Unyango ngamachizaukwenzakalisas isibindi kunye nezintso ngelixaLingzhnam (ndikwabizwaI-Ganoderma lucidum okanye Reishi mushroom) ikhusela isibindi kunye nezintso.

NgabaI-Ganoderma lucidum ukumelana nesibindi kunye nomonakalo wezintso obangelwa yichemotherapy?

Iqela elenziwe nguNjingalwazi uHanan M Hassan osuka kwiFaculty of Pharmacy yeDyunivesithi yaseDelta yeSayensi nobuChwepheshe eJiphutha kunye noNjingalwazi uYasmen F Mahran osuka kwiFaculty of Pharmacy yeYunivesithi yaseAin Shams yaseYiputa wasebenzisa i-cisplatin, elona chiza lixhaphakileyo lechemotherapy, ukuvavanya. ukuba nokwenzeka kweI-Ganoderma lucidum ekukhuseleni isibindi kunye neeseli zezintso kwingozi ye-cisplatin.

Iziphumo zabo zophando zohlulwe zibe ngamanqaku amabini: elinye likhusela isibindi ngelixa elinye likhusela izintso.Baye bapapashwa "kuYilo lweDrug, uPhuhliso kunye noNyango" kunye "ne-Oxidative Medicine kunye ne-Cellular Longevity" ngoJuni nangoJulayi ka-2020, ngokulandelanayo.

I-anti-oxidant, i-anti-inflammatory kunye ne-anti-apoptotic iziphumo zeI-Ganoderma lucidum Ngokucacileyo inokuthintela umonakalo omninzi we-oxidative, umonakalo ovuthayo kunye ne-cell apoptosis eyenziwa yi-cisplatin, kwaye ukhuseleko olunjalo lusebenza kwiiseli zesibindi okanye iiseli zezintso.Oku akuqaqambisi nje kuphela ixabiso lamayeza amabiniI-Ganoderma lucidum kodwa ikwabonelela ngendlela yokhuseleko oluncedisayo lwechemotherapy yomhlaza.

Ukuze unqande ukwenza eli nqaku libe lide kakhulu, umbhali uya kwazisa indimaI-Ganoderma lucidum kulo mba kumacandelo amabini ngethemba lokuba ezi datha zisekelwe ngokwenzululwazi kunye nobungqina ziya kuzisa ukuzithemba ngakumbi kubahlobo abafuna ukunciphisa iziphumo ebezingalindelekanga zechemotherapy.

Icandelo loku-1I-Ganoderma lucidum ikhusela isibindi vs. cisplatin hepatotoxicity

I-rAbaphandi bathelekisa umahlukosphakathi kokusebenzisa nokungasebenzisiI-Ganoderma lucidumngexesha lonyango lwe-cisplatinkumaqela amathandathu eempuku eziphilileyo kunye nokwahlukana ekukhuselweni kokulimala kwesibindi ngokwahlukileyoI-Ganoderma lucidum iindlela zolawulo.Bazi:

◆Iqela lolawulo (Qhuba): iqela elingafumani naluphi na unyango;

◆I-Ganoderma lucidumIqela(GL): iqela elingatofwanga nge-cisplatin kodwa liyatyaI-Ganoderma lucidum yonke imihla;

◆Iqela leCisplatin (CP): iqela elitofwe ngecisplatin kuphela kodwa lingatyiI-Ganoderma lucidum;

◆Iqela lemihla ngemihla (Mihla le): iqela elitofwe nge cisplatinkwaye uyatyaGanoderma Lucidum yonke imihla;

◆Yonke Iqela Elinye Usuku (EOD): iqela elitofwe nge cisplatinkwaye uyatyaI-Ganoderma lucidum naliphi na usuku;

◆Iqela le-Intraperitoneal (ip): iqela elitofwayo cisplatinkwaye ufumana ii-traperitonealiukwenziwa kweGi-anoderma lucidum.

Bonke abo bafumana i-cisplatin bafakwe ngaphakathi kwe-intraperitoneally kunye ne-12 mg / kg yeCisplatinngosuku lokuqala lovavanyo lokuqalisa ukwenzakala okukhulu kwesibindi;abo bafumana inaliti ye-intraperitoneal yeI-Ganoderma lucidum zatofwa kanye ngosuku lwesibini nolwesithandathu lovavanyo.

