Ndira 13, 2017 / Fujian Medical University, iyo University yeArizona, nezvimwewo / "Oncotarget"

Chinyorwa/Wu Tingyao

Varwere vazhinji vegomarara vakapfuura nemumatambudziko asingaverengeki mukurapwa vari kunetsekana kuti sei bundu ravanofunga kuti "rapora" richizotangazve mushure menguva refu yekunyarara.Iyo crux iri mugomarara stem masero.

Mukutarisana nekurwiswa kwezvinodhaka kwakawanda, mamwe masero egomarara anozopinda munzvimbo yakarara omisa kupatsanurwa kwesero kuti ararame.Ichi ndicho chimwe chezvikonzero nei mishonga "inorwisa masero ari kukurumidza kuwanda sevavariro" haigone kuuraya boka iri rebundu stem masero.Mamota akashata anosiya kumashure kwe "mbeu" chete kuti awane mukana wekurwa zvakare rimwe zuva.

Naizvozvo, chero bedzi boka iri remarara tumarara stem masero anogona "kumutswa" uye kubvumidzwa kupinda zvakare nekukurumidza-kupatsanura kupararira mamiriro, pane mukana wekuvauraya nemishonga iripo.

Chikwata chinotungamirwa naProfessor Jian-Hua Xu kubva kuCollege of Pharmacy yeFujian Medical University uye University of Arizona vakabatana vakaburitsa chidzidzo pa "Oncotarget" muna Ndira 2017 vachiratidza kuti.Ganoderma lucidum(Lingzhi, Reishi howa) sterols uye triterpenes zvinogona kuita basa rekurwisa bundu nekudzikisa kudzikama kwemaseru egomarara.

Vatsvakurudzi vakaparadzanisa zvinhu zviviri zvakasikwa zvinoshanda kubva kune ethanol yakatorwa yeGanoderma lucidumMitumbi inobereka michero: ergosterol peroxide uye ganodermanondiol.

Molecular formula uye chimiro chemakemikari eergosterol peroxide uye ganodermanondiol (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Ongororo dzakaona kuti hadzingogone kuvharidzira zvinokurumidza kuwedzera maseru egomarara uye kuderedza huwandu hwekurarama kwavo asiwo kukurudzira maseru akanyarara, anononoka-mabhasikoro kuti apoptosis.Yavo cytotoxic mhedzisiro inopesana neiyo yekupedzisira yakatonaka kupfuura iyo yechemotherapeutics yakadai seDoxorubicin, Paclitaxel uye Topotecan.

Sei izvi zvakaitika?Zvinoitika kuti iyo Rb-E2F molecule mumaseru akanyarara anozoitwa neaya maviri.Ganoderma lucidumzvikamu.Ishanduko inotara kuti sero rinopatsanurwa here kana kuti kwete.Kana basa rayo richiwedzera, runyararo rwesero ruchachinja kubva pakadzika kusvika pakadzika ── Sero rinoita serinodhonzwa kubva pakurara kwakadzika kwekutanga kusvika pakurara kwechiedza.Chero bedzi iyo inokurudzirwa zvishoma, zviri nyore "kumutswa" uye kubereka nesimba zvakare (sezvinoratidzwa mumufananidzo unotevera).

SeiGanoderma luciduminoputsa mamiriro ekurara emasero egomarara

Dormant cancer maseru, mushure mekurapwa nawoGanoderma lucidumsterols kana triterpenes, kudzika kwadzo kwakanyarara (kumisa kana kunonoka kupatsanurwa kwesero) kuchave kushoma, uye zviri nyore kudzoka kune mamiriro ekukurumidza kuwanda nekuda kwezvimwe zvinokurudzira.Panguva ino, zvakaoma kutiza kurwiswa kwezvinodhaka zvinonangana nemasero ari kukurumidza kuwanda (Source/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Kuedza kurapa maseru egomarara rezamu (MCF-7) uye masero emuzamu akajairwa (MCF-10A) neergosterol peroxide kana ganodermanondiol yakaratidza kuti padanho rimwe chete (20 μg/mL), huwandu hwemaseru egomarara rezamu akanyarara huchave hwakanyanya. yakaderedzwa nehafu kana ichienzaniswa neyakajairwa maseru (munguva pfupi pfupi), zvichiratidza kuti mamiriro ekunyarara kwemasero egomarara haana kugadzikana seaya emazuva ese, saka aya maviriLingzhizvikamu zvichapaza nepakati pekuvhara kare (sezvakaratidzwa pazasi).

Musiyano mukuita pakati peakajairwa uye cancer maseru

Chinhu chinonyanya kukosha chemasero egomarara ndechekuti anogona kuwanda nekusingaperi.Naizvozvo, kunyangwe munhanho yakanyarara ye "kudzikira kana kumisa kupatsanurwa kwesero", kudzika kwakadzikama kwemaseru egomarara (sezvinoratidzwa kurudyi) kuchiri kushoma pane kuya kwemaseru akajairwa (sezvinoratidzwa kuruboshwe), saka iwo akawanda. nyore kumutswa kubva mudormancy naReishi mushroomsterols uye triterpenes.(Kwakabva/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

TinotozvizivaGanoderma lucidumpolysaccharides inogona kuwedzera kusadzivirirwa panguvaGanoderma lucidumtriterpenes inogona kutadzisa bundu masero kuwanda.Migumisiro yetsvakurudzo iyi inoratidza izvozvoGanoderma lucidumsterols uyeGanoderma lucidumtriterpenes inogona zvakare kumisa masero emota akarara (kazhinji tumor stem masero), ayo anobatsira chemotherapeutics kubvisa bundu maseru uye kuderedza mukana webundu kudzoka.

Ndizvo zvinoitawoGanoderma lucidumkuvimba nechinhu chimwe chete chinoshanda kuti inhibit tumors?Ganoderma lucidumine zvikamu zvakakwana zvinogona kurwisa mapundu nenzira yakawanda;chete iyo yakawanda-pronged anti-bundu nzira inogona kuderedza simba remamota masero.

[Kwakabva] Dai J, et al.Kubviswa kwemaseru anononoka-anomhanya bhasikoro kuburikidza nekudzikisa kudzika kwe quiescence nemasikirwo emakomisheni akacheneswa kubva kuGanoderma lucidum.Oncotarget.2017 Jan 13. doi: 10.18632/oncotarget.14634.

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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.