Kubvumbi 2019 / Xuanwu Hospital, Capital Medical University, Beijing / Acta Pharmacologica Sinica

Chinyorwa/Wu Tingyao

Ko Ganoderma lucidum inobatsira kune varwere vane chirwere cheParkinson (PD)?
Chikwata chinotungamirwa naChen Biao, purofesa weneurology uye director weParkinson's Disease Research, Diagnose and Treatment Center paXuanwu Hospital, Capital Medical University, Beijing, yakaburitsa tsvakiridzo muActa Pharmacologica Sinica (Chinese Journal of Pharmacology) muna Kubvumbi 2019. It yakakodzera kutaurwa kwako.
Kuona kugona kweGanoderma lucidum yekuvandudza chirwere cheParkinson kubva kukiriniki miedzo uye masero ekuedza.

Chikwata chekutsvagisa chakataura mumushumo uyu kuti vakamboona kushanda kweGanoderma lucidum kutorwa muvarwere ve300 vane chirwere cheParkinson mune randomized, double-blind, placebo-controlled controlled clinical trial: the subject’s course of disease from the first phase (zviratidzo kuonekwa kune rumwe rutivi rwomuviri) kusvika kuchikamu chechina (murwere anoda rubatsiro muupenyu hwezuva nezuva asi anogona kufamba ega).Mushure memakore maviri ekutevera, zvinoonekwa kuti kubatwa nemuromo kwe4 gramu yeGanoderma lucidum extract pazuva kunogona kuderedza kuderera kwechirwere che dyskinesia.Kunyangwe mhedzisiro yetsvagiridzo iyi isati yaburitswa, yakatopa boka rekutsvagisa tarisiro yemamwe mikana yeGanoderma lucidum muvarwere.
Pamusoro pezvo, vakambowana mukuedza kwesero kuti Ganoderma lucidum yakatorwa inogona kuvharidzira kushandiswa kwemicroglia (masero ekudzivirira muviri muuropi) uye kudzivirira kukanganisa kune dopamine neurons (masero etsinga anobudisa dopamine) nekunyanya kuzvimba.Mhedzisiro iyi yekutsvagisa yakabudiswa mu "Evidence-Based Complementary and Alternative Medicine" muna 2011.
Kufa kukuru kwe dopamine neurons mu substantia nigra ndiyo honzeri yechirwere cheParkinson, nekuti dopamine chinhu chakakosha mutsinga kuti uropi hugadzirise kuita kwemhasuru.Kana huwandu hwe dopamine huchideredzwa kusvika kune imwe nhanho, varwere vanozotanga kuona zviratidzo zveParkinson zvakadai sekusagadzikana kwemaoko nemakumbo, mitezo yakaoma, kufamba zvishoma nezvishoma, uye kusagadzikana kwemaitiro (zviri nyore kudonha nekuda kwekurasikirwa kwekuenzanisa).
Naizvozvo, zviedzo zviri pamusoro zvinoratidza kuti Ganoderma lucidum yakatorwa ine mhedzisiro yekudzivirira dopamine neurons, iyo inofanirwa kuve yakakosha kune chirwere cheParkinson.Kunyangwe kudzivirira kwakadaro kunogona kusimbiswa mumuviri, uye ndeipi nzira yekuita iyo Ganoderma lucidum inoshandisa kuchengetedza dopamine neurons ndiyo inotarisa yeboka rekutsvagisa mumushumo wakabudiswa.
Mbeva dzine chirwere cheParkinson dzinodya Ganoderma lucidum dzine makumbo anononoka kupera simba.

