Ubwino waGanoderma lucidumKuchotsa kwa odwala omwe ali ndi matenda a Parkinson

“KodiGanoderma lucidumkuthetsa zizindikiro za odwala matenda a Parkinson?Limeneli ndi funso limene odwala ambiri, mabanja awo, achibale ndi abwenzi amafuna kufunsa.

Mu lipoti lofalitsidwa muActa Pharmacologica Sinicamu Epulo 2019, gulu lofufuza motsogozedwa ndi Director Biao Chen, Pulofesa wa Neurology department of Xuanwu Hospital, Capital Medical University, adanenanso kuti adawona odwala 300 omwe ali ndi matenda a Parkinson pakuyesa kwachipatala kosasinthika, kwakhungu kawiri, koyendetsedwa ndi placebo:

Odwalawa adachokera ku siteji 1 ("zizindikiro zimawonekera kumbali imodzi ya thupi koma sizimakhudza bwino") mpaka siteji 4 ("kulephera kuyenda bwino koma amatha kuyenda ndi kuyima paokha").Ofufuzawo amalola odwalawo kutenga 4 magalamu aGanoderma lucidumkutulutsa pakamwa tsiku lililonse kwa zaka ziwiri, ndipo adapeza kuti "zizindikiro zamagalimoto" za odwala zimathadi kutsitsimutsidwa ndi kulowererapo kwaGanoderma lucidum.

Zomwe zimatchedwa motor motor matenda a Parkinson ndi:

◆ Kunjenjemera: Kugwedezeka kosalamulirika kwa miyendo.

◆ Kuuma kwa miyendo: Kumangirira kosalekeza kwa minofu chifukwa cha kukanidwa kowonjezereka, kumapangitsa kuti miyendo ikhale yovuta kuyenda.

◆ Hypokinesia: Kuyenda pang'onopang'ono komanso kulephera kusuntha motsatizana kapena kuchita zosiyana siyana panthawi imodzi.

◆ Kaimidwe kosakhazikika: kosavuta kugwa chifukwa cha kutayika bwino.

KutengaGanoderma lucidumTingafinye tsiku lililonse akhoza kuchepetsa kuwonongeka kwa zizindikiro izi.Ngakhale kuti padakali njira yayitali yochiritsira matendawa, n’zotheka kuti moyo wa odwala matenda a Parkinson ukhale wabwino.

Ganoderma lucidumKuchotsa kumachepetsa kukula kwa matenda a Parkinson, omwe amagwirizana ndi chitetezo cha dopamine neurons.

Gulu lofufuza la Chipatala cha Xuanwu ku Capital Medical University lapeza kudzera muzoyeserera zanyama kuti kuwongolera pakamwa tsiku lililonse kwa 400 mg/kg.Ganoderma lucidumTingafinye amatha kukhala bwino galimoto mbewa ndi matenda Parkinson a.Chiwerengero cha ma dopamine neurons muubongo wa mbewa omwe ali ndi matenda a Parkinson ndi ochulukirapo kuwirikiza kawiri kuposa mbewa popandaGanoderma lucidumchitetezo (Kuti mumve zambiri, onani "Gulu la Pulofesa Biao Chen waku chipatala cha Beijing Xuanwu adatsimikiza izi.Ganoderma lucidumamateteza dopamine neurons ndikuchotsa zizindikiro za matenda a Parkinson ").

Dopamine yotulutsidwa ndi ma dopamine neurons ndi neurotransmitter yofunikira kuti ubongo uzitha kuwongolera magwiridwe antchito a minofu.Kufa kwakukulu kwa dopamine neurons ndizomwe zimayambitsa matenda a Parkinson.Mwachiwonekere,Ganoderma lucidumadachepetsa kukula kwa matenda a Parkinson, omwe amalumikizidwa ndi kuwonongeka kochepa kwa ma dopamine neurons.

Chomwe chimayambitsa kufa kwachilendo kwa ma dopamine neurons ndikuti mapuloteni ambiri oopsa adaunjikana mu substantia nigra ya muubongo (malo aubongo omwe ma dopamine neurons ali).Kuphatikiza pakuwopseza mwachindunji kupulumuka ndi kugwira ntchito kwa ma dopamine neurons, mapuloteniwa adzayambitsanso ma microglia (maselo a chitetezo chamthupi omwe amakhala muubongo) mozungulira ma cell a minyewa, kuwapangitsa kuti azitulutsa mosalekeza ma cytokines oyambitsa kutupa kuti awononge ma dopamine neurons.

