Chemotherapymerụọ ahụs imeju na akụrụ mgbeLingzhm (a na-akpọkwaGanoderma lucidum ma ọ bụ Reishi ero) na-echebe imeju na akụrụ.

Nwere ikeGanoderma lucidum nagide mmebi imeju na akụrụ nke chemotherapy kpatara?

Otu nke Prọfesọ Hanan M Hassan sitere na ngalaba na-ahụ maka ọgwụ na Mahadum Delta maka Sayensị & Teknụzụ dị n'Ijipt na Prọfesọ Yasmen F Mahran sitere na ngalaba na-ahụ maka ọgwụ na Mahadum Ain Shams dị n'Ijipt jiri cisplatin, ọgwụ chemotherapy ọdịnala a na-ahụkarị. ekwe omume nkeGanoderma lucidum na-echebe mkpụrụ ndụ imeju na akụrụ site na mmerụ ahụ cisplatin.

A na-ekewa nsonaazụ nyocha ha ụzọ abụọ: otu na-echebe imeju ebe onye ọzọ na-echebe akụrụ.Ebipụtara ha na "Ọdịbe Ọgwụ, Mmepe na Ọgwụgwọ" na "Oxidative Medicine and Cellular Longevity" na June na Julaị 2020, n'otu n'otu.

Ihe mgbochi oxidant, mgbochi mkpali na mgbochi apoptotic mmetụta nkeGanoderma lucidum nwere ike n'ụzọ doro anya igbochi ọtụtụ mmebi oxidative, mmebi mkpali na cell apoptosis nke cisplatin kpatara, na nchebe dị otú ahụ na-emetụta mkpụrụ ndụ imeju ma ọ bụ akụrụ.Nke a abụghị naanị na-akọwapụta uru ọgwụ abụọ nkeGanoderma lucidum mana ọ na-enyekwa ụzọ nchekwa inyeaka ga-ekwe omume maka chemotherapy.

Iji zere ime ka akụkọ a dị ogologo, onye edemede ga-ewebata ọrụ nkeGanoderma lucidum n'akụkụ a n'akụkụ abụọ n'olileanya na data ndị a dabeere na sayensị na ihe akaebe ga-eme ka obi ike karịa ndị enyi na-achọ ibelata mmetụta nke chemotherapy.

Akụkụ 1Ganoderma lucidum na-echebe imeju vs. cisplatin hepatotoxicity

Ihe rndị na-eme nchọpụta tụnyere ihe dị ichesn'etiti iji na ịghara ijiGanoderma lucidumn'oge ọgwụgwọ cisplatinn'ime ìgwè isii nke oke ahụike na ọdịiche dị na nchebe megide mmerụ imeju dị iche icheGanoderma lucidum ụzọ nchịkwa.Ha bụ:

◆Otu njikwa (Ọga n'ihu): otu ndị na-adịghị enweta ọgwụgwọ ọ bụla;

◆Ganoderma lucidumOtu(GL): otu ndị a na-agbaghị na cisplatin ma na-eri nriGanoderma lucidum kwa ụbọchị;

◆Ndị otu Cisplatin (CP): otu a na-agba naanị cisplatin ma anaghị eri nriGanoderma lucidum;

◆Otu ụbọchị niile (kwa ụbọchị): otu a na-agba ya na cisplatinna-eriGanoderma Lucidum kwa ụbọchị;

◆Otu ụbọchị ọ bụla ọzọ (EOD): otu a na-agba ya na cisplatinna-eriGanoderma lucidum ụbọchị ọ bụla ọzọ;

◆Intraperitoneal Group (ip): otu a na-agba cisplatinwee nata mntraperitonealinjection nkeGanoderma lucidum.

Ndị niile natara cisplatin ka agbanyere intraperitoneal na 12 mg / kg nkeCisplatinn'ụbọchị mbụ nke nnwale iji kpalite nnukwu mmerụ ahụ imeju;ndị natara intraperitoneal injections nkeGanoderma lucidum a gbanyere ya otu ugboro n'ụbọchị nke abụọ na nke isii nke nnwale ahụ.

