AmfaninGanoderma lucidumcirewa a kan marasa lafiya da cutar Parkinson

“iyaGanoderma lucidumkawar da alamun marasa lafiya da cutar Parkinson?"Wannan tambaya ce da yawancin majiyyata, danginsu, dangi da abokai suke son yi.

A wani rahoto da aka buga aActa Pharmacologica Sinicaa cikin Afrilu 2019, ƙungiyar binciken karkashin jagorancin Darakta Biao Chen, Farfesa na Sashen Neurology na Asibitin Xuanwu, Jami'ar Kiwon Lafiya ta Capital, ya ambata cewa sun lura da marasa lafiya 300 da cutar Parkinson a cikin bazuwar, makafi biyu, gwajin asibiti mai sarrafa wuribo:

Wadannan marasa lafiya sun fito ne daga mataki na 1 ("alamomi sun bayyana a gefe ɗaya na jiki amma ba su shafi ma'auni") zuwa mataki na 4 ("motsi mai rauni mai tsanani amma yana iya tafiya da tsayawa da kansa").Masu binciken sun bar marasa lafiya su dauki gram 4 naGanoderma lucidumAna cire baki a kowace rana har tsawon shekaru 2, kuma an gano cewa "alamomin motoci" na marasa lafiya na iya samun sauƙi ta hanyar sa baki.Ganoderma lucidum.

Abubuwan da ake kira alamun motsa jiki na cutar Parkinson sun haɗa da:

◆ Girgiza kai: girgiza gaɓoɓi marasa ƙarfi.

◆ Taurin gaɓoɓi: Ci gaba da matse tsokoki saboda yawan tashin hankali, yana sa gaɓoɓi suna da wahalar motsawa.

◆ Hypokinesia: Saurin motsi da rashin iya yin motsi a jere ko yin motsi daban-daban a lokaci guda.

◆ Matsayi mara kyau: sauƙin faɗuwa saboda asarar ma'auni.

DaukewaGanoderma lucidumcirewa kowace rana na iya rage raguwar lalacewar waɗannan alamun.Ko da har yanzu akwai sauran rina a kaba don warkar da cutar, ana iya tunanin cewa za a iya inganta rayuwar masu fama da cutar Parkinson.

Ganoderma lucidumcirewa yana rage ci gaban cutar Parkinson, wanda ke da alaƙa da kariyar ƙwayoyin cuta na dopamine.

Tawagar bincike na asibitin Xuanwu na Jami'ar Kiwon Lafiya ta Capital sun gano ta hanyar gwaje-gwajen dabbobi cewa gudanar da baki na yau da kullun na 400 mg/kg.Ganoderma lucidumcirewa zai iya kula da mafi kyawun aikin mota a cikin beraye tare da cutar Parkinson.Yawan dopamine neurons a cikin kwakwalwar beraye tare da cutar Parkinson ya ninka na mice ba tare daGanoderma lucidumkariya (Don cikakkun bayanai, duba “Tawagar Farfesa Biao Chen daga Asibitin Xuanwu na Beijing sun tabbatar da hakanGanoderma lucidumyana kare jijiyoyi na dopamine kuma yana kawar da alamun cutar Parkinson).

Dopamine da aka ɓoye ta ƙwayoyin ƙwayoyin cuta na dopamine shine maƙasudin neurotransmitter don ƙwaƙwalwa don daidaita ayyukan tsoka.Yawan mutuwar dopamine neurons shine abin da ke haifar da cutar Parkinson.A fili,Ganoderma lucidumya rage ci gaban cutar Parkinson, wanda ke da alaƙa da ƙarancin lalacewa ga ƙwayoyin ƙwayoyin cuta na dopamine.

Tushen mutuwar rashin daidaituwa na ƙwayoyin ƙwayoyin cuta na dopamine shine cewa yawancin sunadaran sunadarai masu guba sun taru a cikin substantia nigra na kwakwalwa (babban yanki na kwakwalwa inda dopamine neurons suke).Bugu da ƙari, kai tsaye barazanar rayuwa da aikin ƙwayoyin ƙwayoyin cuta na dopamine, waɗannan sunadaran za su kuma kunna microglia (kwayoyin rigakafi da ke zaune a cikin kwakwalwa) a kusa da kwayoyin jijiya, suna sa su ci gaba da ɓoye cytokines masu kumburi don lalata ƙwayoyin dopamine.

