Ianuali 13, 2017 / Fujian Medical University, ke Kulanui o Arizona, etc. / "Oncotarget"

Text/Wu Tingyao

He nui nā poʻe maʻi maʻi maʻi i hele i loko o nā pilikia nui ʻole i ka mālama ʻana e noʻonoʻo nei i ke kumu e hoʻihoʻi hou ai ka maʻi maʻi a lākou i manaʻo ai ua "hoʻōla ʻia" ma hope o ka manawa lōʻihi o ka noho mālie.Aia ka crux i loko o nā pūnana maʻi kanesa.

I ke alo o ka nui o ka hoʻouka ʻana i nā lāʻau lapaʻau, e komo kekahi mau pūnana maʻi maʻi ʻaʻai i kahi noho moe a hoʻopau i ka mahele cell i mea e ola ai.ʻO kēia kekahi o nā kumu i hiki ʻole ai i nā lāʻau "hoʻouka wikiwiki i nā cell proliferating e like me nā pahuhopu" ʻaʻole hiki ke pepehi i kēia pūʻulu o nā pūnaewele tumo.Ke waiho nei nā maʻi maʻi ʻino i ke ala hou ʻana o nā "hua" wale nō e loaʻa kahi manawa e hakakā hou ai i kekahi lā.

No laila, i ka wā e hiki ai ke "ho'ala'ia" kēia pū'ulu o nā pu'upu'u pu'upu'u moe moe a 'ae'ia e komo hou i kahi moku'āina ho'olaha wikiwiki, aia ka manawa e pepehi ai iā lākou me nā lā'au lapa'au.

ʻO kahi hui i alakaʻi ʻia e Professor Jian-Hua Xu mai ke Kulanui o Pharmacy o Fujian Medical University a me ke Kulanui o Arizona i hoʻopuka pū i kahi noiʻi ma "Oncotarget" ma Ianuali 2017 e kuhikuhi ana i kēlā.ʻO Ganoderma lucidum(Lingzhi, Reishi mushroom) hiki i nā sterols a me nā triterpenes ke pāʻani i ka hana anti-tumor ma o ka hoʻemi ʻana i ka hohonu o ka maʻi kanesa.

Ua hoʻokaʻawale nā ​​mea noiʻi i ʻelua mau mea hana maoli mai ka ethanol extract oʻO Ganoderma lucidumnā kino hua: ergosterol peroxide a me ganodermanondiol.

Molecular formula and chemical structure of ergosterol peroxide and ganodermanondiol (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Ua ʻike nā hoʻokolohua ʻaʻole hiki iā lākou ke pale wale i ka hoʻomāhuahua wikiwiki ʻana o nā maʻi maʻi maʻi a hoʻemi i ko lākou ola ola akā hoʻoulu pū kekahi i nā cell quiescent, lohi-paikikala i apoptosis.ʻOi aku ka maikaʻi o kā lākou hopena cytotoxic ma mua o ka chemotherapeutics e like me Doxorubicin, Paclitaxel a me Topotecan.

No ke aha i hana ai kēia?ʻIke ʻia e hoʻāla ʻia ka mole Rb-E2F i loko o nā keena kuʻi e kēia mau mea ʻelua.ʻO Ganoderma lucidumʻāpana.He hoʻololi ia e hoʻoholo ai i ka māhele ʻana a i ʻole ka puʻunaue.Ke piʻi aʻe kāna hana, e hoʻololi ʻia ka noho mālie o ke kelepona mai ka hohonu a i ka pāpaʻu.ʻOiai e hoʻoulu iki ʻia, maʻalahi ke "ala ʻia" a hana hou me ka ikaika (e like me ka mea i hōʻike ʻia ma ke kiʻi aʻe).