II-Ganoderma lucidum isetyenziswe kuvavanyo iqulethe izithako ezisebenzayo ezifana ne-triterpenes, i-sterols, i-polysaccharides, i-polyphenols kunye ne-flavonoids.II-Ganoderma lucidum inikwe kwiimvavanyo zezilwanyana, nokuba ithathwa ngomlomo okanye ngesitofu, ibalwa kwi-dose yemihla ngemihla ye-500 mg / kg.

(1)I-Ganoderma lucidum kunciphisa ukulimala kwe-hepatocellular

Emva kweentsuku ezili-10, kunokubonwa ukuba i-cisplatin iya kwandisa isalathisi se-hepatitis kunye nenqanaba le-bilirubin epheleleyo kwi-serum yegundane.Ezi zonke ziimpawu zokulimala kwe-hepatocellular.Kodwa ukubaI-Ganoderma lucidum ibandakanyeka ngexesha elifanayo, ixabiso elongezelelweyo lingancitshiswa kakhulu (Umfanekiso 1).

Umthombo weDatha / iDrug Des Devel Ther.2020;14: 2335-2353.

Umzobo 1 Iziphumo ze-cisplatin kunyeI-Ganoderma lucidum kwizalathi zokulimala kwesibindi

Beka icandelo lezicubu zesibindi phantsi kwe-microscope, kwaye uyabona ukuba i-cisplatin inokubangela ukuxinana kwesibindi (igazi elimele libuyele entliziyweni livaliwe kwaye ligxininise kwi-hepatic veins), ukuchithwa kweeseli (i-vacuoles ibonakala, eyona nto inguqu yokuqala ukulimala kweselula), i-apoptosis kunye ne-necrosis, kodwa ezi meko nazo zinokuncitshiswa ngokusebenzisaI-Ganoderma lucidum.

Umzobo we-2 Iziphumo ze-cisplatin kunyeI-Ganoderma lucidum kwi-hepatocytes

(2)I-Ganoderma lucidum kuphucula amandla e-antioxidant kwiiseli zesibindi

Eli nqaku liphinda lithelekise umonakalo owenziwe nge-oxidative kwiqela ngalinye lezicubu zesibindi.Kukho izalathi zokuqwalasela ezibini: i-MDA (malondialdehyde), imveliso eyenziwe emva kokutshatyalaliswa kweembrane zeseli ngeeradicals zamahhala, kunye ne-H₂O₂ (i-hydrogen peroxide), imveliso ephakathi eyenziwe emva kwe-metabolism ye-radicals yamahhala nge-antioxidant enzymes.

Zombini ezi mveliso zineempawu ze-oxidative ze-radicals zamahhala kwaye kufuneka zinyangwe ngakumbi ngaphambi kokuba "zihlanjululwe" ngokwenene, ngoko ke inani labo lingasixelela umonakalo owenziwe yi-oxidative ukuba izicubu zesibindi. “Unayo ubandezelekile” kwaye “uya kubandezeleka”.

Ngokucacileyo, i-cisplatin iya kubangela umonakalo omkhulu we-oxidative kwizicubu zesibindi, kodwa ukubaI-Ganoderma lucidum ibandakanyeka Kunyango ngexesha elifanayo, umonakalo onjalo unokuncitshiswa (Umfanekiso 3).

Ngenxa yokuba utshintsho kugxininiso lwe-antioxidant enzymes (i-SOD kunye ne-GSH) kwizicubu zesibindi zeqela ngalinye kunye notshintsho kwizibonakaliso zomonakalo we-oxidative zibonise umkhwa ochasene ngokupheleleyo., kunokuchazwa ukubaI-Ganoderma lucidumiya kwandisa amandla e-antioxidant yezicubu zesibindi kunye nokunciphisa umonakalo "ngokwandisa i-antioxidant enzymes".

