Marichi 25, 2018/Hokkaido University & Hokkaido Pharmaceutical University/Journal of Ethnopharmacology

Zolemba/ Hong Yurou, Wu Tingyao

IgA antibody ndi defensin ndi mzere woyamba wa chitetezo chamthupi ku matenda akunja a tizilombo m'matumbo.Malinga ndi kafukufuku wofalitsidwa ndi Hokkaido University ndi Hokkaido Pharmaceutical University mu Journal of Ethnopharmacology mu December 2017,Ganoderma lucidumimatha kulimbikitsa kutulutsidwa kwa ma antibodies a IgA ndikuwonjezera chitetezo popanda kuyambitsa kutupa.Mwachiwonekere ndi wothandizira wabwino pakuwongolera chitetezo cham'mimba komanso kuchepetsa matenda a m'mimba.

Pamene mabakiteriya a pathogenic alowa,Ganoderma lucidumimawonjezera kutulutsa kwa ma antibodies a IgA.

Matumbo ang'onoang'ono sikuti ndi chiwalo chodyera komanso chitetezo cha mthupi.Kuphatikiza pa kugaya ndi kuyamwa zakudya m'zakudya, imatetezanso tizilombo toyambitsa matenda tosiyanasiyana tomwe timachokera mkamwa.

Chifukwa chake, kuwonjezera pa ma villi osawerengeka (amayamwa michere) mkati mwa khoma lamatumbo, palinso minofu yam'mimba yotchedwa "Peyer's patches (PP)" m'matumbo ang'onoang'ono, omwe amagwira ntchito ngati oteteza chitetezo.Kamodzi mabakiteriya tizilombo tapezeka ndi macrophages kapena dendritic maselo Peyer a yamawangamawanga, sikudzatenga nthawi B maselo secrete ma antibodies IgA kugwira tizilombo tizilombo ndi kumanga woyamba firewall kwa matumbo thirakiti.

Kafukufuku watsimikizira kuti kutulutsa kwakukulu kwa ma antibodies a IgA, kumakhala kovuta kwambiri kuti mabakiteriya a tizilombo toyambitsa matenda aberekane, kufooka kwa kuyenda kwa tizilombo toyambitsa matenda, kumakhala kovuta kwambiri kuti tizilombo toyambitsa matenda tidutse m'matumbo ndikulowa m'magazi.Kufunika kwa ma antibodies a IgA kumatha kuwonedwa kuchokera ku izi.

Kuti timvetse zotsatira zaGanoderma lucidumpa ma antibodies a IgA opangidwa ndi zigamba za Peyer pakhoma la matumbo aang'ono, ofufuza ochokera ku yunivesite ya Hokkaido ku Japan adatulutsa zigamba za Peyer pakhoma la matumbo aang'ono a makoswe ndikulekanitsa ma cell mu zigamba ndikuzikulitsa ndi lipopolysaccharide (LPS). ) kuchokera ku Escherichia coli kwa maola 72.Iwo anapeza kuti ngati ndithu kuchuluka kwaGanoderma lucidumanaperekedwa panthawiyi, kutulutsidwa kwa ma antibodies a IgA kukanakhala kwakukulu kuposa popanda Ganoderma lucidum - koma mlingo wochepa.Ganoderma lucidumzinalibe zotsatira zoterozo.

Komabe, pansi pazimenezi nthawi, ngati Peyer a yamawangamawanga maselo otukuka ndiGanoderma lucidumpopanda kukondoweza kwa LPS, kutulutsidwa kwa ma antibodies a IgA sikudzawonjezeka makamaka (monga momwe tawonetsera m'chithunzichi).Mwachiwonekere, pamene matumbo akukumana ndi chiopsezo cha matenda akunja,Ganoderma lucidumamatha kuwonjezera chitetezo cha m'matumbo polimbikitsa kutulutsa kwa IgA, ndipo izi zimayenderana ndi mlingo waGanoderma lucidum.

Zotsatira zaGanoderma lucidumpa katulutsidwe ka ma antibodies ndi ma lymph nodes a m'matumbo aang'ono (Peyer's patches)

[Zindikirani] "-" pansi pa tchati amatanthauza "osaphatikizidwa", ndipo "+" amatanthauza "kuphatikizidwa".LPS imachokera ku Escherichia coli, ndipo ndondomeko yomwe imagwiritsidwa ntchito poyesera ndi 100μg / mL;Ganoderma lucidumZomwe zimagwiritsidwa ntchito poyesera ndi kuyimitsidwa kopangidwa ndi ufa wowuma wa Reishi wa bowa wokhala ndi zipatso zamthupi ndi mchere wamthupi, ndipo milingo yoyesera ndi 0.5, 1, ndi 5 mg / kg, motsatana.(Source/J Ethnopharmacol. 2017 Dec 14;214:240-243.)