Iyo Ganoderma lucidum inoshandiswa mukuedza igadziriro yakagadzirwa neGanoderma lucidum fruiting body extract, ine 10% polysaccharides, 0.3-0.4% ganoderic acid A uye 0.3-0.4% ergosterol.
Vatsvakurudzi vakatanga kubaya neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mumakonzo kuti vaunze zviratidzo zvakafanana nechirwere cheParkinson ndokuzobata mbeva nemazuva ese intragastric administration ye400 mg/kg. Ganoderma lucidum extract.Mushure memavhiki mana, mbeva dzakaongororwa kukwanisa kwavo kudzora kufamba kwemakumbo nekuenzanisa danda rekufamba bvunzo uye bvunzo ye rotarod.
Zvigumisiro zvakaratidza kuti zvichienzaniswa nembeva dzine chirwere cheParkinson dzakanga dzisina kudzivirirwa neGanoderma lucidum, mbeva dzine chirwere cheParkinson dzakadya Ganoderma lucidum dzinogona kudarika bhanhire rekuenzanisa nokukurumidza uye dzinoramba dzichimhanya pa rotarod kwenguva yakareba, kunyanya kuswedera kune boka rinodzora. yemakonzo akajairika muyedzo ye rotarod (Mufananidzo 1).Mhedzisiro iyi yese inoratidza kuti kuramba uchishandiswa kweGanoderma lucidum extract inogona kuderedza kusagadzikana kwemakumbo kunokonzerwa nechirwere cheParkinson.

Mufananidzo 1 Mhedzisiro yekudya Ganoderma lucidum kwemavhiki mana pakufamba kwemakumbo emakonzo ane chirwere cheParkinson.

Beam kufamba basa
Bango rekufamba raisanganisira kuisa mbeva padanda rakarembera (50 masendimita pamusoro peuriri), danda rakatetepa (masendimita 100 kureba, 1.0 cm paupamhi, uye 1.0 cm kureba).Munguva yekudzidziswa uye kuyedzwa, mbeva yakaiswa panzvimbo yekutanga yakatarisana nekeji yemba, uye stopwatch yakatanga pakarepo pakuburitswa kwemhuka.Kuita kwakaongororwa nekurekodha latency yemhuka kuyambuka danda.
Rotarod basa
Mubasa re rotarod, zviyero zvakagadzirirwa sezvinotevera: kukurumidza kwekutanga, kutenderera kushanu paminiti (rpm);kukurumidza kumhanya, 30 uye 40 rpm pamusoro pekufamba kwe300 s.Nguva iyo mbeva dzakaramba dziri pa rotarod dzakangonyorwa.
Mbeva dzine chirwere cheParkinson dzinodya Ganoderma lucidum dzine kurasikirwa kwakanyanya kwedopamine neurons.

Mukuongorora kwehuropi hwemakonzo ekuedzwa pamusoro, zvakaonekwa kuti nhamba ye dopamine neurons mu substantia nigra pars compacta (SNpc) kana striatum yemakonzo ane chirwere cheParkinson akanga adyiswa Ganoderma lucidum yakapetwa kaviri kana kupfuura. kupfuura iyo yemakonzo ane chirwere pasina Ganoderma lucidum kudzivirira (Mufananidzo 2).
Iyo dopamine neurons yeiyo substantia nigra tishu yehuropi inonyanya kuiswa mu substantia nigra pars compacta, uye dopamine neurons pano zvakare inotambanukira kune striatum.Dopamine kubva ku substantia nigra pars compacta inopfuudzwa kune striatum munzira iyi, uye yobva yapfuudza meseji yekudzora kufamba ichidzika.Nokudaro, nhamba ye dopamine neurons muzvikamu zviviri izvi zvakakosha zvikuru pakukura kwechirwere cheParkinson.
Zviripachena, mhedzisiro yekuyedza muMufananidzo 2 inoratidza kuti kune mbeva dzine chirwere cheParkinson, iyo Ganoderma lucidum yakatorwa inogona kudzivirira iyo dopamine neurons ye substantia nigra pars compacta uye striatum panguva imwe chete.Uye izvi zvinodzivirira zvinotsanangurawo kusvika pamwero wakati nei mbeva dzine chirwere cheParkinson dzinodya Ganoderma lucidum dziine mota iri nani.