▲ Ma neurons omwe amapanga dopamine mu ubongo amakhala mu gawo lophatikizika la "substantia nigra".Dopamine yopangidwa pano idzatumizidwa kumadera osiyanasiyana a ubongo kuti ikatengepo gawo limodzi ndi tinyanga tambiri ta dopamine neurons.Kusokonezeka kwamayendedwe a matenda a Parkinson makamaka chifukwa cha kusowa kwa dopamine yotengedwa kuchokera ku substantia nigra kupita ku striatum.Chifukwa chake, kaya ndi ma dopamine neurons omwe ali mu substantia nigra kapena ma tentacles a dopamine neurons omwe amafikira ku striatum, kuchuluka kwawo komanso malo ozungulira ndikofunikira kuti matenda a Parkinson apitirire.

M'mbuyomu, gulu lofufuza la Xuanwu Hospital of Capital Medical University latsimikizira iziGanoderma lucidumKuchotsa kumatha kuchepetsa chiwopsezo cha kuwonongeka kwa dopamine neuron kuchokera kunjira yolimbana ndi kuvulala poteteza njira ya mitochondria (majenereta a cell) m'malo oyankha otupa (Kuti mumve zambiri, onani "Gulu la Pulofesa Biao Chen waku chipatala cha Beijing Xuanwu adatsimikiza kutiGanoderma lucidumamateteza dopamine neurons ndikuchotsa zizindikiro za matenda a Parkinson ").

Mu Seputembala 2022, kafukufuku wa gululo adasindikizidwa muZopatsa thanzianatsimikiziranso zimenezoGanoderma lucidumKutulutsa kumatha kuchepetsa kutulutsa kwa ma cytokines oyambitsa kutupa kudzera munjira ya "kuletsa kuyambitsa kwambiri kwa microglia", potero kuteteza ma dopamine neurons kunjira yochepetsera kuwonongeka.

Mbewa za matenda a Parkinson amene anadyaGanoderma lucidumkuchotsa anali atatsegulidwa zochepamicrogliamu substantia nigra ndi striatum.

Malinga ndi lipoti lofalitsidwa kumeneli, mbewa poyamba anabayidwa ndi neurotoxin MPTP kuti apangitse matenda a Parkinson ngati anthu, kenako 400 mg/kg yaGanoderma lucidumGLE idaperekedwa pakamwa tsiku lililonse kuyambira tsiku lotsatira (matenda a Parkinson +Ganoderma lucidumTingafinye gulu) pamene mbewa osachiritsidwa ndi matenda a Parkinson (okha jekeseni ndi MPTP) ndi mbewa wamba ankagwiritsidwa ntchito monga zowongolera zoyesera.

Pambuyo pa masabata a 4, chiwerengero chachikulu cha microglia chogwiritsidwa ntchito chinawonekera mu striatum ndi substantia nigra pars compacta (malo ogawa kwambiri a dopamine neurons) mu ubongo wa mbewa ndi matenda a Parkinson, koma izi sizinachitike mu mbewa ndi matenda a Parkinson omwe amadya.Ganoderma lucidumkuchotsa tsiku lililonse - chikhalidwe chawo chiri pafupi ndi mbewa zabwinobwino (chithunzi pansipa).

▲ [Mafotokozedwe]Ganoderma lucidumili ndi cholepheretsa pa microglia m'chigawo chaubongo komwe ma dopamine neurons ali (striatum ndi substantia nigra pars compacta) mu mbewa zomwe zili ndi matenda a Parkinson.Chithunzi 1 ndi chithunzi chodetsedwa cha ma microglia otsegulidwa m'magawo a minofu, ndipo Chithunzi 2 ndi kuchuluka kwa ma microglia oyambitsidwa.

Mbewa za matenda a Parkinson amene anadyaGanoderma lucidumChotsitsacho chinali ndi ma cytokines oyambira otupa mu midbrain ndi striatum.

Maselo a microglia omwe atsegulidwa amatulutsa ma cytokines kapena chemokines osiyanasiyana kuti alimbikitse kutupa ndikuwonjezera kuwonongeka kwa ma dopamine neurons.Komabe, pozindikira za midbrain ndi striatum za nyama zoyesera zomwe tatchulazi, ofufuzawo adapeza kuti kumwa tsiku lililonseGanoderma lucidumKutulutsa kumatha kulepheretsa kupanga ma cytokines oyambitsa kutupa omwe amachulukirachulukira chifukwa cha kuyambika kwa matenda a Parkinson (monga momwe tawonetsera pachithunzichi pansipa).