Ganoderma lucidumNthawi zambiri imathandizanso kuti ma defensins awonetsedwe

Ntchito ina yofunika kwambiri pachitetezo cha m'mimba ndi "defensin", yomwe ndi molekyulu ya protein yomwe imatulutsidwa ndi maselo a Paneth mu epithelium yaing'ono yamatumbo.Kuchepa pang'ono kwa defensin kumatha kuletsa kapena kupha mabakiteriya, bowa ndi mitundu ina ya ma virus.

Maselo a Paneth amakhala makamaka mu ileamu (theka lachiwiri la matumbo aang'ono).Malinga ndi kuyesa kwa nyama pa kafukufukuyu, pakalibe kukondoweza kwa LPS, makoswe amapatsidwa intragastric.Ganoderma lucidum(pa mlingo wa 0.5, 1, 5 mg pa kilogalamu ya kulemera kwa thupi) kwa maola 24, milingo ya jini ya defensin-5 ndi defensin-6 mu ileamu idzawonjezeka ndi kuwonjezeka kwaGanoderma lucidummlingo, ndipo ndi wokwera kuposa milingo yamafotokozedwe akakokedwa ndi LPS (monga momwe zikuwonekera pachithunzichi pansipa).

Zachidziwikire, ngakhale munthawi yamtendere pomwe palibe chiwopsezo cha mabakiteriya a pathogenic,Ganoderma lucidumadzasunga ma defensins m'matumbo m'malo okonzekera nkhondo kuti athe kuyankha mwadzidzidzi nthawi iliyonse.

Mawonekedwe a jini a defensins amayezedwa mu rat ileum (gawo lomaliza komanso lalitali kwambiri lamatumbo aang'ono)

Ganoderma lucidumsichimayambitsa kutupa kwakukulu

Pofuna kumveketsa bwino makina omweGanoderma lucidumimayambitsa chitetezo chokwanira, ofufuzawo adayang'ana kwambiri momwe TLR4 imagwirira ntchito.TLR4 ndi cholandilira pama cell a chitetezo chamthupi chomwe chimatha kuzindikira olowa akunja (monga LPS), kuyambitsa ma molekyulu otumiza uthenga m'maselo a chitetezo chamthupi, ndikupanga maselo oteteza chitetezo kuyankha.

Kuyesera anapeza kuti kayaGanoderma lucidumimalimbikitsa kutulutsidwa kwa ma antibodies a IgA kapena kukulitsa kuchuluka kwa ma jini a defensins kumagwirizana kwambiri ndi kuyambitsa kwa TLR4 receptors - TLR4 receptors ndiye chinsinsi chaGanoderma lucidumkuonjezera chitetezo cha m'mimba.

Ngakhale kuyambitsa TLR4 kungapangitse chitetezo cha mthupi, kutsegula kwambiri kwa TLR4 kumapangitsa kuti maselo a chitetezo cha mthupi atulutse TNF-α (chotupa cha necrosis factor), kuchititsa kutupa kwakukulu ndi kuopseza thanzi.Choncho, ochita kafukufuku adayesanso ma TNF-α m'matumbo aang'ono a makoswe.

Zinapezeka kuti mafotokozedwe a TNF-α ndi kuchuluka kwa katulutsidwe m'zigawo zam'mbuyo ndi zam'mbuyo zam'matumbo ang'onoang'ono (jejunum ndi ileum) komanso pazigamba za Peyer pakhoma lamatumbo a makoswe sizinachuluke makamaka pamene.Ganoderma lucidumidaperekedwa (monga momwe tawonetsera m'chithunzichi), ndi mlingo waukulu waGanoderma lucidumimatha kuletsanso TNF-α.

TheGanoderma lucidumzipangizo ntchito zoyeserera pamwamba zonse zakonzedwa ndi akupera zoumaGanoderma lucidummatupi a fruiting kukhala ufa wabwino ndikuwonjezera mchere wamchere.Ofufuzawo ananena kuti chifukwaGanoderma lucidumZomwe zimagwiritsidwa ntchito poyesera zimakhala ndi ganoderic acid A, ndipo kafukufuku wam'mbuyomu awonetsa kuti ganoderic acid A imatha kuletsa kutupa, amalingalira kuti pakuwonjezera chitetezo cham'mimba ndiGanoderma lucidumma polysaccharides, ganoderic acid A mwina adachitapo kanthu pa nthawi yoyenera.

Kufotokozera kwa jini ya TNF-α kuyesedwa m'madera osiyanasiyana a matumbo aang'ono a makoswe

[Source] Kubota A, et al.Bowa wa Reishi Ganoderma lucidum modulates IgA kupanga ndi alpha-defensin kufotokoza m'matumbo aang'ono a makoswe..J Ethnopharmacol.2018 Marichi 25; 214:240-243.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.
★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.
★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.
★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.