Pono oʻO Ganoderma lucidumka lawe ʻana i nā mea maʻi me ka maʻi o Parkinson

“HikiʻO Ganoderma lucidumhoʻomaha i nā hōʻailona o nā maʻi me ka maʻi Parkinson?"He nīnau kēia a ka poʻe maʻi, ko lākou ʻohana, ʻohana a me nā hoaaloha makemake e nīnau.

Ma kahi hōʻike i paʻi ʻia maActa Pharmacologica Sinicai ʻApelila 2019, ua ʻōlelo ka hui noiʻi i alakaʻi ʻia e ka Luna Hoʻokele ʻo Biao Chen, ke Kumu o ka Neurology Department o Xuanwu Hospital, Capital Medical University, ua ʻike lākou i 300 mau mea maʻi me ka maʻi Parkinson i loko o kahi hoʻāʻo hoʻāʻo hoʻāʻo ʻia, pālua-makapō, placebo.

ʻO kēia mau maʻi mai ka pae 1 ("ʻike ʻia nā hōʻailona ma kekahi ʻaoʻao o ke kino akā ʻaʻole pili i ke kaulike") a hiki i ka pae 4 ("he pilikia ka neʻe ʻana akā hiki ke hele a kū kūʻokoʻa").Ua ʻae nā mea noiʻi i nā mea maʻi e lawe i 4 grams oʻO Ganoderma lucidumunuhi waha i kēlā me kēia lā no 2 mau makahiki, a ʻike ʻia e hiki ke hoʻomaha ʻia nā "hōʻailona kaʻa" o ka poʻe maʻi e ka hanaʻO Ganoderma lucidum.

ʻO nā hōʻailona kaʻa o ka maʻi Parkinson i kapa ʻia:

◆ Haʻalulu: Nalu hiki ʻole i nā lālā.

◆ ʻOoleʻa o nā lālā: ʻO ka hoʻopaʻa mau ʻana o nā ʻiʻo ma muli o ka piʻi ʻana o ka haʻalulu, e paʻakikī ai ka neʻe ʻana o nā lālā.

◆ Hypokinesia: Ka neʻe mālie a me ka hiki ʻole ke hana i nā neʻe ʻokoʻa i ka manawa like.

◆ ʻO ke kūlana paʻa ʻole: hiki ke hāʻule ma muli o ka nalowale o ke kaulike.

Lawe anaʻO Ganoderma lucidumhiki i ka extract i kēlā me kēia lā ke hoʻolohi i ka pōʻino o kēia mau hōʻailona.ʻOiai inā he ala lōʻihi e hele ai e hoʻōla i ka maʻi, hiki ke hoʻomaikaʻi ʻia ka maikaʻi o ke ola o nā maʻi me ka maʻi Parkinson.

ʻO Ganoderma lucidumHoʻolohi ka extract i ka holomua o ka maʻi o Parkinson, kahi e pili ana i ka pale o nā neurons dopamine.

Ua loaʻa i ka hui noiʻi o Xuanwu Hospital o Capital Medical University ma o nā hoʻokolohua holoholona i kēlā me kēia lā o ka lawelawe waha o 400 mg / kgʻO Ganoderma lucidumHiki i ka extract ke mālama i ka hana ʻoi aku ka maikaʻi o nā ʻiole me ka maʻi o Parkinson.ʻOi aku ka nui o nā neurons dopamine i loko o ka lolo o nā ʻiole me ka maʻi Parkinson ma mua o ka pālua o nā ʻiole me ka ʻole.ʻO Ganoderma lucidumpale (No nā kikoʻī, e ʻike i ka "Ua hōʻoia ka hui o Profesor Biao Chen mai ka Halemai Xuanwu ʻo BeijingʻO Ganoderma lucidumpale i nā neurons dopamine a hoʻomaha i nā hōʻailona o ka maʻi o Parkinson").

ʻO ka Dopamine i hūnā ʻia e nā neurons dopamine he mea neurotransmitter koʻikoʻi no ka lolo e hoʻoponopono i ka hana ʻiʻo.ʻO ka make nui o nā neurons dopamine ke kumu o ka maʻi o Parkinson.Me he mea lā,ʻO Ganoderma lucidumUa hoʻolohi i ka piʻi ʻana o ka maʻi o Parkinson, i pili me ka liʻiliʻi o ka pōʻino i nā neurons dopamine.

ʻO ke kumu o ka make ʻino o nā neurons dopamine ʻo ia ka nui o nā protein ʻona i hōʻiliʻili ʻia i loko o ka substantia nigra o ka lolo (ka wahi lolo nui kahi e loaʻa ai nā neurons dopamine).Ma waho aʻe o ka hoʻoweliweli pololei ʻana i ke ola a me ka hana o nā neurons dopamine, e hoʻāla pū kēia mau protein i ka microglia (nā cell immune e noho ana i loko o ka lolo) a puni nā cell nerve, e hoʻomau iā lākou e hūnā i nā cytokine pro-inflammatory e hōʻino i nā neurons dopamine.