Mufananidzo 2 Mhedzisiro yekudya Ganoderma lucidum kwemavhiki mana pane dopamine neurons muhuropi hwembeva dzine chirwere cheParkinson.
[Cherechedza] Mufananidzo C unoratidza kusvibiswa kwechikamu chepfungwa chembeva.Zvikamu zvine mavara ndeye dopamine neurons.Iyo yakasviba ruvara, iyo yakakura nhamba ye dopamine neurons.Mifananidzo A uye B yakavakirwa paMufananidzo C kuyera dopamine neurons.
Ganoderma lucidum inodzivirira kupona kwemasero etsinga uye inochengetedza basa remitochondria.

Kuti unzwisise kuti Ganoderma lucidum extract inodzivirira sei dopamine neurons, vatsvakurudzi vakawedzera kuiongorora kuburikidza nekuedza kwesero.Yakawanikwa kuti kubatanidza neurotoxin 1-methyl-4-phenylpyridinium (MPP +) uye mouse nerve masero zvakakonzera kwete chete nhamba huru yemasero emagetsi kufa asiwo mitochondrial dysfunction mukati memasero (Mufananidzo 3).
Mitochondria inonzi "sero jenareta", iro sosi yekushanda kwesero.Kana iyo mitochondria inowira mudambudziko rekusashanda, kwete chete simba (ATP) rinogadzirwa rinoderedzwa zvakanyanya, asi mamwe mahara radicals anoburitswa, ayo anokurumidza kuchembera uye kufa kwemasero.
Matambudziko ataurwa pamusoro apa anozonyanya kukura nekurebesa kweMPP + nguva yekuita, asi kana Ganoderma lucidum yakawedzera kwairi panguva imwe chete, inogona kubvisa chikamu chekuuraya kweMPP +, uye kuchengetedza mamwe masero etsinga uye yakajairika kushanda mitochondria (Mufananidzo. 3).

Mufananidzo 3 Iyo inodzivirira mhedzisiro yeGanoderma lucidum pambeva nerve masero uye mitochondria.

[Cherechedza] Mufananidzo A unoratidza mwero wekufa kwembeva nerve maseru akagadzirwa mu vitro.Iyo yakareba nguva yekuita ye neurotoxin MPP+ (1 mM), iyo inowedzera huwandu hwerufu.Zvisinei, kana Ganoderma lucidum yakawedzerwa (800 μg / mL), chiyero chekufa kwesero chichaderedzwa zvikuru.

Mufananidzo B ndiyo mitochondria muchitokisi.Iyo tsvuku fluorescent ndiyo mitochondria ine basa rakajairwa (yakajairika membrane kugona), uye yegirini fluorescent ndiyo mitochondria ine impaired function (yakadzikira membrane kugona).Iyo yakawanda uye yakasimba iyo yegirini fluorescence, iyo yakawanda mitochondria isina kujairika.
Iyo inogoneka nzira iyo Ganoderma lucidum inodzivirira dopamine neurons

