Cov txiaj ntsig ntawmGanoderma lucidumextract rau cov neeg mob Parkinson's disease

“MuajGanoderma lucidumtxo cov tsos mob ntawm cov neeg mob Parkinson tus kab mob?Nov yog ib lo lus nug uas ntau tus neeg mob, lawv tsev neeg, cov txheeb ze thiab cov phooj ywg xav nug.

Nyob rau hauv ib tsab ntawv ceeb toom luam tawm nyob rau hauvActa Pharmacologica SinicaThaum lub Plaub Hlis 2019, pab pawg tshawb fawb los ntawm Thawj Coj Biao Chen, xibfwb ntawm Neurology Department ntawm Xuanwu Tsev Kho Mob, Capital Medical University, tau hais tias lawv tau soj ntsuam 300 tus neeg mob Parkinson tus kab mob hauv kev sib tw, ob qhov muag tsis pom, cov tshuaj placebo tswj kev sim tshuaj:

Cov neeg mob no nyob ntawm theem 1 ("cov tsos mob tshwm sim ntawm ib sab ntawm lub cev tab sis tsis cuam tshuam rau qhov sib npaug") mus rau theem 4 ("mob hnyav hnyav tab sis tuaj yeem taug kev thiab sawv ntawm nws tus kheej").Cov kws tshawb fawb tau cia cov neeg mob noj 4 grams ntawmGanoderma lucidumrho tawm qhov ncauj txhua hnub rau 2 xyoos, thiab pom tias cov neeg mob 'cov tsos mob ntawm lub cev muaj zog' tuaj yeem pab tau tiag tiag los ntawm kev cuam tshuam ntawmGanoderma lucidum.

Yog li hu ua cov tsos mob ntawm tus kab mob Parkinson muaj xws li:

◆ Kev tshee tshee: tshee tshee tshee tsis tau.

◆ Ntws txhav: Nruam nruj ntawm cov nqaij ntshiv vim muaj zog nro, ua rau ceg ceg tawv txav.

◆ Hypokinesia: Kev txav qeeb thiab tsis muaj peev xwm ua tau sib law liag lossis ua haujlwm sib txawv ib txhij.

◆ lub cev tsis khov kho: yooj yim poob vim poob ntawm qhov sib npaug.

nojGanoderma lucidumrho tawm txhua hnub tuaj yeem ua rau qeeb ntawm cov tsos mob no.Txawm hais tias tseem muaj txoj hauv kev mus rau kev kho tus kab mob ntev ntev, nws pom tau tias kev ua neej zoo ntawm cov neeg mob Parkinson tuaj yeem txhim kho.

Ganoderma lucidumextract slows qhov kev loj hlob ntawm Parkinson tus kab mob, uas muaj feem xyuam rau kev tiv thaiv ntawm dopamine neurons.

Pab neeg tshawb fawb ntawm Xuanwu Tsev Kho Mob ntawm Capital Medical University tau pom los ntawm kev sim tsiaj uas siv qhov ncauj txhua hnub ntawm 400 mg / kg.Ganoderma lucidumExtract tuaj yeem tswj xyuas lub cev muaj zog zoo hauv cov nas uas muaj tus kab mob Parkinson.Tus naj npawb ntawm dopamine neurons nyob rau hauv lub hlwb ntawm cov nas uas muaj tus kab mob Parkinson yog ntau tshaj ob npaug ntawm cov nas tsis muaj.Ganoderma lucidumkev tiv thaiv (Yog xav paub ntxiv, saib "Xib Fwb Biao Chen pab neeg los ntawm Beijing Xuanwu Tsev Kho Mob tau lees paub qhov ntawdGanoderma lucidumtiv thaiv dopamine neurons thiab txo cov tsos mob ntawm Parkinson tus kab mob”).

Dopamine secreted los ntawm dopamine neurons yog ib qho tseem ceeb neurotransmitter rau lub hlwb los tswj cov leeg nqaij.Kev tuag loj ntawm dopamine neurons yog dab tsi ua rau Parkinson tus kab mob.Thaj,Ganoderma lucidumUa kom qeeb ntawm kev loj hlob ntawm Parkinson tus kab mob, uas cuam tshuam nrog kev puas tsuaj tsawg rau dopamine neurons.

Lub hauv paus ua rau kev tuag tsis zoo ntawm dopamine neurons yog tias muaj ntau cov proteins uas muaj kuab lom tau tsim nyob rau hauv substantia nigra ntawm lub hlwb (qhov chaw hauv lub hlwb uas dopamine neurons nyob).Ntxiv rau kev hem ncaj qha rau kev ciaj sia thiab kev ua haujlwm ntawm dopamine neurons, cov proteins no tseem yuav ua rau microglia (cov kab mob tsis muaj zog nyob hauv lub hlwb) nyob ib puag ncig cov paj hlwb, ua rau lawv tsis tu ncua zais cov pro-inflammatory cytokines kom puas dopamine neurons.