Ganoderma lucidumTingafinye kumathandiza kuchedwetsa kupitirira kwa matenda a Parkinson, amene ndi chifukwa cha mogwirizana angapo yogwira zosakaniza.

Gulu la asayansi latsimikizira kuti kuyankha kwa kutupa komwe kumachitika chifukwa cha kuyambika kwa microglia ndizomwe zimayambitsa kufa kwa dopamine neurons komanso kuwonongeka kwa matenda a Parkinson.Chifukwa chake, kuletsa kwa microglia activation ndiGanoderma lucidumkuchotsa mosakayikira kumapereka tsatanetsatane wofunikira chifukwa chakeGanoderma lucidumTingafinye akhoza kuchepetsa njira ya matenda a Parkinson.

Kodi zigawo zake ndi zitiGanoderma lucidumzomwe zimagwira ntchito izi?

TheGanoderma lucidumTingafinye GLE ntchito mu kafukufukuyu amapangidwa kuchokera matupi fruiting aGanoderma lucidumkudzera mu njira zingapo zochotseramo ethanol ndi madzi otentha.Ili ndi pafupifupi 9.8% Ganoderma lucidumpolysaccharides, 0.3-0.4% ganoderic acid A (imodzi mwa triterpenoids yofunika kwambiri muGanoderma lucidumzipatso) ndi 0.3-0.4% ergosterol.

Kafukufuku wina wam'mbuyomu adatsimikizira kuti ma polysaccharides, triterpenes, ndi ganoderic acid A muGanoderma lucidumonse ali ndi ntchito za "kuwongolera kuyankha kwa kutupa" ndi "kuteteza maselo a mitsempha".Choncho, ofufuza amakhulupirira kuti zotsatira zaGanoderma lucidumpa kuchedwetsa kupitirira kwa matenda a Parkinson si zotsatira za zochita za chigawo chimodzi koma zotsatira za kugwirizanitsa kwa zigawo zingapo zaGanoderma lucidumm'thupi.

Sizingakhale zoonekeratu mmene zosiyanasiyanaGanoderma lucidumZigawo zomwe zimadyedwa m'mimba zimadutsa "chotchinga chamagazi-ubongo" ndiyeno zimakhala ndi zotsatira zake pa ma microglia ndi dopamine neurons muubongo.Koma mulimonse momwe zingakhalire, ndi mfundo yosatsutsika kutiGanoderma lucidumzigawo zikuluzikulu akhoza kulowerera pathogenesis kuchedwa kupitirira kwa matendawa.

Kuwonongeka kwa dopamine neurons komwe kumayambitsa matenda a Parkinson si njira imodzi yokha koma njira yopita patsogolo yomwe imawononga pang'ono tsiku lililonse.Poyang'anizana ndi matendawa omwe sangathe kuthetsedwa ndipo amatha kuthamangitsidwa nawo kwa moyo wonse, odwala amatha kugwira ntchito mwakhama tsiku ndi tsiku kuti apempherere kuchepetsa kuchepa tsiku lililonse.

Choncho, m'malo moyembekezera mankhwala atsopano omwe atembenuza dziko lapansi, ndi bwino kulanda nthawi ndikutenga chuma choperekedwa patsogolo panu ndikuyesa molimba mtima.Siziyenera kukhala loto kutulutsanso zotsatira za kuyezetsa zomwe zatchulidwa pamwambapa zomwe zafotokozedwa mwachidule kuchokera kwa odwala 300 podya chakudya chokwanira.Ganoderma lucidumkwa nthawi yayitali.

Gwero:

1. Zhili Ren, et al.Ganoderma lucidumImasintha Mayankho Otupa Otsatira 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration mu Mice.Zopatsa thanzi.2022;14(18):3872.doi: 10.3390/nu14183872.

2. Zhi-Li Ren, et al.Ganoderma lucidumExtract Ameliorates MPTP-Induced Parkinsonism and Protect Dopaminergic Neurons from Oxidative Stress through Regulating Mitochondrial Function, Autophagy, and Apoptosis.Acta Pharmacol Sin.2019; 40 (4): 441-450.doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, et al.Ganoderma lucidumKuteteza Dopaminergic Neuron Degeneration kudzera mu Kuletsa kwa Microglial Activation.Evid Based Complement Alternat Med.2011;2011:156810.doi: 10.1093/ecam/nep075.

4. Hui Ding, et al.Ganoderma lucidumKuchotsa kumateteza ma dopaminergic neurons poletsa kuyambitsa kwa microglial.Acta Physiologica Sinica, 2010, 62 (6): 547-554.

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