January 13, 2017 / Fujian Medical University, University of Arizona, etc. / "Oncotarget"

Mawu/Wu Tingyao

Odwala khansa ambiri omwe adakumana ndi zovuta zosaneneka pakulandira chithandizo akudabwa chifukwa chake chotupa chomwe akuwona kuti "chachira" chidzayambiranso pambuyo pakukhala chete kwa nthawi yayitali.Crux ili m'maselo a khansa.

Poyang'anizana ndi zovuta zambiri za mankhwala, maselo ena a khansa amatha kulowa m'malo osagona ndikuyimitsa magawano a cell kuti apulumuke.Ichi ndi chimodzi mwa zifukwa zomwe mankhwala omwe "amaukira maselo omwe akuchulukirachulukira monga chandamale" sangathe kupha gulu ili la maselo otupa.Zotupa zowopsa zimasiya kuyambiranso kwa "mbewu" kuti apeze mwayi womenyananso tsiku lina.

Choncho, malinga ngati gulu ili la maselo ogona chotupa tsinde akhoza "kudzutsidwa" ndi kuloledwa kulowanso mofulumira kugawikana boma kuchulukana, pali mwayi kuwapha ndi mankhwala alipo.

Gulu lotsogozedwa ndi Pulofesa Jian-Hua Xu wochokera ku College of Pharmacy ya Fujian Medical University ndi University of Arizona pamodzi adafalitsa kafukufuku pa "Oncotarget" mu Januwale 2017 akunena kuti.Ganoderma lucidum(Lingzhi, bowa wa Reishi) ma sterols ndi triterpenes amatha kutenga gawo lodana ndi chotupa pochepetsa kuya kwa ma cell a khansa.

Ofufuzawo anapatula zigawo ziwiri zachilengedwe zogwira ntchito kuchokera ku ethanol Tingafinye waGanoderma lucidummatupi a zipatso: ergosterol peroxide ndi ganodermanondiol.

Mapangidwe a maselo a ergosterol peroxide ndi ganodermanondiol (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Zoyeserera zapeza kuti sangalepheretse maselo a khansa omwe akuchulukirachulukira komanso kuchepetsa kupulumuka kwawo komanso kulimbikitsa ma cell omwe amayenda pang'onopang'ono kukhala apoptosis.Mphamvu yawo ya cytotoxic motsutsana ndi yotsirizirayi ndiyabwinoko kuposa yamankhwala a chemotherapeutics monga Doxorubicin, Paclitaxel ndi Topotecan.

N’chifukwa chiyani zimenezi zinachitika?Zikuoneka kuti mamolekyu a Rb-E2F m'maselo opanda phokoso adzatsegulidwa ndi awiriwa.Ganoderma lucidumzigawo.Ndi kusintha komwe kumatsimikizira ngati selo ligawanika kapena ayi.Ntchito yake ikawonjezeka, malo opanda phokoso a selo adzasintha kuchokera kukuya mpaka osaya ── Selo likuwoneka kuti likukokedwa kuchokera ku tulo tambirimbiri tomwe tinkagona.Malingana ngati zimalimbikitsidwa pang'ono, zimakhala zosavuta "kudzutsidwa" ndikuberekanso mwamphamvu (monga momwe tawonetsera m'chithunzi chotsatira).

BwanjiGanoderma lucidumimaphwanya malo ogona a maselo a khansa

Maselo a khansa ogona, atachiritsidwaGanoderma lucidumma sterols kapena triterpenes, kuya kwawo kwapang'onopang'ono (kusiya kapena kuchepetsa kugawanika kwa maselo) kudzakhala kozama, ndipo n'kosavuta kubwerera ku chikhalidwe chofulumira chifukwa cha zokopa zina.Panthawiyi, zimakhala zovuta kuthawa mankhwala omwe amalimbana ndi maselo omwe akuchulukirachulukira (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Kuyesera pochiza ma cell a khansa ya m'mawere (MCF-7) ndi ma cell am'mawere abwinobwino (MCF-10A) ndi ergosterol peroxide kapena ganodermanondiol adawonetsa kuti pamlingo womwewo (20 μg/mL), kuchuluka kwa ma cell a khansa ya m'mawere kumakhala koyenera. kuchepetsedwa ndi theka poyerekeza ndi maselo abwinobwino (m'kanthawi kochepa), kusonyeza kuti kusakhazikika kwa maselo a khansa sikokhazikika ngati maselo abwinobwino, kotero awiriwa.Lingzhizigawo zidzadutsa blockade kale (monga tawonetsera pansipa).

Kusiyana kwa ntchito pakati pa maselo abwinobwino ndi khansa

Chofunikira kwambiri cha maselo a khansa ndikuti amatha kuchulukana mpaka kalekale.Chifukwa chake, ngakhale mu gawo laling'ono la "kuchedwetsa kapena kuyimitsa kugawikana kwa ma cell", kuya kwapang'onopang'ono kwa maselo a khansa (monga momwe kumanja kusonyezera) kumakhalabe kozama kuposa kwa maselo abwinobwino (monga kumanzere), kotero amakhala ochulukirapo. mosavuta kudzutsidwa ku dormancy ndiReishi bowasterols ndi triterpenes.(Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Ife tikudziwa kale zimenezoGanoderma lucidumma polysaccharides amatha kuwonjezera chitetezo chokwaniraGanoderma lucidumtriterpenes imatha kuletsa kuchuluka kwa maselo a chotupa.Zotsatira za kafukufukuyu zikusonyeza kutiGanoderma lucidumsterols ndiGanoderma lucidumma triterpenes amathanso kuyambitsa ma cell chotupa ogona (nthawi zambiri ma cell tsinde), omwe amathandiza chemotherapeutics kuchotsa ma cell chotupa ndikuchepetsa mwayi wobwereranso.

MomwemonsoGanoderma lucidumkudalira chinthu chimodzi chokha chogwira ntchito kuti chilepheretse zotupa?Ganoderma lucidumndi zigawo wathunthu akhoza kulimbana zotupa mu njira Mipikisano pronged;njira yokhayo yolimbana ndi chotupa yomwe ingachepetse mphamvu zama cell chotupa.

[Source] Dai J, et al.Kuchotsa ma cell oyenda pang'onopang'ono pochepetsa kuya kwa quiescence ndi zinthu zachilengedwe zoyeretsedwa kuchokera ku Ganoderma lucidum.Oncotarget.2017 Jan 13. doi: 10.18632 / oncotarget.14634.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.