GLE inononoka kufambira mberi kwechirwere cheParkinson (1)

Benefits ofGanoderma lucidumkubviswa kune varwere vane chirwere cheParkinson

“CanGanoderma lucidumkubvisa zviratidzo zvevarwere vane chirwere cheParkinson?Uyu mubvunzo unoda kubvunzwa nevarwere vazhinji, mhuri dzavo, hama neshamwari.

Mumushumo wakabudiswa munaActa Pharmacologica Sinicamuna Kubvumbi 2019, timu yekutsvagisa inotungamirwa naDirector Biao Chen, Muzvinafundo weNeurology Dhipatimendi reXuanwu Hospital, Capital Medical University, akataura kuti vakacherekedza varwere mazana matatu vane chirwere cheParkinson muyedzo yekiriniki isina kurongeka, yakapetwa kaviri, inodzorwa ne placebo:

Varwere ava vakabva padanho rekutanga ("zviratidzo zvinoonekwa kune rumwe rutivi rwemuviri asi hazvikanganisi kuenzanisa") kusvika padanho rechina ("kutadza zvakanyanya kufamba asi anokwanisa kufamba nekumira akazvimiririra").Vatsvakurudzi vakabvumira varwere kutora 4 gramu yeGanoderma lucidumkubvisa nemuromo zuva rega rega kwemakore maviri, uye akawana kuti "zviratidzo zvemotokari" zvevarwere zvinogona kunyatsogadziriswa nekupindira kweGanoderma lucidum.

Zvinonzi mota zviratidzo zvechirwere cheParkinson zvinosanganisira:

◆ Kudedera: Kuzununguka kusingadzoreki kwemakumbo nemaoko.

◆ Kuoma kwemakumbo: Kuramba kusungirirwa kwetsandanyama nekuda kwekuwedzera kwehutano, zvichiita kuti mitezo yakaoma kufamba.

◆ Hypokinesia: Kufamba zvishoma nezvishoma uye kusakwanisa kuita mafambiro akatevedzana kana kuita mafambiro akasiyana panguva imwe chete.

◆ Chimiro chisina kugadzikana: nyore kudonha nekuda kwekurasikirwa kwekuenzanisa.

KutoraGanoderma lucidumkubvisa zuva rega rega kunogona kuderedza kuderera kwezviratidzo izvi.Kunyange kana kuchine nzira yakareba yekurapa chirwere ichi, zvinofungidzirwa kuti hupenyu hwevarwere vane chirwere cheParkinson hunogona kuvandudzwa.

GLE inononoka kufambira mberi kwechirwere cheParkinson (2) GLE inononoka kufambira mberi kwechirwere cheParkinson (3)

Ganoderma luciduminobvisa inononoka kufambira mberi kwechirwere cheParkinson, icho chine hukama nekuchengetedzwa kwedopamine neurons.

Chikwata chekutsvagisa cheXuanwu Hospital cheCapital Medical University chakawana kuburikidza nekuedza kwemhuka kuti zuva nezuva kutonga kwemuromo kwe400 mg/kg.Ganoderma luciduminobvisa inogona kuchengetedza zvirinani kuita mota mumakonzo ane chirwere cheParkinson.Huwandu hwema dopamine neurons muhuropi hwembeva dzine chirwere cheParkinson inodarika kaviri yembeva dzisina.Ganoderma lucidumdziviriro (Kuti uwane ruzivo, ona "Chikwata chaProfessor Biao Chen kubva kuBeijing Xuanwu Hospital chakasimbisa izvozvo.Ganoderma luciduminodzivirira dopamine neurons uye inobvisa zviratidzo zvechirwere cheParkinson”).

Dopamine yakavanzika ne dopamine neurons chinhu chakakosha neurotransmitter kuti uropi hugadzirise kuita kwemhasuru.Kufa kukuru kwe dopamine neurons ndiko kunokonzera chirwere cheParkinson.Sezviri pachena,Ganoderma lucidumyakadzora kufambira mberi kwechirwere cheParkinson, icho chaisanganiswa nekukuvadzwa kushoma kune dopamine neurons.

Mhedzisiro yekufa kusina kujairika kwe dopamine neurons ndeyekuti nhamba huru yemapuroteni ane chepfu akaungana mu substantia nigra yeuropi (nzvimbo huru yeuropi iyo dopamine neurons iripo).Pamusoro pekutyisidzira kwakananga kupona uye kushanda kwe dopamine neurons, mapuroteni aya anozoitawo microglia (masero ekudzivirira anodzivirira muviri anogara muuropi) akatenderedza masero etsinga, achivaita kuti varambe vachiburitsa pro-inflammatory cytokines kukuvadza dopamine neurons.

