January 13, 2017 / Fujian Medical University, Univesithi ea Arizona, joalo-joalo / "Oncotarget"

Mongolo/Wu Tingyao

Bakuli ba bangata ba mofetše ba fetileng mathateng a mangata a ho phekoloa baa ipotsa hore na ke hobane’ng ha hlahala eo ba ikutloang hore e “phekolehile” e tla khutla hape ka mor’a ho khutsa ha nako e telele.Crux e ka har'a lisele tsa mofetše.

Ha ho tobane le litlhaselo tse ngata tsa lithethefatsi, lisele tse ling tsa mofetše li tla kena sebakeng se khutsitseng ebe li emisa karohano ea lisele hore li phele.Lena ke le leng la mabaka a etsang hore lithethefatsi tse "hlasellang lisele tse atang ka potlako e le liphofu" li ke ke tsa bolaea sehlopha sena sa lisele tsa kutu ea hlahala.Lihlahala tse kotsi li siea "peo" e ncha ho fumana monyetla oa ho loana hape ka letsatsi le leng.

Ka hona, hafeela sehlopha sena sa lisele tsa stem tse robetseng li ka "tsosoa" 'me tsa lumelloa ho kena hape sebakeng sa ho ata ka potlako, ho na le monyetla oa ho li bolaea ka lithethefatsi tse teng.

Sehlopha se etelletsoeng pele ke Moprofesa Jian-Hua Xu oa Koleche ea Pharmacy ea Fujian Medical University le Univesithi ea Arizona ka kopanelo e phatlalalitse thuto ka "Oncotarget" ka Pherekhong 2017 e supang hore.Ganoderma lucidum(Lingzhi, Reishi mushroom) li-sterol le li-triterpenes li ka bapala karolo e khahlanong le hlahala ka ho fokotsa botebo ba lisele tsa mofetše.

Bafuputsi ba khethile likarolo tse peli tsa tlhaho tse sebetsang ho tsoa ho qotsulo ea ethanol eaGanoderma lucidum'mele oa litholoana: ergosterol peroxide le ganodermanondiol.

Foromo ea molek'hule le sebopeho sa lik'hemik'hale tsa ergosterol peroxide le ganodermanondiol (Mohloli/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Liteko li fumane hore ha li khone ho thibela feela lisele tsa mofetše tse ntseng li ata ka potlako le ho fokotsa sekhahla sa ho phela empa hape li hohela lisele tse khutsitseng, tse tsamaeang butle ho apoptosis.Tšusumetso ea bona ea cytotoxic khahlano le ea morao-rao e betere ho feta ea chemotherapeutics e kang Doxorubicin, Paclitaxel le Topotecan.

Ke hobane’ng ha see se etsahetse?Hoa fumaneha hore molek'hule ea Rb-E2F e liseleng tse khutsitseng e tla kengoa tšebetsong ke tsena tse peli.Ganoderma lucidumdikarolo.Ke switjha e etsang qeto ea hore na sele ea arohana kapa che.Ha ts'ebetso ea eona e ntse e eketseha, boemo bo khutsitseng ba sele bo tla fetoha ho tloha botebong ho ea bolibeng ── Ho bonahala eka sele e huloa ho tloha boroko bo tebileng ba pele ho ea boroko bo bobebe.Hafeela e ntse e tsosoa hanyenyane, ho bonolo ho "tsosoa" le ho ikatisa ka matla hape (joalokaha ho bontšitsoe setšoantšong se latelang).

JoangGanoderma lucidume senya boemo ba ho robala ba lisele tsa mofetše

Lisele tsa mofets'e tse robetseng, kamora ho phekoloaGanoderma lucidumli-sterols kapa triterpenes, botebo ba tsona bo khutsitseng (ho emisa kapa ho liehisa karohano ea lisele) bo tla fokotseha, 'me ho bonolo ho khutlela boemong ba ho ata ka potlako ka lebaka la lintho tse ling tse susumetsang.Ka nako ena, ba thatafalloa ke ho phonyoha tlhaselo ea lithethefatsi tse lebisang liseleng tse ntseng li ata ka potlako (Mohloli/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Teko ea ho phekola lisele tsa mofetše oa matsoele (MCF-7) le lisele tse tloaelehileng tsa matsoele (MCF-10A) ka ergosterol peroxide kapa ganodermanondiol e bonts'itse hore ka tekanyo e ts'oanang (20 μg/mL), palo ea lisele tse khutsitseng tsa mofetše oa matsoele e tla khethoa ka ho khetheha. e fokotsehile ka halofo ha e bapisoa le lisele tse tloaelehileng (ka nako e batlang e le khutšoanyane), e leng se bontšang hore boemo bo khutsitseng ba lisele tsa kankere ha boa tsitsa joaloka lisele tse tloaelehileng, kahoo tsena tse peliLingzhilikarolo li tla phunyeletsa ho thibela pele (joalokaha ho bontšitsoe ka tlase).

Phapang ea ts'ebetso lipakeng tsa lisele tse tloaelehileng le tsa mofetše

Ntho ea bohlokoa ka ho fetisisa ea lisele tsa kankere ke hore li ka ata ka ho sa feleng.Ka hona, le mokhahlelong o khutsitseng oa "ho fokotsa kapa ho emisa karohano ea lisele", botebo bo khutsitseng ba lisele tsa mofetše (joalo ka ha ho bonts'itsoe ka ho le letona) bo ntse bo sa teba ho feta ba lisele tse tloaelehileng (joalokaha ho bontšitsoe ka letsohong le letšehali), kahoo li ngata haholo. ho tsosoa ha bonolo ho tloha borokong kaReishi li-mushroomsterols le triterpenes.(Mohloli/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Re se re ntse re tseba seoGanoderma lucidumli-polysaccharides li ka matlafatsa sesole sa 'meleGanoderma lucidumtriterpenes e ka thibela ho ata ha lisele tsa tumor.Liphello tsa lipatlisiso tsena li bontša horeGanoderma lucidumsterols leGanoderma lucidumtriterpenes e ka boela ea kenya lisele tsa hlahala tse robetseng (hangata li-tumor stem cell), tse thusang khemotherapeutics ho felisa lisele tsa hlahala le ho fokotsa monyetla oa ho khutla hape.

Ho joalo le ka eenaGanoderma lucidumho itšetleha ka karolo e le 'ngoe feela e sebetsang ho thibela lihlahala?Ganoderma lucidumka likarolo tse feletseng li ka loantša lihlahala ka mekhoa e mengata;ke feela mekhoa e mengata ea anti-tumor e ka fokotsang matla a lisele tsa hlahala.

[Mohloli] Dai J, et al.Ho felisoa ha lisele tse tsamaeang butle tse tsamaeang butle ka ho fokotsa botebo ba khutso ka metsoako ea tlhaho e hloekisitsoeng ho tsoa ho Ganoderma lucidum.Oncotarget.2017 Jan 13. doi: 10.18632/oncotarget.14634.

QETA

Mabapi le mongoli/ Mme Wu Tingyao
Wu Tingyao esale a tlaleha ka litaba tsa Ganoderma tsa pele ho tloha 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).
 
★ Sengoliloeng sena se hatisitsoe tlas'a tumello e khethehileng ea mongoli.★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli.★ Bakeng sa tlōlo ea polelo e ka holimo, mongoli o tla phehella boikarabelo bo nepahetseng ba molao.★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Wu Tingyao mme se fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.