Janairu 13, 2017 / Jami'ar Kiwon Lafiya ta Fujian, Jami'ar Arizona, da sauransu / "Oncotarget"

Rubutu/Wu Tingyao

Yawancin masu fama da cutar kansa da suka sha wahala da yawa a cikin jiyya suna mamakin dalilin da yasa wani ƙari da suke jin an “warke” zai sake komawa bayan dogon shiru.Ƙunƙarar ta ta'allaka ne a cikin ƙwayoyin cutar kansa.

A cikin fuskantar hare-haren miyagun ƙwayoyi da yawa, wasu ƙwayoyin cutar kansa za su shiga cikin yanayin barci kuma su dakatar da rarrabuwa don tsira.Wannan shi ne daya daga cikin dalilan da ya sa magungunan da ke "kai hari da sauri da yaduwa a matsayin hari" ba za su iya kashe wannan rukuni na ƙwayoyin cuta ba.Ciwace-ciwacen ciwace-ciwace suna barin sake dawowar “tsabo” kawai don samun damar sake yin yaƙi wata rana.

Sabili da haka, muddin wannan rukunin na ƙwararrun ƙwayoyin cuta na iya zama "farkawa" kuma ana ba da damar sake shigar da su da magungunan da ke ƙasa.

Wata tawaga karkashin jagorancin Farfesa Jian-Hua Xu daga kwalejin harhada magunguna ta jami'ar kiwon lafiya ta Fujian da jami'ar Arizona sun buga wani bincike a kan "Oncotarget" a cikin watan Janairun 2017 tare da nuna cewa.Ganoderma lucidum(Lingzhi, Reishi naman kaza) sterols da triterpenes na iya taka rawar anti-tumor ta hanyar rage zurfin zurfin ƙwayoyin cutar kansa.

Masu binciken sun ware abubuwa biyu masu aiki na halitta daga tsantsar ethanol naGanoderma lucidumJikunan 'ya'yan itace: ergosterol peroxide da ganodermanondiol.

Tsarin kwayoyin halitta da tsarin sinadarai na ergosterol peroxide da ganodermanondiol (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Gwaje-gwaje sun gano cewa ba wai kawai ba za su iya hana ƙwayoyin cutar daji masu saurin yaɗuwa cikin sauri ba da kuma rage yawan rayuwarsu amma kuma su haifar da jinkirin sel zuwa apoptosis.Tasirinsu na cytotoxic akan na karshen ya fi na chemotherapeutics kamar Doxorubicin, Paclitaxel da Topotecan.

Me yasa hakan ya faru?Ya bayyana cewa kwayoyin Rb-E2F a cikin ƙwayoyin quiescent za a kunna su ta waɗannan biyun.Ganoderma lucidumaka gyara.Sauyawa ce da ke tantance ko tantanin halitta ya raba ko a'a.Lokacin da aikinsa ya ƙaru, yanayin tantanin halitta zai canza daga zurfi zuwa zurfi ─ ─ Tantanin halitta kamar an cire shi daga ainihin barci mai zurfi zuwa barci mai haske.Muddin ya ɗan motsa shi, yana da sauƙi a “tashi” kuma a sake haifuwa da ƙarfi (kamar yadda aka nuna a adadi mai zuwa).

YayaGanoderma lucidumyana karya yanayin barcin kwayoyin cutar kansa

Kwayoyin ciwon daji na barci, bayan an yi musu maganiGanoderma lucidumsterols ko triterpenes, zurfin zurfafawar su (tsayawa ko rage rarrabuwar tantanin halitta) zai zama mai zurfi, kuma suna da sauƙin komawa cikin yanayin haɓaka cikin sauri saboda wasu abubuwan motsa jiki.A wannan lokacin, suna da wuyar tserewa harin kwayoyi waɗanda ke kaiwa ga ƙwayoyin ƙwayoyin cuta da sauri (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Gwajin maganin ciwon daji na nono (MCF-7) da ƙwayoyin nono na al'ada (MCF-10A) tare da ergosterol peroxide ko ganodermanondiol ya nuna cewa a daidai wannan kashi (20 μg / mL), adadin ƙwayoyin ciwon daji na nono zai fi dacewa. raguwa da rabi idan aka kwatanta da kwayoyin halitta na yau da kullum (a cikin ɗan gajeren lokaci), yana nuna cewa yanayin yanayin ciwon daji ba shi da kwanciyar hankali kamar na kwayoyin halitta, don haka waɗannan biyun.Lingzhiabubuwan da aka gyara zasu karya ta hanyar toshewa a baya (kamar yadda aka nuna a kasa).

Bambanci a cikin aiki tsakanin al'ada da kwayoyin cutar kansa

Mafi mahimmancin fasalin ƙwayoyin kansa shine cewa zasu iya yaduwa har abada.Sabili da haka, ko da a cikin matakin quiescent na "hannun raguwa ko dakatar da rarrabawar kwayar halitta", zurfin zurfin ƙwayoyin ciwon daji (kamar yadda aka nuna a hannun dama) har yanzu yana da zurfi fiye da na kwayoyin halitta (kamar yadda aka nuna a hagu), don haka sun fi yawa. cikin sauki a tashe shi daga barci taReishi naman kazasterols da triterpenes.(Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Mun riga mun san hakaGanoderma lucidumpolysaccharides na iya inganta rigakafi yayin daGanoderma lucidumtriterpenes na iya hana yaduwar kwayar cutar tumo.Sakamakon wannan bincike ya nuna cewaGanoderma lucidumsterols kumaGanoderma lucidumtriterpenes kuma na iya kunna ƙwayoyin tumor da ke kwance (yawanci ƙwayoyin ƙwayar ƙwayar cuta), wanda ke taimakawa chemotherapeutics kawar da ƙwayoyin tumo da rage damar sake dawowa.

Haka maGanoderma lucidumdogara ga wani sashi mai aiki kawai don hana ciwace-ciwacen daji?Ganoderma lucidumtare da cikakkun abubuwan da aka gyara na iya yaki da ciwace-ciwacen daji ta hanyoyi da yawa;kawai hanyar anti-tumor mai nau'i-nau'i da yawa za ta iya rage ƙarfin ƙwayoyin tumor.

[Source] Dai J, et al.Kawar da sel jinkirin hawan keke ta hanyar rage zurfin zurfafawa ta mahalli na halitta waɗanda aka tsarkake daga Ganoderma lucidum.Oncotarget.2017 Jan 13. doi: 10.18632/oncotarget.14634.

KARSHE

Game da marubucin / Ms. Wu Tingyao
Wu Tingyao ta kasance tana ba da rahoto game da bayanan Ganoderma na farko tun 1999. Ita ce marubucin labarun Ganoderma.Waraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).
 
★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin.★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin marubuci ba.★ Don keta bayanin da ke sama, marubucin zai bi alhakin da ya dace na shari'a.★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.