 

GLE inononoka kufambira mberi kwechirwere cheParkinson (4)

 

▲ Maneuroni anogadzira dopamine muuropi anowanikwa muchikamu che "substantia nigra".Iyo dopamine inogadzirwa pano inotumirwa kumatunhu akasiyana ehuropi kuita basa pamwe chete neantennae yakawedzerwa ye dopamine neurons.Kusagadzikana kwekufamba kwechirwere cheParkinson kunonyanya kukonzerwa nekushaikwa kwe dopamine inotakurwa kubva ku substantia nigra kuenda ku striatum.Naizvozvo, ingave iri dopamine neurons iri mu substantia nigra kana matende e dopamine neurons anotambanudzira kune striatum, nhamba yavo nenzvimbo yakapoteredza zvakakosha mukufambira mberi kwechirwere cheParkinson.

Pakutanga, timu yekutsvagisa yeXuanwu Hospital yeCapital Medical University yakasimbisa izvozvoGanoderma luciduminobvisa inogona kuderedza njodzi yekukuvadzwa kwe dopamine neuron kubva munzira yekukuvara-inodzivirira nekuchengetedza maitiro ekuita mitochondria (sero jenareta) munzvimbo yekuzvimba mhinduro (Kuti uwane ruzivo, ona "Chikwata chaProfessor Biao Chen kubva kuBeijing Xuanwu Hospital chakasimbisa izvozvo.Ganoderma luciduminodzivirira dopamine neurons uye inobvisa zviratidzo zvechirwere cheParkinson”).

MunaGunyana 2022, tsvagiridzo yechikwata yakaburitswa mukatiNutrientsakasimbisazve izvozvoGanoderma lucidumkubvisa kunogona kuderedza kuvharidzirwa kwe-pro-inflammatory cytokines kuburikidza nemaitiro e "kudzivisa kushandiswa kwakanyanya kwe microglia", nokudaro kudzivirira dopamine neurons kubva munzira inoderedza kukuvara.

 GLE inononoka kufambira mberi kwechirwere cheParkinson (5)

Mbeva dzine chirwere cheParkinson dzakadyaGanoderma lucidumextract yanga yaitwa shomamicrogliamune substantia nigra uye striatum.

Zvinoenderana neshumo ichangobva kuburitswa iyi, mbeva dzakatanga kubaiwa neurotoxin MPTP kukonzeresa chirwere cheParkinson chemunhu, uyezve 400 mg/kg yeGanoderma lucidumGLE yaitorwa nemuromo zuva rega rega kubva pazuva raitevera (chirwere cheParkinson +Ganoderma lucidumboka rekubvisa) nepo mbeva dzisina kurapwa nechirwere cheParkinson (chakangobaiwa chete neMPTP) uye mbeva dzakajairwa dzakashandiswa sekuyedza kudzora.

Mushure memavhiki mana, nhamba huru ye microglia yakashandiswa yakaonekwa mu striatum uye substantia nigra pars compacta (nzvimbo huru yekugovera dopamine neurons) muuropi hwembeva dzine chirwere cheParkinson, asi izvi hazvina kuitika mumakonzo ane chirwere cheParkinson aidya.Ganoderma lucidumkubvisa zuva rega rega - mamiriro avo ari padyo neaya emakonzo akajairwa (inoratidzwa pazasi).

GLE inononoka kufambira mberi kwechirwere cheParkinson (6)

▲ [Tsanangudzo]Ganoderma lucidumine inhibitory effect pa microglia munharaunda yeuropi umo dopamine neurons inowanikwa (striatum uye substantia nigra pars compacta) mumakonzo ane chirwere cheParkinson.Mufananidzo 1 mufananidzo wakasvibiswa weiyo activated microglia muzvikamu zvematishu, uye Mufananidzo 2 ndiyo nhamba yehuwandu hweiyo activated microglia.

Mbeva dzine chirwere cheParkinson dzakadyaGanoderma lucidumkuburitsa kwaive kwakadzika kudzika kwepro-inflammatory cytokines mukatikati mebrain uye striatum.

Activated microglia masero anoburitsa akasiyana cytokines kana chemokines kukurudzira kuzvimba uye kuwedzera kukuvadzwa kwe dopamine neurons.Nekudaro, mukuonekwa kweiyo midbrain uye striatum yemhuka dzataurwa pamusoro apa, vaongorori vakawana kuti kudyiwa kwemazuva eseGanoderma lucidumkubvisa kunogona kutadzisa kugadzirwa kwepro-inflammatory cytokines iyo inowedzera zvakanyanya nekuda kwekutanga kwechirwere cheParkinson (sezvinoratidzwa mumufananidzo uri pasi apa).

GLE inononoka kufambira mberi kwechirwere cheParkinson (7)

 

GLE inononoka kufambira mberi kwechirwere cheParkinson (8)

 

Ganoderma lucidumkuburitsa kunobatsira kunonoka kufambira mberi kwechirwere cheParkinson, chinova chikonzero chekudyidzana kwezvishandiso zvakawanda.