Umzobo3 Iziphumo ze-cisplatin kunyeI-Ganoderma lucidum kumonakalo we-oxidative wezicubu zesibindi

(3)I-Ganoderma lucidum kwandisa amandla okuchasa ukudumba kweeseli zesibindi

I-Cisplatin isongela ukusinda kweeseli ngokonakalisa i-DNA kunye nokunyanzeliswa kwenani elikhulu leeradicals zamahhala;iiseli eziphantsi koxinzelelo ziya kuvula i-master switch NF-kB elawula impendulo yokudumba, ikhuthaza iiseli ukuba zidibanise kwaye zikhulule i-tumor necrosis factor (TNF-α) kunye nezinye ii-cytokines ukuze kusebenze i-wave yokuqala ye-inflammation reactions kunye ne-alarm ye-immunity.

Ngokukhawuleza emva koko, ezo seli zibulewe ngumonakalo we-oxidative okanye ukudumba ziya kukhulula enye i-cytokine, i-HMGB-1, ukuze isebenze iiseli ezininzi ze-immune, ezibangela amaza okuvuvukala.

Ukuvuvukala okuqhubekayo akuyi kuqinisa umonakalo we-oxidative kuphela, kodwa kuya kuqhuba iiseli ezininzi ekufeni, kwaye kubangele ukuba izicubu zesibindi ziphuhlise i-fibrosis ngexesha lenkqubo yokuvuvukala okuphindaphindiweyo kunye nokulungiswa.

Ngethamsanqa, njeI-Ganoderma lucidum inokunciphisa umonakalo we-oxidative obangelwa yi-cisplatin, iimvavanyo zezilwanyana ziqinisekisile ukuba ukusetyenziswa okudibeneyo kwe-cisplatin kunyeI-Ganoderma lucidum inokuthintela ukusebenza kwe-inflammation switch NF-kB, ukunciphisa i-TNF ekhuthaza ukuvuvukala-αkunye HMGB-1, kunye nokwandai-cytokine ye-IL-10 echasayokwizicubu zesibindi ngexesha elifanayo (Umfanekiso 4).

Kuthatyathwe kunye, ezi ziphumo azigcini nje ukuthintela ukuvuvukala kodwa zinciphisa ukuchithwa kwe-collagen kunye nokuthintela ukuqhubela phambili kwe-fibrosis yesibindi (Umfanekiso 5).

Umthombo weDatha / iDrug Des Devel Ther.2020;14: 2335-2353.

Umfanekiso we-4 Iziphumo ze-cisplatin kunyeI-Ganoderma lucidum ekudumbeni kwezicubu zesibindi

Umthombo weDatha / iDrug Des Devel Ther.2020;14: 2335-2353.

Umfanekiso we-5 Iziphumo ze-cisplatin kunye ne-Ganoderma lucidum kwi-fibrosis yesibindi

(4)I-Ganoderma lucidum kuphucula amandla e-anti-apoptotic kwiiseli zesibindi

Nokuba kungenxa yomonakalo owenziwe nge-oxidative okanye ngomonakalo wokudumba, i-cisplatin iya kuthi ekugqibeleni isebenze "i-apoptosis" indlela kwaye inyanzelise iiseli zesibindi ukuba zife.

Ngamanye amazwi, ukuba iiseli zesibindi zinokubamba umgca wokugqibela wokukhusela, ziya kuba namathuba amaninzi okuphila kunye nokunciphisa ubunzima bokulimala kwesibindi.

Zininzi iimolekyuli zeprotheyini ezilawula i-apoptosis.Phakathi kwabo, abona bamele kakhulu: p53, enokukhuthaza i-apoptosis, i-Bcl-2, enokuthintela i-apoptosis, kunye ne-caspase-3, eyenza i-apoptosis ngomzuzu wokugqibela.

Ngokutsho kwabaphandi'uhlalutyo lwezicubu zesibindi zezilwanyana zokulinga kwiqela ngalinye,I-Ganoderma lucidum ayikwazi nje ukukhuthaza ukubonakaliswa kwe-Bcl-2 kodwa iphinde ivimbele ukubonakaliswa kwe-p53 kunye ne-caspase-3, enokubonelela ngamandla anamandla e-anti-apoptotic kwiiseli zesibindi.

(5) I-Ganoderic acids idlala indima ebalulekileyo echasayo

Ukusuka kwi-anti-oxidation, i-anti-inflammation, i-anti-apoptosis kwintsebenzo yangempela yokunciphisa umonakalo wesibindi, abaphandi baye baqulunqa indlela yokwenzaI-Ganoderma lucidum ekunqandeni i-cisplatin hepatotoxicity kulo mzobo ulandelayo wereferensi yakho.