NkeGanoderma lucidum ejiri mee nnwale ahụ nwere ihe ndị na-arụ ọrụ dị ka triterpenes, sterols, polysaccharides, polyphenols na flavonoids.NkeGanoderma lucidum enyere na nnwale anụmanụ, ma ọ bụ ọnụ ma ọ bụ ntụtụ, a na-agbakọ kwa ụbọchị nke 500 mg / kg.

(1)Ganoderma lucidum na-ebelata mmerụ ahụ hepatocellular

Mgbe ụbọchị 10 gachara, enwere ike ịhụ na cisplatin ga-eme ka ọnụọgụ ịba ọcha n'anya na mkpokọta bilirubin dị na serum oke.Ihe ndị a niile bụ ihe ịrịba ama nke mmerụ ahụ hepatocellular.Ma ọ bụrụGanoderma lucidum na-etinye aka n'otu oge ahụ, ọnụ ahịa na-abawanye ụba nwere ike ibelata nke ukwuu (Fig 1).

Isi mmalite data/Ọgwụ Devel Ther.2020;14:2335-2353.

Ọgụgụ 1 Mmetụta nke cisplatin naGanoderma lucidum na ihe ngosi mmerụ imeju

Tinye akụkụ anụ ahụ imeju n'okpuru microscope, ị ga-ahụkwa na cisplatin nwere ike ime ka imeju imeju (ọbara nke kwesịrị ịlaghachi n'ime obi na-egbochi ma na-adaba na veins imeju), mmebi cell (vacuoles na-apụta, nke bụ mgbanwe mbụ na ya. mmerụ ahụ cellular), apoptosis na necrosis, mana ọnọdụ ndị a nwekwara ike ibelata site na ijiGanoderma lucidum.

Ọgụgụ 2 Mmetụta nke cisplatin naGanoderma lucidum na hepatocytes

(2)Ganoderma lucidum na-akwalite ikike antioxidant nke sel imeju

Akụkọ a tụlere n'ihu n'ịtụle mmebi oxidative nke otu ọ bụla nke anụ ahụ imeju na-ata.Enwere ihe ngosi abụọ: MDA (malondialdehyde), ngwaahịa a kpụrụ mgbe e bibichara membranes cell site na free radicals, na H.₂O₂ (hydrogen peroxide), ngwaahịa dị n'etiti etolite ka metabolism nke radicals efu site na enzymes antioxidant.

Ngwaahịa abụọ a nwere mmetụta oxidative nke free radicals na a ghaghị ịgwọ ya tupu ha enwee ike "detoxified" n'ezie, ya mere ọnụ ọgụgụ ha nwere ike ịgwa anyị mmebi oxidative nke anụ ahụ imeju. "nwere tara ahụhụ" na "ga-ata ahụhụ".

N'ụzọ doro anya, cisplatin ga-eme ka nnukwu oxidative mebiri anụ ahụ imeju, ma ọ bụrụGanoderma lucidum na-etinye aka na ọgwụgwọ n'otu oge ahụ, mmebi dị otú ahụ nwere ike ibelata (Fig 3).

N'ihi na mgbanwe na ntinye nke enzymes antioxidant (SOD na GSH) na anụ ahụ imeju nke otu ọ bụla na mgbanwe ndị na-egosi mmebi oxidative gosipụtara omume na-emegideghị kpamkpam., enwere ike ịpụta naGanoderma lucidumga-abawanye ikike antioxidant nke anụ ahụ imeju ma belata mmebi site na "ịba ụba enzymes antioxidant".

Onyonyo3 Mmetụta nke cisplatin naGanoderma lucidum na mmebi oxidative nke anụ ahụ imeju

(3)Ganoderma lucidum na-akwalite ikike mgbochi mkpali nke mkpụrụ ndụ imeju

Cisplatin na-eyi ndụ nke mkpụrụ ndụ egwu site n'imebi DNA na ime ka ọnụ ọgụgụ buru ibu nke free radicals;sel ndị nọ n'okpuru nrụgide ga-agbanye onye isi mgba ọkụ NF-kB nke na-achịkwa nzaghachi mbufụt, na-eme ka mkpụrụ ndụ na-emepụta ma hapụ ụbụrụ necrosis factor (TNF-α) na cytokines ndị ọzọ iji mee ka ikuku mbụ nke mmeghachi omume mkpasu iwe na-ada ụda maka mgbochi.