Mapuroteni akawanda asina kujairika anoungana musubstantia nigra yeuropi anokonzera kufa kwenhamba yakawanda yedopamine neurons, iyo inonyanya kukosha yehutano hweParkinson's disease.Kuti mapuroteni aya anokonzera sei kufa kwe dopamine neurons, kunyange zvazvo isati yanyatsojekeswa, inozivikanwa kuva yakanyatsobatana ne "mitochondrial dysfunction" uye "oxidative stress inowedzera" mumasero etsinga.Naizvozvo, kuchengetedzwa kwemitochondria inova kiyi yakakosha yekunonoka kuderera kwechirwere.
Vatsvakurudzi vakati zvidzidzo zvakawanda munguva yakapfuura zvakataura kuti Ganoderma lucidum inodzivirira masero etsinga kuburikidza nemaitiro e antioxidant, uye kuedza kwavo kwakacherechedza kuti Ganoderma lucidum extract inogona kuchengetedza basa uye kunaka kwemitochondria pasi pechikonzero chekuvhiringidza kwekunze kuitira kuti mitochondria isingashande irege kuunganidza. yakawandisa mumasero etsinga uye kupfupisa hupenyu hwemasero etsinga;kune rumwe rutivi, Ganoderma lucidum inobvisa inogonawo kudzivirira iyo nzira yeapoptosis uye autophagy kubva pakuitwa, kuderedza mukana wekuti masero etsinga azviuraye nekuda kwekunetseka kwekunze.
Zvinoitika kuti Ganoderma lucidum inogona kuchengetedza dopamine neurons nenzira yakawanda-yakasiyana-siyana, ichivabvumira kurarama pasi pekurwiswa kwemapuroteni ane chepfu.
Pamusoro pezvo, vaongorori vakacherekedzawo muuropi tsinga masero evacheche mbeva vacheche kuti neurotoxin MPP + ichaderedza zvakanyanya kufamba kwemitochondria mumaaxon, asi kana yakadzivirirwa neGanoderma lucidum inobvisa panguva imwe chete, kufamba kwemitochondria kuchaita. iva agile.
Masero etsinga akasiyana neakajairika masero.Pamusoro pemuviri wesero, inokura zvakare "matende" akareba kubva musero muviri kuendesa makemikari zvinhu zvakavanzwa nesero muviri.Kana iyo mitochondria ikafamba nekukurumidza, nzira yekufambisa inova yakapfava.Ichi chingangove chimwe chikonzero nei varwere kana mbeva dzine chirwere cheParkinson vanodya Ganoderma lucidum vanogona kuchengetedza kugona kurovedza muviri kuri nani.
Ganoderma lucidum inobatsira varwere kugara murunyararo nechirwere cheParkinson

Parizvino, hapana mushonga unogona kudzorera chirwere cheParkinson.Vanhu vanogona kungoyedza kunonoka kudzikira kwechirwere uku kuchengetedza basa remitochondria mumasero etsinga kunoonekwa seanogoneka anogadzirisa zano.
Pane zvakawanda zvakafanana pakati pemaurotoxins anoshandiswa muyedzero yemhuka yataurwa pamusoro uye kuyedza kwesero uye puroteni ine muchetura inokonzera chirwere cheParkinson muvanhu munzira yavo yekukuvadza dopamine neurons.Naizvozvo, mhedzisiro yeGanoderma lucidum yakatorwa muongororo iri pamusoro ingangove nzira iyo Ganoderma lucidum inobvisa inodzivirira varwere vane chirwere cheParkinson mukurapa kwekiriniki, uye mhedzisiro yacho inogona kuwanikwa ne "kudya".
Nekudaro, semhedzisiro inowanikwa muvanhu, mhuka nemasero, Ganoderma lucidum inobatsira kunonoka kuderera kwechirwere pane kubvisa chirwere.Naizvozvo, basa reGanoderma lucidum rakatorwa muchirwere cheParkinson harifanirwe kuve rekusangana kwechinguvana asi kushamwaridzana kwenguva refu.
Sezvo tisingagoni kupedza chirwere chacho, tinogona kudzidza kurarama nacho uye kuderedza kupindira kwacho kumiviri yedu noupenyu.Izvi zvinofanirwa kuve kukosha kweGanoderma lucidum yechirwere cheParkinson.
[Kwakabva] Ren ZL, et al.Ganoderma lucidum inobvisa inosimudzira MPTP-induced parkinsonism uye inodzivirira dopaminergic neurons kubva kune oxidative kusagadzikana kuburikidza nekudzora mitochondrial basa, autophagy, uye apoptosis.Acta Pharmacol Sin.2019 Kubvumbi 40(4):441-450.
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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weHealing with Ganoderma (yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.