▲ Aia nā neurons e hoʻoulu i ka dopamine i loko o ka lolo ma ka ʻāpana paʻa o ka "substantia nigra".E hoʻouna ʻia ka dopamine i hana ʻia ma ʻaneʻi i nā ʻāpana like ʻole o ka lolo e pāʻani i kahi kuleana me nā antennae lōʻihi o nā neurons dopamine.ʻO ka maʻi maʻamau o ka maʻi Parkinson ma muli o ka nele o ka dopamine i lawe ʻia mai ka substantia nigra i ka striatum.No laila, inā he mau neurons dopamine aia i loko o ka substantia nigra a i ʻole nā ​​​​tentacles o nā neurons dopamine e hoʻonui ana i ka striatum, ko lākou helu a me nā kaiapuni e pili ana i ka holomua o ka maʻi o Parkinson.

Ma mua, ua hōʻoia ka hui noiʻi o Xuanwu Hospital o Capital Medical UniversityʻO Ganoderma lucidumhiki i ka extract ke ho'ēmi i ka pilikia o ka dopamine neuron poino mai ke ala kū'ē i kaʻeha ma o ka paleʻana i keʻano o ka hana o ka mitochondria (cell generators) i loko o ke kaiapuni o ka pane inflammatory (No nā kiko'ī, e nānā "Ua hōʻoia ka hui o Professor Biao Chen mai ka Halemai Beijing Xuanwu.ʻO Ganoderma lucidumpale i nā neurons dopamine a hoʻomaha i nā hōʻailona o ka maʻi o Parkinson").

I Kepakemapa 2022, ua paʻi ʻia ka noiʻi a ka hui maNā meaʻaiua hōʻoia hou i kēlāʻO Ganoderma lucidumhiki i ka extract ke hoʻemi i ka huna ʻana o nā cytokine pro-inflammatory ma o ke ʻano o ka "inhibiting the excessive activation of microglia", no laila e pale ana i nā neurons dopamine mai ke ala e hōʻemi ai i ka pōʻino.

ʻIole me ka maʻi Parkinson i ʻaiʻO Ganoderma lucidumʻoi aku ka liʻiliʻi o ka extract i hoʻāla ʻiamicrogliai loko o ka substantia nigra a me ka striatum.

Wahi a kēia hōʻike hou i paʻi ʻia, ua hoʻokomo mua ʻia nā ʻiole me ka neurotoxin MPTP e hoʻoulu i ka maʻi o Parkinson e like me ke kanaka, a laila 400 mg/kg oʻO Ganoderma lucidumHoʻohana waha ʻia ka extract GLE i kēlā me kēia lā mai ka lā aʻe (Parkinson's disease +ʻO Ganoderma lucidumhui puʻupuʻu) aʻo nā ʻiole i mālama ʻole ʻia me ka maʻi o Parkinson (i hoʻopaʻa ʻia me MPTP wale nō) a ua hoʻohana ʻia nā ʻiole maʻamau e like me nā mana hoʻokolohua.

Ma hope o nā pule he 4, ua ʻike ʻia ka nui o nā microglia i hoʻāla ʻia i ka striatum a me ka substantia nigra pars compacta (ka mahele nui o nā neurons dopamine) i loko o ka lolo o nā ʻiole me ka maʻi Parkinson, akā ʻaʻole i loaʻa kēia i nā ʻiole me ka maʻi Parkinson i ʻai.ʻO Ganoderma lucidume unuhi i kēlā me kēia lā - ua kokoke ko lākou kūlana i ko nā ʻiole maʻamau (kiʻi ʻia ma lalo).

▲ [Wehewehe]ʻO Ganoderma lucidumLoaʻa ka hopena pale i ka microglia ma ka ʻāpana lolo kahi i loaʻa ai nā neurons dopamine (striatum a me substantia nigra pars compacta) i nā ʻiole me ka maʻi o Parkinson.ʻO ka Figure 1 ke kiʻi ʻeleʻele o ka microglia i hoʻāla ʻia i nā ʻāpana kiko, a ʻo ka Figure 2 ka helu helu helu o ka microglia hoʻāla ʻia.

ʻIole me ka maʻi Parkinson i ʻaiʻO Ganoderma lucidumHe haʻahaʻa ka haʻahaʻa o nā cytokine pro-inflammatory i loko o ka lolo waena a me ka striatum.

Hoʻopili ʻia nā cell microglia i nā ʻano cytokines a i ʻole chemokines e hoʻoikaika i ka mumū a hoʻonui i ka pōʻino o nā neurons dopamine.Eia nō naʻe, i ka ʻike ʻana o ka midbrain a me ka striatum o nā holoholona hoʻokolohua i ʻōlelo ʻia ma luna nei, ua ʻike nā mea noiʻi i ka ʻai ʻana i kēlā me kēia lā.ʻO Ganoderma lucidumhiki i ka extract ke keʻakeʻa i ka hana ʻana o nā cytokines pro-inflammatory i hoʻonui nui ʻia ma muli o ka hoʻomaka ʻana o ka maʻi o Parkinson (e like me ka hōʻike ʻana ma ke kiʻi ma lalo).