Ozugbo emechara, mkpụrụ ndụ ndị ahụ nke mmebi oxidative ma ọ bụ mbufụt gburu ga-ahapụ cytokine ọzọ, HMGB-1, iji mee ka mkpụrụ ndụ ndị ọzọ na-alụso ọrịa ọgụ rụọ ọrụ, na-ebute ebili mmiri nke mbufụt.

Na-aga n'ihu mbufụt ga-ọ bụghị naanị, n'aka nke ya, na-abawanye mmebi nke oxidative kamakwa na-eme ka mkpụrụ ndụ ndị ọzọ na-anwụ anwụ, na ọbụna mee ka anụ ahụ imeju jiri nwayọọ nwayọọ malite fibrosis n'oge usoro mbufụt na nrụzi ugboro ugboro.

Ọ dabara nke ọma, dị kaGanoderma lucidum nwere ike ibelata mmebi oxidative nke cisplatin na-akpata, nnwale anụmanụ gosikwara na ijikọ cisplatin na ijikọ ọnụ.Ganoderma lucidum nwere ike igbochi mmalite nke mbufụt mgba ọkụ NF-kB, belata mbufụt-akwalite TNF-ana HMGB-1, ma na-abawanyecytokine mgbochi mkpali IL-10na anụ ahụ nke imeju n'otu oge (Fig 4).

Ejikọtara ọnụ, mmetụta ndị a ọ bụghị nanị na-egbochi mbufụt kamakwa belata ntinye nke collagen ma gbochie ọganihu nke fibrosis imeju (Nyocha 5).

Isi mmalite data/Ọgwụ Devel Ther.2020;14: 2335-2353 .

Ọgụgụ 4 Mmetụta nke cisplatin naGanoderma lucidum na mbufụt nke imeju anụ ahụ

Isi mmalite data/Ọgwụ Devel Ther.2020;14: 2335-2353 .

Ọgụgụ 5 Mmetụta nke cisplatin na Ganoderma lucidum na imeju fibrosis

(4)Ganoderma lucidum na-akwalite ikike mgbochi apoptotic nke mkpụrụ ndụ imeju

Ma site na mmebi oxidative ma ọ bụ mmebi mkpali, cisplatin ga-emecha rụọ ọrụ "apoptosis" ma mee ka mkpụrụ ndụ imeju nwụọ.

N'ikwu ya n'ụzọ ọzọ, ọ bụrụ na mkpụrụ ndụ imeju nwere ike ijide usoro nchebe ikpeazụ, ha ga-enwekwu ohere ịlanarị ma belata oke mmebi imeju.

Enwere ọtụtụ mkpụrụ ndụ protein na-achịkwa apoptosis.N'ime ha, ndị nnọchiteanya kachasị bụ: p53, nke nwere ike ịkwalite apoptosis, Bcl-2, nke nwere ike igbochi apoptosis, na caspase-3, nke na-eme apoptosis na nkeji ikpeazụ.

Dị ka ndị nchọpụta si kwuo'nyocha nke anụ ahụ imeju nke anụmanụ nnwale na otu ọ bụla,Ganoderma lucidum nwere ike ọ bụghị nanị na-akwalite okwu nke Bcl-2 kamakwa igbochi okwu nke p53 na caspase-3, nke nwere ike inye ike mgbochi apoptotic ike maka imeju mkpụrụ ndụ.

(5) Ganoderic acid na-arụ ọrụ dị mkpa na-egbochi mkpali

Site na mgbochi-oxidation, mgbochi mbufụt, mgbochi apoptosis na-arụ ọrụ n'ezie nke ibelata mmebi imeju, ndị nchọpụta achịkọtara usoro nkeGanoderma lucidum na igbochi hepatotoxicity cisplatin n'ime eserese a maka ntụaka gị.

