Faa'iidooyinkaGanoderma lucidumlaga soosaaray bukaanada qaba cudurka Parkinson

“ karaaGanoderma lucidumnafiso calaamadaha bukaanada qaba cudurka Parkinson?Tani waa su'aal ay rabaan bukaanno badan, qoysaskooda, qaraabadooda iyo asxaabtooda inay waydiiyaan.

Warbixin lagu daabacayActa Pharmacologica SinicaBishii Abriil 2019, kooxda cilmi-baarista ee uu hoggaamiyo Agaasimaha Biao Chen, oo ah borofisar ka tirsan Waaxda Neerfaha ee Isbitaalka Xuanwu, Jaamacadda Caafimaadka, ayaa sheegay inay arkeen 300 bukaan oo qaba cudurka Parkinson si aan kala sooc lahayn, indho-la'aan ah, tijaabo caafimaad oo la xakameynayo placebo:

Bukaannadani waxay u dhexeeyaan marxaladda 1 ("calaamadaha waxay ka muuqdaan hal dhinac oo jirka ah laakiin ma saameeyaan dheelitirka") ilaa marxaladda 4 ("dhaqdhaqaaq aad u liidata laakiin wuxuu awoodaa inuu socdo oo uu si madaxbanaan u istaago").Cilmi-baarayaashu waxay u oggolaadeen bukaannada inay qaataan 4 garaam oo ahGanoderma lucidumafka laga soo saaro maalin kasta muddo 2 sano ah, waxaana la ogaaday in "calamadaha mootada" bukaannada ay runtii nafis u noqon karaan faragelintaGanoderma lucidum.

Waxa loogu yeero calaamadaha dhaqaaqa ee cudurka Parkinson waxaa ka mid ah:

◆ Gariir: Gacan-gariir aan la xakamayn karin.

◆ adkaanshaha addimada: murqaha oo si joogto ah u adkeeya sababtoo ah kacsanaanta sii kordhaysa, taas oo ka dhigaysa addimada mid adag inay dhaqaaqdo.

◆ Hypokinesia: Dhaqdhaqaaq gaabis ah iyo awood la'aanta in la sameeyo dhaqdhaqaaqyo xiriir ah ama isku mar la sameeyo dhaqdhaqaaqyo kala duwan.

◆ Joogsi la'aan: way fududahay in la dhaco sababtoo ah luminta dheelitirka.

QaadashadaGanoderma lucidumsoosaar maalin kasta waxay hoos u dhigi kartaa sii xumaanshaha calaamadahan.Xataa haddii ay jirto waddo dheer oo loo maro si loo daweeyo cudurka, waxaa la qiyaasi karaa in tayada nolosha bukaannada qaba cudurka Parkinson la horumarin karo.

Ganoderma lucidumsoosaarku wuxuu yareeyaa horumarka cudurka Parkinson, kaas oo la xiriira ilaalinta neerfayaasha dopamine.

Kooxda cilmi-baarista ee Xuanwu Hospital of Capital Medical University waxay ku heleen tijaabooyin xayawaan ah in maamulka afka maalinlaha ah ee 400 mg / kgGanoderma lucidumsoosaarku wuxuu ilaalin karaa waxqabadka dhaqdhaqaaqa dhaqdhaqaaqa ee jiirarka qaba cudurka Parkinson.Tirada dopamine neurons ee maskaxda jiirarka qaba cudurka Parkinson waa in ka badan laban laabma jiirka iyada oo aan lahayn.Ganoderma lucidumilaalinta (Wixii faahfaahin ah, eeg “Kooxda Proffessor Bio Chen ee ka socota Cusbitaalka Beijing Xuanwu ayaa xaqiijiyay taasGanoderma lucidumwaxay ilaalisaa dopamine neurons waxayna yaraynaysaa calaamadaha cudurka Parkinson).

Dopamine-ka ay soo dartay neerfaha dopamine waa neurotransmitter lagama maarmaan u ah maskaxda si ay u maamusho dhaqdhaqaaqa muruqa.Dhimashada tirada badan ee neurons dopamine waa waxa sababa cudurka Parkinson.Sida muuqata,Ganoderma lucidumwaxay hoos u dhigtay horumarka cudurka Parkinson, kaas oo la xidhiidha dhaawac yar oo soo gaadhay neerfaha dopamine.

