Izinzuzo zeI-Ganoderma lucidumukukhishwa ezigulini ezine-Parkinson's disease

“AngakwaziI-Ganoderma lucidumukukhulula izimpawu zeziguli ezinesifo sikaParkinson?”Lona ngumbuzo iziguli eziningi, imindeni yazo, izihlobo nabangane abafuna ukuwubuza.

Embikweni oshicilelwe kuI-Acta Pharmacologica Sinicango-Ephreli 2019, ithimba labacwaningi eliholwa uMqondisi u-Biao Chen, uProfessor we-Neurology Department esibhedlela i-Xuanwu, i-Capital Medical University, lathi libone iziguli ezingama-300 ezinesifo sika-Parkinson esivivinyweni somtholampilo esilawulwa ngokungahleliwe, esingaboni kabili, esilawulwa yi-placebo:

Lezi ziguli zazisuka esiteji 1 ("izimpawu zivela ohlangothini olulodwa lomzimba kodwa akuthinti ibhalansi") kuya kusigaba sesi-4 ("ukunyakaza okukhubazeka kakhulu kodwa uyakwazi ukuhamba nokuma ngokuzimela").Abacwaningi bavumela iziguli ukuthi zithathe amagremu angu-4 weI-Ganoderma lucidumkhipha ngomlomo nsuku zonke iminyaka emi-2, futhi wathola ukuthi "izimpawu zemoto" zeziguli zingakhululeka ngokungenelelaI-Ganoderma lucidum.

Okubizwa ngokuthi izimpawu zezimoto zesifo sikaParkinson zifaka:

◆ Ukundindizela: Ukunyakaziswa kwezitho zomzimba okungalawuleki.

◆ Ukuqina kwezitho: Ukuqiniswa okuqhubekayo kwemisipha ngenxa yokwanda kokuqina, okwenza izitho zomzimba zibe nzima ukunyakaza.

◆ I-Hypokinesia: Ukunyakaza kancane nokungakwazi ukwenza ukunyakaza okulandelanayo noma ukwenza ukunyakaza okuhlukile ngesikhathi esisodwa.

◆ Ukuma okungaqinile: kulula ukuwa ngenxa yokulahlekelwa ibhalansi.

UkuthathaI-Ganoderma lucidumukukhipha nsuku zonke kunganciphisa ukuwohloka kwalezi zimpawu.Noma ngabe luselude ukhalo okusamele luhanjwe ukuze kwelashwe lesi sifo, kuyacatshangwa ukuthi izinga lempilo yeziguli ezinesifo sikaParkinson lingathuthukiswa.

I-Ganoderma lucidumukukhishwa kubambezela ukuqhubeka kwesifo sikaParkinson, esihlobene nokuvikelwa kwama-dopamine neurons.

Ithimba labacwaningi besibhedlela i-Xuanwu sase-Capital Medical University lithole ngokuhlolwa kwezilwane ukuthi ukulawulwa ngomlomo nsuku zonke kwe-400 mg/kgI-Ganoderma lucidumi-extract ingagcina ukusebenza okungcono kwemoto kumagundane ane-Parkinson's disease.Inani lama-dopamine neurons ebuchosheni bamagundane anesifo sika-Parkinson lingaphezu kokuphindwe kabili kwelamagundane ngaphandleI-Ganoderma lucidumukuvikelwa (Ukuze uthole imininingwane, bheka “Ithimba likaProfessor Biao Chen wase-Beijing Xuanwu Hospital likuqinisekisile lokho.I-Ganoderma lucidumivikela ama-dopamine neurons futhi ikhulule izimpawu zesifo sikaParkinson”).

I-Dopamine ekhiqizwa yi-dopamine neurons iyi-neurotransmitter ebalulekile ukuze ubuchopho bulawule ukusebenza kwemisipha.Ukufa okukhulu kwe-dopamine neurons yikho okubangela isifo sikaParkinson.Ngokusobala,I-Ganoderma lucidumyehlisa ukuqhubeka kwesifo sikaParkinson, esasihlotshaniswa nomonakalo omncane kuma-dopamine neurons.

Imbangela eyinhloko yokufa okungavamile kwama-dopamine neurons ukuthi inani elikhulu lamaprotheni anobuthi anqwabelene ku-substantia nigra yobuchopho (indawo yobuchopho eyinhloko lapho ama-dopamine neurons atholakala khona).Ngaphezu kokusongela ngokuqondile ukusinda nokusebenza kwe-dopamine neurons, lawa maprotheni azophinde enze i-microglia (amangqamuzana amasosha omzimba ahlala ebuchosheni) azungeze amangqamuzana ezinzwa, okubangele ukuthi akhiphe ngokuqhubekayo ama-cytokines abangela ukuvuvukala ukuze alimaze ama-dopamine neurons.

