I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (1)

Iinzuzo zeI-Ganoderma lucidumisicatshulwa kwizigulane ezine-Parkinson's disease

“NgabaI-Ganoderma lucidumukuphelisa iimpawu zabaguli abanesifo sikaParkinson?”Lo ngumbuzo ukuba izigulane ezininzi, iintsapho zabo, izalamane kunye nabahlobo bafuna ukubuza.

Kwingxelo epapashwe kwiActa Pharmacologica Sinicango-Epreli ka-2019, iqela lophando elikhokelwa nguMlawuli u-Biao Chen, unjingalwazi weSebe leNeurology kwiSibhedlele saseXuanwu, kwiYunivesithi yaseCapital Medical, ukhankanye ukuba babone abaguli abangama-300 abanesifo sikaParkinson kulingo lweklinikhi olungahleliwe, olungaboni kakuhle, olulawulwa yi-placebo:

Ezi zi gulane zivela kwinqanaba le-1 ("impawu zivela kwelinye icala lomzimba kodwa azichaphazeli ukulinganisela") ukuya kwinqanaba le-4 ("ukuhamba okungahambi kakuhle kodwa kukwazi ukuhamba nokuma ngokuzimela").Abaphandi bavumela izigulane ukuba zithathe i-4 grams yeI-Ganoderma lucidumikhupha ngomlomo yonke imihla iminyaka emi-2, kwaye yafumanisa ukuba "iimpawu zeemoto" zesigulana zinokukhululeka ngokungenelelaI-Ganoderma lucidum.

Iimpawu ezibizwa ngokuba yimoto yesifo sikaParkinson ziquka:

◆ Ukungcangcazela: Ukushukuma okungalawulekiyo kwamalungu.

◆ Ukuqina kwemilenze: Ukuqiniswa ngokuqhubekayo kwemisipha ngenxa yokwanda koxinzelelo, okwenza imilenze ibe nzima ukuhamba.

◆ I-Hypokinesia: Ukunyakaza okucothayo kunye nokungakwazi ukwenza ukunyakaza okulandelelanayo okanye ukwenza iintshukumo ezahlukeneyo ngaxeshanye.

◆ Ukuma okungazinzanga: kulula ukuwa ngenxa yokulahlekelwa ngumlinganiselo.

UkuthathaI-Ganoderma lucidumisicatshulwa yonke imihla inokucothisa ukuwohloka kwezi mpawu.Nokuba kusekho indlela ende yokunyanga esi sifo, kuyacingeleka ukuba umgangatho wobomi bezigulana ezinesifo sikaParkinson unokuphuculwa.

I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (2) I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (3)

I-Ganoderma lucidumisicatshulwa sicotha ukuqhubeka kwesifo sikaParkinson, esinxulumene nokukhuselwa kwe-dopamine neurons.

Iqela lophando lweSibhedlele saseXuanwu seYunivesithi yaseCapital Medical lifumene ngovavanyo lwezilwanyana ukuba ulawulo lomlomo lwemihla ngemihla lwe-400 mg / kgI-Ganoderma lucidumisicatshulwa singagcina ukusebenza ngcono kweempuku ngesifo sikaParkinson.Inani le-dopamine neurons ebuchotsheni beempuku ezinesifo sikaParkinson lingaphezulu kokuphindwe kabini kunelo leempuku ngaphandle.I-Ganoderma lucidumukhuseleko (Ukufumana iinkcukacha, bona "iqela likaNjingalwazi uBiao Chen ovela kwisibhedlele saseBeijing Xuanwu ukuqinisekisile ukubaI-Ganoderma lucidumikhusela i-dopamine neurons kwaye ithomalalisa iimpawu zesifo sikaParkinson”).

