Kemoterapihōʻehas ke ake a me na puupaa oiaiLingzhi (kapa ʻiaʻO Ganoderma lucidum a i ʻole ʻo Reishi mushroom) pale i ke akepaʻa a me nā puʻupaʻa.

HikiʻO Ganoderma lucidum pale i ke akepaʻa a me ka hōʻino ʻia e ka chemotherapy?

He hui i haku ʻia ʻo Polofesa Hanan M Hassan mai ka Faculty of Pharmacy o Delta University for Science & Technology in Egypt a me Professor Yasmen F Mahran mai ka Faculty of Pharmacy of Ain Shams University ma ʻAigupita i hoʻohana i ka cisplatin, ka lāʻau lapaʻau maʻamau maʻamau maʻamau, e hoʻāʻo. ka hiki oʻO Ganoderma lucidum i ka pale ʻana i ke akepaʻa a me nā puʻupaʻa mai ka ʻeha cisplatin.

Hoʻokaʻawale ʻia kā lākou mau hopena noiʻi i ʻelua ʻatikala: mālama kekahi i ke ake aʻo kekahi e pale ana i nā puʻupaʻa.Ua paʻi ʻia lākou ma "Drug Design, Development and Therapy" a me "Oxidative Medicine and Cellular Longevity" i Iune a me Iulai 2020.

ʻO nā hopena anti-oxidant, anti-inflammatory a me anti-apoptotic oʻO Ganoderma lucidum Hiki iā ia ke ālai i nā pōʻino oxidative he nui, nā pōʻino inflammatory a me ka apoptosis cell i hoʻokomo ʻia e cisplatin, a pili ia pale i nā pūnaeka ate a i ʻole nā ​​​​pūnaewele puʻupaʻa.ʻAʻole kēia e hōʻike wale i ka waiwai lapaʻau pālua oʻO Ganoderma lucidum akā hāʻawi pū kekahi i kahi ala palekana kōkua kūpono no ka chemotherapy maʻi maʻi.

I mea e pale ʻole ai i ka lōʻihi o kēia ʻatikala, e hoʻolauna ka mea kākau i ke kuleana oʻO Ganoderma lucidum ma kēia ʻāpana i ʻelua ʻāpana me ka manaʻolana e lawe mai kēia mau ʻikepili a me nā hōʻike ʻepekema i ka hilinaʻi hou aku i nā hoaaloha e ʻimi nei e hōʻemi i nā hopena ʻaoʻao o ka chemotherapy.

Mahele 1ʻO Ganoderma lucidum pale i ka ate vs. cisplatin hepatotoxicity

ʻO ka rua hoʻohālikelike nā mea noiʻi i ka ʻokoʻasma waena o ka hoʻohana ʻana a me ka hoʻohana ʻoleʻO Ganoderma lucidumi ka wā mālama cisplatini ʻeono pūʻulu o nā ʻiole olakino a me nā ʻokoʻa o ka pale ʻana i ka ʻeha o ke ake me nā ʻokoʻaʻO Ganoderma lucidum ʻano hoʻokele.ʻo lākou:

◆Pūʻulu Mana (Cont): ka hui i loaa ole ka lapaau ana;

◆ʻO Ganoderma lucidumPūʻulu(GL): ka hui ʻaʻole i hoʻopaʻa ʻia me ka cisplatin akā ʻaiʻO Ganoderma lucidum nā lā āpau;

◆Hui Cisplatin (CP): ka pūʻulu i hoʻokomo wale ʻia me ka cisplatin akā ʻaʻole ʻaiʻO Ganoderma lucidum;

◆Pūʻulu i kēlā me kēia lā (i kēlā me kēia lā): ka hui i hookomoia me cisplatina aiGanoderma Lucidum nā lā āpau;

◆ʻO kēlā me kēia lā hui ʻē aʻe (EOD): ka hui i hookomoia me cisplatina aiʻO Ganoderma lucidum i kēlā me kēia lā;

◆Pūʻulu Intraperitoneal (ip): ka hui i hookomoia cisplatina loaa intraperitonealinjection oGanoderma lucidum.

ʻO ka poʻe a pau i loaʻa i ka cisplatin i hoʻopaʻa ʻia intraperitoneally me 12 mg / kg oʻO Cisplatini ka lā mua o ka hoʻokolohua e hoʻoulu ai i ka ʻeha o ka ate;ka poe i loaa i ka intraperitoneal injection oʻO Ganoderma lucidum ua hoʻokomo ʻia i hoʻokahi manawa ma ka lua a me ke ono o nā lā o ka hoʻokolohua.

