Lub Peb Hlis 25, 2018 / Hokkaido University & Hokkaido Pharmaceutical University / Phau ntawv Journal ntawm Ethnopharmacology

Text/Hong Yurou, Wu Tingyao

IgA antibody thiab defensin yog thawj kab ntawm kev tiv thaiv kab mob tiv thaiv kab mob sab nraud microbial hauv cov hnyuv.Raws li kev tshawb fawb luam tawm los ntawm Hokkaido University thiab Hokkaido Pharmaceutical University hauv Phau Ntawv Xov Xwm ntawm Ethnopharmacology thaum Lub Kaum Ob Hlis 2017,Ganoderma lucidumtuaj yeem txhawb kev tso tawm ntawm IgA cov tshuaj tiv thaiv kab mob thiab nce cov tshuaj tiv thaiv tsis ua rau mob.Nws yog qhov pom tseeb tias yog tus pab zoo rau kev txhim kho plab hnyuv thiab txo cov kab mob hauv plab.

Thaum cov kab mob pathogenic nkag mus,Ganoderma lucidumyuav ua rau kom qhov tso tawm ntawm IgA cov tshuaj tiv thaiv.

Cov hnyuv me tsis yog tsuas yog lub plab zom mov xwb tab sis kuj yog lub cev tiv thaiv kab mob.Ntxiv nrog rau kev zom thiab nqus cov as-ham hauv cov zaub mov, nws tseem tiv thaiv ntau yam kab mob pathogenic uas tuaj hauv lub qhov ncauj.

Yog li ntawd, ntxiv rau suav tsis txheeb villi (absorbing as-ham) nyob rau hauv lub puab txheej ntawm lub plab hnyuv phab ntsa, kuj muaj cov lymphatic ntaub so ntswg hu ua "Peyer's thaj ua rau thaj (PP)" nyob rau hauv cov hnyuv me, uas ua hauj lwm raws li lub cev tiv thaiv goalkeepers.Thaum cov kab mob pathogenic tau tshawb pom los ntawm macrophages lossis dendritic hlwb hauv Peyer's thaj ua rau thaj, nws yuav tsis siv sij hawm ntev rau B hlwb los tso cov tshuaj tiv thaiv IgA los ntes cov kab mob pathogenic thiab tsim thawj qhov hluav taws xob rau txoj hnyuv.

Cov kev tshawb fawb tau lees paub tias qhov ntau dua qhov tso tawm ntawm IgA cov tshuaj tiv thaiv kab mob, qhov nyuaj dua rau cov kab mob pathogenic kom rov ua dua, qhov tsis muaj zog ntawm cov kab mob pathogenic, qhov nyuaj rau cov kab mob pathogenic kis los ntawm txoj hnyuv thiab nkag mus rau hauv cov hlab ntsha.Qhov tseem ceeb ntawm IgA cov tshuaj tiv thaiv tuaj yeem pom los ntawm qhov no.

Yuav kom nkag siab txog cov nyhuv ntawmGanoderma lucidumntawm IgA cov tshuaj tiv thaiv zais cia los ntawm Peyer thaj ua rau thaj ntawm phab ntsa ntawm cov hnyuv me, cov kws tshawb fawb los ntawm Hokkaido University hauv Nyij Pooj tau tshem Peyer cov thaj ua rau thaj tsam ntawm phab ntsa ntawm cov hnyuv me ntawm cov nas thiab tom qab ntawd cais cov hlwb hauv thaj ua rau thaj ua rau thaj tsam thiab coj lawv nrog lipopolysaccharide (LPS. ) los ntawm Escherichia coli rau 72 teev.Nws tau pom tias yog tias muaj ntau npaum li cas ntawmGanoderma lucidumtau muab rau lub sijhawm no, qhov tso tawm ntawm IgA cov tshuaj tiv thaiv yuav ntau dua li qhov tsis muaj Ganoderma lucidum - tab sis koob tshuaj tsawg.Ganoderma lucidumtsis muaj teebmeem li.

Txawm li cas los xij, nyob rau hauv tib lub sijhawm, yog tias tsuas yog Peyer's thaj ua rau thaj ua rau lub hlwb raug coj los nrogGanoderma lucidumYog tias tsis muaj kev txhawb nqa ntawm LPS, qhov tso tawm ntawm IgA cov tshuaj tiv thaiv yuav tsis tau nce ntxiv (raws li qhia hauv daim duab hauv qab no).Pom tseeb, thaum txoj hnyuv tab tom ntsib kev hem thawj ntawm kev kis kab mob sab nraud,Ganoderma lucidumtuaj yeem nce qib kev tiv thaiv ntawm txoj hnyuv los ntawm kev txhawb nqa kev tso tawm ntawm IgA, thiab cov nyhuv no yog proportional rau cov koob tshuaj.Ganoderma lucidum.

Cov nyhuv ntawmGanoderma lucidumntawm qhov tso tawm ntawm cov tshuaj tiv thaiv los ntawm cov qog ntshav ntawm cov hnyuv me (Peyer's thaj ua rau thaj)

[Ceeb Toom] Qhov "-" nyob rau hauv qab ntawm daim ntawv txhais tau tias "tsis suav", thiab "+" txhais tau tias "nrog".LPS los ntawm Escherichia coli, thiab cov concentration siv hauv qhov kev sim yog 100μg / mL;Ganoderma lucidumsiv nyob rau hauv qhov kev sim yog ib tug ncua kev kawm ntawv ua los ntawm cov av qhuav Reishi nceb txiv hmab txiv ntoo lub cev hmoov thiab physiological saline, thiab kev sim koob tshuaj yog 0.5, 1, thiab 5 mg / kg, feem.(Source/J Ethnopharmacol. 2017 Dec 14; 214:240-243.)

