NgoJanuwari 13, 2017 / iYunivesithi yezoNyango yaseFujian, iYunivesithi yaseArizona, njl. / “Oncotarget”

Umbhalo/Wu Tingyao

Uninzi lwabaguli abanomhlaza abaye badlula kubunzima obungachazwanga kunyango bayazibuza ukuba kutheni ithumba abaziva ngathi "linyangekile" liya kuphinda libuyele emva kwexesha elide lokuthula.I-crux ilele kwiiseli zomhlaza.

Xa sijongene nohlaselo oluninzi lweziyobisi, ezinye iiseli ezinomhlaza ziya kungena kwindawo eleleyo kwaye ziyeke ukwahlukana kweeseli ukuze ziphile.Esi sesinye sezizathu zokuba kutheni amachiza "ahlasela iiseli ezanda ngokukhawuleza njengoko kujoliswe kuko" akanakulibulala eli qela leeseli ze-tumor stem.Amathumba amabi ashiya emva kokuvela kwakhona "kwembewu" ukufumana ithuba lokulwa kwakhona ngenye imini.

Ngoko ke, okoko nje eli qela leeseli ze-tumor ezileleyo "linokuvuswa" kwaye livunyelwe ukuba liphinde lingene kwimeko yokwandisa ngokukhawuleza, kukho ithuba lokubabulala ngamachiza akhoyo.

Iqela elikhokelwa nguNjingalwazi Jian-Hua Xu ovela kwiKholeji ye-Pharmacy yeYunivesithi yezoNyango yaseFujian kunye neYunivesithi yaseArizona ngokudibeneyo yapapasha isifundo kwi "Oncotarget" ngoJanuwari 2017 ebonisa ukubaI-Ganoderma lucidum(i-Lingzhi, i-Reishi mushroom) ii-sterols kunye ne-triterpenes zinokudlala indima echasene ne-tumor ngokunciphisa ubunzulu be-quiescence yeeseli zomhlaza.

Abaphandi bahlukanisa izinto ezimbini zendalo ezisebenzayo kwisicatshulwa se-ethanolI-Ganoderma lucidumimizimba eneziqhamo: ergosterol peroxide kunye ganodermanondiol.

I-molecular formula kunye nesakhiwo sekhemikhali ye-ergosterol peroxide kunye ne-ganodermanondiol (Umthombo / i-Oncotarget. 2017 Jan 13. doi: 10.18632 / oncotarget.14634.)

Iimvavanyo zifumanise ukuba azinakuthintela kuphela iiseli zomhlaza ezanda ngokukhawuleza kwaye zinciphise izinga lokusinda kwazo kodwa ziphinde ziphembelele iiseli ezipholileyo, ezihamba kancinci ngebhayisekile ukuba zibe yi-apoptosis.Impembelelo yabo ye-cytotoxic ngokuchasene nale yokugqibela ibhetele ngakumbi kunaleyo ye-chemotherapeutics efana ne-Doxorubicin, i-Paclitaxel kunye ne-Topotecan.

Kwakutheni ukuze kwenzeke oku?Kuyavela ukuba imolekyuli ye-Rb-E2F kwiiseli ezithe cwaka izakwenziwa zisebenze zezi zimbini.I-Ganoderma lucidumamacandelo.Lutshintsho olumisela ukuba iseli iyahlula okanye hayi.Xa umsebenzi wayo usanda, imo epholileyo yeseli iya kutshintsha ukusuka enzulu ukuya enzulu ── Iseli ibonakala itsalwa kubuthongo obunzulu bokuqala ukuya kubuthongo obukhanyayo.Ngethuba nje ivuselelwe kancinane, kulula ukuba "ivuswe" kwaye ivelise kwakhona ngamandla (njengoko kuboniswe kulo mfanekiso ulandelayo).