ʻO Ganoderma lucidumkōkua ka extract e hoʻopaneʻe i ka piʻi ʻana o ka maʻi o Parkinson, ʻo ia ka hopena o ka hoʻopili ʻana o nā mea hana he nui.

Ua hōʻoia ʻia e ke kaiāulu ʻepekema ʻo ka pane ʻana o ka maʻi ma muli o ka hoʻoulu ʻana o microglia ma hope o ka make wikiwiki ʻana o nā neurons dopamine a me ka hōʻino ʻana o ka maʻi o Parkinson.No laila, ka inhibition o ka microglia activation eʻO Ganoderma lucidumʻO ka extract me ke kānalua ʻole he wehewehe koʻikoʻi no ke kumuʻO Ganoderma lucidumhiki ke ho'ēmi i ke ala o ka maʻi o Parkinson.

He aha nā ʻāpana oʻO Ganoderma lucidume hoʻokō nei i kēia mau hana?

ʻO kaʻO Ganoderma lucidumʻO ka extract GLE i hoʻohana ʻia ma kēia noiʻi ua hana ʻia mai nā kino hua oʻO Ganoderma lucidumma o ka nui o ka ethanol a me ka wai wela.Aia ma kahi o 9.8% Ganoderma lucidumpolysaccharides, 0.3-0.4% ganoderic acid A (kekahi o nā triterpenoids nui loa i lokoʻO Ganoderma lucidumnā kino hua) a me 0.3-0.4% ergosterol.

Ua hōʻike kekahi mau haʻawina pili i ka wā ma mua i ka polysaccharides, triterpenes, a me ka ganoderic acid A i loko.ʻO Ganoderma lucidumLoaʻa i nā mea a pau nā hana o ka "hoʻoponopono i ka pane inflammatory" a me ka "pale ʻana i nā cell nerve".No laila, manaʻo ka poʻe noiʻi i ka hopena oʻO Ganoderma lucidumʻO ka hoʻopaneʻe ʻana i ka piʻi ʻana o ka maʻi o Parkinson ʻaʻole ia ka hopena o ka hana o kahi mea hoʻokahi akā ʻo ka hopena o ka hoʻohui ʻana o nā ʻāpana he nui.ʻO Ganoderma lucidumma ke kino.

ʻAʻole maopopo loa ke ʻano o nā ʻano like ʻoleʻO Ganoderma lucidumʻAi ʻia nā mea ʻai i loko o ka ʻōpū i ka "pale koko-lolo" a laila hoʻoikaika i kā lākou hopena i nā neurons microglia a me dopamine i loko o ka lolo.Akā i kekahi hihia, he mea hiki ʻole ke hoʻopaʻapaʻa ʻiaʻO Ganoderma lucidumhiki i nā mea ke komo i ka pathogenesis e hoʻopaneʻe i ka holomua o ka maʻi.

ʻO ka hoʻohaʻahaʻa ʻana o nā neurons dopamine e hoʻoulu ai i ka maʻi o Parkinson ʻaʻole ia he kaʻina hana hoʻokahi akā he kaʻina holomua e hoʻohaʻahaʻa iki i kēlā me kēia lā.Ke alo nei i kēia maʻi ʻaʻole hiki ke hoʻopau ʻia a hiki ke marathoned me ia no ke ola a pau, hiki i nā mea maʻi ke hana ikaika i kēlā me kēia lā i mea e pule ai no ka emi ʻana o ka regression i kēlā me kēia lā.

No laila, ma mua o ke kali ʻana i ka lāʻau hou e hoʻohuli ai i ka honua, ʻoi aku ka maikaʻi o ka hopu ʻana i ka manawa a lawe i ka waiwai i hāʻawi ʻia i mua ou a hoʻāʻo me ka wiwo ʻole.ʻAʻole ia he moeʻuhane e hoʻopuka hou i nā hopena hoʻokolohua lapaʻau i ʻōlelo ʻia ma luna i hōʻuluʻulu ʻia mai nā maʻi 300 ma o ka ʻai ʻana i ka nuiʻO Ganoderma lucidumno ka manawa loihi.

Puna：

1. Zhili Ren, et al.ʻO Ganoderma lucidumHoʻololi i nā pane Inflammatory ma hope o 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration in Mice.Nā meaʻai.2022;14(18):3872.doi: 10.3390/nu14183872.

2. Zhi-Li Ren, et al.ʻO Ganoderma lucidumHoʻopau i ka Ameliorates MPTP-Induced Parkinsonism a pale i nā Neurons Dopaminergic mai ka Oxidative Stress ma o ka hoʻoponopono ʻana i ka hana Mitochondrial, Autophagy, a me Apoptosis.Acta Pharmacol Sin.2019;40(4):441-450.doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, et al.ʻO Ganoderma lucidumPalekana ʻo Dopaminergic Neuron Degeneration ma o ka Inhibition of Microglial Activation.Evid Based Complement Alternat Med.2011;2011:156810.doi: 10.1093/ecam/nep075.

4. Hui Ding, et al.ʻO Ganoderma lucidumMālama ka extract i nā neuron dopaminergic ma ke kāohi ʻana i ka hoʻoulu ʻana o microglial.Acta Physiologica Sinica, 2010, 62 (6): 547-554.

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