▲ Neurons da ke haifar da dopamine a cikin kwakwalwa suna cikin ƙaramin ɓangaren "substantia nigra".Dopamine da aka samar a nan za a aika zuwa yankuna daban-daban na kwakwalwa don taka rawa tare da fadada eriya na kwayoyin dopamine.Halin yanayin motsi na cutar Parkinson ya samo asali ne saboda rashin dopamin da ake jigilar su daga ma'aunin nigra zuwa striatum.Sabili da haka, ko ƙwayoyin ƙwayoyin cuta na dopamine waɗanda ke cikin substantia nigra ko tentacles na neurons na dopamine waɗanda ke haɓaka zuwa striatum, adadin su da yanayin kewaye suna da mahimmanci ga ci gaban cutar Parkinson.

A baya, tawagar bincike na asibitin Xuanwu na Jami'ar Kiwon Lafiya ta Capital sun tabbatar da hakanGanoderma lucidumcirewa zai iya rage haɗarin lalacewar neuron na dopamine daga hanyar da ke jure rauni ta hanyar kare tsarin aikin mitochondria (masu samar da tantanin halitta) a cikin yanayi na amsa kumburi (Don cikakkun bayanai, duba "Tawagar Farfesa Biao Chen daga Asibitin Xuanwu na Beijing sun tabbatar da cewaGanoderma lucidumyana kare jijiyoyi na dopamine kuma yana kawar da alamun cutar Parkinson).

A cikin Satumba 2022, an buga binciken ƙungiyar a cikinAbubuwan gina jikiya kara tabbatar da cewaGanoderma lucidumcirewa zai iya rage ɓoyewar cytokines masu kumburi ta hanyar hanyar "hana yawan kunna microglia", ta haka ne ke kare kwayoyin cutar dopamine daga hanyar rage lalacewa.

Mice masu cutar Parkinson da suka ciGanoderma lucidumcirewa ya ɗan kunnamicrogliaa cikin substantia nigra da striatum.

Bisa ga wannan sabon rahoton da aka buga, an fara allurar beraye da neurotoxin MPTP don haifar da cutar Parkinson mai kama da mutum, sannan kuma 400 mg / kg naGanoderma lucidumAn cire GLE da baki kowace rana daga rana mai zuwa (Cutar Parkinson +Ganoderma lucidumcire rukuni) yayin da berayen da ba a kula da su ba tare da cutar Parkinson (an yi allura da MPTP kawai) da kuma mice na yau da kullun an yi amfani da su azaman sarrafa gwaji.

Bayan makonni 4, adadi mai yawa na microglia da aka kunna ya bayyana a cikin striatum da substantia nigra pars compacta (babban yanki na rarraba dopamine neurons) a cikin kwakwalwar beraye tare da cutar Parkinson, amma wannan bai faru ba a cikin mice tare da cutar Parkinson da suka ci abinci.Ganoderma lucidumcirewa kowace rana - yanayin su ya fi kusa da na al'ada na al'ada (hoton da ke ƙasa).

▲ [bayani]Ganoderma lucidumyana da tasiri mai hanawa akan microglia a cikin yankin kwakwalwa inda ake samun jijiyoyi na dopamine (striatum da substantia nigra pars compacta) a cikin mice tare da cutar Parkinson.Hoto na 1 shine tabon hoton microglia da aka kunna a cikin sassan nama, kuma Hoto na 2 shine ƙididdiga masu yawa na microglia da aka kunna.

Mice masu cutar Parkinson da suka ciGanoderma lucidumtsantsa yana da ƙananan ƙididdiga na cytokines masu kumburi a cikin tsakiyar kwakwalwa da striatum.

Kwayoyin microglia da aka kunna suna ɓoye nau'ikan cytokines ko chemokines don haɓaka kumburi da haɓaka lalacewar ƙwayoyin cuta na dopamine.Duk da haka, a cikin gano tsakiyar kwakwalwa da striatum na dabbobin gwaji da aka ambata a sama, masu binciken sun gano cewa cin abinci kullum.Ganoderma lucidumtsantsa na iya hana samar da cytokines masu kumburi waɗanda ke ƙaruwa sosai saboda farawar cutar Parkinson (kamar yadda aka nuna a cikin hoton da ke ƙasa).