NjaniI-Ganoderma lucidumkwaphula imeko yokulala yeeseli zomhlaza

Iiseli zomhlaza ezileleyo, emva kokunyangwaI-Ganoderma lucidumiisterols okanye iitriterpenes, ubunzulu bazo obuzolileyo (ukuyeka okanye ukucotha ulwahlulo lweeseli) buya kuba nzulu, kwaye kulula ukubuyela kwimeko yokwanda ngokukhawuleza ngenxa yezivuseleli ezithile.Ngeli xesha, kunzima ukubaleka uhlaselo lweziyobisi ezijolise kwiiseli ezikhula ngokukhawuleza (Umthombo/Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634.)

Uvavanyo lokunyanga iiseli zomhlaza webele (MCF-7) kunye neeseli zebele eziqhelekileyo (MCF-10A) nge-ergosterol peroxide okanye i-ganodermanondiol ibonise ukuba kwidosi enye (20 μg/mL), inani leeseli zomhlaza webele ezipholileyo ziya kukhethwa. kuncitshiswe ngesiqingatha xa kuthelekiswa neeseli eziqhelekileyo (ngexesha elifutshane), nto leyo ebonisa ukuba imeko ezolileyo yeeseli zomhlaza ayizinzanga njengaleyo yeeseli eziqhelekileyo, ngoko ke ezi zimbiniLingzhiamacandelo aya kugqobhoza ibhlokhi ngaphambili (njengoko kubonisiwe ngezantsi).

Umahluko kumsebenzi phakathi kweeseli eziqhelekileyo kunye nomhlaza

Olona phawu lubalulekileyo lweeseli zomhlaza kukuba zinokukhula ngokungenasiphelo.Ke ngoko, nakwinqanaba elizolileyo “lokucotha okanye lokumisa ukwahlukana kweeseli”, ubunzulu obuzolileyo beeseli zomhlaza (njengoko kubonisiwe ngasekunene) busengaba nzulu ngakumbi kunobo beeseli eziqhelekileyo (njengoko kubonisiwe ngasekhohlo), ngoko zingaphezulu. lula ukuvuswa kwi-dormancy ngeReishi mushroomiisterols kunye neetriterpenes.(Umthombo / Oncotarget. 2017 Jan 13. doi: 10.18632 / oncotarget.14634.)

Sele siyayazi loo ntoI-Ganoderma lucidumi-polysaccharides inokunyusa ukhuseleko ngelixaI-Ganoderma lucidumI-triterpenes inokuthintela ukwanda kweeseli zethumba.Iziphumo zolu phando zibonisa ukubaI-Ganoderma lucidumsterols kunyeI-Ganoderma lucidumI-triterpenes inokuvula iiseli zethumba ezileleyo (ngokuqhelekileyo iiseli ze-tumor stem), ezinceda i-chemotherapeutics ukuphelisa iiseli zethumba kunye nokunciphisa ithuba lokuphindaphinda kwethumba.

Kunjalo keI-Ganoderma lucidumukuthembela kwicandelo elinye kuphela elisebenzayo ukunqanda amathumba?I-Ganoderma lucidumkunye namacandelo apheleleyo angalwa namathumba ngeendlela ezininzi;kuphela iindlela ezininzi ezichasene nethumba ezinokunciphisa amandla eeseli zethumba.

[Umthombo] uDai J, et al.Ukupheliswa kweeseli ezicothayo zokuhamba ngebhayisikile ngokunciphisa ubunzulu be-quiescence ngekhompawundi zendalo ezicocwe kwiGanoderma lucidum.Oncotarget.2017 Jan 13. doi: 10.18632 / oncotarget.14634.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao unike ingxelo ngolwazi lweGanoderma lokuqala ukusukela ngo-1999. Ungumbhali wencwadiUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
 
★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali.★ Le misebenzi ingasentla ayinakuphinda iveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali.★ Ukwaphulwa kwengxelo engentla, umbhali uya kulandela uxanduva olusemthethweni olufanelekileyo.★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.