Lub Ib Hlis 13, 2017 / Fujian Medical University, University of Arizona, thiab lwm yam. / "Oncotarget"

Text/Wu Tingyao

Ntau tus neeg mob qog noj ntshav uas tau dhau los ntawm kev nyuaj siab hauv kev kho mob xav tsis thoob vim li cas cov qog nqaij hlav uas lawv xav tias tau "kho" yuav rov qab zoo dua tom qab lub sijhawm ntev.Lub crux yog nyob rau hauv cov qog nqaij hlav cancer.

Nyob rau hauv lub ntsej muag ntawm ntau yam tshuaj tawm tsam, qee cov kab mob qog noj ntshav yuav nkag mus rau hauv lub xeev dormant thiab tso tseg cov cell faib kom muaj sia nyob.Qhov no yog ib qho ntawm cov laj thawj vim li cas cov tshuaj "sib ntaus sib tua sai sai li lub hom phiaj" tsis tuaj yeem tua cov kab mob qog no.Malignant hlav tawm tom qab ib qho kev rov tshwm sim ntawm "cov noob" tsuas yog nrhiav txoj hauv kev los tawm tsam ib hnub.

Yog li ntawd, ntev npaum li cov pab pawg ntawm cov qog hlwb dormant tuaj yeem "tsim" thiab tso cai rau rov nkag mus rau lub xeev kev loj hlob sai, muaj txoj hauv kev los tua lawv nrog cov tshuaj uas twb muaj lawm.

Ib pab neeg coj los ntawm xibfwb Jian-Hua Xu los ntawm Tsev Kawm Qib Siab Pharmacy ntawm Fujian Medical University thiab University of Arizona koom ua ke luam tawm kev tshawb fawb ntawm "Oncotarget" thaum Lub Ib Hlis 2017 taw qhia tiasGanoderma lucidum(Lingzhi, Reishi nceb) sterols thiab triterpenes tuaj yeem ua lub luag haujlwm tiv thaiv qog los ntawm kev txo qis qhov tob ntawm cov qog nqaij hlav cancer.

Cov kws tshawb fawb tau cais ob lub ntuj tsim tawm los ntawm ethanol extract ntawmGanoderma lucidumTxiv hmab txiv ntoo lub cev: ergosterol peroxide thiab ganodermanondiol.

Molecular mis thiab tshuaj qauv ntawm ergosterol peroxide thiab ganodermanondiol (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Cov kev sim tau pom tias lawv tuaj yeem tsis tsuas yog cuam tshuam cov kab mob qog noj ntshav sai sai thiab txo lawv txoj sia nyob, tab sis kuj ua rau cov hlwb quiescent, qeeb-cycling hlwb rau apoptosis.Lawv cov nyhuv cytotoxic tawm tsam tom kawg yog qhov zoo dua li cov kws khomob xws li Doxorubicin, Paclitaxel thiab Topotecan.

Vim li cas qhov no tshwm sim?Nws hloov tawm hais tias Rb-E2F molecule nyob rau hauv lub quiescent hlwb yuav qhib tau los ntawm ob no.Ganoderma lucidumcov khoom.Nws yog qhov hloov pauv uas txiav txim siab seb lub cell faib los yog tsis.Thaum nws cov dej num nce, lub xeev quiescent ntawm lub cell yuav hloov los ntawm qhov tob mus rau ntiav ── Lub cell zoo li tau rub los ntawm qhov qub tob tob mus rau lub teeb pw tsaug zog.Tsuav nws tau txais kev txhawb zog me ntsis, nws yooj yim rau "sawv" thiab rov tsim dua tshiab (raws li qhia hauv daim duab hauv qab no).

Yuav ua li casGanoderma lucidumrhuav tshem lub xeev dormant ntawm cov qog nqaij hlav cancer

Dormant mob qog noj ntshav, tom qab kho nrogGanoderma lucidumsterols los yog triterpenes, lawv qhov tob quiescent (nres los yog qeeb ntawm cell division) yuav ua rau ntiav, thiab lawv yooj yim rov qab mus rau lub xeev ntawm kev loj hlob sai vim qee qhov stimuli.Lub sijhawm no, lawv nyuaj rau kev khiav tawm ntawm kev tawm tsam ntawm cov tshuaj uas lub hom phiaj proliferating sai sai (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Qhov kev sim ntawm kev kho cov qog nqaij hlav cancer mis quiescent (MCF-7) thiab lub mis ib txwm muaj (MCF-10A) nrog ergosterol peroxide lossis ganodermanondiol tau pom tias ntawm tib koob tshuaj (20 μg / mL), tus naj npawb ntawm cov qog nqaij hlav cancer mis quiescent yuav zoo dua. txo los ntawm ib nrab piv rau lub cev ib txwm muaj (hauv lub sijhawm luv luv), qhia tau hais tias lub xeev quiescent ntawm cov qog nqaij hlav qog nqaij hlav tsis ruaj khov li ntawm cov hlwb li qub, yog li ob qho no.Lingzhicov khoom yuav tawg los ntawm kev thaiv ua ntej (raws li qhia hauv qab no).

Qhov sib txawv ntawm kev ua haujlwm ntawm lub cev thiab cov qog nqaij hlav cancer

Qhov tseem ceeb tshaj plaws ntawm cov qog nqaij hlav cancer yog tias lawv tuaj yeem loj hlob mus ib txhis.Yog li ntawd, txawm nyob rau hauv lub quiescent theem ntawm "slow down los yog nres ntawm cell division", qhov quiescent qhov tob ntawm cov qog nqaij hlav cancer (raws li qhia nyob rau sab xis) tseem ntiav ntiav tshaj li cov cell li qub (raws li qhia nyob rau sab laug), yog li lawv muaj ntau dua. yooj yim kom sawv los ntawm dormancy los ntawmReishi ncebsterols thiab triterpenes.(Source/Oncotarget. 2017 Lub Ib Hlis 13. doi: 10.18632/oncotarget.14634.)

Peb twb paub lawmGanoderma lucidumpolysaccharides tuaj yeem txhim kho kev tiv thaiv thaum lub sijhawmGanoderma lucidumtriterpenes tuaj yeem cuam tshuam cov qog cell proliferation.Cov txiaj ntsig ntawm kev tshawb fawb no qhia tau tiasGanoderma lucidumsterols thiabGanoderma lucidumtriterpenes kuj tseem tuaj yeem qhib cov qog hlwb (feem ntau cov qog qog hlwb), uas pab cov kws khomob khomob tshem tawm cov qog hlwb thiab txo cov qog nqaij hlav.

Yog li ntawdGanoderma lucidumcia siab rau tsuas yog ib qho active tivthaiv los inhibit qog?Ganoderma lucidumnrog cov khoom tiav tuaj yeem tua cov qog hauv ntau txoj kev;tsuas yog txoj kev tiv thaiv kab mob ntau yam tuaj yeem txo qhov tseem ceeb ntawm cov qog hlwb.

[Source] Dai J, et al.Kev tshem tawm ntawm quiescent qeeb-cycling hlwb los ntawm kev txo qis quiescence qhov tob los ntawm natural compounds purified los ntawm Ganoderma lucidum.Oncotarget.2017 Jan 13. doi: 10.18632/oncotarget.14634.

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Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma thawj zaug txij li xyoo 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).
 
★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau.★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai los ntawm tus sau.★ Rau kev ua txhaum ntawm cov lus hais saum toj no, tus sau yuav ua raws li cov luag haujlwm raug cai.★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.