Isi mmalite data/Ọgwụ Devel Ther.2020;14: 2335-2353 .

Ọgụgụ 6 Usoro Ganoderma lucidum na-egbochi nsị imeju nke cisplatin

Na njedebe nke ọmụmụ a, nyocha nke"usoro ịme anwansị docking molekụla”chọpụtara na ọ dịkarịa ala 14 ganoderic acid na triterpenes nkeGanoderma lucidum (dị ka egosiri na tebụl dị n'okpuru) nwere ike jikọta ozugbo na nke ọma na cytokine HMGB-1, si otú a na-eme ka ọrụ pro-inflammatory nke HMGB-1 kwụsị.

Ebe ọ bụ na mgbochi mbufụt bụ otu n'ime usoro dị mkpa nkeGanoderma lucidum iji belata hepatotoxicity nke Cisplatin,"ọgaranya na Ganoderic acid”aghọwo ihe egosi akụrụngwa nkeGanoderma lucidum iji chebe imeju.

Kedu ụdịGanoderma lucidum mgwa ihes nwere ike ịnwe nnukwu Ganoderic acids?Dị ka nchọpụta gara aga, a maara na ha na-abụkarị na "Ganoderma lucidum mkpụrụ osisiing mmanya na-egbu ahụ”.

Ọ bụ uru na-ekwu na oke naGanoderma lucidum otu na-eri naanịGanoderma lucidum fọrọ nke nta ka ọ dị ka oke nanjikwa otu n'ime nsonaazụ nnwale ndị a kpọtụrụ aha n'elu, na-egosi naGanoderma lucidum dị oke mma maka oriri.

Na mgbakwunye, usoro nke ijiGanoderma lucidum dịkwa oke mkpa.Ọ bụrụ na ị dị njikere reviw chaatị e gosiri n’isiokwu a, ọ naghị esiri ike ịhụ na “Enke ukwuuDay Otu” nwere mmetụta kacha mma.

N'ezie, Enke ukwuuDay Otu has mmetụta kacha mma n'ibelata ịba ọcha n'anyana Nsi gbasara akụrụ nke cisplatin na nnwale anụmanụ,nke bu ichet si ọzọGanoderma lucidum otu.

Gịnị bụ ngosipụta kpọmkwem nke mmetụta ọma ndị ahụ e kwuru n’elu?Nọrọ na-ekiri maka "Nkebi nke 2Ganoderma lucidum na-echebe akụrụ vs. Cisplatin nephrotoxicity”.

[Ebe data]

1.Hanan M Hassan, et al.Mgbochi nke mmerụ ịba ọcha n'anya Cisplatin kpatara na oke site na Alarmin High-Mobility Group Box-1 PathwayGanoderma lucidum: Ihe omumu ihe omumu na nnwale.Drug Des Devel Ther.2020;14: 2335-2353 .

2.Yasmen F Mahran, et al.Ganoderma lucidumNa-egbochi Nephrotoxicity Cisplatin na-ebute site na Mgbochi nke Epidermal Growth Factor Retator Signaling na Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao

Wu Tingyao na-akọ akụkọ mbụGanoderma lucidumozi kemgbe 1999. O bu odeeỌgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede, na onye nwe ya bụ GANOHERB ★ Ọrụ ndị dị n'elu enweghị ike ịmegharị, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke GanoHerb ★ Ọ bụrụ na enyere ikike iji ọrụ ndị ahụ, ha ekwesịrị iji ya mee ihe n'ime oke ikike ma gosipụta isi iyi: GanoHerb ★ Mmebi nke nkwupụta ahụ dị n'elu, GanoHerb ga-agbaso ọrụ iwu metụtara ya ★ Wu Tingyao dere ederede mbụ nke isiokwu a n'asụsụ Chinese wee sụgharịa ya n'asụsụ Bekee site n'aka Alfred Liu.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.

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