▲ Cov neurons uas tsim dopamine nyob rau hauv lub hlwb yog nyob rau hauv lub compact ib feem ntawm "substantia nigra".Cov dopamine tsim tawm ntawm no yuav raug xa mus rau ntau thaj tsam ntawm lub hlwb los ua lub luag haujlwm nrog rau cov kav hlau txais xov txuas ntxiv ntawm dopamine neurons.Qhov kev txav mus los ntawm Parkinson tus kab mob feem ntau yog vim tsis muaj dopamine thauj los ntawm substantia nigra mus rau striatum.Yog li ntawd, txawm tias nws yog dopamine neurons nyob rau hauv substantia nigra los yog tentacles ntawm dopamine neurons txuas mus rau striatum, lawv cov naj npawb thiab ib puag ncig ib puag ncig yog qhov tseem ceeb rau kev loj hlob ntawm tus kab mob Parkinson.

Yav dhau los, pab pawg tshawb fawb ntawm Xuanwu Tsev Kho Mob ntawm Capital Medical University tau lees paub qhov ntawdGanoderma lucidumextract tuaj yeem txo qhov kev pheej hmoo ntawm dopamine neuron puas los ntawm txoj kev raug mob-tiv thaiv los ntawm kev tiv thaiv cov txheej txheem ntawm kev txiav txim ntawm mitochondria (cell generators) nyob rau hauv ib puag ncig ntawm inflammatory teb (Rau cov ntsiab lus, saib "Xib Fwb Biao Chen pab neeg los ntawm Beijing Xuanwu Tsev Kho Mob tau lees tias.Ganoderma lucidumtiv thaiv dopamine neurons thiab txo cov tsos mob ntawm Parkinson tus kab mob”).

Thaum lub Cuaj Hlis 2022, pab pawg tshawb fawb tau luam tawm hauvKhoom noj khoom hausntxiv tau lees paub tiasGanoderma lucidumextract tuaj yeem txo qhov tso tawm ntawm pro-inflammatory cytokines los ntawm cov txheej txheem ntawm "inhibiting ntau dhau ntawm microglia", yog li tiv thaiv dopamine neurons los ntawm kev puas tsuaj-txo txoj kev.

Cov nas uas muaj tus kab mob Parkinson uas nojGanoderma lucidumextract tau tsawg activatedmicroglianyob rau hauv lub substantia nigra thiab striatum.

Raws li tsab ntawv tshaj tawm tshiab no, cov nas tau xub txhaj tshuaj neurotoxin MPTP los ua rau tib neeg zoo li Parkinson tus kab mob, thiab tom qab ntawd 400 mg / kg ntawmGanoderma lucidumextract GLE tau hais lus txhua hnub los ntawm hnub tom qab (Parkinson tus kab mob +Ganoderma lucidumextract pawg) thaum cov nas tsis kho nrog Parkinson tus kab mob (tsuas yog txhaj nrog MPTP) thiab cov nas ib txwm siv los ua kev sim tswj.

Tom qab 4 lub lis piam, ib tug loj tus naj npawb ntawm activated microglia tshwm nyob rau hauv lub striatum thiab substantia nigra pars compacta (qhov chaw faib loj ntawm dopamine neurons) nyob rau hauv lub hlwb ntawm cov nas uas muaj tus kab mob Parkinson, tab sis qhov no tsis tshwm sim nyob rau hauv cov nas uas muaj tus kab mob Parkinson noj.Ganoderma lucidumrho tawm txhua hnub - lawv tus mob yog ze rau cov nas ib txwm (daim duab hauv qab).

▲ [Kev piav qhia]Ganoderma lucidummuaj inhibitory nyhuv ntawm microglia nyob rau hauv lub paj hlwb cheeb tsam uas cov dopamine neurons nyob (striatum thiab substantia nigra pars compacta) nyob rau hauv nas nrog Parkinson tus kab mob.Daim duab 1 yog cov duab stained ntawm activated microglia hauv cov ntaub so ntswg, thiab daim duab 2 yog cov txheeb cais ntau ntawm cov tshuab txais microglia.

Cov nas uas muaj tus kab mob Parkinson uas nojGanoderma lucidumextract tau qis dua cov ntsiab lus ntawm pro-inflammatory cytokines nyob rau hauv midbrain thiab striatum.

Activated microglia hlwb secrete ntau yam cytokines lossis chemokines los txhawb kev mob thiab ua rau muaj kev puas tsuaj ntawm dopamine neurons.Txawm li cas los xij, hauv kev tshawb pom ntawm midbrain thiab striatum ntawm cov tsiaj sim saum toj no, cov kws tshawb fawb pom tias kev noj txhua hnub ntawmGanoderma lucidumextract tuaj yeem inhibit qhov tsim ntawm pro-inflammatory cytokines uas tau nce ntxiv vim qhov pib ntawm Parkinson tus kab mob (raws li qhia hauv daim duab hauv qab no).

Ganoderma lucidumextract pab ncua kev loj hlob ntawm tus kab mob Parkinson, uas yog tshwm sim los ntawm kev sib cuam tshuam ntawm ntau yam khoom xyaw.

