Inyungu zaGanoderma lucidumgukuramo abarwayi bafite indwara ya Parkinson

“BirashobokaGanoderma lucidumkugabanya ibimenyetso by'abarwayi bafite indwara ya Parkinson? ”Iki nikibazo abarwayi benshi, imiryango yabo, abavandimwe n'inshuti bashaka kubaza.

Muri raporo yasohotse muriActa Pharmacologica Sinicamuri Mata 2019, itsinda ry’ubushakashatsi riyobowe n’umuyobozi Biao Chen, umwarimu w’ishami rya Neurologiya ry’ibitaro bya Xuanwu, muri kaminuza y’ubuvuzi ya Capital, yavuze ko babonye abarwayi 300 barwaye indwara ya Parkinson mu isuzuma ry’amavuriro ryateganijwe, rihumye-rihumye, rigenzurwa na platbo:

Aba barwayi kuva ku cyiciro cya 1 (“ibimenyetso bigaragara ku ruhande rumwe rw'umubiri ariko ntibigire ingaruka ku buringanire”) kugeza ku cyiciro cya 4 (“kugenda nabi cyane ariko birashobora kugenda no kwihagararaho”).Abashakashatsi baretse abarwayi bafata garama 4 zaGanoderma lucidumgukuramo umunwa buri munsi mumyaka 2, ugasanga "ibimenyetso bya moteri" byabarwayi birashobora rwose koroherezwa no gutabarwa kwaGanoderma lucidum.

Ibyo bita ibimenyetso bya moteri yindwara ya Parkinson harimo:

Rem Guhinda umushyitsi: Kunyeganyega kutanyeganyega ingingo.

Kwinangira amaguru: Gukomeza kwinangira imitsi kubera kwiyongera kwinshi, bigatuma ingingo zigora kugenda.

◆ Hypokinesia: Buhoro buhoro no kudashobora gukora ingendo zikurikirana cyangwa gukora icyarimwe icyarimwe.

Ure Umwanya udahagaze: byoroshye kugwa kubera gutakaza uburimbane.

GufataGanoderma lucidumgukuramo buri munsi birashobora kugabanya umuvuduko mubi byibi bimenyetso.Nubwo hakiri inzira ndende yo gukiza indwara, birashoboka ko ubuzima bw'abarwayi barwaye indwara ya Parkinson bushobora kunozwa.

Ganoderma lucidumgukuramo bidindiza iterambere ryindwara ya Parkinson, ifitanye isano no kurinda neuron ya dopamine.

Itsinda ry’ubushakashatsi bw’ibitaro bya Xuanwu byo muri kaminuza y’ubuvuzi ya Capital ryasanze binyuze mu bushakashatsi bw’inyamaswa ko buri munsi iminwa 400 mg / kgGanoderma lucidumibiyikuramo birashobora gukomeza imikorere myiza ya moteri mu mbeba n'indwara ya Parkinson.Umubare wa neuron ya dopamine mubwonko bwimbeba nindwara ya Parkinson wikubye inshuro zirenga ebyiri imbeba zidafiteGanoderma lucidumkurinda (Ushaka ibisobanuro birambuye, reba "Ikipe ya Professor Biao Chen yo mu bitaro bya Beijing Xuanwu yemeje koGanoderma lucidumirinda neuron ya dopamine kandi igabanya ibimenyetso byindwara ya Parkinson ”).

Dopamine isohorwa na neuron ya dopamine ni neurotransmitter yingirakamaro kugirango ubwonko bugenzure imikorere yimitsi.Urupfu rwinshi rwa dopamine neurons nicyo gitera indwara ya Parkinson.Ikigaragara ni uko,Ganoderma lucidumbyadindije iterambere ry’indwara ya Parkinson, ifitanye isano no kwangirika gake kuri neuron ya dopamine.

Intandaro y'urupfu rudasanzwe rwa neurone ya dopamine ni uko umubare munini wa poroteyine z'ubumara zegeranije muri nigra yo mu bwonko (igice kinini cy'ubwonko aho neurone ya dopamine iherereye).Usibye guhungabanya ubuzima bwa mikorere ya neurone ya dopamine, izo poroteyine zizanakora mikorobe (selile immunite iba mu bwonko) ikikije selile nervice, bigatuma bahora basohora cytokine itera inflammatory yangiza neurone ya dopamine.