Sababta asaasiga ah ee dhimashada aan caadiga ahayn ee dopamine neurons waa in tiro badan oo borotiinno sun ah ay ku urureen substantia nigra maskaxda (aagga maskaxda ee ugu weyn halkaas oo dopamine neurons ay ku yaalaan).Marka laga soo tago in si toos ah loogu hanjabayo badbaadada iyo shaqada dopamine neurons, borotiinnadani waxay sidoo kale kicin doonaan microglia (unugyada difaaca jirka ee maskaxda ku jira) agagaarka unugyada dareemayaasha, taas oo keenaysa inay si joogto ah u qariyaan cytokines pro-inflammatory si ay u dhaawacaan neerfaha dopamine.

v Neurons ee soo saara dopamine ee maskaxda waxay ku yaalaan qaybta is haysta ee "substantia nigra".Dopamine-ka laga soo saaro halkan waxaa loo diri doonaa gobollada kala duwan ee maskaxda si ay door uga ciyaaraan anteenooyinka fidsan ee neerfaha dopamine.Ciladda dhaqdhaqaaqa caadiga ah ee cudurka Parkinson waxaa inta badan sabab u ah la'aanta dopamine ee laga soo raro substantia nigra oo la geeyo striatum.Sidaa darteed, haddii ay tahay dopamine neurons oo ku yaal substantia nigra ama teendhada dareemayaasha dopamine ee ku fidsan striatum, tiradooda iyo deegaanka ku hareeraysan ayaa muhiim u ah horumarka cudurka Parkinson.

Markii hore, kooxda cilmi-baarista ee Xuanwu Hospital of Capital Medical University ayaa xaqiijiyay taasGanoderma lucidumsoosaarku wuxuu yarayn karaa halista dhaawaca neuron-ka dopamine ee dariiqa u adkaysta dhaawaca iyadoo la ilaalinayo habka ficilka mitochondria (matoorayaasha unugyada) ee jawiga jawaabta bararkaGanoderma lucidumwaxay ilaalisaa dopamine neurons waxayna yaraynaysaa calaamadaha cudurka Parkinson).

Sebtembar 2022, cilmi-baadhista kooxda ayaa lagu daabacayNafaqooyinkaoo sii xaqiijiyayGanoderma lucidumsoosaarku wuxuu yarayn karaa dheecaanka cytokines-ka-bararka iyada oo loo marayo habka "la joojiyo firfircoonida xad-dhaafka ah ee microglia", taas oo ka ilaalinaysa neerfayaasha dopamine ee dariiqa yaraynta dhaawaca.

Jiirar qaba cudurka Parkinson oo cunayGanoderma lucidumwax soo saarku waxa uu lahaa hawl yarmicrogliaee substantia nigra iyo striatum.

Sida laga soo xigtay warbixintan cusub ee la daabacay, jiirarka ayaa markii hore lagu duray neurotoxin MPTP si ay u keento cudurka Parkinson u eg, ka dibna 400 mg/kg oo ahGanoderma lucidumlaga soosaaray GLE waxaa afka laga maamuli jiray maalin kasta laga bilaabo maalinta xigta (Cudurka Parkinson +Ganoderma lucidumkooxda la soosaaray) halka jiirarka aan la daweynin ee qaba cudurka Parkinson (kaliya lagu duray MPTP) iyo jiirarka caadiga ah ayaa loo isticmaalay kontaroolo tijaabo ah.

4 todobaad ka dib, tiro badan oo ah microglia firfircoon ayaa ka soo muuqday striatum iyo substantia nigra pars compacta (aagga ugu weyn ee loo qaybiyo dopamine neurons) ee maskaxda jiirarka ee qaba cudurka Parkinson, laakiin taasi kama dhicin jiirarka qaba cudurka Parkinson ee cunayGanoderma lucidumsoosaar maalin kasta - xaaladdoodu waxay ku dhowdahay jiirarka caadiga ah (sawirka hoose).

v [Sharaxaad]Ganoderma lucidumwaxay saameyn ku yeelanaysaa microglia ee gobolka maskaxda halkaasoo dopamine neurons ay ku yaalliin (striatum iyo substantia nigra pars compacta) ee jiirarka qaba cudurka Parkinson.Jaantuska 1 waa sawirka wasakhaysan ee microglia firfircoon ee qaybaha unugyada, iyo Jaantuska 2 waa tirakoobka tirada ee microglia firfircoon.

Jiirar qaba cudurka Parkinson oo cunayGanoderma lucidumsoosaarku wuxuu lahaa uruurin hoose oo ah cytokines pro-inflammatory ee maskaxda dhexe iyo striatum.

Unugyada microglia ee firfircoon ayaa siinaya noocyo kala duwan oo cytokines ama chemokines si kor loogu qaado bararka oo ay uga sii daraan dhaawaca dareemayaasha dopamine.Si kastaba ha ahaatee, markii la ogaaday maskaxda dhexe iyo striatum ee xayawaanka tijaabada ah ee aan kor ku soo sheegnay, cilmi-baarayaashu waxay ogaadeen in isticmaalka maalinlaha ahGanoderma lucidumsoosaarku wuxuu joojin karaa soo saarista cytokines pro-bararka kuwaas oo si weyn u kordhay sababtoo ah bilawga cudurka Parkinson (sida ku cad sawirka hoose).

Ganoderma lucidumsoosaarku wuxuu caawiyaa dib u dhaca horumarka cudurka Parkinson, taas oo ah natiijada isdhexgalka maaddooyinka firfircoon ee badan.

