Maris 25, 2018 / Jami'ar Hokkaido & Jami'ar Magunguna ta Hokkaido / Jaridar Ethnopharmacology

Rubutu/ Hong Yurou, Wu Tingyao

IgA antibody da defensin sune layin farko na kariya daga cututtukan ƙwayoyin cuta na waje a cikin hanji.Dangane da binciken da Jami'ar Hokkaido da Jami'ar Magunguna ta Hokkaido suka buga a cikin Journal of Ethnopharmacology a cikin Disamba 2017,Ganoderma lucidumzai iya inganta siginar rigakafi na IgA da kuma kara yawan kariya ba tare da haifar da kumburi ba.Babu shakka mataimaki ne mai kyau don inganta rigakafi na hanji da rage cututtuka na hanji.

Lokacin da kwayoyin pathogenic suka mamaye,Ganoderma lucidumzai kara fitar da kwayoyin IgA.

Ƙananan hanji ba kawai gabobin narkewa bane amma har ma da rigakafi.Baya ga narkar da abinci mai gina jiki da kuma shayar da abinci, tana kuma kare kariya daga kwayoyin cuta daban-daban da ke shigowa daga baki.

Don haka, baya ga villi marasa adadi (mai shayar da abinci mai gina jiki) akan rufin ciki na bangon hanji, akwai kuma ƙwayoyin lymphatic da ake kira "Peyer's patches (PP)" a cikin ƙananan hanji, wanda ke aiki a matsayin masu tsaron gida na rigakafi.Da zarar an gano ƙwayoyin cuta ta hanyar macrophages ko sel dendritic a cikin facin Peyer, ba zai ɗauki lokaci mai tsawo ba don ƙwayoyin B su ɓoye ƙwayoyin rigakafi na IgA don kama ƙwayoyin cuta da kuma gina bangon bango na farko don sashin hanji.

Bincike ya tabbatar da cewa, yayin da mafi yawan fitowar kwayoyin cutar IgA, da wahala wajen haifuwar kwayoyin cuta, da raunana motsin kwayoyin cuta, da wuya kwayoyin cuta su wuce ta hanji su shiga cikin jini.Ana iya ganin mahimmancin rigakafin IgA daga wannan.

Domin fahimtar tasirinGanoderma lucidumA kan ƙwayoyin rigakafi na IgA da Peyer's patches suka ɓoye a bangon ƙananan hanji, masu bincike daga Jami'ar Hokkaido da ke Japan sun fitar da facin Peyer a bangon ƙananan hanjin berayen sannan kuma suka ware ƙwayoyin da ke cikin facin kuma sun haɓaka su da lipopolysaccharide (LPS). ) daga Escherichia coli na tsawon awanni 72.An gano cewa idan mai yawa adadinGanoderma lucidumAn ba da shi a wannan lokacin, ɓoyewar ƙwayoyin rigakafi na IgA zai kasance mafi girma fiye da haka ba tare da Ganoderma lucidum ba - amma ƙananan kashi.Ganoderma lucidumba shi da irin wannan tasiri.

Koyaya, a ƙarƙashin sharuɗɗan lokaci ɗaya, idan kawai sel facin Peyer an haɓaka su daGanoderma lucidumba tare da haɓakawa na LPS ba, ɓoyewar ƙwayoyin rigakafi na IgA ba za a ƙara musamman ba (kamar yadda aka nuna a cikin hoton da ke ƙasa).Babu shakka, lokacin da hanji ke fuskantar barazanar kamuwa da cuta daga waje.Ganoderma lucidumna iya ƙara matakin kariya na hanji ta hanyar inganta siginar IgA, kuma wannan tasirin ya yi daidai da kashi naGanoderma lucidum.

TasirinGanoderma luciduma kan fitar da ƙwayoyin rigakafi ta ƙwayoyin lymph na ƙananan hanji (Patches Peyer)

[Lura] "-" a ƙasan ginshiƙi na nufin "ba a haɗa shi ba", kuma "+" yana nufin "an haɗa".LPS ya fito ne daga Escherichia coli, kuma maida hankali da aka yi amfani da shi a cikin gwajin shine 100μg / ml;Ganoderma lucidumda aka yi amfani da shi a cikin gwajin shine dakatarwar da aka yi da bushewar Reishi naman kaza mai 'ya'yan itace na jiki foda da saline na jiki, kuma gwajin gwajin shine 0.5, 1, da 5 mg / kg, bi da bi.(Madogararsa/J Ethnopharmacol. 2017 Dec 14; 214:240-243.)

