Uru nkeGanoderma lucidumwepụ na ndị ọrịa nwere ọrịa Parkinson

"Enwere ikeGanoderma lucidumbelata mgbaàmà nke ndị ọrịa nwere ọrịa Parkinson?”Nke a bụ ajụjụ ọtụtụ ndị ọrịa, ezinụlọ ha, ndị ikwu na ndị enyi chọrọ ịjụ.

Na akụkọ e bipụtara naActa Pharmacologica SinicaN'April 2019, ndị otu nyocha nke Director Biao Chen, Prọfesọ nke Ngalaba Neurology nke Xuanwu Hospital, Capital Medical University, kwuru na ha hụrụ ndị ọrịa 300 na-arịa ọrịa Parkinson n'ụdị a na-enweghị usoro, kpuru ìsì abụọ, na-achịkwa placebo:

Ndị ọrịa a sitere na ogbo 1 ("mgbaàmà na-apụta n'otu akụkụ nke ahụ ma ọ dịghị emetụta nguzozi") ruo ọkwa 4 ("mmegharị ahụ na-adịghị mma mana ọ nwere ike ịga ije ma guzoro onwe ya").Ndị nchọpụta ahụ kwere ka ndị ọrịa were gram 4 nkeGanoderma lucidumwepụta ọnụ ọnụ kwa ụbọchị maka afọ 2, wee chọpụta na “mgbaàmà nke moto” nke ndị ọrịa nwere ike belata n'ezie site na ntinye aka.Ganoderma lucidum.

Ihe a na-akpọ mgbaàmà moto nke ọrịa Parkinson gụnyere:

◆ ịma jijiji: ịma jijiji nke akụkụ ụkwụ na-enweghị nchịkwa.

◆ Isi ike: akwara na-aga n'ihu na-emechi ya n'ihi oke mgbakasị ahụ, na-eme ka akụkụ ahụ sie ike ịkwaga.

◆ Hypokinesia: Ntugharị nwayọ na enweghị ike ịme mmegharị n'usoro ma ọ bụ mee mmegharị dị iche iche n'otu oge.

◆ Ọnọdụ na-adịghị agbanwe agbanwe: ọ dị mfe ịda n'ihi nkwụsị nke nguzozi.

Na-ewereGanoderma lucidumwepụ kwa ụbọchị nwere ike belata mmebi nke mgbaàmà ndị a.Ọ bụrụgodị na a ka nwere ogologo ụzọ iji gwọọ ọrịa ahụ, a ga-eche na ndụ ndị ọrịa nwere ọrịa Parkinson nwere ike ime ka mma.

Ganoderma lucidumMwepụta na-ebelata ọganihu nke ọrịa Parkinson, nke metụtara nchebe nke neurons dopamine.

Ndị otu nyocha nke Xuanwu Hospital nke Capital Medical University achọpụtala site na nnwale anụmanụ na nchịkwa ọnụ kwa ụbọchị nke 400 mg / kg.Ganoderma lucidumwepụ nwere ike ịnọgide na-arụ ọrụ moto ka mma na ụmụ oke nwere ọrịa Parkinson.Ọnụọgụ dopamine neurons na ụbụrụ ụmụ oke nwere ọrịa Parkinson karịrị okpukpu abụọ nke ụmụ oke na-enweghị.Ganoderma lucidumnchekwa (Maka nkọwapụta, lee “Ndị otu Prọfesọ Bio Chen si n'ụlọọgwụ Beijing Xuanwu kwadoro nke ahụGanoderma lucidumna-echebe neurons dopamine ma na-ebelata ihe mgbaàmà nke ọrịa Parkinson).

Dopamine zoro ezo site na neurons dopamine bụ ihe dị mkpa neurotransmitter maka ụbụrụ iji mezie ọrụ akwara.Ọnwụ oke nke neurons dopamine bụ ihe na-akpata ọrịa Parkinson.O doro anya,Ganoderma lucidumbelatara ọganihu nke ọrịa Parkinson, nke jikọtara ya na obere mmebi nke neurons dopamine.

Ihe na-akpata ọnwụ na-adịghị ahụkebe nke neurons dopamine bụ na ọnụ ọgụgụ dị ukwuu nke protein na-egbu egbu agbakọbawo na substantia nigra nke ụbụrụ (akụkụ ụbụrụ bụ isi ebe dopamine neurons dị).Na mgbakwunye na iyi egwu ndụ na ọrụ nke neurons dopamine, ndị na-edozi ahụ ga-emekwa ka microglia (sel ndị na-alụso ọrịa ọgụ bi na ụbụrụ) rụọ ọrụ gburugburu mkpụrụ ndụ akwara, na-eme ka ha na-ezobe cytokines pro-inflammatory na-aga n'ihu iji mebie neurons dopamine.