Bulshada sayniska ayaa xaqiijisay in jawaabta bararka ee ay keento firfircoonida aan caadiga ahayn ee microglia ay ka dambeysay dhimashada degdegga ah ee dopamine neurons iyo sii xumaanshaha cudurka Parkinson.Sidaa darteed, joojinta firfircoonida microglia byGanoderma lucidumsoosaarku shaki la'aan wuxuu bixiyaa sharraxaad muhiim ah sababtaGanoderma lucidumsoosaarku wuxuu yareyn karaa koorsada cudurka Parkinson.

Maxay yihiin qaybahaGanoderma lucidumkuwaas oo qabta hawlahan?

TheGanoderma lucidumsoosaar GLE loo isticmaalo cilmi-baadhistan waxa laga sameeyaa jidhka midhaha eeGanoderma lucidumiyada oo loo marayo ethanol badan iyo hababka soo saarista biyaha kulul.Waxay ka kooban tahay qiyaastii 9.8% Ganoderma lucidumpolysaccharides, 0.3-0.4% ganoderic acid A (mid ka mid ah triterpenoidyada ugu muhiimsanGanoderma lucidumMiraha miraha) iyo 0.3-0.4% ergosterol.

Qaar ka mid ah cilmi-baarisyada la xidhiidha ee hore waxay caddeeyeen in polysaccharides, triterpenes, iyo ganoderic acid A inGanoderma lucidumdhamaantood waxay leeyihiin shaqooyinka "habaynta jawaabta bararka" iyo "ilaalinta unugyada dareemayaasha".Sidaa darteed, cilmi-baarayaashu waxay aaminsan yihiin in saameyntaGanoderma lucidumdib u dhigista horumarka cudurka Parkinson ma aha natiijada ficilka hal qayb laakiin natiijada isku duwidda qaybo badanGanoderma lucidumjirka dhexdiisa.

Marna ma cadda sida ay u kala duwan yihiinGanoderma lucidumQaybaha lagu cunay caloosha ayaa ka gudba "caqabadda dhiigga-maskaxda" ka dibna waxay saameyntooda ku yeeshaan microglia iyo dopamine neurons ee maskaxda.Laakin si kastaba arrintu ha ahaatee, waa xaqiiqo aan la murmi karinGanoderma lucidumQaybaha ayaa faragelin kara pathogenesis si ay u daahiyaan horumarka cudurka.

Hoosudhaca dopamine neurons ee sababa cudurka Parkinson ma aha nidaam hal-tallaabo ah laakiin waa geedi socod horumarsan oo wax yar hoos u dhiga maalin kasta.Wajaha cudurkan oo aan la joojin karin oo lagu maarayn karo oo keliya inta nool, bukaanku waxay kaliya u shaqeyn karaan si adag maalin kasta si ay ugu duceeyaan dib-u-celinta maalin kasta.

Haddaba, intii aad ka sugi lahayd dawada cusub ee dunida u rogi doonta, waxa fiican in aad wakhtiga ka faa’iidaysato oo aad ka qaadato hantida hortaada lagu soo dhiibay oo aad si geesinimo leh u tijaabiso.Ma aha riyo in dib loo soo saaro natiijooyinka baadhitaanka caafimaad ee kor lagu soo sheegay oo laga soo koobay 300 bukaan iyadoo la cunayo qadar ku filanGanoderma lucidummuddo dheer.

Xigasho:

1. Zhili Ren, iyo al.Ganoderma lucidumBeddelka jawaabaha caabuqa ee raacaya 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Maamulka ee Jiirarka.Nafaqooyinka.2022;14 (18):3872.doi: 10.3390/nu14183872.

2. Zhi-Li Ren, iyo al.Ganoderma lucidumSoo saarta waxay hagaajisaa Parkinsonism-ka MPTP-ku-soo-baxa waxayna ka ilaalisaa Dopaminergic Neurons-ka Cadaadiska Oxidative iyada oo loo marayo Nidaaminta Shaqada Mitochondrial, Autophagy, iyo Apoptosis.Acta Pharmacol Sin.2019;40 (4):441-450.doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, iyo al.Ganoderma lucidumWaxay ilaalisaa xumaanshaha Neuron Dopaminergic iyada oo la joojinayo Dhaqdhaqaaqa Microglial.Evid Based Complement Alternat Med.2011;2011:156810.doi: 10.1093/ecam/nep075.

4. Hui Ding, iyo al.Ganoderma lucidumsoosaarku wuxuu ilaaliyaa dopaminergic neurons iyadoo la joojinayo firfircoonida microglial.Acta Physiologica Sinica, 2010, 62 (6): 547-554.

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★ Qoraalka asalka ah ee maqaalkan waxaa ku qoray Shiinaha Wu Tingyao, waxaana u turjumay Ingiriisi Alfred Liu.Haddii uu jiro farqi u dhexeeya tarjumaada (Ingiriiska) iyo kan asalka ah (Shiineyska), Shiinaha asalka ah ayaa guulaysan doona.Haddii akhristayaasha ay qabaan wax su'aalo ah, fadlan la xiriir qoraaga asalka ah, Ms. Wu Tingyao.