Januwari 13, 2017 / Fujian Medical University, University of Arizona, njll. / “Oncotarget”

Umbhalo/Wu Tingyao

Iziguli eziningi ezinomdlavuza eziye zabhekana nobunzima obungachazeki ekwelapheni ziyazibuza ukuthi kungani isimila ezinomuzwa wokuthi “seselaphekile” sizophinde siqale kabusha ngemva kokuthula isikhathi eside.I-crux ilele kumaseli omdlavuza.

Lapho kubhekene nokuhlaselwa kwezidakamizwa okuningi, amanye ama-stem cell cell azongena endaweni ethule futhi amise ukuhlukana kwamaseli ukuze asinde.Lesi ngesinye sezizathu zokuthi kungani izidakamizwa “ezihlasela amangqamuzana akhula ngokushesha njengalokho okuhlosiwe” zingakwazi ukubulala leli qembu lamaseli esiqu sesimila.Izimila eziyingozi zishiya ngemuva “kwembewu” ukuze zithole ithuba lokulwa futhi ngolunye usuku.

Ngakho-ke, inqobo nje uma leli qembu lama-stem cell cell alele lingavuswa futhi livunyelwe ukuthi liphinde lingene esimweni sokwanda okusheshayo, kunethuba lokuwabulala ngezidakamizwa ezikhona.

Ithimba eliholwa nguSolwazi Jian-Hua Xu ovela eKolishi Lekhemisi laseFujian Medical University kanye neNyuvesi yase-Arizona lishicilele ngokuhlanganyela ucwaningo nge-“Oncotarget” ngoJanuwari 2017 liveza ukuthi.I-Ganoderma lucidum(I-Lingzhi, i-Reishi mushroom) ama-sterol nama-triterpenes angadlala indima elwa nesimila ngokunciphisa ukujula kokuthula kwamaseli omdlavuza.

Abacwaningi bahlukanise izingxenye ezimbili zemvelo ezisebenzayo ku-ethanol ekhishweI-Ganoderma lucidumimizimba enezithelo: i-ergosterol peroxide ne-ganodermanondiol.

Ifomula yemolekyuli nesakhiwo samakhemikhali se-ergosterol peroxide ne-ganodermanondiol (Umthombo/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Izivivinyo zithole ukuthi azikwazi ukuvimbela kuphela ngempumelelo amangqamuzana omdlavuza anda ngokushesha futhi zinciphise izinga lokusinda kwawo kodwa futhi zenze amaseli athule, ahamba kancane ngamabhayisikili abe yi-apoptosis.Umphumela wabo we-cytotoxic ngokumelene nokwakamuva ungcono nakakhulu kunalowo we-chemotherapeutics njenge-Doxorubicin, i-Paclitaxel ne-Topotecan.

Kungani lokhu kwenzeka?Kuvele ukuthi i-molecule ye-Rb-E2F kumaseli athule izokwenziwa isebenze yilawa amabili.I-Ganoderma lucidumizingxenye.Kuwushintsho olunquma ukuthi iseli liyahlukana noma cha.Lapho umsebenzi wayo ukhula, isimo esithule seseli sizoshintsha sisuka ekujuleni siye ekujuleni ── Iseli libonakala lidonswa ebuthongweni obujulile bokuqala liye ebuthongweni obukhanyayo.Uma nje ikhuthazwa kancane, kulula ukuba "ivuswe" futhi ikhiqize ngamandla futhi (njengoba kuboniswe esithombeni esilandelayo).

KanjaniI-Ganoderma lucidumkwephula isimo sokungalali samaseli omdlavuza

Amaseli omdlavuza alele, ngemva kokwelashwa ngawoI-Ganoderma lucidumama-sterol noma ama-triterpenes, ukujula kwawo okuthule (ukumisa noma wehlise ijubane ukuhlukana kwamaseli) kuzoba ncane, futhi kulula ukubuyela esimweni sokwanda ngokushesha ngenxa yezisusa ezithile.Ngalesi sikhathi, kunzima ukubalekela ukuhlaselwa kwezidakamizwa eziqondise amaseli anda ngokushesha (Umthombo/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Ukuhlolwa kokwelapha amangqamuzana omdlavuza webele athule (MCF-7) namaseli webele avamile (MCF-10A) nge-ergosterol peroxide noma i-ganodermanondiol kubonise ukuthi kumthamo ofanayo (20 μg/mL), inani lamaseli omdlavuza webele othule lizokhethwa ngokukhethekile. ancishiswe ngesigamu uma kuqhathaniswa namaseli avamile (ngesikhathi esifushane kakhulu), okubonisa ukuthi isimo esithule samangqamuzana omdlavuza asizinzile njengaleso samangqamuzana avamile, ngakho lawa amabiliLingzhiizingxenye zizodabula i-blockade ngaphambili (njengoba kuboniswe ngezansi).

Umehluko emsebenzini phakathi kwamangqamuzana avamile nawomdlavuza

Isici esibaluleke kakhulu samangqamuzana omdlavuza ukuthi angakwazi ukwanda unomphela.Ngakho-ke, ngisho nasesigabeni esithule “sokwehlisa ijubane noma ukumisa ukuhlukana kwamangqamuzana”, ukujula okuthule kwamangqamuzana omdlavuza (njengoba kukhonjisiwe kwesokudla) kusekuncane kakhulu kunamaseli avamile (njengoba kukhonjisiwe kwesokunxele), ngakho-ke maningi. kalula ukuvuswa ebuthongweni byReishi amakhoweama-sterols nama-triterpenes.(Umthombo/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Sesiyakwazi lokhoI-Ganoderma lucidumama-polysaccharides angathuthukisa ukuzivikela ngenkathiI-Ganoderma lucidumama-triterpenes angavimbela ukwanda kwamaseli e-tumor.Imiphumela yalolu cwaningo ikhombisa lokhoI-Ganoderma lucidumsterols kanyeI-Ganoderma lucidumama-triterpenes angakwazi futhi ukusebenzisa amangqamuzana e-tumor alele (imvamisa ama-tumor stem cell), esiza i-chemotherapeutics iqede amangqamuzana e-tumor futhi inciphise ithuba lokuphindaphinda kwesimila.

KanjaloI-Ganoderma lucidumukuthembela engxenyeni eyodwa kuphela esebenzayo ukuvimbela izimila?I-Ganoderma lucidumngezingxenye eziphelele zingalwa nezimila ngendlela enezinhlangothi eziningi;kuphela indlela yokulwa nesimila enamacala amaningi enganciphisa ubungqabavu bamaseli wesimila.

[Umthombo] Dai J, et al.Ukuqedwa kwamaseli ahamba kancane ahamba kancane ngokunciphisa ukujula kwe-quiescence ngezinhlanganisela zemvelo ezihlanzwe ku-Ganoderma lucidum.I-Oncotarget.2017 Jan 13. doi: 10.18632/oncotarget.14634.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao
UWu Tingyao ubelokhu ebika ngolwazi lwe-Ganoderma lokuqala kusukela ngo-1999. Ungumbhali wencwadiUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali.★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali.★ Ngokuphulwa kwesitatimende esingenhla, umbhali uzolandela izibopho ezingokomthetho ezifanele.★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.