Ganoderma lucidumyawanci kuma yana inganta matakan kariya

Wata muhimmiyar rawa a gaba na rigakafi na hanji shine "defensin", wanda shine kwayoyin sunadarai da kwayoyin Paneth suka ɓoye a cikin ƙananan hanji epithelium.Kadan kaɗan na defensin zai iya hana ko kashe ƙwayoyin cuta, fungi da wasu nau'ikan ƙwayoyin cuta.

Kwayoyin Paneth sun fi mayar da hankali a cikin ileum (rabin na biyu na ƙananan hanji).Dangane da gwajin dabba na binciken, idan babu haɓakar LPS, an gudanar da berayen cikin ciki.Ganoderma lucidum(a kashi na 0.5, 1, 5 MG a kowace kilogiram na nauyin jiki) na tsawon sa'o'i 24, matakan maganganun kwayoyin halitta na defensin-5 da defensin-6 a cikin ileum za su karu tare da karuwa.Ganoderma lucidumkashi, kuma sun fi matakan magana lokacin da LPS ta motsa shi (kamar yadda aka nuna a hoton da ke ƙasa).

Babu shakka, ko da a lokutan zaman lafiya lokacin da babu barazanar ƙwayoyin cuta.Ganoderma lucidumzai kiyaye kariya a cikin hanji cikin yanayin shirye-shiryen yaki don amsa gaggawa a kowane lokaci.

Matakan bayyanar cututtuka na kariya da aka auna a cikin bera ileum (banshi na ƙarshe da mafi tsayi na ƙananan hanji)

Ganoderma lucidumbaya haifar da kumburi da yawa

Domin fayyace hanyar daGanoderma lucidumyana kunna rigakafi, masu binciken sun mayar da hankali kan aikin TLR4.TLR4 mai karɓa ne akan ƙwayoyin rigakafi wanda zai iya gano mahara na kasashen waje (irin su LPS), kunna kwayoyin da ke aikawa da sako a cikin ƙwayoyin rigakafi, da kuma sa ƙwayoyin rigakafi su amsa.

Gwajin ya gano cewa koGanoderma lucidumyana haɓaka ɓoyewar ƙwayoyin rigakafi na IgA ko haɓaka matakan maganganun kwayoyin halitta na defensins yana da alaƙa da kunna masu karɓar TLR4 - masu karɓar TLR4 sune maɓalli donGanoderma lucidumdon haɓaka rigakafi na hanji.

Ko da yake kunna TLR4 zai iya inganta rigakafi, fiye da kunna TLR4 zai haifar da ƙwayoyin rigakafi don ci gaba da ɓoye TNF-a (factor necrosis factor), haifar da kumburi mai yawa da kuma haifar da barazanar lafiya.Sabili da haka, masu binciken sun kuma gwada matakan TNF-α a cikin ƙananan hanji na berayen.

An gano cewa maganganun TNF-α da matakan ɓoyewa a cikin sassan gaba da na baya na ƙananan hanji (jejunum da ileum) da kuma a cikin peyer's patches a kan bangon hanji na berayen ba a ƙara girma ba lokacin da aka ba da izini.Ganoderma luciduman gudanar da shi (kamar yadda aka nuna a cikin hoton da ke ƙasa), da kuma yawan allurai naGanoderma lucidumzai iya ma hana TNF-a.

TheGanoderma lucidumAbubuwan da aka yi amfani da su a cikin gwaje-gwajen da ke sama duk an shirya su ta hanyar niƙa busassunGanoderma lucidum'ya'yan itace a cikin lafiya foda da kuma ƙara physiological Saline.Masu binciken sun ce sabodaGanoderma lucidumAn yi amfani da shi a cikin gwajin ya ƙunshi ganoderic acid A, kuma binciken da aka yi a baya ya nuna cewa ganoderic acid A zai iya hana kumburi, sun yi hasashe cewa a cikin tsarin inganta rigakafi na hanji ta hanyar.Ganoderma lucidumpolysaccharides, ganoderic acid A na iya taka rawar daidaitawa a daidai lokacin.

Maganar kwayar halittar TNF-α da aka auna a sassa daban-daban na ƙananan hanjin berayen

[Madogararsa] Kubota A, et al.Reishi naman kaza Ganoderma lucidum yana daidaita samar da IgA da furcin alpha-defensin a cikin ƙananan hanji..J Ethnopharmacol.2018 Maris 25; 214: 240-243.

KARSHE

Game da marubucin / Ms. Wu Tingyao

Wu Tingyao ta kasance tana ba da rahoto game da bayanan Ganoderma na farko tun 1999. Ita ce marubucin labarun Ganoderma.Waraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).

★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin.
★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin marubuci ba.
★ Don keta bayanin da ke sama, marubucin zai bi alhakin da ya dace na shari'a.
★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.