Chemotherapyntša kotsis sebete le liphio haLingzhke (hape ke bitsoaGanoderma lucidum kapa li-mushroom tsa Reishi) e sireletsa sebete le liphio.

KaGanoderma lucidum mamella tšenyo ea sebete le liphio e bakoang ke chemotherapy?

Sehlopha se entsoeng ke Moprofesa Hanan M Hassan oa Lefapha la Pharmacy la Univesithi ea Delta ea Saense le Theknoloji e Egepeta le Moprofesa Yasmen F Mahran oa Lefapha la Pharmacy la Ain Shams University e Egepeta ba sebelisitse cisplatin, e leng sethethefatsi se tloaelehileng sa chemotherapy sa setso, ho etsa liteko. monyetla oaGanoderma lucidum ho sireletsa lisele tsa sebete le liphio ho tsoa kotsi ea cisplatin.

Liphetho tsa bona tsa lipatlisiso li arotsoe ka lihlooho tse peli: e 'ngoe e sireletsa sebete ha e' ngoe e sireletsa liphio.Li phatlalalitsoe ho "Derug Design, Development and Therapy" le "Oxidative Medicine le Cellular Longevity" ka Phuptjane le Phupu 2020, ka ho latellana.

The anti-oxidant, anti-inflammatory le anti-apoptotic liphello tsaGanoderma lucidum ho hlakile hore e ka thibela tšenyo e ngata ea oxidative, tšenyo ea ho ruruha le apoptosis ea sele e bakoang ke cisplatin, 'me tšireletso e joalo e sebetsa ho lisele tsa sebete kapa lisele tsa liphio.Sena ha se totobatse feela boleng ba moriana o habeli oaGanoderma lucidum empa hape e fana ka mokhoa o ka khonehang oa ts'ireletso bakeng sa chemotherapy ea mofetše.

E le ho qoba ho etsa hore sengoloa sena se be telele haholo, mongoli o tla hlahisa karolo eaGanoderma lucidum karolong ena likarolong tse peli ka tšepo ea hore lintlha tsena tse thehiloeng saense le bopaki bo tla tlisa kholiseho e eketsehileng ho metsoalle e batlang ho fokotsa litla-morao tsa chemotherapy.

Karolo ea 1Ganoderma lucidum e sireletsa sebete khahlanong le cisplatin hepatotoxicity

The rbafuputsi ba ile ba bapisa phapangspakeng tsa ho sebedisa le ho se sebediseGanoderma lucidumnakong ea kalafo ea cisplatinka lihlopha tse tšeletseng tsa likhoto tse phetseng hantle le phapang ea tšireletso khahlanong le kotsi ea sebete e fapanengGanoderma lucidum mekhoa ea tsamaiso.Ke:

◆Sehlopha sa Taolo (Tsoelang Pele): sehlopha se sa fumaneng phekolo leha e le efe;

◆Ganoderma lucidumSehlopha(GL): sehlopha se sa keneng ka cisplatin empa se jaGanoderma lucidum letsatsi le letsatsi;

◆Sehlopha sa Cisplatin (CP): sehlopha se kentsoeng ka cisplatin feela empa se sa jeGanoderma lucidum;

◆Sehlopha sa Letsatsi le Letsatsi (Letsatsi le letsatsi): sehlopha se kentsoeng ka cisplatinle ho jaMofuta oa "Ganoderma Lucidum". letsatsi le letsatsi;

◆Sehlopha se seng le se seng sa Letsatsi (EOD): sehlopha se kentsoeng ka cisplatinle ho jaGanoderma lucidum letsatsi le leng le le leng;

◆Sehlopha sa Intraperitoneal (ip): sehlopha se entetsoeng cisplatinmme o amohela intraperitonealinjection ofGanoderma lucidum.

Bohle ba amohetseng cisplatin ba ne ba entoa ka intraperitoneally ka 12 mg/kg eaCisplatinletsatsing la pele la teko ea ho tsosa kotsi e mpe ea sebete;ba fumaneng ente ea intraperitoneal eaGanoderma lucidum li ile tsa entoa hang ka letsatsi la bobeli le la botšelela la teko.