Cov kws tshawb fawb hauv zej zog tau lees paub tias cov lus teb inflammatory tshwm sim los ntawm kev ua kom tsis zoo ntawm microglia yog tom qab kev tuag sai ntawm dopamine neurons thiab kev puas tsuaj ntawm Parkinson tus kab mob.Yog li ntawd, inhibition ntawm microglia activation los ntawmGanoderma lucidumextract undoubtedly muab ib qho tseem ceeb piav qhia vim li casGanoderma lucidumExtract tuaj yeem txo cov kab mob Parkinson.

Dab tsi yog cov khoom ntawmGanoderma lucidumuas siv cov haujlwm no?

CovGanoderma lucidumextract GLE siv nyob rau hauv qhov kev tshawb fawb no yog tsim los ntawm fruiting lub cev ntawmGanoderma lucidumlos ntawm ntau yam ethanol thiab dej kub extraction txheej txheem.Nws muaj txog 9.8% Ganoderma lucidumpolysaccharides, 0.3-0.4% ganoderic acid A (ib qho tseem ceeb tshaj plaws triterpenoids hauvGanoderma lucidumtxiv hmab txiv ntoo lub cev) thiab 0.3-0.4% ergosterol.

Qee qhov kev tshawb fawb txog yav dhau los tau ua pov thawj tias polysaccharides, triterpenes, thiab ganoderic acid A hauvGanoderma lucidumTxhua yam muaj lub luag haujlwm ntawm "kev tswj cov kab mob inflammatory" thiab "tiv thaiv cov paj hlwb".Yog li ntawd, cov kws tshawb fawb ntseeg tias cov nyhuv ntawmGanoderma lucidumntawm kev ncua kev loj hlob ntawm tus kab mob Parkinson tsis yog qhov tshwm sim ntawm kev ua ntawm ib qho kev tiv thaiv tab sis yog qhov tshwm sim ntawm kev sib koom tes ntawm ntau yam ntawmGanoderma lucidumhauv lub cev.

Tej zaum nws yuav tsis paub meej tias qhov sib txawv li casGanoderma lucidumCheebtsam noj nyob rau hauv lub plab hla qhov "ntshav-hlwb barrier" thiab ces exert lawv cov teebmeem ntawm microglia thiab dopamine neurons nyob rau hauv lub hlwb.Tab sis nyob rau hauv txhua rooj plaub, nws yog ib tug indisputable qhov tseeb hais tiasGanoderma lucidumCheebtsam tuaj yeem cuam tshuam rau hauv pathogenesis kom ncua kev loj hlob ntawm tus kabmob.

Qhov degeneration ntawm dopamine neurons uas ua rau Parkinson tus kab mob tsis yog ib qho txheej txheem tab sis cov txheej txheem kev loj hlob uas degrades me ntsis txhua hnub.Tau ntsib tus kab mob no uas tsis tuaj yeem xaus thiab tsuas tuaj yeem ua marathon nrog nws mus tas li, cov neeg mob tsuas tuaj yeem ua haujlwm hnyav dua txhua hnub txhawm rau thov Vajtswv kom txo qis dua txhua hnub.

Yog li ntawd, tsis txhob tos rau cov tshuaj tshiab uas tig lub ntiaj teb ib ncig, nws yog qhov zoo dua los txeeb lub sijhawm thiab nqa cov khoom muaj nqis tso rau pem hauv ntej thiab sim ua siab tawv.Nws yuav tsum tsis txhob npau suav kom rov tsim dua cov txiaj ntsig tau hais los saum toj no kev soj ntsuam cov ntsiab lus los ntawm 300 tus neeg mob los ntawm kev noj cov nyiaj txaus.Ganoderma lucidumntev.

Qhov chaw:

1. Zhili Li, et al.Ganoderma lucidumModulates Inflammatory Responses tom qab 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Kev tswj hwm hauv nas.Khoom noj khoom haus.2022; 14(18):3872.doi: 10.3390 / nr 14183872.

2. Zhi-Li Ren, et al.Ganoderma lucidumExtract Ameliorates MPTP-Induced Parkinsonism thiab tiv thaiv Dopaminergic Neurons los ntawm Oxidative Stress ntawm Regulating Mitochondrial Function, Autophagy, thiab Apoptosis.Acta Pharmacol Sin.2019; 40(4): 441-450.doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, et al.Ganoderma lucidumTiv thaiv Dopaminergic Neuron Degeneration los ntawm Inhibition ntawm Microglial Activation.Evid Based Complement Alternat Med.2011; 2011: 156810.doi: 10.1093/ecam/nep075.

4. Hui Ding, et al.Ganoderma lucidumExtract tiv thaiv dopaminergic neurons los ntawm inhibiting microglial activation.Acta Physiologica Sinica, 2010, 62(6): 547-554.

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab nws cov tswv cuab yog GanoHerb.

★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai ntawm GanoHerb.

★ Yog tias txoj haujlwm raug tso cai siv, nws yuav tsum tau siv nyob rau hauv qhov kev tso cai thiab qhia qhov chaw: GanoHerb.

★ Rau ib qho kev ua txhaum cai ntawm cov lus hais saum toj no, GanoHerb yuav ua raws li cov luag haujlwm raug cai.

★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.