▲ Neuron itanga dopamine mu bwonko iba mu gice cyegeranye cya “substantia nigra”.Dopamine ikorerwa hano izoherezwa mu bice bitandukanye byubwonko kugirango igire uruhare hamwe na antenne yagutse ya neuron ya dopamine.Indwara isanzwe yindwara ya Parkinson iterwa ahanini no kubura dopamine itwarwa muri substantia nigra ikajya kuri striatum.Kubwibyo, yaba neuron ya dopamine iherereye muri substantia nigra cyangwa amahema ya dopamine neuron igera kuri striatum, umubare wabo hamwe nibidukikije ni ngombwa kugirango iterambere rya Parkinson ryiyongere.

Mbere, itsinda ry’ubushakashatsi bw’ibitaro bya Xuanwu bya Capital Medical University byemeje koGanoderma lucidumibiyikuramo birashobora kugabanya ibyago byo kwangirika kwa dopamine neuron biva munzira irwanya imvune mukurinda uburyo bwibikorwa bya mitochondriya (generator selile) mubidukikije kugirango habeho igisubizo (Ushaka ibisobanuro birambuye, reba "Ikipe ya Professor Biao Chen wo mubitaro bya Beijing Xuanwu yemeje koGanoderma lucidumirinda neuron ya dopamine kandi igabanya ibimenyetso byindwara ya Parkinson ”).

Muri Nzeri 2022, ubushakashatsi bw'itsinda bwasohotse muriIntungamubiribyongeye kubyemezaGanoderma lucidumibiyikuramo birashobora kugabanya ururenda rwa cytokine ikwirakwiza binyuze mu buryo bwo “kubuza gukora cyane microglia”, bityo bikarinda neurone ya dopamine inzira igabanya ibyangiritse.

Imbeba n'indwara ya Parkinson yariyeGanoderma lucidumgukuramo byari bikemicrogliamuri substantia nigra na striatum.

Nk’uko iyi raporo iherutse gusohoka ibivuga, imbeba zabanje guterwa na neurotoxine MPTP kugira ngo zandure indwara ya Parkinson, hanyuma 400 mg / kg yaGanoderma lucidumgukuramo GLE yatanzwe mu kanwa buri munsi guhera ejobundi (Indwara ya Parkinson +Ganoderma lucidumgukuramo itsinda) mugihe imbeba zitavuwe nindwara ya Parkinson (zatewe gusa na MPTP) nimbeba zisanzwe zakoreshejwe nkigenzura.

Nyuma yibyumweru 4, microglia nyinshi ikora yagaragaye muri striatum na substantia nigra pars compacta (agace gakwirakwizwa na neuron ya dopamine) mubwonko bwimbeba nindwara ya Parkinson, ariko ibi ntibyabaye mumbeba nindwara ya Parkinson yariyeGanoderma lucidumgukuramo buri munsi - imiterere yabo yegereye imbeba zisanzwe (ku ishusho hepfo).

▲ [Ibisobanuro]Ganoderma lucidumigira ingaruka mbi kuri microglia mukarere k'ubwonko aho dopamine neuron iherereye (striatum na substantia nigra pars compacta) mu mbeba n'indwara ya Parkinson.Igishushanyo 1 nigishusho cyanditseho microglia ikora mubice bya tissue, naho ishusho ya 2 ni imibare yuzuye ya microglia ikora.

Imbeba n'indwara ya Parkinson yariyeGanoderma lucidumibiyikuramo byari bifite ubukana buke bwa cytokine yo gutwika mu bwonko bwo hagati na striatum.

Ingirabuzimafatizo ya microglia ikora isohora cytokine zitandukanye cyangwa chemokine kugirango itere umuriro kandi yongere kwangirika kwa neurone ya dopamine.Nyamara, mugushakisha ubwonko bwo hagati na striatum yinyamaswa zigeragezwa zavuzwe haruguru, abashakashatsi basanze kurya buri munsiGanoderma lucidumibiyikuramo birashobora kubuza umusaruro wa cytokine pro-inflammatory yiyongera cyane kubera indwara ya Parkinson itangiye (nkuko bigaragara ku gishushanyo gikurikira).

Ganoderma lucidumibiyikuramo bifasha gutinza iterambere ryindwara ya Parkinson, nigisubizo cyimikoranire yibintu byinshi bikora.