TheGanoderma lucidum e sebelisitsoeng tekong e na le metsoako e sebetsang e kang triterpenes, sterols, polysaccharides, polyphenols le flavonoids.TheGanoderma lucidum e fanoeng litekong tsa liphoofolo, ebang e nkoa ka molomo kapa ka ente, e baloa ka tekanyo ea letsatsi le letsatsi ea 500 mg/kg.

(1)Ganoderma lucidum e fokotsa kotsi ea hepatocellular

Kamora matsatsi a 10, ho ka bonoa hore cisplatin e tla eketsa index ea lefu la sebete le kakaretso ea bilirubin serum ea rat.Tsena kaofela ke matšoao a kotsi ea hepatocellular.Empa haebaGanoderma lucidum e ameha ka nako e ts'oanang, boleng bo eketsehileng bo ka fokotseha haholo (Setšoantšo sa 1).

Mohloli oa Boitsebiso / Lithethefatsi Des Devel Ther.2020;14:2335-2353 .

Setšoantšo sa 1 Liphello tsa cisplatin leGanoderma lucidum ka matšoao a kotsi ea sebete

Beha karolo ea lisele tsa sebete ka tlas'a microscope, 'me u ka bona hore cisplatin e ka baka tšubuhlellano ea sebete (mali a lokelang ho khutlela pelong a koetsoe 'me a thekesela methapong ea sebete), ho senyeha ha lisele (li-vacuoles li hlaha, e leng phetoho ea pele ho lefu la sebete). kotsi ea cellular), apoptosis le necrosis, empa maemo ana a ka boela a fokotsoa ka ho sebelisaGanoderma lucidum.

Setšoantšo sa 2 Liphello tsa cisplatin leGanoderma lucidum ka li-hepatocytes

(2)Ganoderma lucidum e ntlafatsa matla a antioxidant a lisele tsa sebete

Sengoliloeng sena se bapisa hape ts'enyo ea oxidative e hlokofalitsoeng ke sehlopha ka seng sa lisele tsa sebete.Ho na le matšoao a mabeli a ho shebella: MDA (malondialdehyde), sehlahisoa se entsoeng ka mor'a ho senyeha ha lisele tsa lisele ke li-radicals tsa mahala, le H₂O₂ (hydrogen peroxide), sehlahisoa sa lipakeng se entsoeng ka mor'a metabolism ea li-radicals tsa mahala ka li-enzyme tsa antioxidant.

Lihlahisoa tsena ka bobeli li na le thepa ea oxidative ea li-radicals tsa mahala mme li tlameha ho phekoloa ka ho eketsehileng pele li ka "detoxified", kahoo palo ea tsona e ka re bolella tšenyo ea oxidative eo lisele tsa sebete li e bakang. “e na le utloa bohloko” le “tla utloa bohloko”.

Ho hlakile hore cisplatin e tla baka tšenyo e kholo ea oxidative ho lisele tsa sebete, empa haebaGanoderma lucidum e ameha Ka kalafo ka nako e ts'oanang, tšenyo e joalo e ka fokotsoa (Setšoantšo sa 3).

Hobane liphetoho tsa khatello ea li-enzyme tsa antioxidant (SOD le GSH) liseleng tsa sebete tsa sehlopha ka seng le liphetoho tsa matšoao a tšenyo ea oxidative li bonts'itse mokhoa o fapaneng ka ho felletseng., ho ka boleloa horeGanoderma lucidume tla eketsa matla a antioxidant a lisele tsa sebete le ho fokotsa tšenyo ka "ho eketsa li-enzyme tsa antioxidant".

Setšoantšo3 Liphello tsa cisplatin leGanoderma lucidum ka tšenyo ea oxidative ea lisele tsa sebete

(3)Ganoderma lucidum e ntlafatsa matla a anti-inflammatory a lisele tsa sebete

Cisplatin e sokela ho phela ha lisele ka ho senya DNA le ho hohela palo e kholo ea li-radicals tsa mahala;lisele tse tlas'a khatello li tla bulela mochine o moholo oa NF-kB o laolang karabo ea ho ruruha, e leng se etsang hore lisele li kopane le ho lokolla tumor necrosis factor (TNF-α) le li-cytokine tse ling ho kenya tšebetsong leqhubu la pele la ho ruruha le ho lla alamo bakeng sa ho itšireletsa mafung.