I-Dopamine efihliweyo yi-dopamine neurons yi-neurotransmitter eyimfuneko ukuze ingqondo ilawule ukusebenza kwezihlunu.Ukufa okukhulu kwe-dopamine neurons kuko okubangela isifo sikaParkinson.Ngokucacileyo,I-Ganoderma lucidumyacotha ukuqhubeka kwesifo sikaParkinson, esasinxulunyaniswa nomonakalo omncinci kwi-dopamine neurons.

Oyena nobangela wokufa okungaqhelekanga kwe-dopamine neurons kukuba inani elikhulu leeprotheyini ezinetyhefu ziqokelele kwi-substantia nigra yengqondo (eyona ndawo iphambili yobuchopho apho i-dopamine neurons ikhona).Ukongeza ekusoyikiseni ngokuthe ngqo ukusinda kunye nokusebenza kwe-dopamine neurons, ezi proteni ziyakuphinda zenze i-microglia (iiseli zamajoni omzimba ezihlala engqondweni) zijikeleze iiseli zemithambo-luvo, zibangele ukuba ziqhubeke zikhupha ii-cytokines ze-pro-inflammatory zokonakalisa i-dopamine neurons.

 

I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (4)

 

▲I-neurons eyenza i-dopamine ebuchosheni ibekwe kwindawo ehlangeneyo ye "substantia nigra".I-dopamine eyenziwe apha iya kuthunyelwa kwimimandla eyahlukeneyo yengqondo ukuze idlale indima kunye ne-eriyali eyandisiweyo ye-dopamine neurons.Ukuphazamiseka kwentshukumo eqhelekileyo yesifo sikaParkinson ikakhulu ngenxa yokunqongophala kwe-dopamine ethuthwa ukusuka kwi-substantia nigra ukuya kwi-striatum.Ke ngoko, nokuba yi-dopamine neurons ebekwe kwi-substantia nigra okanye iintente ze-dopamine neurons eziya kwi-striatum, inani labo kunye nokusingqongileyo zibalulekile ekuqhubekeni kwesifo sikaParkinson.

Ngaphambili, iqela lophando kwisibhedlele iXuanwu kwiYunivesithi yaseCapital Medical ikuqinisekisile okoI-Ganoderma lucidumisicatshulwa sinokunciphisa umngcipheko we-dopamine neuron umonakalo ovela kwindlela echasayo yokulimala ngokukhusela indlela yokusebenza ye-mitochondria (ijenereyitha zeseli) kwindawo yempendulo yokuvuvukala (Ukufumana iinkcukacha, bona "iqela likaNjingalwazi uBiao Chen ovela kwisibhedlele saseBeijing Xuanwu uqinisekisile ukubaI-Ganoderma lucidumikhusela i-dopamine neurons kwaye ithomalalisa iimpawu zesifo sikaParkinson”).

NgoSeptemba 2022, uphando lweqela lupapashwe kwiIzondloyaqinisekisa ngakumbi ukubaI-Ganoderma lucidumisicatshulwa sinokunciphisa ukukhuselwa kwe-cytokines e-pro-inflammatory ngokusebenzisa indlela "yokuthintela ukusebenza ngokugqithiseleyo kwe-microglia", ngaloo ndlela ikhusela i-dopamine neurons kwindlela yokunciphisa umonakalo.

 I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (5)

Iimpuku ezinesifo sikaParkinson ezityileyoI-Ganoderma lucidumisicatshulwa siye sasebenza ezimbalwamicrogliakwi-substantia nigra kunye ne-striatum.

Ngokwale ngxelo isanda kupapashwa, iimpuku zaqala ukutofwa nge-neurotoxin MPTP ukukhuthaza isifo se-Parkinson esifana nomntu, kwaye emva koko i-400 mg / kgI-Ganoderma lucidumIsicatshulwa se-GLE sasilawulwa ngomlomo yonke imihla ukususela ngosuku olulandelayo (isifo sikaParkinson +I-Ganoderma lucidumextract group) ngelixa iimpuku ezinganyangwanga ezinesifo sikaParkinson (zitofwe kuphela ngeMPTP) kunye neempuku eziqhelekileyo zisetyenziswe njengolawulo lovavanyo.

