Chemotherapyraunatas hanta da koda yayinLingzhi (kuma ake kiraGanoderma lucidum ko Reishi naman kaza) yana kare hanta da koda.

CanGanoderma lucidum jure lalacewar hanta da koda ta hanyar chemotherapy?

Tawagar da ta kunshi Farfesa Hanan M Hassan daga tsangayar harhada magunguna ta jami'ar Delta ta kimiyya da fasaha a kasar Masar da kuma Farfesa Yasmen F Mahran daga tsangayar hada magunguna ta jami'ar Ain Shams da ke kasar Masar sun yi amfani da cisplatin, maganin da aka fi sani da chemotherapy. yiwuwarGanoderma lucidum a cikin kare hanta da ƙwayoyin koda daga raunin cisplatin.

Sakamakon binciken su ya kasu kashi biyu: daya yana kare hanta yayin da wani kuma yana kare koda.An buga su a cikin "Magungunan Magunguna, Ci gaba da Farfa" da "Magungunan Oxidative da Tsawon Rayuwa" a cikin Yuni da Yuli 2020, bi da bi.

A anti-oxidant, anti-mai kumburi da anti-apoptotic effects naGanoderma lucidum a fili zai iya toshe lalacewa da yawa na oxidative, lalacewar kumburi da apoptosis tantanin halitta wanda cisplatin ya haifar, kuma irin wannan kariyar yana aiki ga ƙwayoyin hanta ko ƙwayoyin koda.Wannan ba wai kawai yana nuna ƙimar magani guda biyu baneGanoderma lucidum amma kuma yana ba da hanyar kariya mai yuwuwa don cutar sankarau.

Don gudun kada wannan labarin ya yi tsawo, marubucin zai gabatar da rawar da ya takaGanoderma lucidum ta wannan fanni a bangarori biyu da fatan wadannan bayanai da hujjoji na kimiyya za su kara samun kwarin gwiwa ga abokai da ke neman rage illar cutar sankarau.

Kashi na 1Ganoderma lucidum yana kare hanta vs. cisplatin hepatotoxicity

A rmasu binciken sun kwatanta bambancinstsakanin amfani da rashin amfaniGanoderma luciduma lokacin jiyya na cisplatina cikin ƙungiyoyi shida na berayen lafiya da bambance-bambance a cikin kariya daga raunin hanta tare da daban-dabanGanoderma lucidum hanyoyin gudanarwa.Su ne:

◆Ƙungiyar Kulawa (Ci gaba): kungiyar da ba ta samun magani;

◆Ganoderma lucidumRukuni(GL): rukunin da ba a yi musu allurar cisplatin ba amma suna ciGanoderma lucidum kowace rana;

◆Ƙungiyar Cisplatin (CP): kungiyar da ake yi wa allurar cisplatin kawai amma ba ta ciGanoderma lucidum;

◆Rukunin Kullum (Kullum): kungiyar da ake yi wa allurar cisplatinkuma yana ciGanoderma Lucidum kowace rana;

◆Rukunin Kowacce Rana (EOD): kungiyar da ake yi wa allurar cisplatinkuma yana ciGanoderma lucidum kowace rana;

◆Ƙungiyar Intraperitoneal (ip): kungiyar da ake yiwa allura cisplatinkuma karba intraperitonealicutar daGanoderma lucidum.

Duk waɗanda suka karɓi cisplatin an yi musu allura ta ciki tare da 12 mg/kg naCisplatina ranar farko ta gwaji don haifar da mummunan rauni na hanta;wadanda suka karbi allurar intraperitoneal naGanoderma lucidum an yi allurar sau ɗaya a rana ta biyu da ta shida na gwajin.

TheGanoderma lucidum da aka yi amfani da shi a cikin gwajin ya ƙunshi abubuwa masu aiki kamar triterpenes, sterols, polysaccharides, polyphenols da flavonoids.TheGanoderma lucidum da aka yi a gwaje-gwajen dabba, ko ana sha da baki ko ta hanyar allura, ana ƙididdige su a adadin yau da kullun na 500 mg/kg.

(1)Ganoderma lucidum yana rage raunin hepatocellular

Bayan kwanaki 10, za a iya ganin cewa cisplatin zai kara yawan adadin hanta da kuma jimlar bilirubin a cikin maganin bera.Waɗannan duk alamun raunin hanta ne.Amma idanGanoderma lucidum yana da hannu a lokaci guda, ana iya rage yawan ƙimar da aka ƙara da yawa (Figure 1).

Tushen Bayanai / Drug Devel Ther.2020;14:2335-2353.

