausi nhengo yekudya chete asiwo nhengo yemuviri inodzivirira zvirwere.Pamusoro pekugaya uye kunwisa michero muchikafu, inodzivirirawo kubva kune akasiyana siyana pathogenic microorganisms anouya kubva mumuromo.

Naizvozvo, mukuwedzera kune isingaverengeki villi (kunwa zvinovaka muviri) mukati memukati memadziro emukati, kune zvakare lymphatic tishu inonzi "Peyer's patches (PP)" mudumbu diki, inoshanda sevaridzi vekudzivirira.Kana mabhakitiriya epathogenic awanikwa nema macrophages kana masero edendritic muPeyer's patches, hazvitore nguva yakareba kuti masero eB abudise IgA masoja ekudzivirira chirwere kuti atore mabhakitiriya epathogenic uye kuvaka yekutanga firewall yemudumbu.

Zvidzidzo zvakasimbisa kuti iyo yakawanda secretion yeIgA antibodies, zvakanyanya kuoma kune pathogenic mabhakitiriya kubereka, iyo isina simba yekufamba kwepathogenic bacteria, zvakanyanya kuoma kuti hutachiona hwepathogenic hupfuure nemudumbu uye kupinda muropa.Kukosha kweIgA antibodies kunogona kuonekwa kubva pane izvi.

Kuti tinzwisise mhedzisiro yeGanoderma lucidumPamasoja ekudzivirira chirwere eIgA akavharirwa neaPeyer's pamadziro emukati memukati memukati memukati memukati memukati memukati memukati medumbu diki, vatsvakurudzi vekuHokkaido University kuJapan vakaburitsa zvigamba zvePeyer pamadziro ematumbo madiki emakonzo ndokuzopatsanura maseru ari mumachira ndokuagadzira ne lipopolysaccharide (LPS). ) kubva kuEscherichia coli kwemaawa makumi manomwe nemaviri.Zvakaonekwa kuti kana yakawanda mariGanoderma lucidumyakapihwa panguva iyi, kuburitswa kweIgA antibodies kwaizove kwakakwira kupfuura iyo isina Ganoderma lucidum - asi yakaderera-dose.Ganoderma lucidumhazvina kuita saizvozvo.

Nekudaro, pasi pemamiriro akafanana enguva, kana chete Peyer's zvigamba masero anogadzirwa nawoGanoderma lucidumpasina kukurudzirwa kweLPS, kuvharwa kweIgA antibodies hakuzowedzerwa zvakanyanya (sezvinoratidzwa mumufananidzo uri pasi apa).Zviri pachena, kana ura huri kutarisana nekutyisidzirwa kwehutachiona hwekunze,Ganoderma luciduminogona kuwedzera chiyero chekudzivirira chedumbu nekusimudzira secretion yeIgA, uye mhedzisiro iyi inoenderana nedosi ye.Ganoderma lucidum.

Mhedzisiro yeGanoderma lucidumpakuvanzika kwemasoja ekudzivirira chirwere nemalymph nodes emudumbu mudiki (Peyer's patches)

[Cherechedza] Iyo "-" pazasi pechati inoreva "isina kubatanidzwa", uye "+" zvinoreva "inosanganisirwa".LPS inobva kuEscherichia coli, uye kushandiswa kunoshandiswa mukuedza ndeye 100μg / mL;Ganoderma luciduminoshandiswa mukuedza ndeyekumiswa kwakagadzirwa nevhu rakaoma Reishi mushroom fruiting body poda uye physiological saline, uye miedzo yekuedza i 0.5, 1, uye 5 mg / kg, zvichiteerana.(Kwakabva/J Ethnopharmacol. 2017 Dec 14;214:240-243.)

Ganoderma lucidumkazhinji inovandudzawo maitiro ekutaura e defensins

Rimwe basa rakakosha pamberi pekudzivirira kwemukati ndeye "defensin", iyo ipuroteni molecule yakavanzwa nePaneth masero mudiki epithelium.Ingori shoma shoma ye defensin inogona kuvharira kana kuuraya mabhakitiriya, fungi uye mamwe marudzi emavhairasi.