Ganoderma lucidumtsantsa yana taimakawa jinkirta ci gaban cutar Parkinson, wanda shine sakamakon hulɗar abubuwa masu aiki da yawa.

Al'ummar kimiyya sun tabbatar da cewa amsawar kumburi da ke haifar da mummunan kunnawa na microglia yana bayan saurin mutuwar ƙwayoyin cuta na dopamine da tabarbarewar cutar Parkinson.Saboda haka, hana microglia kunnawa taGanoderma lucidumcirewa babu shakka yana ba da bayani mai mahimmanci ga dalilinGanoderma lucidumcirewa zai iya rage yanayin cutar Parkinson.

Menene sassanGanoderma lucidumwanda ke aiwatar da waɗannan ayyuka?

TheGanoderma lucidumcire GLE da aka yi amfani da shi a cikin wannan binciken an yi shi ne daga jikin 'ya'yan itaceGanoderma lucidumta hanyar ethanol da yawa da matakan hakar ruwan zafi.Ya ƙunshi kusan 9.8% Ganoderma lucidumpolysaccharides, 0.3-0.4% ganoderic acid A (daya daga cikin mafi mahimmancin triterpenoid a ciki).Ganoderma lucidum'ya'yan itace) da 0.3-0.4% ergosterol.

Wasu bincike masu alaƙa a baya sun tabbatar da cewa polysaccharides, triterpenes, da ganoderic acid AGanoderma lucidumduk suna da ayyuka na "daidaita amsawar kumburi" da "kare ƙwayoyin jijiya".Saboda haka, masu bincike yi imani da cewa sakamakonGanoderma luciduma kan jinkirta ci gaban cutar Parkinson ba sakamakon aikin wani sashi ba ne amma sakamakon daidaitawar abubuwa da yawa naGanoderma luciduma cikin jiki.

Yana iya taba bayyana yadda daban-dabanGanoderma lucidumabubuwan da ake ci a cikin ciki sun haye “shamakin jini-kwakwalwa” sannan suyi tasirin su akan microglia da dopamine neurons a cikin kwakwalwa.Amma ta kowane hali, wannan lamari ne da ba za a iya tantama baGanoderma lucidumsassan zasu iya shiga tsakani a cikin pathogenesis don jinkirta ci gaban cutar.

Ragewar ƙwayoyin ƙwayoyin cuta na dopamine waɗanda ke haifar da cutar Parkinson ba tsari ne na mataki ɗaya ba amma tsari mai ci gaba wanda ke raguwa kaɗan kowace rana.Fuskantar wannan cutar da ba za a iya ƙarewa ba kuma za a iya yin tsere da ita har tsawon rayuwa, marasa lafiya za su iya yin aiki tuƙuru a kowace rana don yin addu'a don ƙarancin koma baya kowace rana.

Don haka, maimakon a jira sabon maganin da zai juya duniya, yana da kyau ku ɓata lokaci ku ɗauki dukiyar da aka ba ku a gabanku ku gwada ta da ƙarfin hali.Bai kamata ya zama mafarki ba don sake haifar da sakamakon gwajin asibiti da aka ambata a baya wanda aka taƙaita daga marasa lafiya 300 ta hanyar cin isasshen adadin kuzari.Ganoderma lucidumna dogon lokaci.

Source:

1. Zhili Ren, et al.Ganoderma lucidumYana daidaita Amsoshi masu kumburin 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Gudanarwa a cikin Mice.Abubuwan gina jiki.2022;14 (18):3872.doi: 10.3390/nu14183872.

2. Zhi-Li Ren, et al.Ganoderma lucidumCire Ameliorates MPTP-Induced Parkinsonism kuma Yana Kare Dopaminergic Neurons daga Matsalolin Oxidative ta Hanyar Gudanar da Ayyukan Mitochondrial, Autophagy, da Apoptosis.Acta Pharmacol Sin.2019; 40 (4): 441-450.doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, et al.Ganoderma lucidumYana Kare Dopaminergic Neuron Degeneration ta hanyar Hana Kunna Microglial.Evid Based Complement Alternat Med.2011; 2011: 156810.doi: 10.1093/ecam/nep075.

4. Hui Ding, da dai sauransu.Ganoderma lucidumtsantsa yana kare ƙwayoyin cuta na dopaminergic ta hanyar hana kunna microglial.Acta Physiologica Sinica, 2010, 62 (6): 547-554.

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