Hoto 1 Tasirin Cisplatin daGanoderma lucidum akan alamun raunin hanta

Saka sashin nama na hanta a karkashin na'urar hangen nesa, kuma zaka iya ganin cewa cisplatin na iya haifar da cunkoso na hanta (jinin da ya kamata ya koma cikin zuciya yana toshe kuma ya tsaya a cikin veins na hanta), lalata cell degeneration (vacuoles ya bayyana, wanda shine farkon canji a cikin jini). raunin salula), apoptosis da necrosis, amma waɗannan yanayi kuma ana iya rage su ta amfani da suGanoderma lucidum.

Hoto 2 Tasirin cisplatin daGanoderma lucidum a kan hepatocytes

(2)Ganoderma lucidum yana haɓaka ƙarfin antioxidant na ƙwayoyin hanta

Wannan labarin ya kara kwatanta lalacewar oxidative da kowane rukuni na kyallen hanta ya sha.Akwai alamomi biyu na lura: MDA (malondialdehyde), wani samfurin da aka kafa bayan lalata ƙwayoyin sel ta hanyar radicals kyauta, da H.₂O₂ (hydrogen peroxide), wani matsakaicin samfurin da aka kafa bayan metabolism na free radicals ta enzymes antioxidant.

Duk waɗannan samfuran biyu suna da kaddarorin oxidative na radicals kyauta kuma dole ne a ƙara bi da su kafin a iya “detoxified” da gaske, don haka adadin su zai iya gaya mana lalacewar oxidative cewa hanta nama. "yana da sha wahala" da "za su sha wahala".

Babu shakka, cisplatin zai haifar da babbar lalacewar hanta, amma idanGanoderma lucidum yana da hannu A cikin jiyya a lokaci guda, ana iya rage irin wannan lalacewa (Figure 3).

Saboda canje-canje a cikin maida hankali na enzymes antioxidant (SOD da GSH) a cikin kyallen hanta na kowane rukuni da canje-canje a cikin alamun lalacewar oxidative sun nuna sabanin yanayin gaba ɗaya., ana iya tunanin hakaGanoderma lucidumzai ƙara ƙarfin antioxidant na hanta hanta kuma ya rage lalacewa ta hanyar "ƙaramar enzymes antioxidant".

Hoto3 Tasirin cisplatin daGanoderma lucidum akan lalacewar oxidative na hanta nama

(3)Ganoderma lucidum yana haɓaka ikon hana kumburin ƙwayoyin hanta

Cisplatin yana barazana ga rayuwar kwayoyin halitta ta hanyar lalata DNA da kuma haifar da adadi mai yawa na free radicals;Kwayoyin da ke ƙarƙashin matsin lamba za su kunna mai sarrafa NF-kB wanda ke daidaita amsawar kumburi, yana haifar da sel don haɗawa da sakin ƙwayar cutar necrosis (TNF-α) da sauran cytokines don kunna tashin farko na halayen kumburi da ƙara ƙararrawa don rigakafi.

Nan da nan bayan haka, waɗancan ƙwayoyin da aka kashe ta hanyar lalacewa ko kumburi za su saki wani cytokine, HMGB-1, don kunna ƙarin ƙwayoyin rigakafi, yana haifar da raƙuman kumburi.

Ci gaba da ƙumburi ba wai kawai, bi da bi, zai ƙara lalacewar oxidative ba amma kuma yana fitar da ƙarin sel zuwa mutuwa, har ma ya haifar da ƙwayar hanta don haɓaka fibrosis a hankali yayin aiwatar da maimaita kumburi da gyarawa.

Abin farin, kamarGanoderma lucidum na iya rage lalacewar oxidative da cisplatin ke haifarwa, gwaje-gwajen dabbobi kuma sun tabbatar da cewa haɗakar amfani da cisplatin daGanoderma lucidum zai iya hana kunna kunnawa na NF-kB mai kumburi, rage kumburi mai haɓaka TNF-ada HMGB-1, da karuwaanti-mai kumburi cytokine IL-10a cikin kyallen hanta a lokaci guda (Figure 4).

Haɗe tare, waɗannan tasirin ba wai kawai hana kumburi ba amma kuma suna rage ƙaddamarwar collagen da hana ci gaban fibrosis na hanta (Hoto 5).

Tushen Bayanai / Drug Devel Ther.2020;14: 2335-2353.

Hoto 4 Tasirin Cisplatin daGanoderma lucidum akan kumburin hanta nama

Tushen Bayanai / Drug Devel Ther.2020;14: 2335-2353.

Hoto 5 Tasirin cisplatin da Ganoderma lucidum akan fibrosis na hanta

(4)Ganoderma lucidum yana haɓaka ikon anti-apoptotic na ƙwayoyin hanta

Ko ta hanyar lalacewar oxidative ko lalacewa mai kumburi, cisplatin zai ƙarshe kunna tsarin "apoptosis" kuma ya tilasta ƙwayoyin hanta su mutu.

A wasu kalmomi, idan ƙwayoyin hanta za su iya riƙe layin tsaro na ƙarshe, za su sami ƙarin damar rayuwa da kuma rage girman lalacewar hanta.