▲ Neuron na-emepụta dopamine na ụbụrụ dị na kọmpat akụkụ nke "substantia nigra".A ga-eziga dopamine emepụtara ebe a na mpaghara dị iche iche nke ụbụrụ ka ọ rụọ ọrụ yana antennae agbatị nke neurons dopamine.Nsogbu mmegharị ahụ nke ọrịa Parkinson bụ nke kachasị n'ihi enweghị dopamine ebuga site na substantia nigra gaa na striatum.Ya mere, ma ọ bụ neurons dopamine dị na substantia nigra ma ọ bụ tentacles nke neurons dopamine na-agbatị na striatum, ọnụọgụ ha na gburugburu ebe obibi dị oke mkpa maka ọganihu nke ọrịa Parkinson.

Na mbụ, ndị otu nyocha nke Xuanwu Hospital nke Capital Medical University kwadoro nke ahụGanoderma lucidumwepụ nwere ike ibelata ihe ize ndụ nke dopamine neuron mebiri site na mmerụ ahụ na-eguzogide ụzọ site n'ichebe usoro nke mitochondria (cell generators) na gburugburu ebe obibi nke nzaghachi mkpali (Maka nkọwa, lee "Ndị otu Prọfesọ Biao Chen si na Beijing Xuanwu Hospital kwadoro naGanoderma lucidumna-echebe neurons dopamine ma na-ebelata ihe mgbaàmà nke ọrịa Parkinson).

Na Septemba 2022, nyocha otu a bipụtara naIhe oririn'ihu kwenye naGanoderma lucidumwepụ nwere ike ibelata nzuzo nke cytokines pro-inflammatory site na usoro nke "na-egbochi oke ịgbalite microglia", si otú ahụ na-echebe neurons dopamine site na ụzọ na-ebelata mmebi.

Oke nwere ọrịa Parkinson ndị ririGanoderma lucidumewepụtara obere ọrụmicrogliana substantia nigra na striatum.

Dị ka akụkọ a e bipụtara ọhụrụ si kwuo, e bu ụzọ gbanye ụmụ oke na neurotoxin MPTP iji mee ka ọrịa Parkinson dị ka mmadụ, na mgbe ahụ 400 mg / kg nkeGanoderma lucidumewepụtara GLE ọnụ kwa ụbọchị site n'echi ya (ọrịa Parkinson +Ganoderma lucidumwepụ otu) ebe ụmụ oke na-adịghị agwọ ọrịa nwere ọrịa Parkinson (naanị na-agbanye ya na MPTP) na ụmụ oke nkịtị ka ejiri mee ihe dị ka njikwa nyocha.

Mgbe izu 4 gachara, ọnụ ọgụgụ buru ibu nke microglia na-arụ ọrụ pụtara na striatum na substantia nigra pars compacta (ebe bụ isi nkesa dopamine neurons) na ụbụrụ ụmụ oke nwere ọrịa Parkinson, mana nke a emeghị na ụmụ oke nwere ọrịa Parkinson bụ ndị riri nri.Ganoderma lucidumwepụ kwa ụbọchị - ọnọdụ ha dị nso na ụmụ oke nkịtị (dị n'okpuru ebe a).

▲ [Nkọwa]Ganoderma lucidumnwere mmetụta mgbochi na microglia na mpaghara ụbụrụ ebe neurons dopamine dị (striatum na substantia nigra pars compacta) na ụmụ oke nwere ọrịa Parkinson.Onyonyo 1 bụ onyonyo ntụpọ nke microglia na-arụ ọrụ na ngalaba anụ ahụ, na eserese 2 bụ ọnụọgụ ọnụọgụ nke microglia arụrụ ọrụ.

Oke nwere ọrịa Parkinson ndị ririGanoderma lucidumMwepụta nwere obere mkpokọta cytokines pro-inflammatory na etiti ụbụrụ na striatum.

Mkpụrụ ndụ microglia arụ ọrụ na-ezochi ụdị cytokines ma ọ bụ chemokines dị iche iche iji kwalite mbufụt ma mee ka mmebi nke neurons dopamine dịkwuo njọ.Otú ọ dị, na nchọpụta nke midbrain na striatum nke anụmanụ nnwale ndị a kpọtụrụ aha n'elu, ndị nchọpụta chọpụtara na oriri kwa ụbọchị.Ganoderma lucidumwepụ nwere ike igbochi mmepụta nke cytokines pro-inflammatory nke na-abawanye nke ukwuu n'ihi mmalite nke ọrịa Parkinson (dị ka egosiri na foto dị n'okpuru).