ʻO kaʻO Ganoderma lucidum hoʻohana ʻia i ka hoʻokolohua he mau mea ikaika e like me triterpenes, sterols, polysaccharides, polyphenols a me flavonoids.ʻO kaʻO Ganoderma lucidum hāʻawi ʻia i nā hoʻokolohua holoholona, ​​inā i lawe ʻia ma ka waha a i ʻole ma ka inikini, ua helu ʻia i kēlā me kēia lā o 500 mg/kg.

(1)ʻO Ganoderma lucidum hoemi i ka eha hepatocellular

Ma hope o 10 mau lā, hiki ke ʻike ʻia e hoʻonui ka cisplatin i ka helu hepatitis a me ka pae bilirubin piha i ka serum o ka ʻiole.He mau hōʻailona kēia o ka hōʻeha hepatocellular.Akā ināʻO Ganoderma lucidum pili i ka manawa like, hiki ke hoʻemi nui ʻia ka waiwai hoʻonui (Figure 1).

PunaʻIkepili/Drug Des Devel Ther.2020;14:2335-2353.

Kiʻi 1 Nā hopena o cisplatin a meʻO Ganoderma lucidum ma nā hōʻailona hōʻeha ate

E kau i ka ʻāpana o ke akepaʻa ma lalo o ka microscope, a hiki iā ʻoe ke ʻike i ka cisplatin hiki ke hoʻoulu i ke akepaʻa (ua paʻa ke koko e hoʻi i ka puʻuwai a paʻa i loko o nā veins hepatic), degeneration cell (hōʻike ʻia nā vacuoles, ʻo ia ka hoʻololi mua loa i loko. ʻeha cellular), apoptosis a me necrosis, akā hiki ke hoʻopau ʻia kēia mau kūlana ma ka hoʻohana ʻanaʻO Ganoderma lucidum.

Kiʻi 2 Nā hopena o cisplatin a meʻO Ganoderma lucidum ma nā hepatocytes

(2)ʻO Ganoderma lucidum hoʻonui i ka mana antioxidant o nā pūpū ate

Hoʻohālikelike kēia ʻatikala i ka pōʻino oxidative i loaʻa i kēlā me kēia hui o nā ʻiʻo ate.ʻElua mau hōʻailona nānā: MDA (malondialdehyde), he huahana i hana ʻia ma hope o ka luku ʻia ʻana o nā membrane cell e nā radical manuahi, a me H.₂O₂ (hydrogen peroxide), he huahana waena i hana ʻia ma hope o ka metabolism o nā radical manuahi e nā enzyme antioxidant.

Loaʻa i kēia mau huahana ʻelua nā waiwai oxidative o nā radical manuahi a pono e mālama hou ʻia ma mua o ka hiki ke "detoxified" maoli, no laila hiki i ka nui o lākou ke haʻi iā mākou i ka pōʻino oxidative i ka ʻiʻo ate. “ua loaʻa pilikia" a "e pilikia".

ʻIke loa, e hoʻopōʻino nui ʻia ka cisplatin i ka ʻiʻo ate, akā ināʻO Ganoderma lucidum pili i ka mālama ʻana i ka manawa like, hiki ke hōʻemi ʻia kēlā pōʻino (Figure 3).

No ka mea, ʻo ka hoʻololi ʻana i ka neʻe ʻana o nā enzyme antioxidant (SOD a me GSH) i loko o nā ʻiʻo ate o kēlā me kēia hui a me nā loli i nā hōʻailona hōʻino oxidative i hōʻike i kahi ʻano kūʻē loa., hiki ke manao iaʻO Ganoderma lucidume hoʻonui i ka mana antioxidant o ke akepaʻa a hoʻemi i ka pōʻino ma o ka "hoʻonui ʻana i nā enzyme antioxidant".