Paneth masero anonyanya kuiswa muileum (chikamu chechipiri chemukati mudiki).Zvinoenderana nekuyedza kwemhuka kwechidzidzo, mukushaikwa kwekukurudzira kweLPS, makonzo aipihwa intragastrically.Ganoderma lucidum(pamuyero we0.5, 1, 5 mg pa kg uremu hwemuviri) kwemaawa makumi maviri nemana, iyo gene kutaura mazinga e defensin-5 uye defensin-6 muileamu ichawedzera nekuwedzera kweiyo.Ganoderma lucidumdose, uye yakakwirira kudarika mazinga ekutaura kana amutswa neLPS (sezvinoratidzwa mumufananidzo uri pasi apa).

Zviripachena, kunyangwe munguva dzerunyararo kana pasina kutyisidzira kwehutachiona hwepathogenic,Ganoderma lucidumichachengetedza defensins mumatumbo mumamiriro ekugadzirira kurwa kupindura kune emergency chero nguva.

Iro geni rekutaura mazinga e defensins akayerwa mune rat ileum (yekupedzisira uye yakareba chikamu chemukati mudumbu)

Ganoderma lucidumhaikonzeri kuzvimba zvakanyanya

Kuti ujekese mashandiro ayoGanoderma luciduminomutsa kusadzivirirwa, vaongorori vakatarisa pakuita kweTLR4.TLR4 inogashira pamaseru edziviriro anogona kuona varwi vekunze (senge LPS), shandisa mamorekuru ekutumira mameseji mumaseru ekudzivirira, uye kuita kuti masero edziviriro apindure.

Kuedza kwakawana kuti kanaGanoderma luciduminosimudzira secretion yeIgA antibodies kana kuwedzera gene expression mazinga e defensins ane hukama zvakanyanya nekuitwa kweTLR4 receptors - TLR4 receptors ndiyo kiyi yeGanoderma lucidumkuwedzera intestinal immune.

Kunyangwe kumisa TLR4 kunogona kuvandudza kusadzivirirwa, kunyanya-activation kweTLR4 kuchaita kuti masero edziviriro arambe achiburitsa TNF-α (tumor necrosis factor), zvichikonzera kuzvimba kwakanyanya uye kutyisidzira hutano.Nokudaro, vatsvakurudzi vakaedzawo TNF-α mazinga mumatumbo maduku emakonzo.

Yakawanikwa kuti TNF-α kutaura uye mazinga ekuvhara mukati memashure uye shure kwezvikamu zvemukati mudumbu (jejunum uye ileum) uye muPeyer's patches pamadziro ematumbo emakonzo haana kunyanya kuwedzera apo.Ganoderma lucidumyakaitwa (sezvinoratidzwa mumufananidzo uri pasi apa), uye madosi makuru eGanoderma luciduminogona kunyange kurambidza TNF-α.

TheGanoderma lucidumzvinhu zvinoshandiswa mukuedza zviri pamusoro zvese zvinogadzirwa nekukuya zvakaomeswaGanoderma luciduminobereka michero kuita hupfu hwakatsetseka uye kuwedzera physiological saline.Vatsvakurudzi vakadaro nokutiGanoderma lucidumyakashandiswa mukuyedza ine ganoderic acid A, uye zvidzidzo zvekare zvakaratidza kuti ganoderic acid A inogona kuvharidzira kuzvimba, vanofungidzira kuti mukuita kwekuwedzera kusadzivirirwa kwematumbo.Ganoderma lucidumpolysaccharides, ganoderic acid A inogona kunge yakaita basa rekuenzanisa panguva chaiyo.

TNF-α gene expression yakayerwa muzvikamu zvakasiyana-siyana zvedumbu diki remakonzo

[Mabviro] Kubota A, et al.Reishi mushroom Ganoderma lucidum modulates IgA kugadzirwa uye alpha-defensin kutaura mugonzo dumbu diki..J Ethnopharmacol.2018 Mar 25;214:240-243.

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Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.
★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.
★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.
★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.