Umuryango w’ubumenyi wemeje ko igisubizo cy’umuriro giterwa no gukora mikorobe idasanzwe ari inyuma y’urupfu rwihuse rwa neurone ya dopamine no kwangirika kw’indwara ya Parkinson.Kubwibyo, kubuza microglia gukora naGanoderma lucidumgukuramo nta gushidikanya bitanga ibisobanuro byingenzi kubwimpamvuGanoderma lucidumibiyikuramo birashobora kugabanya inzira yindwara ya Parkinson.

Nibihe bigizeGanoderma lucidumGukora iyi mirimo?

UwitekaGanoderma lucidumgukuramo GLE ikoreshwa muri ubu bushakashatsi ikozwe mu mibiri yera imbuto yaGanoderma lucidumbinyuze muri Ethanol nyinshi nuburyo bwo kuvoma amazi ashyushye.Irimo hafi 9.8% G.anoderma lucidumpolysaccharide, 0.3-0.4% acide ganoderic A (imwe muri triterpenoide ikomeye muriGanoderma lucidumimibiri yera imbuto) na 0.3-0.4% ergosterol.

Ubushakashatsi bumwe bufitanye isano kera bwerekanye ko polysaccharide, triterpène, na aside ganoderic A muriGanoderma lucidumbose bafite imirimo yo "kugenzura igisubizo kibabaza" no "kurinda ingirabuzimafatizo".Kubwibyo, abashakashatsi bemeza ko ingaruka zaGanoderma lucidumku gutinza iterambere ryindwara ya Parkinson ntabwo ari ibisubizo byibikorwa byikintu kimwe ahubwo ni ibisubizo byo guhuza ibice byinshi byaGanoderma lucidummu mubiri.

Ntabwo bishobora gusobanuka neza uburyo butandukanyeGanoderma lucidumibice biribwa mu gifu byambuka “inzitizi y'amaraso-ubwonko” hanyuma bikagira ingaruka kuri microglia na neuron ya dopamine mu bwonko.Ariko uko biri kwose, ni ukuri kudashidikanywaho koGanoderma lucidumibice birashobora kwivanga mubitera indwara kugirango bidindiza iterambere ryindwara.

Kwangirika kwa neurone ya dopamine itera indwara ya Parkinson ntabwo ari intambwe imwe ahubwo ni inzira igenda itera agaciro gato buri munsi.Guhura niyi ndwara idashobora kurangira kandi ishobora gusa na marato nayo ubuzima bwabo bwose, abarwayi barashobora gukora cyane burimunsi kugirango basenge basubira inyuma buri munsi.

Kubwibyo, aho gutegereza imiti mishya ihindura isi, nibyiza gufata umwanya ugafata ubutunzi bwatanzwe imbere yawe ukabigerageza ubutwari.Ntibikwiye kuba inzozi kubyara ibisubizo byavuzwe haruguru byavuzwe mu barwayi 300 barya bihagijeGanoderma lucidumigihe kirekire.

Inkomoko ：

1. Zhili Ren, n'abandi.Ganoderma lucidumIhindura Ibisubizo Bitwikurikira 1-Methyl-4-Phenyl-1,2,3,6-Ubuyobozi bwa Tetrahydropyridine (MPTP) mu mbeba.Intungamubiri.2022; 14 (18): 3872.doi: 10.3390 / nu14183872.

2. Zhi-Li Ren, n'abandi.Ganoderma lucidumGukuramo Ameliorate ya MPTP iterwa na Parkinsonism kandi ikarinda Neuron Dopaminergique ya Oxidative Stress ikoresheje imikorere ya Mitochondrial, Autophagy, na Apoptose.Acta Pharmacol Icyaha.2019; 40 (4): 441-450.doi: 10.1038 / s41401-018-0077-8.

3. Ruiping Zhang, n'abandi.Ganoderma lucidumIrinda Dopaminergic Neuron Kwangirika binyuze mu Kubuza Gukora Microglial.Ibimenyetso Bishingiye Kwuzuza Ubundi Med.2011; 2011: 156810.doi: 10.1093 / ecam / nep075.

4. Hui Ding, n'abandi.Ganoderma lucidumibiyikuramo birinda neuron ya dopaminergique ibuza gukora mikorobe.Acta Physiologica Sinica, 2010, 62 (6): 547-554.

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Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.