Hang ka mor'a moo, lisele tse bolailoeng ke tšenyo ea oxidative kapa ho ruruha li tla lokolla cytokine e 'ngoe, HMGB-1, ho kenya lisele tse ngata tsa' mele tsa ho itšireletsa mafung, ho baka maqhubu a ho ruruha.

Ho ruruha ho sa khaotseng ho ke ke ha matlafatsa tšenyo ea oxidative feela, empa hape ho tla khanna lisele tse ngata ho isa lefung, esita le ho etsa hore lisele tsa sebete li hlahise fibrosis butle-butle nakong ea ho ruruha le ho lokisoa khafetsa.

Ka lehlohonolo, joalo kaGanoderma lucidum e ka fokotsa tšenyo ea oxidative e bakiloeng ke cisplatin, liteko tsa liphoofolo li boetse li netefalitse hore ts'ebeliso e kopaneng ea cisplatin leGanoderma lucidum e ka thibela ts'ebetso ea phetoho ea ho ruruha NF-kB, ea fokotsa TNF e khothalletsang ho ruruha-ale HMGB-1, le ho eketsehaanti-inflammatory cytokine IL-10liseleng tsa sebete ka nako e le 'ngoe (Setšoantšo sa 4).

Ha li kopane, liphello tsena ha li thibele ho ruruha feela empa hape li fokotsa ho kenngoa ha collagen le ho thibela tsoelo-pele ea sebete sa fibrosis (Setšoantšo sa 5).

Mohloli oa Boitsebiso / Lithethefatsi Des Devel Ther.2020;14: 2335-2353 .

Setšoantšo sa 4 Liphello tsa cisplatin leGanoderma lucidum ka ho ruruha ha lisele tsa sebete

Mohloli oa Boitsebiso / Lithethefatsi Des Devel Ther.2020;14: 2335-2353 .

Setšoantšo sa 5 Liphello tsa cisplatin le Ganoderma lucidum ho sebete sa fibrosis

(4)Ganoderma lucidum e ntlafatsa matla a anti-apoptotic a lisele tsa sebete

Ebang ke ka tšenyo ea oxidative kapa tšenyo ea ho ruruha, cisplatin e tla qetella e kenya tšebetsong mochine oa "apoptosis" le ho qobella lisele tsa sebete ho shoa.

Ka mantsoe a mang, haeba lisele tsa sebete li ka tšoara moeli oa ho qetela oa tšireletso, li tla ba le menyetla e mengata ea ho phela le ho fokotsa ho teba ha tšenyo ea sebete.

Ho na le limolek'hule tse ngata tsa protheine tse laolang apoptosis.Har'a tsona, tse emelang ka ho fetisisa ke: p53, e ka khothalletsang apoptosis, Bcl-2, e ka thibelang apoptosis, le caspase-3, e phethahatsang apoptosis motsotso oa ho qetela.

Ho ea ka bafuputsi'tlhahlobo ea lisele tsa sebete tsa liphoofolo tsa liteko sehlopheng ka seng,Ganoderma lucidum e ke ke ea khothalletsa feela polelo ea Bcl-2 empa hape e thibela polelo ea p53 le caspase-3, e ka fanang ka matla a matla a anti-apoptotic bakeng sa lisele tsa sebete.

(5) Li-ganoderic acid li bapala karolo ea bohlokoa e khahlanong le ho ruruha

Ho tloha ho anti-oxidation, anti-inflammation, anti-apoptosis ho ea ts'ebetsong ea sebele ea ho fokotsa tšenyo ea sebete, bafuputsi ba hlophisitse mochine oaGanoderma lucidum ka ho thibela cisplatin hepatotoxicity setšoantšong se latelang bakeng sa referense ea hau.