Nharaunda yesainzi yakasimbisa kuti mhinduro yekuzvimba inokonzerwa neabnormal activation ye microglia iri seri kwekukurumidza kufa kwedopamine neurons uye kudzikira kwechirwere cheParkinson.Naizvozvo, inhibition ye microglia activation naGanoderma lucidumkuburitsa pasina mubvunzo kunopa tsananguro yakakosha yekuti neiGanoderma lucidumkubvisa kunogona kuderedza nzira yechirwere cheParkinson.

Ndezvipi zvikamu zveGanoderma lucidumanoita mabasa aya?

TheGanoderma lucidumbvisa GLE inoshandiswa mukutsvagisa iyi inogadzirwa kubva kumitumbi inobereka michero yeGanoderma lucidumkuburikidza neakawanda ethanol uye nzira dzekubvisa mvura inopisa.Iyo ine inenge 9.8% Ganoderma lucidumpolysaccharides, 0.3-0.4% ganoderic acid A (imwe yeakanyanya kukosha triterpenoids muGanoderma lucidummichero yemichero) uye 0.3-0.4% ergosterol.

GLE inononoka kufambira mberi kwechirwere cheParkinson (9)

Zvimwe zvidzidzo zvine hukama munguva yakapfuura zvakaratidza kuti polysaccharides, triterpenes, uye ganoderic acid A mukati.Ganoderma lucidumese ane mabasa e "kuronga mhinduro yekuzvimba" uye "kudzivirira masero etsinga".Naizvozvo, vaongorori vanotenda kuti mhedzisiro yeGanoderma lucidumpakunonotsa kufambira mberi kwechirwere cheParkinson hachisi chikonzero chekuita kwechikamu chimwe chete asi mugumisiro wekubatana kwezvikamu zvakawanda zveGanoderma lucidummumuviri.

Zvinogona kunge zvisiri pachena kuti zvakasiyana seiGanoderma lucidumzvinodyiwa mudumbu zvinoyambuka "blood-brain barrier" uye zvino shandisa zvazvinoita pamicroglia uye dopamine neurons muuropi.Asi chero zvakadaro, ichokwadi chisingarambiki kutiGanoderma lucidumzvikamu zvinogona kupindira mune pathogenesis kunonoka kufambira mberi kwechirwere.

Kuderera kwe dopamine neurons kunokonzeresa chirwere cheParkinson haisi nhanho imwe chete asi danho rinofambira mberi rinodzikisira zvishoma zuva rega rega.Kutarisana nechirwere ichi chisingagoni kupera uye chinogona kungobatanidzwa nacho kwehupenyu hwose, varwere vanogona kungoshanda nesimba zuva rega rega kuitira kuti vanamatire kuderedza kuderera zuva rega rega.

Nokudaro, panzvimbo yekumirira mushonga mutsva unoshandura nyika, zviri nani kutora nguva uye kutora pfuma yakapiwa pamberi pako uye edza noushingi.Hazvifanirwe kuve kurota kuburitsa zvakataurwa pamusoro pekiriniki bvunzo mhinduro dzakapfupikiswa kubva kuvarwere mazana matatu nekudya huwandu hwakakwanaGanoderma lucidumkwenguva refu.

GLE inononoka kufambira mberi kwechirwere cheParkinson (10)

Kwakabva:

1. Zhili Ren, nevamwe.Ganoderma lucidumModulates Inflammatory Responses inotevera 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration muMice.Nutrients.2022;14(18):3872.doi: 10.3390/nu14183872.

2. Zhi-Li Ren, nevamwe.Ganoderma lucidumBvisa Ameliorates MPTP-Induced Parkinsonism uye Inodzivirira Dopaminergic Neurons kubva kuOxidative Stress kuburikidza neRegulating Mitochondrial Function, Autophagy, uye Apoptosis.Acta Pharmacol Sin.2019;40(4):441-450.doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, nevamwe.Ganoderma lucidumInodzivirira Dopaminergic Neuron Degeneration kuburikidza neInhibition yeMicroglial Activation.Evid Based Complement Alternat Med.2011;2011:156810.doi: 10.1093/ecam/nep075.

4. Hui Ding, nevamwe.Ganoderma luciduminobvisa inodzivirira dopaminergic neurons nekudzivisa microglial activation.Acta Physiologica Sinica, 2010, 62(6): 547-554.

GLE inononoka kufambira mberi kwechirwere cheParkinson (11)

★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi wacho ndeweGanoHerb.

★ Basa riri pamusoro harigone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb.

★ Kana basa racho rakabvumirwa kushandiswa, rinofanira kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb.

★ Pakutyorwa kwechirevo chiri pamusoro, GanoHerb ichatevera mabasa anoenderana nemutemo.

★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.


Nguva yekutumira: May-04-2023

Tumira meseji yako kwatiri:

Nyora meseji yako pano uye titumire kwatiri
<