▲Ama-neurons akhiqiza i-dopamine ebuchosheni atholakala engxenyeni ehlangene ye-“substantia nigra”.I-dopamine ekhiqizwa lapha izothunyelwa ezifundeni ezihlukahlukene zobuchopho ukuze idlale indima kanye nezimpondo ezinwetshiwe zama-dopamine neurons.Ukuphazamiseka kokunyakaza okujwayelekile kwesifo sikaParkinson kubangelwa ikakhulukazi ukuntuleka kwe-dopamine ethuthwa isuka ku-substantia nigra iye ku-striatum.Ngakho-ke, kungakhathaliseki ukuthi ama-dopamine neurons atholakala ku-substantia nigra noma amatende e-dopamine neurons adlulela ku-striatum, inani lawo nendawo ezungezile kubalulekile ekuqhubekeleni phambili kwesifo sika-Parkinson.

Phambilini, ithimba labacwaningi base-Xuanwu Hospital of Capital Medical University likuqinisekisile lokhoI-Ganoderma lucidumukukhishwa kunganciphisa ubungozi bokulimala kwe-dopamine neuron endleleni yokumelana nokulimala ngokuvikela indlela yokusebenza ye-mitochondria (amajeneretha amaseli) endaweni yokusabela kokuvuvukala (Ukuze uthole imininingwane, bheka “ithimba likaProfesa Biao Chen lasesibhedlela sase-Beijing Xuanwu likuqinisekisile lokho.I-Ganoderma lucidumivikela ama-dopamine neurons futhi ikhulule izimpawu zesifo sikaParkinson”).

NgoSepthemba 2022, ucwaningo lweqembu lwashicilelwa ngoIzakhamzimbaukuqinisekisile lokhoI-Ganoderma lucidumukukhishwa kunganciphisa ukukhishwa kwama-cytokines abangela ukuvuvukala ngokusebenzisa indlela "yokuvimbela ukusebenza ngokweqile kwe-microglia", ngaleyo ndlela kuvikelwe ama-dopamine neurons endleleni yokunciphisa umonakalo.

Amagundane anesifo sikaParkinson ayedlaI-Ganoderma lucidumokukhishiwe kwenziwe kwasebenza okumbalwai-microgliaku-substantia nigra kanye ne-striatum.

Ngokwalo mbiko osanda kushicilelwa, amagundane aqale ajovwa nge-neurotoxin MPTP ukuze anxenxe isifo sikaParkinson esifana nesomuntu, kwase kuba ngu-400 mg/kgI-Ganoderma lucidumI-GLE ikhishwe ngomlomo nsuku zonke kusukela ngakusasa (isifo sikaParkinson +I-Ganoderma lucidumextract group) kuyilapho amagundane angelashiwe anesifo sika-Parkinson (ajovwe kuphela nge-MPTP) kanye namagundane avamile asetshenziswa njengezilawuli zokuhlola.

Ngemva kwamasonto ama-4, inani elikhulu le-microglia ecushiwe yavela ku-striatum kanye ne-substantia nigra pars compacta (indawo eyinhloko yokusabalalisa i-dopamine neurons) ebuchosheni bamagundane anesifo sika-Parkinson, kodwa lokhu akuzange kwenzeke kumagundane ane-Parkinson's disease.I-Ganoderma lucidumkhipha nsuku zonke - isimo sabo siseduze nesamagundane avamile (okufanekiselwe ngezansi).

▲ [Incazelo]I-Ganoderma luciduminomphumela ovimbelayo ku-microglia endaweni yobuchopho lapho kutholakala khona ama-dopamine neurons (i-striatum ne-substantia nigra pars compacta) kumagundane anesifo sika-Parkinson.Umfanekiso 1 uyisithombe esinamabala se-microglia eyenziwe yasebenza ezigabeni zezicubu, futhi Umfanekiso 2 uyizibalo zobuningi ze-microglia ecushiwe.

Amagundane anesifo sikaParkinson ayedlaI-Ganoderma lucidumukukhishwa bekunokugxila okuphansi kwama-cytokines ane-pro-inflammatory ku-midbrain kanye ne-striatum.

Amaseli e-microglia acushiwe akhiqiza ama-cytokines noma ama-chemokines ahlukahlukene ukuze akhuthaze ukuvuvukala futhi andise umonakalo wama-dopamine neurons.Kodwa-ke, ekutholeni i-midbrain kanye ne-striatum yezilwane zokuhlola ezishiwo ngenhla, abacwaningi bathola ukuthi ukusetshenziswa kwansuku zonke kwezidakamizwa.I-Ganoderma lucidumukukhishwa kungavimbela ukukhiqizwa kwama-cytokines ane-pro-inflammatory anda kakhulu ngenxa yokuqala kwesifo sika-Parkinson (njengoba kuboniswe esithombeni esingezansi).

I-Ganoderma lucidumukukhishwa kusiza ukubambezela ukuqhubeka kwesifo sikaParkinson, okuwumphumela wokusebenzelana kwezithako eziningi ezisebenzayo.