Akwai kwayoyin furotin da yawa waɗanda ke daidaita apoptosis.Daga cikin su, mafi yawan wakilai sune: p53, wanda zai iya inganta apoptosis, Bcl-2, wanda zai iya hana apoptosis, da caspase-3, wanda ke aiwatar da apoptosis a minti na karshe.

A cewar masu binciken'nazarin kyallen hanta na dabbobin gwaji a kowane rukuni,Ganoderma lucidum ba zai iya inganta bayyanar Bcl-2 kawai ba amma kuma ya hana maganganun p53 da caspase-3, wanda zai iya samar da makamashi mai karfi na anti-apoptotic ga ƙwayoyin hanta.

(5) Ganoderic acid yana taka muhimmiyar rawa wajen hana kumburi

Daga anti-oxidation, anti-inflammation, anti-apoptosis zuwa ainihin aikin rage lalacewar hanta, masu bincike sun tsara tsarin tsarin.Ganoderma lucidum a cikin hana cisplatin hepatotoxicity a cikin zane mai zuwa don tunani.

Tushen Bayanai / Drug Devel Ther.2020;14: 2335-2353.

Hoto 6 Hanyar Ganoderma lucidum a cikin hana hanta mai guba na cisplatin

A karshen wannan binciken, nazarin binciken"tsarin simintin docking na kwayoyin halitta”gano cewa akalla 14 ganoderic acid a cikin triterpenes naGanoderma lucidum (kamar yadda aka nuna a cikin tebur da ke ƙasa) na iya ɗaure kai tsaye da yadda ya kamata ga maɓalli na cytokine HMGB-1, don haka yana hana ayyukan haɓakawa na HMGB-1.

Tunda anti-kumburi yana daya daga cikin muhimman hanyoyin daGanoderma lucidum don rage cisplatin-induced hepatotoxicity,"arziki a Ganoderic acid”ya zama mai nuna alama bangarenGanoderma lucidum don kare hanta.

Wani irinGanoderma lucidum sashis na iya ƙunsar irin wannan yawan Ganoderic acids?Bisa ga binciken da ya gabata, an san cewa suna da yawa a cikin "Ganoderma lucidum 'ya'yan itaceing Cire barasar jiki”.

Yana da daraja a ambata cewa berayen a cikinGanoderma lucidum kungiyar da kawai ta ciGanoderma lucidum kusan iri ɗaya ne da berayen a cikinsarrafawa rukuni a cikin sakamakon gwajin da aka ambata a sama, yana nuna cewaGanoderma lucidum yana da aminci sosai don amfani.

Bugu da kari, hanyar yin amfani daGanoderma lucidum yana da matukar muhimmanci.Idan kuna son yin revyiw ginshiƙi da aka nuna a cikin wannan labarin, ba shi da wahala a sami hakan "EsosaiDay Rukuni” yana da mafi kyawun tasiri.

A hakika, EsosaiDay Rukuni has mafi kyawun tasiri a rage ciwon hantakuma Cisplatin na koda a cikin gwaje-gwajen dabba,wanda shine dabant daga sauranGanoderma lucidum ƙungiyoyi.

Menene takamaiman bayyanannun tasirin da aka ambata a sama?Ku kasance da shirin ''Kashi na 2Ganoderma lucidum yana kare koda vs. Cisplatin nephrotoxicity”.

[Tsarin Bayanai]

1.Hanan M Hassan, et al.Cire raunin Hanta da Cisplatin ya haifar a cikin beraye Ta hanyar Alarmin High-Mobility Group Box-1 Pathway byGanoderma lucidum: Nazarin Ka'idar da Gwaji.Drug Des Devel Ther.2020; 14: 2335-2353.

2.Yasmen F Mahran, et al.Ganoderma lucidumYana Hana Cisplatin-Induced Nephrotoxicity ta hanyar Hana Siginar Karɓar Factor Factor Factor Epidermal da Apoptosis-Mediated Autophagy.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

KARSHE

Game da marubucin / Ms. Wu Tingyao

Wu Tingyao ya kasance yana bayar da rahoto da farkoGanoderma lucidumbayanai tun 1999. Ita ce marubucinWaraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).

★ Wannan labarin an buga shi ne a ƙarƙashin izini na musamman na marubucin, kuma mallakin GANOHERB ne ★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin GanoHerb ba ★ Idan ayyukan sun sami izini a yi amfani da su. Ya kamata a yi amfani da shi a cikin iyakar izini kuma a nuna tushen: GanoHerb ★ keta bayanin da ke sama, GanoHerb za ta ci gaba da ayyukanta na shari'a ★ Wu Tingyao ne ya rubuta ainihin rubutun wannan labarin da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.

Haɓaka Al'adun Kiwon Lafiyar Millennia

Taimakawa Wajen Lafiya Ga Kowa