PeheaʻO Ganoderma lucidumwawahi i ka noho moe ana o na ma'i ma'i

ʻO nā maʻi kanesa moe, ma hope o ka mālama ʻia ʻana meʻO Ganoderma lucidumsterols a i ʻole triterpenes, ʻoi aku ka pāpaʻu o ko lākou hohonu mālie (hoʻokuʻu a hoʻolohi paha i ka mahele cell), a maʻalahi lākou e hoʻi i kahi kūlana o ka ulu wikiwiki ʻana ma muli o kekahi mau mea hoʻoulu.I kēia manawa, paʻakikī lākou e pakele i ka hoʻouka ʻana o nā lāʻau lapaʻau e kuhikuhi ana i nā cell proliferating wikiwiki (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

ʻO ka hoʻokolohua o ka mālama ʻana i nā maʻi maʻi maʻi umauma quiescent (MCF-7) a me nā pūpū umauma maʻamau (MCF-10A) me ka ergosterol peroxide a i ʻole ganodermanondiol i hōʻike ʻia ma ka nui like (20 μg/mL), e ʻoi aku ka maikaʻi o ka nui o nā maʻi maʻi umauma quiescent. hoemiia e ka hapalua i ka hoohalikeia me na keena ma'amau (i loko o ka manawa pokole loa), e hoike ana i ka noho malie ana o na ma'i ma'i 'a'ole i pa'a e like me ko na mea ma'amau.Lingzhie haki nā mea i ka poloka ma mua (e like me ka mea i hōʻike ʻia ma lalo nei).

ʻO ka ʻokoʻa o ka hana ma waena o nā maʻi maʻamau a me nā maʻi kanesa

ʻO ka hiʻohiʻona koʻikoʻi o nā maʻi maʻi maʻi ʻo ia ka hiki ke hoʻonui mau loa.No laila, ʻoiai i ka wā mālie o ka "hoʻolohi a hoʻōki paha i ka hoʻokaʻawale cell", ʻoi aku ka pāpaʻu o ka hohonu mālie o nā maʻi maʻi maʻi (e like me ka hōʻike ʻana ma ka ʻākau) ma mua o nā cell maʻamau (e like me ka hōʻike ʻana ma ka hema), no laila ua ʻoi aku lākou. hiki wawe ke hoala ia mai ka hiamoe ana eʻO Reishi mushroomnā sterols a me nā triterpenes.(Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Ua ʻike mua mākou i kēlāʻO Ganoderma lucidumHiki i nā polysaccharides ke hoʻonui i ka palekana i ka wāʻO Ganoderma lucidumHiki i nā triterpenes ke pale i ka hoʻonui ʻana o nā cell tumor.Hōʻike nā hopena o kēia noiʻiʻO Ganoderma lucidumsterols a meʻO Ganoderma lucidumHiki i nā triterpenes ke hoʻoikaika i nā pūnaewele tumo moe (ʻo ia hoʻi nā pūnaewele maʻamau maʻamau), e kōkua ana i nā chemotherapeutics e hoʻopau i nā cell tumo a hōʻemi i ka manawa o ka hoʻi hou ʻana.

Pela noʻO Ganoderma lucidumhilinaʻi i hoʻokahi wale nō mea hana e pale ai i nā maʻi maʻi?ʻO Ganoderma lucidumme nā ʻāpana piha hiki ke hakakā i nā maʻi koko ma ke ʻano he nui;ʻO ke ala anti-tumor multi-pronged wale nō e hiki ke hoʻemi i ka ikaika o nā cell tumor.

[Puna] Dai J, et al.ʻO ka hoʻopau ʻia ʻana o nā pūnaewele lohi lohi ma o ka hōʻemi ʻana i ka hohonu quiescence e nā pūhui kūlohelohe i hoʻomaʻemaʻe ʻia mai Ganoderma lucidum.Oncotarget.2017 Jan 13. doi: 10.18632/oncotarget.14634.

HOPE

No ka mea kākau/ Ms. Wu Tingyao
Ua hōʻike ʻo Wu Tingyao i ka ʻike Ganoderma lima mua mai 1999. ʻO ia ka mea kākau oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).
 
★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau.★ ʻAʻole hiki ke paʻi hou ʻia nā hana i luna, ʻokiʻoki a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻia e ka mea kākau.★ No ka uhaki ʻana i ka ʻōlelo ma luna, e ʻimi ka mea kākau i nā kuleana pili kānāwai.★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.