Ganoderma lucidumfeem ntau kuj txhim kho kev qhia qib ntawm defensins

Lwm lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob hauv plab yog "defensin", uas yog cov protein molecule secreted los ntawm Paneth hlwb nyob rau hauv cov hnyuv me epithelium.Tsuas yog ib qho me me ntawm defensin tuaj yeem cuam tshuam lossis tua cov kab mob, fungi thiab qee yam kab mob.

Paneth hlwb feem ntau yog nyob rau hauv ileum (qhov thib ob ib nrab ntawm cov hnyuv).Raws li kev sim tsiaj ntawm txoj kev tshawb no, thaum tsis muaj LPS stimulation, nas tau muab tshuaj intragastrically.Ganoderma lucidum(ntawm koob tshuaj 0.5, 1, 5 mg rau ib kg lub cev qhov hnyav) rau 24 teev, cov qib qhia cov noob ntawm defensin-5 thiab defensin-6 hauv ileum yuav nce ntxiv nrog kev nce ntxiv ntawm cov piam thaj hauv cov ntshav.Ganoderma lucidumkoob tshuaj, thiab siab dua cov theem qhia thaum txhawb los ntawm LPS (raws li qhia hauv daim duab hauv qab no).

Obviously, txawm nyob rau lub sijhawm muaj kev thaj yeeb nyab xeeb thaum tsis muaj kev hem thawj ntawm cov kab mob pathogenic,Ganoderma lucidumyuav ua kom cov defensins nyob rau hauv cov hnyuv nyob rau hauv lub xeev ntawm kev npaj kev sib ntaus sib tua los teb rau thaum muaj xwm ceev txhua lub sij hawm.

Cov qib qhia cov noob ntawm defensins ntsuas hauv cov nas ileum (qhov kawg thiab qhov ntev tshaj plaws ntawm txoj hnyuv)

Ganoderma lucidumtsis ua rau mob ntau dhau

Nyob rau hauv thiaj li yuav qhia meej lub mechanism uasGanoderma lucidumactivates kev tiv thaiv kab mob, cov kws tshawb fawb tau tsom mus rau kev ua haujlwm ntawm TLR4.TLR4 yog ib qho receptor ntawm lub cev tiv thaiv kab mob uas tuaj yeem txheeb xyuas cov neeg tawm tsam txawv teb chaws (xws li LPS), ua kom cov lus xa mus rau hauv lub cev tiv thaiv kab mob, thiab ua rau lub cev tiv thaiv kab mob.

Qhov kev sim pom tias sebGanoderma lucidumtxhawb kev tso tawm ntawm IgA cov tshuaj tiv thaiv los yog nce cov noob qhia qib ntawm defensins yog ze ze rau kev ua kom TLR4 receptors - TLR4 receptors yog tus yuam sij rauGanoderma lucidumtxhawm rau txhim kho plab hnyuv.

Txawm hais tias ua kom TLR4 tuaj yeem txhim kho kev tiv thaiv kab mob, kev ua kom dhau ntawm TLR4 yuav ua rau lub cev tiv thaiv kab mob tsis tu ncua TNF-α (cov qog nqaij hlav necrosis), ua rau mob ntau dhau thiab ua rau muaj kev hem thawj rau kev noj qab haus huv.Yog li ntawd, cov kws tshawb fawb kuj tau sim TNF-α qib hauv cov hnyuv me ntawm cov nas.

Nws tau pom tias TNF-α qhia thiab qib secretion nyob rau hauv lub anterior thiab posterior ntu ntawm cov hnyuv me (jejunum thiab ileum) thiab nyob rau hauv Peyer lub thaj ua rau ntawm lub plab hnyuv phab ntsa ntawm nas tsis tau tshwj xeeb yog nce thaumGanoderma lucidumtau muab tshuaj (raws li qhia hauv daim duab hauv qab no), thiab cov koob tshuaj ntauGanoderma lucidumtuaj yeem inhibit TNF-α.

CovGanoderma lucidumcov ntaub ntawv siv nyob rau hauv cov kev sim saum toj no yog tag nrho npaj los ntawm kev sib tsoo qhuavGanoderma lucidumfruiting lub cev rau hauv cov hmoov zoo thiab ntxiv physiological saline.Cov kws tshawb fawb tau hais tias vim li casGanoderma lucidumsiv nyob rau hauv qhov kev sim muaj ganoderic acid A, thiab cov kev tshawb fawb yav dhau los tau pom tias ganoderic acid A tuaj yeem cuam tshuam qhov mob, lawv xav tias nyob rau hauv cov txheej txheem ntawm kev txhim kho plab hnyuv los ntawmGanoderma lucidumpolysaccharides, ganoderic acid A yuav zoo tau ua lub luag haujlwm sib npaug ntawm lub sijhawm.

TNF-α gene qhia ntsuas nyob rau hauv ntau qhov chaw ntawm cov hnyuv me ntawm nas

[Source] Kubota A, et al.Reishi Mushroom Ganoderma lucidum modulates IgA ntau lawm thiab alpha-defensin qhia nyob rau hauv nas me me..J Ethnopharmacol.2018 Mar 25; 214:240-243.

END

Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma thawj zaug txij li xyoo 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau.
★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai los ntawm tus sau.
★ Rau kev ua txhaum ntawm cov lus hais saum toj no, tus sau yuav ua raws li cov luag haujlwm raug cai.
★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.