Umphakathi wesayensi ukuqinisekisile ukuthi ukusabela kokuvuvukala okubangelwa ukusebenza okungavamile kwe-microglia kuyimbangela yokufa okusheshayo kwama-dopamine neurons kanye nokuwohloka kwesifo sika-Parkinson.Ngakho-ke, ukuvinjelwa kokusebenza kwe-microglia nguI-Ganoderma lucidumukukhishwa ngokungangabazeki kunikeza incazelo ebalulekile yokuthi kunganiI-Ganoderma lucidumukukhishwa kunganciphisa inkambo yesifo sikaParkinson.

Yiziphi izingxenye zeI-Ganoderma lucidumezenza le misebenzi?

II-Ganoderma lucidumkhipha i-GLE esetshenziswe kulolu cwaningo yenziwe emizimbeni ethela izitheloI-Ganoderma lucidumngokusebenzisa i-ethanol eminingi kanye nezinqubo zokukhipha amanzi ashisayo.Iqukethe cishe u-9.8% Gi-anoderma lucidumi-polysaccharides, i-0.3-0.4% i-ganoderic acid A (enye yama-triterpenoid abaluleke kakhuluI-Ganoderma lucidumimizimba enezithelo) kanye ne-ergosterol engu-0.3-0.4%.

Ezinye izifundo ezihlobene esikhathini esidlule ziye zafakazela ukuthi i-polysaccharides, i-triterpenes, ne-ganoderic acid AI-Ganoderma lucidumzonke zinemisebenzi “yokulawula ukusabela kokuvuvukala” kanye “nokuvikela amangqamuzana ezinzwa”.Ngakho-ke, abacwaningi bakholelwa ukuthi umphumela weI-Ganoderma lucidumekubambezelekeni kokuqhubeka kwesifo sikaParkinson akuwona umphumela wesenzo sengxenye eyodwa kodwa umphumela wokuxhumanisa izingxenye eziningi zeI-Ganoderma lucidumemzimbeni.

Kungase kungacaci ukuthi ezihlukahlukene kanjaniI-Ganoderma lucidumizingxenye ezidliwe esiswini zeqa “isithiyo sobuchopho begazi” bese zenza imiphumela yazo ku-microglia nama-dopamine neurons ebuchosheni.Kodwa kunoma yikuphi, kuyiqiniso elingephikiswe ukuthiI-Ganoderma lucidumizingxenye zingangenelela ku-pathogenesis ukubambezela ukuqhubeka kwesifo.

Ukuwohloka kwama-dopamine neurons okubangela isifo sikaParkinson akuyona inqubo eyisinyathelo esisodwa kodwa inqubo eqhubekayo eyehlisa isithunzi kancane nsuku zonke.Njengoba zibhekene nalesi sifo esingenakuqedwa futhi esingahlangatshezwana naso impilo yonke, iziguli zingasebenza kanzima nsuku zonke ukuze zithandazele ukuhlehla kancane nsuku zonke.

Ngakho-ke, esikhundleni sokulinda umuthi omusha oguqula umhlaba, kungcono ukuthatha isikhathi futhi uthathe umcebo onikezwe phambi kwakho futhi uzame ngesibindi.Akufanele kube iphupho ukukhiqiza kabusha imiphumela yokuhlolwa komtholampilo eshiwo ngenhla efingqiwe ezigulini ezingama-300 ngokudla inani elaneleI-Ganoderma lucidumisikhathi eside.

Umthombo:

1. UZhili Ren, et al.I-Ganoderma lucidumIlungisa Izimpendulo Ezivuthayo ezilandela i-1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Ukuphatha kumagundane.Izakhamzimba.2022;14(18):3872.doi: 10.3390/nu14183872.

2. UZhi-Li Ren, et al.I-Ganoderma lucidumI-Ameliorates ye-MPTP-Induced Parkinsonism futhi Ivikela i-Dopaminergic Neurons kusukela ekucindezelekeni kwe-Oxidative nge-Regulating Mitochondrial Function, Autophagy, ne-Apoptosis.I-Acta Pharmacol Sin.2019;40(4):441-450.doi: 10.1038/s41401-018-0077-8.

3. Ruiping Zhang, et al.I-Ganoderma lucidumIvikela I-Dopaminergic Neuron Degeneration Ngokuvinjelwa Kwe-Microglial Activation.I-Evid Based Complement Alternat Med.2011;2011:156810.doi: 10.1093/ecam/nep075.

4. U-Hui Ding, et al.I-Ganoderma lucidumi-extract ivikela ama-neurons e-dopaminergic ngokuvimbela ukusebenza kwe-microglial.Acta Physiologica Sinica, 2010, 62(6): 547-554.

★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali, futhi ubunikazi baso bungobe-GanoHerb.

★ Umsebenzi ongenhla awukwazi ukuphinda ukhiqizwe, ucashunwe noma usetshenziswe ngezinye izindlela ngaphandle kwemvume ye-GanoHerb.

★ Uma umsebenzi ugunyazwe ukusetshenziswa, kufanele usetshenziswe ngaphakathi kobubanzi bokugunyazwa futhi ubonise umthombo: GanoHerb.

★ Kunoma yikuphi ukwephulwa kwesitatimende esingenhla, i-GanoHerb izolandela izibopho ezingokomthetho ezihlobene.

★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.