Umthombo weDatha / iDrug Des Devel Ther.2020;14: 2335-2353.

Umzobo 6 Indlela yeGanoderma lucidum ekunqandeni ubutyhefu besibindi se-cisplatin

Ekupheleni kolu phando, uhlalutyo lwe“inkqubo yokulinganisa i-molecular docking”wafumanisa ukuba ubuncinane 14 ganoderic acid kwi triterpenes ofI-Ganoderma lucidum (njengoko kuboniswe kwitheyibhile engezantsi) inokubophelela ngokuthe ngqo nangempumelelo kwi-cytokine engundoqo i-HMGB-1, ngaloo ndlela ingasebenzi umsebenzi we-pro-inflammatory we-HMGB-1.

Ekubeni i-anti-inflammation yenye yeendlela ezibalulekileyoI-Ganoderma lucidum ukunciphisa i-hepatotoxicity eyenziwe yiCisplatin,“ubutyebi eGanoderic iasidi”ibe licandelo lesalathisi seI-Ganoderma lucidum ukukhusela isibindi.

Loluphi uhloboI-Ganoderma lucidum isithakos inokuqulatha iGanoder eninziic iasidis?Ngokophando oludlulileyo, kuyaziwa ukuba bakhona ikakhulu kwi “I-Ganoderma lucidum iziqhamonge isicatshulwa sotywala somzimba".

Kufanelekile ukukhankanya ukuba iimpuku kwiI-Ganoderma lucidum iqela elalidla kuphelaI-Ganoderma lucidum ziphantse zifane neempuku kwiulawulo iqela kwiziphumo zovavanyo ezikhankanywe ngasentla, ebonisa ukubaI-Ganoderma lucidum ikhuseleke kakhulu ukuba ingasetyenziswa.

Ukongeza, indlela yokusetyenziswaI-Ganoderma lucidum nayo ibaluleke kakhulu.Ukuba uzimisele ukuhlaziyaewe itshathi eboniswe kweli nqaku, akukho nzima ukufumanisa ukuba “EkakhuluDay Iqela” inomphumo omhle.

Inyaniso, EkakhuluDay Iqela has isiphumo esihle ekunciphiseni i-hepatickwaye ityhefu yezintso ye-cisplatin kuvavanyo lwezilwanyana,oko ikukuthi yahlukat ukusuka enyeGi-anoderma lucidum amaqela.

Ziziphi iimpawu ezicacileyo zeziphumo ezilungileyo ezikhankanywe ngasentla?Hlala ubukele “Icandelo lesi-2I-Ganoderma lucidum ikhusela intso vs. Cisplatin nephrotoxicity”.

[Umthombo weDatha]

1.Hanan M Hassan, et al.Ukucinezelwa kweCisplatin-Induced Hepatic Injury in Rats Ngokusebenzisa i-Alarmin High-Mobility Group Box-1 Pathway byI-Ganoderma lucidum: Uphononongo lwethiyori kunye novavanyo.Drug Des Devel Ther.2020;14: 2335-2353.

2.Yasmen F Mahran, et al.I-Ganoderma lucidumIkhusela i-Cisplatin-Induced Nephrotoxicity ngokusebenzisa i-Inhibition ye-Epidermal Growth Factor Receptor Signaling kunye ne-Autophagy-Mediated Apoptosis.Oxid Med Iseli Longev.2020. doi: 10.1155/2020/4932587.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao

UWu Tingyao unike ingxelo okokuqalaI-Ganoderma lucidumulwazi ukususela ngo-1999. Ungumbhali weUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).

★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali, kwaye ubunini bubo be-GANOHERB ★ Le misebenzi ingentla ayinakuphinda iphinde iphinde iphinde iphinde isetyenziswe, ikhutshwe okanye isetyenziswe ngezinye iindlela ngaphandle kogunyaziso lweGanoHerb ★ Ukuba imisebenzi igunyazisiwe ukuba isetyenziswe, kufuneka isetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ibonise umthombo: GanoHerb ★ Ukwaphulwa kwengxelo engentla, iGanoHerb iya kulandela uxanduva lwayo olusemthethweni oluhambelanayo ★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao kwaye waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.

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