Kiʻi3 Nā hopena o cisplatin a meʻO Ganoderma lucidum i ka poino oxidative o ke akepaʻa

(3)ʻO Ganoderma lucidum hoʻonui i ka mana anti-inflammatory o nā pūnaeho ate

Hoʻoweliweli ʻo Cisplatin i ke ola ʻana o nā cell ma o ka hōʻino ʻana i ka DNA a me ka hoʻoulu ʻana i ka nui o nā radical manuahi;ʻO nā pūnaewele ma lalo o ke kaomi e hoʻohuli i ka master switch NF-kB e hoʻoponopono i ka pane ʻana o ka mumū, e koi ana i nā cell e synthesize a hoʻokuʻu i ka helu necrosis tumor (TNF-α) a me nā cytokines ʻē aʻe e hoʻāla i ka nalu mua o nā hopena inflammatory a kani i ke kani ʻana no ka pale ʻana.

Ma hope koke iho, e hoʻokuʻu ʻia kēlā mau cell i pepehi ʻia e ka pōʻino oxidative a i ʻole ka mumū e hoʻokuʻu i kekahi cytokine, HMGB-1, e hoʻāla hou i nā cell immune, e hoʻoulu ai i nā nalu o ka mumū.

ʻO ka hoʻomau mau ʻana, ʻaʻole wale ia e hoʻoikaika i ka pōʻino oxidative akā e hoʻokau pū aku i nā cell hou aʻe i ka make, a hiki nō hoʻi i ke kumu o ke akepaʻa e ulu mālie i ka fibrosis i ka wā o ke kaʻina hana o ka hoʻoulu hou ʻana a me ka hoʻoponopono ʻana.

ʻO ka pōmaikaʻi, e like meʻO Ganoderma lucidum hiki ke hōʻemi i ka pōʻino oxidative i hoʻokumu ʻia e cisplatin, ua hōʻoia pū nā hoʻokolohua holoholona i ka hoʻohana pū ʻana o cisplatin a meʻO Ganoderma lucidum hiki ke kāohi i ka hoʻoulu ʻana o ka hoʻololi ʻana i ka mumū NF-kB, e hoʻemi i ka TNF hoʻoulu ʻia-aa me HMGB-1, a mahuahuaka anti-inflammatory cytokine IL-10i loko o nā kiko o ke ake i ka manawa like (Figure 4).

ʻO ka hui pū ʻana, ʻaʻole wale kēia mau hopena e kāohi i ka mumū akā e hōʻemi pū i ka waiho ʻana o ka collagen a pale i ka holomua o ka fibrosis ate (Figure 5).

PunaʻIkepili/Drug Des Devel Ther.2020;14: 2335-2353.

Kiʻi 4 Nā hopena o cisplatin a meʻO Ganoderma lucidum ma luna o ka mumū o ke akepaʻa

PunaʻIkepili/Drug Des Devel Ther.2020;14: 2335-2353.

Kiʻi 5 Nā hopena o cisplatin a me Ganoderma lucidum i ka fibrosis ate

(4)ʻO Ganoderma lucidum hoʻonui i ka mana anti-apoptotic o nā pūnaʻi ate

Inā ma muli o ka pōʻino oxidative a i ʻole ka pōʻino inflammatory, e hoʻāla ka cisplatin i ke ʻano hana "apoptosis" a hoʻoikaika i nā pūpū ate e make.

I nā huaʻōlelo ʻē aʻe, inā hiki i nā pūpū ate ke hoʻopaʻa i ka laina hope o ka pale, e ʻoi aku ka nui o nā manawa e ola ai a hoʻemi i ka paʻakikī o ka pōʻino o ke ake.

Nui nā molekole protein e hoʻoponopono i ka apoptosis.Ma waena o lākou, ʻo ka p53, hiki ke hoʻoikaika i ka apoptosis, Bcl-2, hiki ke kāohi i ka apoptosis, a me ka caspase-3, e hoʻokō i ka apoptosis i ka minuke hope.

Wahi a nā mea noiʻi'ka nānā ʻana o nā ʻiʻo ate o nā holoholona hoʻokolohua i kēlā me kēia hui,ʻO Ganoderma lucidum ʻAʻole hiki ke hoʻolaha wale i ka hōʻike o Bcl-2 akā ke kāohi pū i ka hōʻike ʻana o ka p53 a me ka caspase-3, hiki ke hāʻawi i ka ikaika anti-apoptotic ikaika no nā pūpū ate.