Mohloli oa Boitsebiso / Lithethefatsi Des Devel Ther.2020;14: 2335-2353 .

Setšoantšo sa 6 Mokhoa oa Ganoderma lucidum ho thibela chefo ea sebete ea cisplatin

Qetellong ea thuto ena, tlhahlobo ea“sisteme ea ketsiso ea limolek'hule”fumana hore bonyane 14 ganoderic acid ka triterpenes eaGanoderma lucidum (joalokaha ho bontšitsoe tafoleng e ka tlase) e ka tlama ka ho toba le ka katleho ho bohlokoa ba cytokine HMGB-1, kahoo e sitisa mosebetsi oa pro-inflammatory oa HMGB-1.

Kaha khahlanong le ho ruruha ke o mong oa mekhoa ea bohlokoa eaGanoderma lucidum ho fokotsa hepatotoxicity e bakoang ke Cisplatin,“leruo la Ganoderic asiti”e se e le karolo ea sesupo saGanoderma lucidum ho tshireletsa sebete.

Ke mofuta ofeGanoderma lucidum motsoakos e ka ba le Ganoder e ngata joaloic asitis?Ho latela lipatlisiso tse fetileng, hoa tsebahala hore ba teng haholo "Ganoderma lucidum tholoanang mmele wa tahi”.

Ke habohlokoa ho bolela hore likhoto kaGanoderma lucidum sehlopha se jang feelaGanoderma lucidum li batla li tšoana le likhoto tsetaolo sehlopha sa liphetho tsa liteko tse boletsoeng ka holimo, tse bontšang seoGanoderma lucidum e bolokehile haholo bakeng sa tšebeliso.

Ho feta moo, mokhoa oa ho sebelisaGanoderma lucidum e boetse e bohlokoa haholo.Haeba u ikemiselitse ho review chate e bontšitsoeng sehloohong sena, ha ho thata ho fumana hore “EhaholoDay Sehlopha” e na le phello e molemohali.

Haele hantle, EhaholoDay Sehlopha has phello e ntle ka ho fetisisa ka ho fokotsa sebetele chefo ea renal ea cisplatin litekong tsa liphoofolo,e leng fapanat ho tloha tse dingGanoderma lucidum lihlopha.

Lipontšo tse tobileng tsa liphello tse molemo tse boletsoeng ka holimo ke life?Lula u mametse "Karolo ea 2Ganoderma lucidum e sireletsa liphio khahlano le Cisplatin nephrotoxicity”.

[Mohloli oa Lintlha]

1.Hanan M Hassan, le ba bang.Khatello ea Kotsi ea Hepatic e Bakiloeng ke Cisplatin ho Likhoto Ka Alarmin High-Mobility Group Box-1 Pathway byGanoderma lucidum: Thuto ea Khopolo le ea Teko.Meriana e Hlahisa Ther.2020;14:2335-2353.

2.Yasmen F Mahran, le ba bang.Ganoderma lucidumE thibela Cisplatin-Induced Nephrotoxicity ka Thibelo ea Epidermal Growth Factor Receptor Signaling le Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

QETA

Mabapi le mongoli/ Mme Wu Tingyao

Wu Tingyao o ntse a tlaleha ka letsoho la peleGanoderma lucidumtlhahisoleseding ho tloha ka 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).

★ Sengoliloeng sena se hatisitsoe ka tumello e khethehileng ea mongoli, 'me thepa ke ea GANOHERB ★ Mesebetsi e ka holimo e ke ke ea hlahisoa, ea qotsoa kapa ea sebelisoa ka litsela tse ling ntle le tumello ea GanoHerb ★ Haeba mesebetsi e lumelletsoe ho sebelisoa, e lokela ho sebelisoa ka har'a sebaka sa tumello le ho bontša mohloli: GanoHerb ★ Tlōlo ea polelo e ka holimo, GanoHerb e tla phehella boikarabelo ba eona ba molao bo amanang le eona ★ Mongolo oa pele oa sehlooho sena o ngotsoe ka Sechaena ke Wu Tingyao 'me oa fetoleloa ka Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.

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