Tariki ya 13 Mutarama 2017 / Kaminuza y'Ubuvuzi ya Fujian, Kaminuza ya Arizona, n'ibindi / “Oncotarget”

Inyandiko / Wu Tingyao

Abenshi mu barwayi ba kanseri bahuye n'ingorane zitavugwa mu kwivuza bibaza impamvu ikibyimba bumva ko "cyakize" kizongera kubaho nyuma yo guceceka igihe kirekire.Ipfundo riri muri selile stem selile.

Imbere y’ibitero byinshi byibiyobyabwenge, ingirabuzimafatizo zimwe na zimwe za kanseri zizinjira mu bitotsi kandi zihagarike amacakubiri kugira ngo zibeho.Iyi ni imwe mu mpamvu zituma ibiyobyabwenge “byibasira ingirabuzimafatizo zikwirakwizwa vuba nk'intego” bidashobora kwica iri tsinda ry'ingirabuzimafatizo.Ibibyimba bibi bisiga inyuma "imbuto" gusa kugirango tubone amahirwe yo kongera kurwana umunsi umwe.

Kubwibyo, mugihe cyose iri tsinda ryingirangingo yibibyimba idasinziriye rishobora "gukanguka" kandi ryemerewe kongera kwinjira mubice bikwirakwizwa byihuse, hari amahirwe yo kubica nibiyobyabwenge bihari.

Itsinda riyobowe na Porofeseri Jian-Hua Xu wo mu Ishuri Rikuru rya Farumasi rya kaminuza y’ubuvuzi ya Fujian na kaminuza ya Arizona bafatanije gusohora ubushakashatsi kuri “Oncotarget” muri Mutarama 2017 berekana koGanoderma lucidum(Lingzhi, Reishi mushroom) sterol na triterpène birashobora kugira uruhare mu kurwanya ibibyimba bigabanya ubujyakuzimu bwa kanseri ya kanseri.

Abashakashatsi batandukanije ibintu bibiri bisanzwe bikora muri Ethanol yaGanoderma lucidumimibiri yera imbuto: ergosterol peroxide na ganodermanondiol.

Imiterere ya molekulire nuburyo bwa chimique ya ergosterol peroxide na ganodermanondiol (Source / Oncotarget. 2017 Mutarama 13. doi: 10.18632 / oncotarget.14634.)

Ubushakashatsi bwerekanye ko budashobora gusa guhagarika ingirabuzimafatizo za kanseri zikwirakwira vuba kandi bikagabanya ubuzima bwazo ariko kandi bigatera no gutuza, kugenda buhoro buhoro kuri apoptose.Ingaruka za cytotoxic zirwanya izanyuma zirenze iziza chimiotherapeutique nka Doxorubicin, Paclitaxel na Topotecan.

Kuki ibyo byabaye?Biragaragara ko molekile ya Rb-E2F muri selile ituje izakorwa naba bombiGanoderma lucidumIbigize.Nibihinduka byerekana niba selile igabanije cyangwa idatandukanijwe.Iyo ibikorwa byayo byiyongereye, ituze ryimikorere ya selile izahinduka kuva ikuzimu igana hasi cell Akagari gasa nkaho gakuwe mubitotsi byambere byimbitse bigasinzira byoroheje.Igihe cyose ikanguriwe gato, biroroshye "gukanguka" no kongera kubyara imbaraga (nkuko bigaragara ku gishushanyo gikurikira).

NiguteGanoderma lucidumisenya ingirabuzimafatizo za kanseri

Ingirabuzimafatizo za kanseri zidasinziriye, nyuma yo kuvurwa hamweGanoderma lucidumsterol cyangwa triterpène, ubujyakuzimu bwazo butuje (guhagarika cyangwa kugabanya umuvuduko w'utugingo ngengabuzima) bizahinduka imbaraga, kandi biroroshye gusubira muburyo bwo gukwirakwira vuba kubera ibitera imbaraga.Muri iki gihe, biragoye guhunga igitero cy’ibiyobyabwenge byibasira ingirabuzimafatizo zikwirakwizwa vuba (Source / Oncotarget. 2017 Mutarama 13. doi: 10.18632 / oncotarget.14634.)

Ubushakashatsi bwo kuvura kanseri y'ibere ituje (MCF-7) hamwe na selile isanzwe y'ibere (MCF-10A) hamwe na ergosterol peroxide cyangwa ganodermanondiol yerekanye ko ku kigero kimwe (20 μg / mL), umubare w'ingirangingo za kanseri y'ibere uzaba utuje. yagabanutseho kimwe cya kabiri ugereranije na selile zisanzwe (mugihe gito ugereranije), byerekana ko ituze rya kanseri ya kanseri idahagaze neza nkiya selile zisanzwe, ubwo rero byombiLingzhiibice bizacamo ibice mbere (nkuko bigaragara hano).

Itandukaniro mubikorwa hagati ya selile zisanzwe na kanseri

Ikintu cyingenzi kiranga kanseri ni uko zishobora kwiyongera ubuziraherezo.Kubwibyo, no mubyiciro byo gutuza byo "gutinda cyangwa guhagarika igabana ry'utugingo", ubujyakuzimu bwa kanseri ya kanseri (nkuko bigaragara iburyo) buracyari buke ugereranije n'uturemangingo dusanzwe (nkuko bigaragara ibumoso), bityo rero ni byinshi byoroshye gukangurwa no gusinzira naReishi mushroomsterol na triterpène.(Inkomoko / Oncotarget. 2017 Mutarama 13. doi: 10.18632 / oncotarget.14634.)

TurabiziGanoderma lucidumpolysaccharide irashobora kongera ubudahangarwa mugiheGanoderma lucidumtriterpène irashobora kubuza ikwirakwizwa ry'uturemangingo.Ibisubizo by'ubu bushakashatsi birerekana koGanoderma lucidumsteroli naGanoderma lucidumtriterpène irashobora kandi gukora selile yibibyimba idasinziriye (mubisanzwe ikibyimba stem selile), ifasha chimiotherapeutics kurandura kanseri yibibyimba no kugabanya amahirwe yo kongera kubaho.

Niko bigendaGanoderma lucidumshingira kubintu bimwe gusa bikora kugirango ubuze ibibyimba?Ganoderma lucidumhamwe nibice byuzuye birashobora kurwanya ibibyimba muburyo bwinshi;gusa inzira nyinshi zo kurwanya ibibyimba zirashobora kugabanya imbaraga za selile yibibyimba.

[Inkomoko] Dai J, n'abandi.Kurandura utugingo ngengabuzima twihuta dukoresheje kugabanya ubujyakuzimu bwa quiescence hamwe nibintu bisanzwe byahanaguwe na Ganoderma lucidum.Oncotarget.2017 Mutarama 13. doi: 10.18632 / oncotarget.14634.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).
 
★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.