Emva kweeveki ezi-4, inani elikhulu le-microglia esebenzayo yavela kwi-striatum kunye ne-substantia nigra pars compacta (eyona ndawo yokusabalalisa i-dopamine neurons) kwingqondo yeempuku ezinesifo sika-Parkinson, kodwa oku akuzange kwenzeke kwiimpuku ezine-Parkinson's disease.I-Ganoderma lucidumisicatshulwa imihla ngemihla - imeko yabo isondele kwiempuku eziqhelekileyo (ezichazwe ngezantsi).

I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (6)

▲ [Inkcazelo]I-Ganoderma luciduminefuthe lokuthintela kwi-microglia kwingingqi yobuchopho apho i-dopamine neurons ikhoyo (i-striatum kunye ne-substantia nigra pars compacta) kwiimpuku ezinesifo sika-Parkinson.Umzobo we-1 ngumfanekiso ongcolileyo we-microglia esebenzayo kumacandelo e-tissue, kunye ne-Figure 2 yi-statistics yobuninzi be-microglia esebenzayo.

Iimpuku ezinesifo sikaParkinson ezityileyoI-Ganoderma lucidumIsicatshulwa sasinoxinzelelo olusezantsi lwe-cytokines e-pro-ukudumba kwi-midbrain kunye ne-striatum.

Iiseli ze-microglia ezisebenzayo zikhupha iindidi ze-cytokines okanye i-chemokines ukukhuthaza ukuvutha kunye nokwandisa umonakalo we-dopamine neurons.Nangona kunjalo, ekubhaqweni kwe-midbrain kunye ne-striatum yezilwanyana zovavanyo ezikhankanywe ngasentla, abaphandi bafumanisa ukuba ukusetyenziswa kwemihla ngemihlaI-Ganoderma lucidumi-extract inokuthintela ukuveliswa kwee-cytokines ze-pro-inflammatory eziye zanda kakhulu ngenxa yokuqala kwesifo sika-Parkinson (njengoko kubonisiwe kumfanekiso ongezantsi).

I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (7)

 

I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (8)

 

I-Ganoderma lucidumisicatshulwa kunceda ukulibazisa ukuqhubeka kwesifo sikaParkinson, esisisiphumo sokusebenzisana kwezinto ezininzi ezisebenzayo.

Uluntu lwezenzululwazi luqinisekisile ukuba impendulo yokuvuvukala ebangelwa kukusebenza okungaqhelekanga kwe-microglia isemva kokukhawuleza kokusweleka kwe-dopamine neurons kunye nokuwohloka kwesifo sikaParkinson.Ke ngoko, inhibition of microglia activation byI-Ganoderma lucidumisicatshulwa ngokungathandabuzekiyo inika ingcaciso ebalulekileyo yokuba kutheniI-Ganoderma lucidumisicatshulwa sinokunciphisa ikhosi yesifo sikaParkinson.

Ngawaphi amacandeloI-Ganoderma lucidumezenza le misebenzi?

II-Ganoderma lucidumisicatshulwa GLE esetyenziswe kolu phando yenziwe kwimizimba yeziqhamo zeI-Ganoderma lucidumnge-ethanol ezininzi kunye neenkqubo zokutsalwa kwamanzi ashushu.Iqulethe malunga ne-9.8% ye-Gi-anoderma lucidumiipolysaccharides, 0.3-0.4% ganoderic acid A (enye yezona triterpenoids ibalulekileyo kwiI-Ganoderma lucidumimizimba eneziqhamo) kunye ne-ergosterol eyi-0.3-0.4%.