(5) He kuleana koʻikoʻi nā ʻakika Ganoderic

Mai ka anti-oxidation, anti-inflammation, anti-apoptosis i ka hana maoli o ka hōʻemi ʻana i ka pōʻino o ka ate, ua hōʻuluʻulu nā mea noiʻi i ka hana oʻO Ganoderma lucidum i ka pale ʻana i ka cisplatin hepatotoxicity i loko o ke kiʻikuhi aʻe no kāu kuhikuhi.

PunaʻIkepili/Drug Des Devel Ther.2020;14: 2335-2353.

Kiʻi 6 ʻO ka hana o Ganoderma lucidum i ka pale ʻana i ka ʻona o ka ate o cisplatin

I ka hopena o kēia haʻawina, ʻo ka nānā ʻana o ka“molecular docking simulation system”ua ʻike ʻia ma kahi o 14 ganoderic acids i loko o nā triterpenes oʻO Ganoderma lucidum (e like me ka mea i hōʻike ʻia ma ka papa ma lalo) hiki ke hoʻopaʻa pololei a hoʻopaʻa pono i ke kī cytokine HMGB-1, pēlā e hoʻopau ai i ka hana pro-inflammatory o HMGB-1.

No ka mea, ʻo ka anti-inflammation kekahi o nā mīkini koʻikoʻi oʻO Ganoderma lucidum e hōʻemi i ka hepatotoxicity i hoʻokomo ʻia e Cisplatin,“waiwai ma Ganoderic ʻakika”ua lilo i mea hoailona oʻO Ganoderma lucidum e hoomalu i ke ake.

He aha ke ʻanoʻO Ganoderma lucidum mea komoHiki iā ia ke loaʻa ka Ganoder nuiic ʻakikas?Wahi a nā noiʻi i hala, ua ʻike ʻia aia lākou ma ka "ʻO Ganoderma lucidum huaana ka waiʻona kino”.

He mea pono ke hai aku i na iole ma kaʻO Ganoderma lucidum hui i ai waleʻO Ganoderma lucidum ua aneane like me na iole ma kahoʻomalu hui i nā hopena hoʻokolohua i ʻōlelo ʻia ma luna, e hōʻike ana i kēlāʻO Ganoderma lucidum palekana loa no ka ʻai ʻana.

Eia kekahi, ke ʻano o ka hoʻohana ʻanaʻO Ganoderma lucidum he mea nui loa.Inā makemake ʻoe e review ka pakuhi i hōʻike ʻia ma kēia ʻatikala, ʻaʻole paʻakikī ke ʻike ʻo "EloaDay Pūʻulu” ka hopena maikaʻi loa.

I ka ʻoiaʻiʻo, EloaDay Pūʻulu has ka hopena maikaʻi loa i ka hoemi ana i ka hepatica ka ʻona o ka cisplatin i nā hoʻokolohua holoholona, ​​​​ʻo ia hoʻi ʻokoʻat mai ʻē aʻeGanoderma lucidum hui.

He aha nā hōʻike kikoʻī o nā hopena maikaʻi i ʻōlelo ʻia ma luna?E hoʻomau no ka "Mahele 2ʻO Ganoderma lucidum pale i ke kīpē vs. Cisplatin nephrotoxicity”.

[Kumu ʻikepili]

1.Hanan M Hassan, et al.Hoʻopau ʻia ʻo Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway eʻO Ganoderma lucidum: Haʻawina Manaʻo a hoʻokolohua.Drug Des Devel Ther.2020;14: 2335-2353.

2.Yasmen F Mahran, et al.ʻO Ganoderma lucidumKāohi ʻo Cisplatin-Induced Nephrotoxicity ma o ke kāohi ʻana i ka Epidermal Growth Factor Receptor Signaling a me Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

HOPE

No ka mea kākau/ Ms. Wu Tingyao

Ua hōʻike ʻo Wu Tingyao ma ka lima muaʻO Ganoderma lucidumʻike mai ka makahiki 1999. ʻO ia ke kumu oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau, a no GANOHERB ka mea nona ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka GanoHerb ★ Inā ua ʻae ʻia nā hana e hoʻohana ʻia, Pono e hoʻohana ʻia i loko o ke ʻano o ka ʻae ʻia a hōʻike i ke kumu: GanoHerb ★ ʻAi ʻole i ka ʻōlelo ma luna, e ʻimi ʻo GanoHerb i kāna mau kuleana pili kānāwai ★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Kina e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.

E hoʻomau i ka Moʻomeheu Ola Millennia

Hāʻawi i ka Ola no nā mea a pau