Ganoderma lucidumMwepụta na-enyere aka igbu oge na-aga n'ihu nke ọrịa ọrịa Parkinson, bụ nke sitere na mmekọrịta nke ọtụtụ ihe na-arụ ọrụ.

Ndị ọkà mmụta sayensị ekwenyela na mmeghachi omume mkpasu iwe kpatara site na ịgbalite microglia na-adịghị mma bụ n'azụ ọnwụ nke neurons dopamine na-akawanye njọ na ọrịa Parkinson.Ya mere, mgbochi nke microglia ịgbalite siteGanoderma lucidumwepụ ihe ịrụ ụka adịghị ya na-enye nkọwa dị mkpa maka ihe kpatara yaGanoderma lucidumMwepụta nwere ike ibelata usoro ọrịa ọrịa Parkinson.

Gịnị bụ components nkeGanoderma lucidumna-arụ ọrụ ndị a?

NkeGanoderma lucidumwepụ GLE eji mee nchọpụta a bụ nke sitere na mkpụrụ osisi nkeGanoderma lucidumsite na otutu ethanol na usoro mmịpụta mmiri ọkụ.Ọ nwere ihe dịka 9.8% Ganoderma lucidumpolysaccharides, 0.3-0.4% ganoderic acid A (otu n'ime triterpenoids kachasị mkpa naGanoderma lucidumahụ mkpụrụ osisi) na 0.3-0.4% ergosterol.

Ụfọdụ nnyocha metụtara ya n'oge gara aga egosila na polysaccharides, triterpenes, na ganoderic acid A na.Ganoderma lucidumha niile nwere ọrụ nke "ịhazi nzaghachi mkpali" na "ichekwa mkpụrụ ndụ akwara".Ya mere, ndị nchọpụta kweere na mmetụta nkeGanoderma lucidumna igbu oge na-aga n'ihu nke ọrịa ọrịa Parkinson abụghị n'ihi omume nke otu akụkụ kama ọ bụ n'ihi nhazi nke otutu components.Ganoderma lucidumn'ime ahụ.

O nwere ike ọ dịghị mgbe doro anya otú dị iche icheGanoderma lucidumihe ndị a na-eri n'ime afọ na-agafe "ihe mgbochi ụbụrụ ọbara" wee tinye mmetụta ha na microglia na dopamine neurons na ụbụrụ.Mana n'ọnọdụ ọ bụla, ọ bụ eziokwu na-enweghị mgbagha naGanoderma lucidumihe ndị mejupụtara nwere ike itinye aka na pathogenesis na-egbu oge na-aga n'ihu nke ọrịa ahụ.

Mbelata nke neurons dopamine nke na-akpata ọrịa Parkinson abụghị usoro otu nzọụkwụ kama usoro na-aga n'ihu nke na-eweda ntakịrị ntakịrị kwa ụbọchị.N'ịbụ ndị nwere ọrịa a na-enweghị ike ịkwụsị ma nwee ike iji ya marathon ruo oge ndụ niile, ndị ọrịa nwere ike ịrụ ọrụ siri ike kwa ụbọchị iji kpee ekpere maka obere nlọghachi kwa ụbọchị.

Ya mere, kama ichere ọgwụ ọhụrụ nke na-atụgharị ụwa, ọ ka mma iwepụta oge na-ewere akụ ahụ e debere n'ihu gị ma nwalee ya n'atụghị egwu.O kwesịghị ịbụ nrọ imepụtaghachi nsonaazụ nyocha ụlọ ọgwụ a kpọtụrụ aha n'elu nke a chịkọtara n'aka ndị ọrịa 300 site na iri nri zuru oke.Ganoderma lucidumogologo oge.

Isi mmalite:

1. Zhili Ren, et al.Ganoderma lucidumNa-emezi nzaghachi mkparị na-eso 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) nchịkwa na ụmụ oke.Ihe oriri.2022;14 (18):3872 .doi: 10.3390/nu14183872.

2. Zhi-Li Ren, et al.Ganoderma lucidumWepụ Ameliorates MPTP-Induced Parkinsonism ma na-echebe Dopaminergic Neurons site na nrụgide Oxidative site na ịhazi Mitochondrial Function, Autophagy, na Apoptosis.Acta Pharmacol Sin.2019; 40 (4): 441-450 .doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, et al.Ganoderma lucidumNa-echebe Dopaminergic Neuron Degeneration site na Mgbochi nke Microglial activation.Evid Based Complement Alternat Med.2011;2011:156810.doi: 10.1093/ecam/nep075.

4. Hui Ding, et al.Ganoderma lucidumMwepụta na-echebe neurons dopaminergic site na igbochi ọrụ microglial.Acta Physiologica Sinica, 2010, 62 (6): 547-554.

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