I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (9)

Ezinye izifundo ezinxulumeneyo kwixesha elidlulileyo zibonise ukuba i-polysaccharides, i-triterpenes, kunye ne-ganoderic acid AI-Ganoderma lucidumzonke zinemisebenzi "yokulawula impendulo yokuvuvukala" kunye "nokukhusela iiseli ze-nerve".Ngoko ke, abaphandi bakholelwa ukuba umphumo weI-Ganoderma lucidumekubambezelekeni kokuqhubela phambili kwesifo sikaParkinson akubangelwa yisenzo secandelo elinye kodwa sisiphumo sokulungelelaniswa kwamacandelo amaninziI-Ganoderma lucidumemzimbeni.

Ayinakuze icace indlela ezahlukeneyoI-Ganoderma lucidumIzinto ezityiwayo esiswini ziwela "umqobo wengqondo yegazi" kwaye emva koko zenze iziphumo zazo kwi-microglia kunye ne-dopamine neurons ebuchosheni.Kodwa kuyo nayiphi na imeko, yinyani engenakuphikiswa ukubaI-Ganoderma lucidumamacandelo anokungenelela kwi-pathogenesis ukulibazisa ukuqhubela phambili kwesi sifo.

Ukuwohloka kwe-dopamine neurons ebangela isifo sikaParkinson ayisiyonkqubo yenyathelo elinye kodwa yinkqubo eqhubekayo ethoba kancinci yonke imihla.Ukujongana nesi sifo esingenakupheliswa kwaye sinokudibana nayo ubomi bonke, abaguli banokusebenza nzima yonke imihla ukuze bathandazele ukuhlehla okuncinci yonke imihla.

Ngoko ke, endaweni yokulinda iyeza elitsha elijika ihlabathi, kungcono ukubamba ixesha kwaye uthathe ubuncwane obunikezelwe phambi kwakho kwaye uzame ngesibindi.Akufanele kube liphupha ukuvelisa iziphumo zovavanyo lweklinikhi ezikhankanywe ngasentla ezishwankathelweyo kwizigulane ezingama-300 ngokutya isixa esaneleyoI-Ganoderma lucidumixesha elide.

I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (10)

Umthombo:

1. UZhili Ren, et al.I-Ganoderma lucidumImodareyitha Iimpendulo ezivuthayo ezilandela i-1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) yoLawulo kwiiMice.Izondlo.2022;14(18):3872.doi: 10.3390/nu14183872.

2. Zhi-Li Ren, et al.I-Ganoderma lucidumI-Ameliorates ye-MPTP-Induced Parkinsonism kunye nokukhusela i-Dopaminergic Neurons kwi-Oxidative Stress ngokuLawulwa kweMitochondrial Function, Autophagy, kunye ne-Apoptosis.Acta Pharmacol Sin.2019;40(4):441-450.doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, et al.I-Ganoderma lucidumIkhusela iDopaminergic Neuron Degeneration ngokuVimba kweMicroglial Activation.I-Evid Based Complement Alternat Med.2011;2011:156810.doi: 10.1093/ecam/nep075.

4. UHui Ding, et al.I-Ganoderma lucidumIsicatshulwa sikhusela i-dopaminergic neurons ngokuthintela ukusebenza kwe-microglial.Acta Physiologica Sinica, 2010, 62 (6): 547-554.

I-GLE ilibazisa ukuqhubeka kwesifo sikaParkinson (11)

★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali, kwaye ubunini balo bubo beGanoHerb.

★ Lo msebenzi ungasentla awunakuphinda uveliswe, ucatshulwe okanye usetyenziswe ngezinye iindlela ngaphandle kogunyaziso lweGanoHerb.

★ Ukuba umsebenzi ugunyazisiweyo ukuba usetyenziswe, kufuneka usetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ubonise umthombo: GanoHerb.

★ Nakuphi na ukuphulwa kwengxelo engentla, i-GanoHerb iya kulandela uxanduva olusemthethweni olunxulumeneyo.

★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.


Ixesha lokuposa: May-04-2023

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